[go: up one dir, main page]

MX2009003727A - Acidos y esteres boronicos como inhibidores de amida hidrolasa de acido graso. - Google Patents

Acidos y esteres boronicos como inhibidores de amida hidrolasa de acido graso.

Info

Publication number
MX2009003727A
MX2009003727A MX2009003727A MX2009003727A MX2009003727A MX 2009003727 A MX2009003727 A MX 2009003727A MX 2009003727 A MX2009003727 A MX 2009003727A MX 2009003727 A MX2009003727 A MX 2009003727A MX 2009003727 A MX2009003727 A MX 2009003727A
Authority
MX
Mexico
Prior art keywords
inhibitors
esters
boronic acids
fatty amide
formulae
Prior art date
Application number
MX2009003727A
Other languages
English (en)
Inventor
Julian Adams
Louis Grenier
Tao Liu
Mark L Behnke
Alfredo C Castro
Catherine A Evans
Michael J Grogan
Daniel A Snyder
Thomas T Tibbitts
Original Assignee
Infinity Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39323893&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2009003727(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Infinity Pharmaceuticals Inc filed Critical Infinity Pharmaceuticals Inc
Publication of MX2009003727A publication Critical patent/MX2009003727A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/05—Cyclic compounds having at least one ring containing boron but no carbon in the ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Anesthesiology (AREA)

Abstract

La presente invención proporciona compuestos, y sus composiciones farmacéuticas, abarcadas por la fórmula (I), (II), o (III). La presente invención también proporciona métodos para tratar enfermedad, trastorno o afección mediada por FAAH mediante la administración de una cantidad terapéuticamente afectiva de un compuesto provisto de la fórmula (I), (II), o (III), o su composición farmacéutica, a un paciente en la necesidad de la misma. Adicionalmente, la presente invención proporciona métodos para inhibir FAAH en un paciente mediante la administración de una cantidad terapéuticamente afectiva de un compuesto de la fórmula (I), (II), o (III), o su composición farmacéutica a un paciente en la necesidad de la misma.
MX2009003727A 2006-10-10 2007-10-10 Acidos y esteres boronicos como inhibidores de amida hidrolasa de acido graso. MX2009003727A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85052006P 2006-10-10 2006-10-10
PCT/US2007/021626 WO2008063300A2 (en) 2006-10-10 2007-10-10 Boronic acids and esters as inhibitors of fatty acid amide hydrolase

Publications (1)

Publication Number Publication Date
MX2009003727A true MX2009003727A (es) 2009-06-26

Family

ID=39323893

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009003727A MX2009003727A (es) 2006-10-10 2007-10-10 Acidos y esteres boronicos como inhibidores de amida hidrolasa de acido graso.

Country Status (26)

Country Link
US (6) US7947663B2 (es)
EP (4) EP2073816B1 (es)
JP (2) JP5641600B2 (es)
KR (2) KR20090085623A (es)
CN (2) CN101563089A (es)
AR (1) AR063165A1 (es)
AT (1) ATE524188T1 (es)
AU (1) AU2007322268B2 (es)
BR (1) BRPI0719218A2 (es)
CA (1) CA2666224C (es)
CL (1) CL2007002910A1 (es)
DK (1) DK2073816T3 (es)
ES (1) ES2373697T3 (es)
IL (2) IL197932A (es)
JO (1) JO3598B1 (es)
MX (1) MX2009003727A (es)
NO (1) NO342439B1 (es)
NZ (1) NZ576851A (es)
PE (1) PE20081172A1 (es)
PH (1) PH12012500765A1 (es)
PT (1) PT2073816E (es)
RU (1) RU2492174C2 (es)
SG (3) SG10201502266RA (es)
TW (1) TWI451870B (es)
UA (1) UA101601C2 (es)
WO (1) WO2008063300A2 (es)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3598B1 (ar) 2006-10-10 2020-07-05 Infinity Discovery Inc الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني
