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MX2009004439A - Composicion de ibuprofeno. - Google Patents

Composicion de ibuprofeno.

Info

Publication number
MX2009004439A
MX2009004439A MX2009004439A MX2009004439A MX2009004439A MX 2009004439 A MX2009004439 A MX 2009004439A MX 2009004439 A MX2009004439 A MX 2009004439A MX 2009004439 A MX2009004439 A MX 2009004439A MX 2009004439 A MX2009004439 A MX 2009004439A
Authority
MX
Mexico
Prior art keywords
water
ibuprofen composition
soluble acid
ibuprofen
solubility
Prior art date
Application number
MX2009004439A
Other languages
English (en)
Inventor
Robert Shen
Original Assignee
Mcneil Ppc Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mcneil Ppc Inc filed Critical Mcneil Ppc Inc
Publication of MX2009004439A publication Critical patent/MX2009004439A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4172—Imidazole-alkanecarboxylic acids, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

La invención se refiere a una tableta de liberación inmediata capaz de ser masticada o desintegrada en la cavidad oral, que comprende una pluralidad de partículas en una matriz; las partículas contienen un ingrediente activo, tal como ibuprofeno, y un primer ácido soluble en agua que tiene una solubilidad mayor que aproximadamente 10 g/100 ml de agua a 20°C; y la matriz contiene un segundo ácido soluble en agua que tiene una solubilidad menor que aproximadamente 5 g/100 ml de agua a 20°C.
MX2009004439A 2006-10-25 2007-10-24 Composicion de ibuprofeno. MX2009004439A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85434906P 2006-10-25 2006-10-25
PCT/US2007/082348 WO2008052033A2 (en) 2006-10-25 2007-10-24 Ibuprofen composition

Publications (1)

Publication Number Publication Date
MX2009004439A true MX2009004439A (es) 2009-05-11

Family

ID=39223093

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009004439A MX2009004439A (es) 2006-10-25 2007-10-24 Composicion de ibuprofeno.

Country Status (8)

Country Link
US (1) US20080113021A1 (es)
EP (1) EP2094248A2 (es)
CN (1) CN101528205A (es)
AU (1) AU2007308986A1 (es)
BR (1) BRPI0718428A2 (es)
CA (1) CA2667207A1 (es)
MX (1) MX2009004439A (es)
WO (1) WO2008052033A2 (es)

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EP2493465B1 (en) 2009-10-26 2014-10-22 Sephoris Pharmaceuticals, LLC Treatment of sunburn using analgesics and antihistamines
WO2012056471A2 (en) * 2010-10-24 2012-05-03 Shasun Pharmaceuticals Limited Novel process for preparing dexibuprofen ready to compress granules
CN102258490B (zh) * 2011-07-01 2012-10-03 中美天津史克制药有限公司 布洛芬咀嚼片
PL2729130T3 (pl) 2011-07-07 2018-02-28 Janssen Sciences Ireland Uc Preparaty kombinowane darunawiru
CN102488681B (zh) * 2011-12-21 2013-03-13 西南大学 布洛芬苯海拉明口腔崩解片及其制备方法
AU2013318356A1 (en) 2012-09-18 2015-03-19 Mcneil-Ppc, Inc. Low melting propionic acid derivative particles for use in oral dosage forms
BR112015005968A2 (pt) 2012-09-18 2017-07-04 Mcneil Ppc Inc formas de dosagem orais de liberação prolongada compreendendo partículas derivadas do ácido propiônico com baixo ponto de fusão
US9636305B2 (en) * 2013-03-14 2017-05-02 Redhill Biopharma Ltd. Antiemetic extended release solid dosage forms
JP6461186B2 (ja) 2014-03-11 2019-01-30 レッド ヒル バイオファーマ リミテッドＲｅｄＨｉｌｌ Ｂｉｏｐｈａｒｍａ Ｌｔｄ． 悪心、嘔吐または下痢の症状を処置するためのオンダンセトロン徐放固形製剤
US20150290174A1 (en) * 2014-04-11 2015-10-15 Resuscitate MOE LLC Pharmaceutical formulations and method of using the same for alleviating symptoms of hangover, stomach flu or migraine
ES2926494T3 (es) * 2015-03-26 2022-10-26 Sen Jam Pharmaceutical Llc Combinación de naproxeno y fexofenadina para inhibir los síntomas asociados con veisalgia
MX383987B (es) * 2015-12-28 2025-03-14 Ssp Co Ltd Japan Preparación farmacéutica compactada.
CN111035764B (zh) * 2018-10-14 2021-09-07 深圳市健元医药科技有限公司 一种治疗类风湿性关节炎的组合物及其制备方法
GB2585411B (en) 2019-02-22 2023-10-04 Catalent Uk Swindon Zydis Ltd Preserving functionally-coated API particles produced by solventless mixing processes in aqueous suspension
PL3927314T3 (pl) * 2019-02-22 2024-02-19 Catalent U.K. Swindon Zydis Limited Minimalizacja aglomeracji materiału powlekającego cząstki leku podczas przechowywania dla ustabilizowania czasów rozpadu produktów farmaceutycznych
PL3927322T3 (pl) 2019-02-22 2024-02-05 Catalent U.K. Swindon Zydis Limited Minimalizacja napowietrzania zawiesin podczas mieszania typu in-line
KR20210129649A (ko) 2019-02-22 2021-10-28 카탈렌트 유.케이. 스윈던 지디스 리미티드 이부프로펜을 포함하는 약학적 조성물의 응집, 에어레이션 최소화 및 코팅 보존
EP4188324A1 (en) 2020-07-31 2023-06-07 Catalent U.K. Swindon Zydis Limited Pharmaceutical compositions comprising coated api

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Also Published As

Publication number Publication date
EP2094248A2 (en) 2009-09-02
BRPI0718428A2 (pt) 2013-11-12
CN101528205A (zh) 2009-09-09
AU2007308986A1 (en) 2008-05-02
US20080113021A1 (en) 2008-05-15
WO2008052033A3 (en) 2008-06-12
CA2667207A1 (en) 2008-05-02
WO2008052033A2 (en) 2008-05-02

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