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MX2009004371A - Proceso para la preparacion de 5-alquil-7h-pirrolo[2,3-d]piri-midi n-2-oles. - Google Patents

Proceso para la preparacion de 5-alquil-7h-pirrolo[2,3-d]piri-midi n-2-oles.

Info

Publication number
MX2009004371A
MX2009004371A MX2009004371A MX2009004371A MX2009004371A MX 2009004371 A MX2009004371 A MX 2009004371A MX 2009004371 A MX2009004371 A MX 2009004371A MX 2009004371 A MX2009004371 A MX 2009004371A MX 2009004371 A MX2009004371 A MX 2009004371A
Authority
MX
Mexico
Prior art keywords
ols
pyrrolo
alkyl
preparing
pyrimidine
Prior art date
Application number
MX2009004371A
Other languages
English (en)
Inventor
Mark S Bednarz
Wenxue Wu
Ramanaiah C Kanamarlapudi
Original Assignee
Lexicon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lexicon Pharmaceuticals Inc filed Critical Lexicon Pharmaceuticals Inc
Publication of MX2009004371A publication Critical patent/MX2009004371A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se describen métodos para la preparación de 5-alquil-7H-pirrolo[2, 3-d]pirimidin-4-oles, como nuevos compuestos útiles en su preparación. Un método específico abarcado por la invención es representado en el siguiente esquema de reacción: (ver fórmula (I), (II), (III)).
MX2009004371A 2006-10-23 2007-10-22 Proceso para la preparacion de 5-alquil-7h-pirrolo[2,3-d]piri-midi n-2-oles. MX2009004371A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85389106P 2006-10-23 2006-10-23
PCT/US2007/082049 WO2008051887A1 (en) 2006-10-23 2007-10-22 Process for preparing 5-alkyl-7h-pyrrolo[2,3-d]pyrimidine-2-ols

Publications (1)

Publication Number Publication Date
MX2009004371A true MX2009004371A (es) 2009-06-11

Family

ID=38962766

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009004371A MX2009004371A (es) 2006-10-23 2007-10-22 Proceso para la preparacion de 5-alquil-7h-pirrolo[2,3-d]piri-midi n-2-oles.

Country Status (18)

Country Link
US (1) US7951941B2 (es)
EP (1) EP2084130B1 (es)
JP (1) JP5253403B2 (es)
KR (1) KR20090091140A (es)
CN (1) CN101535251B (es)
AU (1) AU2007309131B2 (es)
BR (1) BRPI0717473A2 (es)
CA (1) CA2667267A1 (es)
DK (1) DK2084130T3 (es)
EA (1) EA016132B1 (es)
ES (1) ES2390366T3 (es)
IL (1) IL198203A0 (es)
MX (1) MX2009004371A (es)
NZ (1) NZ576291A (es)
PL (1) PL2084130T3 (es)
PT (1) PT2084130E (es)
WO (1) WO2008051887A1 (es)
ZA (1) ZA200902715B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA019488B1 (ru) * 2008-04-21 2014-04-30 Лексикон Фармасьютикалз, Инк. Ингибиторы limk2 и способы их применения

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5753664A (en) 1995-03-16 1998-05-19 Takeda Chemical Industries, Ltd. Heterocyclic compounds, their production and use
FR2881742B1 (fr) * 2005-02-10 2007-09-07 Aventis Pharma Sa Pyrroles substitues, compositions les contenant, procede de fabrication et utilisation

Also Published As

Publication number Publication date
CN101535251A (zh) 2009-09-16
ZA200902715B (en) 2010-07-28
ES2390366T3 (es) 2012-11-12
PL2084130T3 (pl) 2012-11-30
JP2010507591A (ja) 2010-03-11
KR20090091140A (ko) 2009-08-26
CN101535251B (zh) 2012-08-22
BRPI0717473A2 (pt) 2014-03-11
JP5253403B2 (ja) 2013-07-31
IL198203A0 (en) 2009-12-24
US7951941B2 (en) 2011-05-31
EA016132B1 (ru) 2012-02-28
US20080097098A1 (en) 2008-04-24
DK2084130T3 (da) 2012-09-17
EP2084130A1 (en) 2009-08-05
CA2667267A1 (en) 2008-05-02
NZ576291A (en) 2011-10-28
HK1132730A1 (en) 2010-03-05
WO2008051887A1 (en) 2008-05-02
PT2084130E (pt) 2012-08-22
AU2007309131A1 (en) 2008-05-02
AU2007309131B2 (en) 2012-06-21
EP2084130B1 (en) 2012-06-27
EA200970406A1 (ru) 2009-10-30

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