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MX2009003838A - Anticuerpos anti-cd20 y metodos de uso. - Google Patents

Anticuerpos anti-cd20 y metodos de uso.

Info

Publication number
MX2009003838A
MX2009003838A MX2009003838A MX2009003838A MX2009003838A MX 2009003838 A MX2009003838 A MX 2009003838A MX 2009003838 A MX2009003838 A MX 2009003838A MX 2009003838 A MX2009003838 A MX 2009003838A MX 2009003838 A MX2009003838 A MX 2009003838A
Authority
MX
Mexico
Prior art keywords
antibodies
compositions
antibody
antigen
methods
Prior art date
Application number
MX2009003838A
Other languages
English (en)
Inventor
Ernest S Smith
Terrence L Fisher Jr
Original Assignee
Vaccinex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vaccinex Inc filed Critical Vaccinex Inc
Publication of MX2009003838A publication Critical patent/MX2009003838A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/565—Complementarity determining region [CDR]
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Abstract

Se proveen composiciones y métodos para tratar enfermedades asociadas con CD2o, incluyendo linfomas, enfermedades autoinmunes y rechazos de transplantes. Las composiciones incluyen anticuerpos anti-CD20 capaces de unirse a un antígeno CD20 humano ubicado sobre la superficie de una célula que expresa CD20 humana, en donde el anticuerpo tiene citotoxicidad mediada por célula dependiente del complemento incrementada (CDC) que es alcanzada al tener al menos una CDR optimizada manipulada dentro de la región variable del anticuerpo. Las composiciones también incluyen fragmentos de unión a antígenos, variantes y derivados de anticuerpos monoclonales, líneas celulares que producen estas de composiciones anticuerpos y moléculas de ácido nucleico aisladas que codifican las secuencias de aminoácidos de los anticuerpos. La invención además incluye composiciones farmacéuticas que comprenden los anticuerpos anti-CD20 de la invención, o fragmentos de unión a antígenos, variantes, o derivados de los mismos, en un portador farmacéuticamente aceptable y métodos de uso de estos anticuerpos anti-CD20.
MX2009003838A 2006-10-10 2007-10-10 Anticuerpos anti-cd20 y metodos de uso. MX2009003838A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US85060406P 2006-10-10 2006-10-10
US11/869,170 US9382327B2 (en) 2006-10-10 2007-10-09 Anti-CD20 antibodies and methods of use
PCT/US2007/080925 WO2008063771A2 (en) 2006-10-10 2007-10-10 Anti-cd20 antibodies and methods of use

Publications (1)

Publication Number Publication Date
MX2009003838A true MX2009003838A (es) 2009-07-02

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MX2009003838A MX2009003838A (es) 2006-10-10 2007-10-10 Anticuerpos anti-cd20 y metodos de uso.

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US (2) US9382327B2 (es)
EP (1) EP2084189B1 (es)
JP (1) JP5129818B2 (es)
KR (2) KR101197542B1 (es)
CN (1) CN101583626B (es)
AU (1) AU2007324130B2 (es)
BR (1) BRPI0717363B8 (es)
CA (1) CA2665728C (es)
DK (1) DK2084189T3 (es)
ES (1) ES2632390T3 (es)
IL (1) IL198020A (es)
MX (1) MX2009003838A (es)
NZ (1) NZ576081A (es)
PT (1) PT2084189T (es)
WO (1) WO2008063771A2 (es)

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WO2008104386A2 (en) 2007-02-27 2008-09-04 Abbott Gmbh & Co. Kg Method for the treatment of amyloidoses
RS53595B1 (sr) 2007-07-16 2015-02-27 Genentech, Inc. Anti-cd79b antitela i imunokonjugati i metode upotrebe
ES2528922T3 (es) 2007-07-16 2015-02-13 Genentech, Inc. Anticuerpos anti-CD79b humanizados e inmunoconjugados y métodos de uso
AU2009274129B2 (en) * 2008-07-21 2016-02-25 Immunomedics Inc. Structural variants of antibodies for improved therapeutic characteristics
EP2405937A4 (en) * 2009-01-16 2012-06-20 Glaxosmithkline Llc CANCER THERAPY USING A COMBINATION OF BENDAMUSTIN AND AN ANTIBODY AGAINST CD20
JP2012517806A (ja) * 2009-02-16 2012-08-09 バイオレックス・セラピューティクス インコーポレイテッド ヒト化抗ｃｄ２０抗体および使用方法
WO2010126898A1 (en) * 2009-04-27 2010-11-04 The Trustees Of The University Of Pennsylvania Methods for reducing the level of alloantibodies in a subject
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