BRPI0717596B8 (pt) 2006-10-18 2021-05-25 Pfizer Prod Inc compostos de éter biarílico uréia, seu uso e composição farmacêutica que os compreende
WO2009126691A1 (en) 2008-04-09 2009-10-15 Infinity Pharmaceuticals, Inc Inhibitors of fatty acid amide hydrolase
BR122013027950A2 (pt) * 2008-12-24 2019-12-10 BIAL PORTELA & Cª S A compostos farmacêuticos
US20100222381A1 (en) 2009-02-27 2010-09-02 Hariprasad Vankayalapati Cyclopentathiophene/cyclohexathiophene DNA methyltransferase inhibitors
EP2417115A4 (en) 2009-04-07 2012-10-31 Infinity Pharmaceuticals Inc FATTY ACID AMIDE HYDROLASE INHIBITORS
WO2010118155A1 (en) 2009-04-07 2010-10-14 Infinity Pharmaceuticals, Inc. Inhibitors of fatty acid amide hydrolase
US9062116B2 (en) 2009-04-23 2015-06-23 Infinity Pharmaceuticals, Inc. Anti-fatty acid amide hydrolase-2 antibodies and uses thereof
AR076687A1 (es) * 2009-05-18 2011-06-29 Infinity Pharmaceuticals Inc Isoxazolinas como inhibidores de la amidahidrolasa de acidos grasos y com-posiciones farmaceuticas que los contienen
US8927551B2 (en) 2009-05-18 2015-01-06 Infinity Pharmaceuticals, Inc. Isoxazolines as inhibitors of fatty acid amide hydrolase
US8765735B2 (en) 2009-05-18 2014-07-01 Infinity Pharmaceuticals, Inc. Isoxazolines as inhibitors of fatty acid amide hydrolase
US9149465B2 (en) 2009-05-18 2015-10-06 Infinity Pharmaceuticals, Inc. Isoxazolines as inhibitors of fatty acid amide hydrolase
US20130150346A1 (en) 2010-01-08 2013-06-13 Quest Ventures Ltd. Use of FAAH Inhibitors for Treating Parkinson's Disease and Restless Legs Syndrome
MX336742B (es) * 2010-02-03 2016-01-29 Infinity Pharmaceuticals Inc Inhibidores de amida hidrolasa de acido graso.
WO2011123719A2 (en) 2010-03-31 2011-10-06 Ironwood Pharmaceuticals, Inc. Use of faah inhibitors for treating abdominal, visceral and pelvic pain
WO2011151822A1 (en) * 2010-05-31 2011-12-08 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. 3-substituted vinylboronates and uses thereof
PL2624696T3 (pl) 2010-10-06 2017-07-31 Glaxosmithkline Llc Pochodne benzimidazolu jako inhibitory kinazy PI3
US20140051661A1 (en) * 2011-02-16 2014-02-20 The Texas A&M University System Novel lipogenic inhibitors and uses thereof
US9630979B2 (en) * 2011-09-29 2017-04-25 Infinity Pharmaceuticals, Inc. Inhibitors of monoacylglycerol lipase and methods of their use
CN104662028B (zh) * 2012-06-25 2017-05-24 托马斯杰弗逊大学 对具有异常的脂肪生成信号的癌症进行治疗的组合物和方法
EP2872506A1 (en) * 2012-07-10 2015-05-20 Bayer Pharma Aktiengesellschaft Method for preparing substituted triazolopyridines
WO2014062794A1 (en) * 2012-10-17 2014-04-24 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Compositions and methods for improving glucose uptake
CN105431435A (zh) * 2013-06-07 2016-03-23 拜耳制药股份公司 具有作为mps-1抑制剂的活性的取代的三唑并吡啶类
GB201516504D0 (en) 2015-09-17 2015-11-04 Astrazeneca Ab Imadazo(4,5-c)quinolin-2-one Compounds and their use in treating cancer
FR3051792B1 (fr) * 2016-05-30 2020-01-24 Ecole Superieure De Physique Et De Chimie Industrielles De La Ville De Paris Nouveaux composes, derives de dioxoborolane ou de dioxaborinane fonctionnalises, leur procede de preparation et leurs utilisations
CA3054138A1 (en) 2017-03-09 2018-09-13 The Penn State Research Foundation Boron-containing small molecules for inhibiting activity of a receptor-like protein tyrosine phosphatase
CN107602550B (zh) * 2017-10-25 2018-10-23 磐安县宸熙工艺品有限公司 一种脂肪酰胺水解酶抑制剂及其制备方法
