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MX2009005949A - Plegamiento de union de oligonucleotido/oligosacarido (ob) usado como estructura para diseño de nuevos enlaces especificos. - Google Patents

Plegamiento de union de oligonucleotido/oligosacarido (ob) usado como estructura para diseño de nuevos enlaces especificos.

Info

Publication number
MX2009005949A
MX2009005949A MX2009005949A MX2009005949A MX2009005949A MX 2009005949 A MX2009005949 A MX 2009005949A MX 2009005949 A MX2009005949 A MX 2009005949A MX 2009005949 A MX2009005949 A MX 2009005949A MX 2009005949 A MX2009005949 A MX 2009005949A
Authority
MX
Mexico
Prior art keywords
target
scaffold
new specific
specific binders
fold
Prior art date
Application number
MX2009005949A
Other languages
English (en)
Inventor
Frederic Pecorari
Pedro Alzari
Original Assignee
Pasteur Institut
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pasteur Institut filed Critical Pasteur Institut
Publication of MX2009005949A publication Critical patent/MX2009005949A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1041—Ribosome/Polysome display, e.g. SPERT, ARM
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C07K16/1228—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C07K16/1228—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K16/1232—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia from Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2318/00—Antibody mimetics or scaffolds
    • C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polyurethanes Or Polyureas (AREA)

Abstract

La presente invención se refiere al campo del diseño proteínico, y proporciona los medios para obtener las moléculas estables que se unen específicamente a un objetivo seleccionado entre una variedad grande de familias de ligandos. Particularmente, la presente invención proporciona los métodos para obtener una molécula que se une específicamente a un objetivo de interés, a través de un método de combinación de mutación/selección con una proteína de plegamiento de OB como molécula inicial. Particularmente, el objetivo de interés puede estar de una diferente forma natural química que la del objetivo nativo de la proteína de plegamiento de OB usada como molécula inicial.
MX2009005949A 2006-12-04 2007-12-04 Plegamiento de union de oligonucleotido/oligosacarido (ob) usado como estructura para diseño de nuevos enlaces especificos. MX2009005949A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06291869A EP1930342B1 (en) 2006-12-04 2006-12-04 OB-fold used as scaffold for engineering new specific binders
PCT/IB2007/004388 WO2008068637A2 (en) 2006-12-04 2007-12-04 Ob-fold used as scaffold for engineering new specific binders

Publications (1)

Publication Number Publication Date
MX2009005949A true MX2009005949A (es) 2009-06-30

Family

ID=37964126

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009005949A MX2009005949A (es) 2006-12-04 2007-12-04 Plegamiento de union de oligonucleotido/oligosacarido (ob) usado como estructura para diseño de nuevos enlaces especificos.

Country Status (12)

