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MX2009005009A - Compuestos heterociclicos biciclicos 4-cianofenilamino sustituidos como inhibidores del virus de inmunodeficiencia humana. - Google Patents

Compuestos heterociclicos biciclicos 4-cianofenilamino sustituidos como inhibidores del virus de inmunodeficiencia humana.

Info

Publication number
MX2009005009A
MX2009005009A MX2009005009A MX2009005009A MX2009005009A MX 2009005009 A MX2009005009 A MX 2009005009A MX 2009005009 A MX2009005009 A MX 2009005009A MX 2009005009 A MX2009005009 A MX 2009005009A MX 2009005009 A MX2009005009 A MX 2009005009A
Authority
MX
Mexico
Prior art keywords
cyanophenylamino
substituted bicyclic
heterocyclic compounds
bicyclic heterocyclic
hiv inhibitors
Prior art date
Application number
MX2009005009A
Other languages
English (en)
Inventor
Zhi Hong
Yung-Hyo Koh
Stephanie Shaw
Jean-Luc Girardet
Original Assignee
Ardea Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ardea Biosciences Inc filed Critical Ardea Biosciences Inc
Publication of MX2009005009A publication Critical patent/MX2009005009A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Esta solicitud involucra ciertos heterociclos bicíclicos 4-cianofenilamino sustituidos de fórmula (I) (ver fórmula (I)) en donde la línea punteada representa un enlace doble que puede ubicarse ya sea entre A y C(V) o entre C(V) y D, en donde A es S o C(Z); D es S o C(W); siempre que uno y solo uno de A y D sea S; en donde T es NH, O o S; y en donde otros sustituyentes se definen aquí; estos compuestos son inhibidores de transcriptasa inversa no nucleósida y tienen potencial como tratamiento anti VIH.
MX2009005009A 2006-11-09 2007-11-09 Compuestos heterociclicos biciclicos 4-cianofenilamino sustituidos como inhibidores del virus de inmunodeficiencia humana. MX2009005009A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85808206P 2006-11-09 2006-11-09
PCT/US2007/084342 WO2008058285A2 (en) 2006-11-09 2007-11-09 4-cyanophenylamino-substituted bicyclic heterocyclic compounds as hiv inhibitors

Publications (1)

Publication Number Publication Date
MX2009005009A true MX2009005009A (es) 2009-09-22

Family

ID=39365405

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009005009A MX2009005009A (es) 2006-11-09 2007-11-09 Compuestos heterociclicos biciclicos 4-cianofenilamino sustituidos como inhibidores del virus de inmunodeficiencia humana.

Country Status (6)

Country Link
US (3) US7595324B2 (es)
EP (1) EP2132211A4 (es)
BR (1) BRPI0718592A2 (es)
CA (1) CA2668997C (es)
MX (1) MX2009005009A (es)
WO (1) WO2008058285A2 (es)