WO2019173394A1 (en) 2018-03-05 2019-09-12 Wylder Nation Foundation Compositions and methods for activating signaling through the cb1 cannabinoid receptor for treating and preventing diseases and disorders characterized by abnormal cellular accumulation of sphingolipids such as sphingomyelin
EP3632908A1 (en) * 2018-10-02 2020-04-08 Inventiva Inhibitors of the yap/taz-tead interaction and their use in the treatment of cancer
MA53808A (fr) * 2018-10-05 2022-01-12 Pfizer Inhibiteurs de pde4 contenant du bore
CN113677350B (zh) * 2019-02-01 2025-01-14 里兰斯坦福初级大学理事会 Enpp1抑制剂和调节免疫反应的方法
BR112021020241A2 (pt) * 2019-04-12 2021-12-07 Riboscience Llc Derivados de heteroarila bicíclica como inibidores de ectonucleotídeo pirofosfatase fosfodiesterase 1
US20220362268A1 (en) * 2019-10-07 2022-11-17 Cornell University Antimicrobial and antiviral effects of c2-c7 alkyl boronic acids
US11058695B2 (en) * 2019-11-08 2021-07-13 Myongji University Industry And Academia Cooperation Foundation Inhibitor of carbapenem-hydrolyzing class D beta-lactamases
US11395829B2 (en) * 2019-11-21 2022-07-26 Myongji University Industry And Academia Cooperation Foundation Inhibitors of metallo-beta-lactamases produced by multidrug-resistant bacteria
CN112321625A (zh) * 2020-11-30 2021-02-05 河西学院 一种基于叶酸的mida硼酸酯-萘二甲酰亚胺类化合物及其制备与应用
EP4334326A1 (en) * 2021-05-04 2024-03-13 Sigma-Aldrich Co. LLC Chemically linkable nuclear targeting tags
WO2024155644A2 (en) * 2023-01-18 2024-07-25 Uwm Research Foundation, Inc. Combination therapy for cancer using ros-activated prodrugs and ros-amplifying therapeutics

Family Cites Families (242)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5025A (en) * 1847-03-20 Horatio allen
US6013A (en) * 1849-01-09 Improvement in molding and compressing cores
DE445224C (de) 1924-04-09 1927-06-01 Edward D Feldman Zarge mit abgeschraegten Seitenkanten
US2693688A (en) * 1951-11-23 1954-11-09 Bocchino Ernest Wrist cigarette lighter
US4270537A (en) 1979-11-19 1981-06-02 Romaine Richard A Automatic hypodermic syringe
US4499082A (en) 1983-12-05 1985-02-12 E. I. Du Pont De Nemours And Company α-Aminoboronic acid peptides
US4596556A (en) 1985-03-25 1986-06-24 Bioject, Inc. Hypodermic injection apparatus
CA1268808A (en) 1985-07-23 1990-05-08 Alan G. Macdiarmid High capacity polyaniline electrodes
CH671400A5 (es) * 1986-12-17 1989-08-31 Nii Prikladnych
CA1283827C (en) 1986-12-18 1991-05-07 Giorgio Cirelli Appliance for injection of liquid formulations
GB8704027D0 (en) 1987-02-20 1987-03-25 Owen Mumford Ltd Syringe needle combination
US4941880A (en) 1987-06-19 1990-07-17 Bioject, Inc. Pre-filled ampule and non-invasive hypodermic injection device assembly
US4940460A (en) 1987-06-19 1990-07-10 Bioject, Inc. Patient-fillable and non-invasive hypodermic injection device assembly
US4790824A (en) 1987-06-19 1988-12-13 Bioject, Inc. Non-invasive hypodermic injection device
DE3807862A1 (de) 1988-03-10 1989-09-21 Merck Patent Gmbh Smektische fluessigkristallphase
US5273680A (en) 1988-03-10 1993-12-28 Merck Patent Gesellschaft Mit Beschrankter Haftung Fluorinated oligophenyls and their use in liquid crystal materials
US5339163A (en) 1988-03-16 1994-08-16 Canon Kabushiki Kaisha Automatic exposure control device using plural image plane detection areas
FR2638359A1 (fr) 1988-11-03 1990-05-04 Tino Dalto Guide de seringue avec reglage de la profondeur de penetration de l'aiguille dans la peau
GB8829296D0 (en) * 1988-12-15 1989-01-25 Ici Plc Anti-tumour compounds
US5312335A (en) 1989-11-09 1994-05-17 Bioject Inc. Needleless hypodermic injection device