Country Link
US (4) US20100145008A1 (es)
EP (3) EP1930342B1 (es)
JP (3) JP2010511691A (es)
CN (2) CN103145812A (es)
AT (1) ATE542830T1 (es)
AU (1) AU2007330409B2 (es)
CA (1) CA2671553C (es)
DK (1) DK2099817T3 (es)
ES (2) ES2602782T3 (es)
IL (1) IL199057A (es)
MX (1) MX2009005949A (es)
WO (1) WO2008068637A2 (es)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9181543B2 (en) 2006-05-26 2015-11-10 Obodies Limited OB fold domains
EP3492488A1 (en) 2007-08-22 2019-06-05 The Regents of The University of California Activatable binding polypeptides and methods of identification and use thereof
WO2010081173A2 (en) 2009-01-12 2010-07-15 Cytomx Therapeutics, Llc Modified antibody compositions, methods of making and using thereof
AU2010215761B2 (en) 2009-02-23 2017-04-06 Cytomx Therapeutics, Inc Proproteins and methods of use thereof
EP2478014A4 (en) * 2009-09-16 2013-11-27 Univ Massey FUSION POLYPEPTIDES AND USES THEREOF
EP2341079A1 (en) 2009-12-23 2011-07-06 Institut Pasteur Immunoglobulin-binding proteins derived from Sac7d and uses thereof
EP2469278A1 (en) 2010-12-21 2012-06-27 Institut Pasteur Reagentless fluorescent biosensors from nanofitins, rational design methods to create reagentless fluorescent biosensors and methods of their use
FR2974816A1 (fr) 2011-05-04 2012-11-09 Centre Nat Rech Scient Methode de generation de proteines
EP3489396B1 (en) 2012-12-27 2021-03-03 National Institute of Advanced Industrial Science and Technology Molecule library constructed on the basis of backbone structure of microprotein
FR3004650B1 (fr) 2013-04-22 2015-05-29 Affilogic Composition topique comprenant un variant d'une protéine sauvage à pli-OB, ainsi que son procédé de préparation
EP2955196A1 (en) 2014-06-10 2015-12-16 Effimune Antibodies directed against CD127
US10562946B2 (en) 2014-06-20 2020-02-18 Genentech, Inc. Chagasin-based scaffold compositions, methods, and uses
FR3027521B1 (fr) * 2014-10-24 2016-12-16 Affilogic Compositions pour administration par voie orale
JP6952605B2 (ja) 2015-04-24 2021-10-20 ジェネンテック， インコーポレイテッド 多特異性抗原結合タンパク質
SMT201900460T1 (it) 2016-02-29 2019-09-09 Ose Immunotherapeutics Anticorpi non antagonisti diretti contro la catena alfa del dominio extracellulare del recettore di il17 e loro uso nel trattamento del cancro
DK3443010T3 (da) 2016-04-14 2024-09-30 Ose Immunotherapeutics Nye anti-SIRPa-antistoffer og terapeutiske anvendelser deraf
EP3509616A1 (en) 2016-09-09 2019-07-17 H. Hoffnabb-La Roche Ag Selective peptide inhibitors of frizzled
CN110300764A (zh) 2017-02-17 2019-10-01 Ose免疫疗法 抗SIRPg抗体的新用途
EP3434692A1 (en) 2017-07-24 2019-01-30 Encefa Compounds which specifically binds to cd38 for use in the treatment of neurodegenerative diseases
WO2019073080A1 (en) 2017-10-13 2019-04-18 Ose Immunotherapeutics ANTI-SIRPA MODIFIED ANTIBODIES AND USES THEREOF
EP3483180A1 (en) * 2017-11-14 2019-05-15 Affilogic Multi specific molecules
US11714090B2 (en) 2017-12-15 2023-08-01 Syngenta Participations Ag Non-antibody ligands for detecting target proteins
CN112105646A (zh) 2018-03-13 2020-12-18 Ose免疫疗法 抗人SIRPa v1抗体的用途和生产抗SIRPa v1抗体的方法
JP2021520210A (ja) 2018-04-03 2021-08-19 オーエスイー・イミュノセラピューティクス 抗ケモカイン様受容体１抗体及びその治療応用
US20230242640A1 (en) 2018-08-22 2023-08-03 Ose Immunotherapeutics ANTI-SIRPg Compounds
EP3632924A1 (en) * 2018-10-07 2020-04-08 Affilogic Binders for inhibiting formation of multimeric proteins
CA3122899A1 (en) 2018-12-21 2020-06-25 Ose Immunotherapeutics Bifunctional molecule directed against human pd-1
EP3914616A1 (en) 2019-01-23 2021-12-01 Encefa Cd31 competitors and uses thereof
AR122263A1 (es) 2019-05-09 2022-08-31 Genentech Inc Métodos para producir anticuerpos
US11597751B2 (en) 2019-05-16 2023-03-07 Massachusetts Institute Of Technology Glycan-binding proteins and related compositions and methods
WO2021122729A1 (en) * 2019-12-18 2021-06-24 Bracco Imaging Spa Anti-her2 polypeptides derivatives as new diagnostic molecular probes
CA3157675A1 (en) * 2019-12-18 2021-06-24 Erika Reitano Anti-her2 polypeptides derivatives as new diagnostic molecular probes
EP3878858A1 (en) 2020-03-11 2021-09-15 Affilogic Variants of sac7d and their use in cancer therapy
GB202019817D0 (en) * 2020-12-15 2021-01-27 Univ Oxford Innovation Ltd Ligand-binding polypeptides and uses thereof
US12428457B2 (en) * 2021-01-29 2025-09-30 University Of South Florida Cold-shock protein scaffold for engineering non-antibody binding proteins
EP4043481A1 (en) 2021-02-15 2022-08-17 Affilogic Compounds and methods for extending half life of biomolecules
US20240166692A1 (en) 2021-03-18 2024-05-23 Affilogic Anti-factor c3 sac7d variants and their medical use for treating complement-mediated disorders
EP4059949A1 (en) 2021-03-18 2022-09-21 Affilogic Anti-factor c3 sac7d variants and their medical use for treating complement-mediated disorders
US20250145673A1 (en) * 2021-03-18 2025-05-08 Affilogic Polypeptides for complement inhibition
WO2023042332A1 (ja) * 2021-09-16 2023-03-23 日立グローバルライフソリューションズ株式会社 クリーンルーム施設
EP4190358A1 (en) 2021-12-05 2023-06-07 Affilogic Polypeptide as carrier for intestinal barrier crossing
JPWO2023140360A1 (es) * 2022-01-20 2023-07-27
TW202448509A (zh) 2023-05-12 2024-12-16 美商建南德克公司 減少抗體黏度之方法及組成物
WO2025073890A1 (en) 2023-10-06 2025-04-10 Institut National de la Santé et de la Recherche Médicale Method to capture circulating tumor extracellular vesicles