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US20060229305A1 (en) * 2005-03-22 2006-10-12 Markus Berger Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
CA2668997C (en) 2006-11-09 2012-10-09 Ardea Biosciences, Inc. 4-cyanophenylamino-substituted bicyclic heterocyclic compounds as hiv inhibitors
CA2701292C (en) * 2007-10-25 2015-03-24 Genentech, Inc. Process for making thienopyrimidine compounds
GB0908394D0 (en) 2009-05-15 2009-06-24 Univ Leuven Kath Novel viral replication inhibitors
GB0913636D0 (en) 2009-08-05 2009-09-16 Univ Leuven Kath Novel viral replication inhibitors
KR101094446B1 (ko) * 2009-11-19 2011-12-15 한국과학기술연구원 단백질 키나아제 저해활성을 가지는 2,4,7-치환된 티에노［3,2-ｄ］피리미딘 화합물
US20140031250A1 (en) 2010-10-07 2014-01-30 David Tsai Ting Biomarkers of Cancer
KR20140003438A (ko) 2010-11-15 2014-01-09 카톨리에케 유니버시테이트 루벤 항바이러스성 축합 헤테로사이클릭 화합물
EP2663312B1 (en) 2011-01-10 2017-10-11 Nimbus Iris, Inc. Irak inhibitors and uses thereof
CN104582705A (zh) 2012-01-10 2015-04-29 林伯士艾瑞斯公司 白介素-1受体相关激酶(irak)抑制剂和其用途
CN104902959A (zh) 2012-07-11 2015-09-09 林伯士艾瑞斯公司 Irak抑制剂和其用途
EP2872144A4 (en) 2012-07-11 2015-12-02 Nimbus Iris Inc IRAQ INHIBITOR AND USES THEREOF
AU2014205577A1 (en) * 2013-01-10 2015-05-28 Nimbus Iris, Inc. IRAK inhibitors and uses thereof
US8778365B1 (en) 2013-01-31 2014-07-15 Merz Pharmaceuticals, Llc Topical compositions and methods for making and using same
CN103242341B (zh) * 2013-04-19 2015-12-09 中国科学院广州生物医药与健康研究院 噻吩并2，4取代嘧啶类化合物及其药物组合物与应用
EP3049086A4 (en) 2013-09-27 2017-02-22 Nimbus Iris, Inc. Irak inhibitors and uses thereof
WO2015200697A1 (en) 2014-06-25 2015-12-30 The General Hospital Corporation Targeting human satellite ii (hsatii)
CN104926829A (zh) * 2015-06-08 2015-09-23 山东大学 一种噻吩并嘧啶类衍生物及其制备方法和应用
CN106831814B (zh) * 2017-02-15 2018-11-23 山东大学 一种噻吩并[3,2-d]嘧啶类HIV-1逆转录酶抑制剂及其制备方法和应用
CN106866699B (zh) * 2017-03-29 2019-03-08 山东大学 一种二芳基噻吩并嘧啶类hiv-1逆转录酶抑制剂及其制备方法和应用
CN109206435B (zh) * 2017-06-29 2020-09-08 中国医药研究开发中心有限公司 噻吩并[3,2-d]嘧啶类化合物及其制备方法和医药用途
JP2021512956A (ja) 2018-02-06 2021-05-20 ザ ジェネラル ホスピタル コーポレイション 腫瘍免疫応答のバイオマーカーとしてのリピートｒｎａ
CN108440559B (zh) * 2018-04-12 2020-06-16 山东大学 二芳基噻吩并嘧啶类hiv-1逆转录酶抑制剂及其制备方法和应用
CN114853781B (zh) * 2022-06-06 2023-09-08 山东大学苏州研究院 一种hiv-1逆转录酶靶向共价抑制剂及其制备方法和应用

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US5280026A (en) * 1989-05-30 1994-01-18 Smithkline Beecham Intercredit B.V. Thienopyrimidines
BRPI9909191B8 (pt) * 1998-03-27 2021-07-06 Janssen Pharmaceutica Nv derivados de pirimidina inibidores do hiv, seu uso e composição farmacêutica que os compreende
ATE240958T1 (de) 1998-11-12 2003-06-15 Neurocrine Biosciences Inc Crf rezeptor-antagonisten und darauf bezogene methoden
JO3429B1 (ar) 2001-08-13 2019-10-20 Janssen Pharmaceutica Nv مشتقات برميدينات مثبطة فيروس الايدز
CA2472619A1 (en) * 2002-01-10 2003-07-24 Bayer Corporation Fused pyrimidine derivates as rho-kinase inhibitors
EA011164B1 (ru) 2003-02-07 2009-02-27 Янссен Фармацевтика Н. В. Производные пиримидина для профилактики вич-инфекции
KR20060121878A (ko) 2003-09-25 2006-11-29 얀센 파마슈티카 엔.브이. Ｈｉｖ를 저해하는 퓨린 유도체
CA2668997C (en) 2006-11-09 2012-10-09 Ardea Biosciences, Inc. 4-cyanophenylamino-substituted bicyclic heterocyclic compounds as hiv inhibitors

Also Published As

Publication number Publication date
CA2668997C (en) 2012-10-09
WO2008058285A3 (en) 2009-04-09
EP2132211A2 (en) 2009-12-16
US20120225894A1 (en) 2012-09-06
BRPI0718592A2 (pt) 2017-06-06
EP2132211A4 (en) 2011-12-07
US8324223B2 (en) 2012-12-04
US20090281124A1 (en) 2009-11-12
US8211898B2 (en) 2012-07-03
US20080176871A1 (en) 2008-07-24
CA2668997A1 (en) 2008-05-15
US7595324B2 (en) 2009-09-29
WO2008058285A2 (en) 2008-05-15

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