US5064413A (en) 1989-11-09 1991-11-12 Bioject, Inc. Needleless hypodermic injection device
DE59108963D1 (de) 1990-02-01 1998-05-20 Merck Patent Gmbh Verfahren zur Umsetzung von fluorierten Aromaten mit Elektrophilen
DE4014488A1 (de) 1990-05-07 1991-11-14 Merck Patent Gmbh Dioxaborinane und fluessigkristallines medium
US5190521A (en) 1990-08-22 1993-03-02 Tecnol Medical Products, Inc. Apparatus and method for raising a skin wheal and anesthetizing skin
US5527288A (en) 1990-12-13 1996-06-18 Elan Medical Technologies Limited Intradermal drug delivery device and method for intradermal delivery of drugs
DE59206518D1 (de) * 1991-02-25 1996-07-18 Hoffmann La Roche Flüssigkristalline Verbindungen mit endständigem 1-Alkinylrest
CA2109526C (en) 1991-04-30 1998-01-20 Dwight M. Peterson Liquid detergents with an aryl boroic acid
GB2258232B (en) 1991-07-31 1995-03-15 Merck Patent Gmbh Alkoxymethylene fluoroterphenyls and liquid crystalline medium
GB9118204D0 (en) 1991-08-23 1991-10-09 Weston Terence E Needle-less injector
SE9102652D0 (sv) 1991-09-13 1991-09-13 Kabi Pharmacia Ab Injection needle arrangement
AU661533B2 (en) * 1992-01-20 1995-07-27 Astrazeneca Ab Quinazoline derivatives
US5328483A (en) 1992-02-27 1994-07-12 Jacoby Richard M Intradermal injection device with medication and needle guard
CH683522A5 (de) 1992-03-13 1994-03-31 Hoffmann La Roche Verfahren zur Herstellung von Diarylen.
FR2688783A1 (fr) 1992-03-23 1993-09-24 Rhone Poulenc Chimie Nouveaux borates d'onium ou de complexe organometallique amorceurs cationiques de polymerisation.
FR2688790B1 (fr) * 1992-03-23 1994-05-13 Rhone Poulenc Chimie Compositions a base de polyorganosiloxanes a groupements fonctionnels reticulables et leur utilisation pour la realisation de revetements anti-adhesifs.
US5541061A (en) 1992-04-29 1996-07-30 Affymax Technologies N.V. Methods for screening factorial chemical libraries
PL167141B1 (pl) 1992-05-12 1995-07-31 Wojskowa Akad Tech Sposób otrzymywania związków ciekłokrystalicznych zawierających pierścień 1,3-dioksa- -2-boranu
JP3255965B2 (ja) 1992-05-26 2002-02-12 昭和シェル石油株式会社 反強誘電性液晶化合物
DE4220065A1 (de) 1992-06-19 1993-12-23 Merck Patent Gmbh Verfahren zur Herstellung von Pyrimidin-Derivaten
US5383851A (en) 1992-07-24 1995-01-24 Bioject Inc. Needleless hypodermic injection device
GB9220189D0 (en) 1992-09-24 1992-11-04 Central Research Lab Ltd Dioxane derivatives
US5569189A (en) 1992-09-28 1996-10-29 Equidyne Systems, Inc. hypodermic jet injector
GB9220750D0 (en) * 1992-10-02 1992-11-18 Merck Patent Gmbh Liquid crystalline material forming ananisotropic
DE4236103A1 (de) * 1992-10-26 1994-04-28 Hoechst Ag Verfahren zur Kreuzkupplung von aromatischen Boronsäuren mit aromatischen Halogenverbindungen oder Perfluoralkylsulfonaten
US5334144A (en) 1992-10-30 1994-08-02 Becton, Dickinson And Company Single use disposable needleless injector
EP0604289B1 (fr) 1992-12-17 1997-09-24 Valeo Systemes D'essuyage Procédé et dispositif d'alimentation d'un moteur électrique d'entrainement d'un bras d'essuie-glace de véhicule automobile
TW240217B (es) 1992-12-30 1995-02-11 Glaxo Group Ltd
US5576220A (en) 1993-02-19 1996-11-19 Arris Pharmaceutical Corporation Thin film HPMP matrix systems and methods for constructing and displaying ligands
FR2702485B1 (fr) 1993-03-10 1995-04-14 Rhone Poulenc Chimie Compositions à base de polyorganosiloxanes réticulables par voie cationique et leur utilisation dans le domaine de l'antiadhérence papier, de la protection des fibres optiques et des circuits imprimés.