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7264963B1 (en) 1995-08-18 2007-09-04 Morphosys Ag Protein(poly)peptide libraries
AU4153497A (en) 1996-08-26 1998-03-19 Eli Lilly And Company Combinatorial process for preparing substituted thiophene libraries
DE60045243D1 (de) 1999-05-26 2010-12-30 Next Biomed Technologies Nbt Oy VERFAHREN UND MATERIALIEN ZUR ERZEUGUNG VON SH3 DOMäNEN MIT ANGEPASSTEN BINDUNGSEIGENSCHAFTEN
WO2001095927A1 (en) * 2000-06-14 2001-12-20 Imagene Co., Ltd. P43 anti-tumor therapeutic agent and three dimensional structure of its cytokine domain
AU1325102A (en) * 2000-10-16 2002-04-29 Phylos Inc Protein scaffolds for antibody mimics and other binding proteins
US7560260B2 (en) * 2002-07-25 2009-07-14 Bio-Rad Laboratories, Inc. Compositions with polymerase activity
US7666645B2 (en) 2002-10-23 2010-02-23 Bio-Rad Laboratories, Inc. Sso7-polymerase conjugate proteins
EP2194123B1 (en) * 2003-03-25 2012-08-22 Stratagene California DNA polymerase fusions and uses thereof
US7462490B2 (en) 2003-10-31 2008-12-09 Chevron Oronite Company Llc Combinatorial lubricating oil composition libraries
JP2007537716A (ja) * 2003-12-16 2007-12-27 コモンウェルス サイエンティフィック アンド インダストリアル リサーチ オーガナイゼイション サイトカイン結合ドメイン
GB0416651D0 (en) * 2004-07-26 2004-08-25 Proteo Target Aps Polypeptide
EP2261243A3 (en) * 2005-01-03 2011-08-10 F. Hoffmann-La Roche AG Hemopexin-like structure as polypeptide-scaffold
GB0500099D0 (en) * 2005-01-05 2005-02-09 Cambridge Antibody Tech Methods and means relating to protein variants
US9181543B2 (en) * 2006-05-26 2015-11-10 Obodies Limited OB fold domains
EP1892248A1 (en) 2006-08-21 2008-02-27 Eidgenössische Technische Hochschule Zürich Specific and high affinity binding proteins comprising modified SH3 domains of FYN kinase

Also Published As

Publication number Publication date
DK2099817T3 (en) 2015-05-18
CA2671553C (en) 2017-09-05
US10584330B2 (en) 2020-03-10
CN101652386A (zh) 2010-02-17
EP2570424B1 (en) 2016-09-28
HK1141304A1 (en) 2010-11-05
US11434585B2 (en) 2022-09-06
JP2010511691A (ja) 2010-04-15
HK1117548A1 (en) 2009-01-16
EP1930342A1 (en) 2008-06-11
US20100145008A1 (en) 2010-06-10
ATE542830T1 (de) 2012-02-15
AU2007330409B2 (en) 2013-04-18
ES2602782T3 (es) 2017-02-22
CA2671553A1 (en) 2008-06-12
WO2008068637A3 (en) 2008-10-30
IL199057A (en) 2016-02-29
EP1930342B1 (en) 2012-01-25
US20200181601A1 (en) 2020-06-11
JP2018035139A (ja) 2018-03-08
AU2007330409A1 (en) 2008-06-12
EP2099817B1 (en) 2015-02-11
US20170166887A1 (en) 2017-06-15
EP2570424A1 (en) 2013-03-20
EP2099817A2 (en) 2009-09-16
JP6684761B2 (ja) 2020-04-22
US9422548B2 (en) 2016-08-23
ES2536509T3 (es) 2015-05-26
CN101652386B (zh) 2013-03-20
US20160010083A1 (en) 2016-01-14
WO2008068637A2 (en) 2008-06-12
CN103145812A (zh) 2013-06-12
JP6253496B2 (ja) 2017-12-27
JP2014169304A (ja) 2014-09-18

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