US5563127A (en) 1993-03-24 1996-10-08 The Dupont Merck Pharmaceutical Company Boronic acid and ester inhibitors of thrombin
GB2278841A (en) * 1993-06-11 1994-12-14 Secr Defence Liquid crystal compounds, mixtures and devices
US5417885A (en) 1993-08-03 1995-05-23 Showa Shell Sekiyu Kabushiki Kaisha Antiferroelectric liquid crystal compound
US5431842A (en) 1993-11-05 1995-07-11 The Procter & Gamble Company Liquid detergents with ortho-substituted phenylboronic acids for inhibition of proteolytic enzyme
JPH07145174A (ja) 1993-11-22 1995-06-06 Takeda Chem Ind Ltd ジオキサボリナン系化合物、それらの製造方法、該化合物を含む液晶組成物および該組成物を用いた液晶光変調装置
JPH07165717A (ja) 1993-12-16 1995-06-27 Sumitomo Chem Co Ltd 複素環化合物およびその製造法
JPH07206715A (ja) 1994-01-21 1995-08-08 Sumitomo Chem Co Ltd 複素環化合物の製造法
DE19502178A1 (de) * 1994-01-27 1995-08-03 Hoechst Ag Thiadiazolderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Vorprodukte zur Herstellung von Flüssigkristallen
WO1995024176A1 (en) 1994-03-07 1995-09-14 Bioject, Inc. Ampule filling device
US5466220A (en) 1994-03-08 1995-11-14 Bioject, Inc. Drug vial mixing and transfer device
US5643893A (en) * 1994-06-22 1997-07-01 Macronex, Inc. N-substituted-(Dihydroxyboryl)alkyl purine, indole and pyrimidine derivatives, useful as inhibitors of inflammatory cytokines
GB2290787B (en) 1994-06-30 1998-10-28 Merck Patent Gmbh Benzene derivatives and a liquid-crystalline medium
JP3702426B2 (ja) 1994-08-03 2005-10-05 関東化学株式会社 トリフルオロメチルベンゼン誘導体および液晶組成物
FR2724660B1 (fr) * 1994-09-16 1997-01-31 Rhone Poulenc Chimie Amorceurs de reticulation, par voie cationique, de polymeres a groupements organofonctionnels, compositions a base de polyorganosiloxanes reticulables et contenant ces amorceurs et application desdites compositions en antiadherence
JPH0892137A (ja) 1994-09-26 1996-04-09 Sumitomo Chem Co Ltd 芳香族エステル化合物、その製造法および用途
FR2727416A1 (fr) 1994-11-24 1996-05-31 Rhone Poulenc Chimie Nouveaux amorceurs cationiques thermoactivables, de polymerisation et/ou de reticulation et compositions monomeres et/ou polymeres fonctionnels les mettant en oeuvre
DE4445224B4 (de) 1994-12-17 2014-03-27 Merck Patent Gmbh Benzolderivate
US5599302A (en) 1995-01-09 1997-02-04 Medi-Ject Corporation Medical injection system and method, gas spring thereof and launching device using gas spring
DE69629413T2 (de) * 1995-04-24 2004-04-01 Semiconductor Energy Laboratory Co., Ltd., Atsugi Flüssigkristallverbindung und diese enthaltende Flüssigkristall-Zusammensetzung
US5730723A (en) 1995-10-10 1998-03-24 Visionary Medical Products Corporation, Inc. Gas pressured needle-less injection device and method
US6271015B1 (en) 1995-06-12 2001-08-07 The Scripps Research Institute Fatty-acid amide hydrolase
JP3783246B2 (ja) 1995-07-18 2006-06-07 大日本インキ化学工業株式会社 ｐ−テルフェニル誘導体
EP0755918B1 (de) * 1995-07-28 2000-09-06 Rolic AG Photovernetzbare flüssigkristalline 1,2-Phenylen-Derivate
EP0846670A4 (en) 1995-08-09 1999-01-13 Chisso Corp CYCLOHEXANE DERIVATIVES AND LIQUID CRYSTAL COMPOSITIONS
US5893397A (en) 1996-01-12 1999-04-13 Bioject Inc. Medication vial/syringe liquid-transfer apparatus
FR2745288B1 (fr) 1996-02-27 1998-04-17 Adir Nouveaux derives de l'acide boronique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
GB9605334D0 (en) 1996-03-13 1996-05-15 British Nuclear Fuels Plc Biodecontamination reactor
GB9607549D0 (en) 1996-04-11 1996-06-12 Weston Medical Ltd Spring-powered dispensing device
JP3555325B2 (ja) 1996-04-12 2004-08-18 チッソ株式会社 ビアリール誘導体の製造方法
US5892131A (en) * 1997-05-29 1999-04-06 American Cyanamid Company Process for the preparation of pesticidal fluoroolefin compounds
US5849958A (en) 1997-03-17 1998-12-15 American Cyanamid Company 1,4,diaryl-2-fluoro-2-butene insecticidal and acaricidal agents
ZA974582B (en) 1996-06-03 1998-11-26 American Cyanamid Co Process and intermediate compounds for the preparation of pesticidal fluoroolefin compounds
PT811593E (pt) 1996-06-03 2002-11-29 Basf Ag Agentes insecticidas e acaricidas 1,4-diaril-2-fluor-2-buteno
US5998673A (en) * 1996-06-03 1999-12-07 American Cyanamid Company 1, 4-diaryl-2-fluoro-2-butene insecticidal and acaricidal agents
CA2206192A1 (en) 1996-06-13 1997-12-13 F. Hoffmann-La Roche Ag Modulation of lc132 (opioid-like) receptor function
JPH101450A (ja) * 1996-06-14 1998-01-06 Chisso Corp フッ素置換アルキルエーテル化合物、液晶組成物および液晶表示素子
US5856537A (en) 1996-06-26 1999-01-05 The Scripps Research Institute Inhibitors of oleamide hydrolase
JPH1025261A (ja) 1996-07-09 1998-01-27 Chisso Corp フェノール誘導体の製造方法
KR100338855B1 (ko) * 1996-07-31 2002-12-28 시오노기세이야쿠가부시키가이샤 신규 파라테르페닐 화합물
JP3899557B2 (ja) 1996-08-21 2007-03-28 大日本インキ化学工業株式会社 フルオロビフェニル誘導体
FR2752582B1 (fr) * 1996-08-21 2003-06-13 Rhone Poulenc Chimie Compositions a base de polyorganosiloxanes a groupements fonctionnels reticulables et leur utilisation pour la realisation de revetements anti-adherents
JP4526605B2 (ja) * 1996-08-28 2010-08-18 チッソ株式会社 ラテラルハロゲン置換基を有する４環化合物および液晶組成物
US6177440B1 (en) * 1996-10-30 2001-01-23 Eli Lilly And Company Substituted tricyclics
JPH10152491A (ja) 1996-11-21 1998-06-09 Dai Ichi Seiyaku Co Ltd 結晶性カルバペネム化合物
EP0959061A4 (en) 1996-11-25 2000-08-23 Chisso Corp 3,3'-DIFLUOROBIPHENYL DERIVATIVES, LIQUID CRYSTAL PREPARATIONS, AND LIQUID CRYSTAL DISPLAY ELEMENTS
US5925672A (en) 1996-12-06 1999-07-20 Neurosciences Research Foundation, Inc. Methods of treating mental diseases, inflammation and pain
FR2757530A1 (fr) 1996-12-24 1998-06-26 Rhodia Chimie Sa Utilisation pour la stereophotolithographie - d'une composition liquide photoreticulable par voie cationique comprenant un photoamorceur du type sels d'onium ou de complexes organometalliques
FR2757870B1 (fr) * 1996-12-30 1999-03-26 Rhodia Chimie Sa Utilisation de compositions silicones reticulables par voie cationique sous uv et d'un photoamorceur du type borate d'onium, pour le revetements de joints plats, notamment de joints de culasse
FR2758329B1 (fr) 1997-01-16 1999-02-12 Synthelabo Derives d'imidazole-4-butane boronique, leur preparation et leur utilisation en therapeutique
FR2758560B1 (fr) 1997-01-20 2000-02-04 Adir Nouveaux derives d'acides aminophenylboronique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2758723B1 (fr) 1997-01-28 1999-04-23 Sanofi Sa Utilisation des antagonistes des recepteurs aux cannabinoides centraux pour la preparation de medicaments
JP4098368B2 (ja) 1997-02-13 2008-06-11 チッソ株式会社 ビシクロ〔１．１．１〕ペンタン構造を有する液晶性化合物、液晶組成物及び液晶表示素子
DE19710614A1 (de) 1997-03-14 1998-09-17 Hoechst Ag (1,2,4)-Thiadiazolderivate, Verfahren zu ihrer Herstellung und ihre Verwendung
TR199902433T2 (xx) * 1997-04-01 2000-04-21 Astra Pharmaceuticals Ltd. Yeni piridin t�revleri ve bunlar� i�eren ispen�iyari bile�imler.
US5993412A (en) 1997-05-19 1999-11-30 Bioject, Inc. Injection apparatus
WO1998056392A1 (en) * 1997-06-13 1998-12-17 Northwestern University INHIBITORS OF β-LACTAMASES AND USES THEREFOR
IT1298087B1 (it) 1998-01-08 1999-12-20 Fiderm S R L Dispositivo per il controllo della profondita' di penetrazione di un ago, in particolare applicabile ad una siringa per iniezioni
PL197331B1 (pl) * 1998-03-31 2008-03-31 Shionogi & Co Sposób wytwarzania pochodnych kwasów 5-hydroksybenzo [b] -tiofeno-3-karboksylowych
DZ2769A1 (fr) 1998-04-17 2003-12-01 Lilly Co Eli Composés tricycliques substitués.
DE19909761A1 (de) 1998-04-17 1999-10-21 Merck Patent Gmbh Benzofuran- und Benzodifuran-Derivate
CA2269561C (en) * 1998-04-22 2007-06-05 Dainippon Ink And Chemicals, Inc. Naphthalene derivative and liquid crystal composition comprising the same
JP2000001463A (ja) 1998-06-12 2000-01-07 Dainippon Ink & Chem Inc ４−シアノベンゼン誘導体の製造方法
GB9814450D0 (en) 1998-07-04 1998-09-02 Sharp Kk Novel compounds
GB2339778A (en) * 1998-07-17 2000-02-09 Secr Defence Terphenyl Liquid Crystals
WO2000020466A1 (de) 1998-10-01 2000-04-13 Targor Gmbh Katalysatorsystem
DE19857765A1 (de) 1998-12-15 2000-06-21 Clariant Gmbh Verfahren zur Herstellung von para-Oxadiazolyl-phenyl-boronsäuren
DE19858594A1 (de) 1998-12-18 2000-06-21 Merck Patent Gmbh Verfahren zur Herstellung von Cyanbenzolboronsäuren
JP2002533349A (ja) * 1998-12-19 2002-10-08 バーゼル、ポリオレフィン、ゲゼルシャフト、ミット、ベシュレンクテル、ハフツング モノオルガノボランまたはジオルガノボランの製造方法
JP4865129B2 (ja) 1999-01-13 2012-02-01 ザ・リサーチ・ファウンデーション・オブ・ステイト・ユニバーシティ・オブ・ニューヨーク タンパク質キナーゼ阻害剤を設計するための新規の方法
JP4507294B2 (ja) 1999-05-27 2010-07-21 チッソ株式会社 ビアリール誘導体の製造方法
JP2001039975A (ja) 1999-07-26 2001-02-13 Eisai Co Ltd スルホキシド誘導体の結晶およびその製造法
JP2003509507A (ja) 1999-09-21 2003-03-11 キネティック リミテッド 液晶化合物
US6309406B1 (en) 1999-11-24 2001-10-30 Hamit-Darwin-Fresh, Inc. Apparatus and method for inducing epileptic seizures in test animals for anticonvulsant drug screening
KR100613176B1 (ko) * 1999-12-03 2006-08-17 오노 야꾸힝 고교 가부시키가이샤 트리아자스피로[5.5]운데칸 유도체 및 이들을유효성분으로 하는 약제
US20030096854A1 (en) 2002-06-12 2003-05-22 Ho-Shen Lin Substituted tricyclics
FR2805273B1 (fr) * 2000-02-18 2006-08-11 Rhodia Chimie Sa Traitement de surface de materiau plastique avec une composition a fonctions reactives polymerisable et/ou reticulable
DE10009714A1 (de) 2000-03-01 2001-09-06 Targor Gmbh Verfahren zur Herstellung von Mono- oder Di-organo-boranen
EP1130114A1 (en) * 2000-03-03 2001-09-05 Dr. van Haeringen Laboratorium B.V. Universal variable fragments
GB2362882A (en) 2000-06-02 2001-12-05 Sharp Kk Liquid crystalline optionally laterally fluorinated terphenyl with chiral 3,4-di[(un)saturated-alkoxy]butoxy or 1,4-di[(un)saturated-alkoxy]but-2-oxy terminus
CA2419238A1 (en) 2000-08-16 2002-02-21 University Of Alberta Non-pressurized methods for the preparation of conjugated solid supports for boronic acids
WO2002018355A1 (en) * 2000-08-23 2002-03-07 Eli Lilly And Company Oxazolyl-aryloxyacetic acid derivatives and their use as ppar agonists
US6927216B2 (en) 2000-10-03 2005-08-09 Bristol-Myers Squibb Pharma Company Cyclic sulfonyl compounds as inhibitors of metalloproteases
WO2002029057A2 (en) 2000-10-05 2002-04-11 Millenium Pharmaceuticals, Inc. 32144, a human fatty acid amide hydrolase and uses thereof
GB0100110D0 (en) * 2001-01-04 2001-02-14 Univ Leeds Modulation of calcium channel activity
WO2002057273A1 (en) * 2001-01-20 2002-07-25 Trigen Limited Serine protease inhibitors comprising a hydrogen-bond acceptor
JP4721027B2 (ja) 2001-03-29 2011-07-13 Ｄｉｃ株式会社 フェニルピリミジン誘導体の製造方法
US20030022864A1 (en) * 2001-04-24 2003-01-30 Ishaq Khalid S. 9-[(5-dihydroxyboryl)-pentyl] purines, useful as an inhibitor of inflammatory cytokines
US6858592B2 (en) * 2001-06-29 2005-02-22 Genzyme Corporation Aryl boronic acids for treating obesity
US7962950B2 (en) * 2001-06-29 2011-06-14 Hewlett-Packard Development Company, L.P. System and method for file system mandatory access control
US6617125B2 (en) * 2001-06-29 2003-09-09 Perkinelmer Life Sciences, Inc. Compositions for enhanced catalyzed reporter deposition
US6890940B2 (en) * 2001-06-29 2005-05-10 Kowa Co., Ltd. Bis(2-aryl-5-pyridyl) derivatives
DE60205824T2 (de) 2001-07-09 2006-05-18 Merck Patent Gmbh Thienothiophenderivate
EP1444981A1 (en) * 2001-10-11 2004-08-11 Katsuhiko Mikoshiba Intracellular calcium concentration increase inhibitors
EP1436332A2 (en) 2001-10-12 2004-07-14 Dow Global Technologies Inc. Metal complex compositions and their use as catalysts to produce polydienes
DE60219569T2 (de) * 2001-11-07 2007-12-27 Merck Patent Gmbh Flüssigkristalline Verbindung, flüssigkristallines Medium und Flüssigkristallanzeige
GB0126844D0 (en) * 2001-11-08 2002-01-02 Qinetiq Ltd Novel compounds
AU2002360453C1 (en) 2001-11-26 2009-06-18 The Brigham And Women's Hospital, Inc. Methods for treating autoimmune disorders, and reagents related thereto
DE10201764A1 (de) 2002-01-18 2003-07-31 Bayer Cropscience Ag Substituierte 4-Aminopyridin-Derivate
WO2003064484A1 (en) 2002-01-28 2003-08-07 Dow Global Technologies Inc. Metal complex compositions based on cobalt and their use as polymerization catalyst for olefins and dienes
DE10206759A1 (de) * 2002-02-19 2003-08-28 Dragoco Gerberding Co Ag Synergistische Mischungen von 1,2-Alkandiolen
DE10211597A1 (de) * 2002-03-15 2003-10-02 Merck Patent Gmbh Verfahren zur Herstellung von Ringverbindungen
WO2003105860A1 (en) * 2002-06-14 2003-12-24 Novo Nordisk A/S Pharmaceutical use of boronic acids and esters thereof
EP1546086A2 (en) * 2002-06-27 2005-06-29 Fujisawa Pharmaceutical Co., Ltd. Aminoalcohol derivatives
US7045652B2 (en) * 2002-07-03 2006-05-16 Pfizer Inc Processes for preparing substituted aryl boronic acids
EP1388538B1 (en) * 2002-07-09 2010-09-01 Merck Patent GmbH Polymerisation Initiator
US20040020447A1 (en) * 2002-08-05 2004-02-05 William Taylor Method and apparatus for advancing air into a fuel reformer by use of an engine vacuum
US20040115475A1 (en) * 2002-08-14 2004-06-17 Matsushita Electric Industrial Co., Ltd. Aromatic methylidene compound, methylstyrul compound for producing the same, production electroluminescent element
CA2505361A1 (en) * 2002-11-11 2004-05-27 Bayer Healthcare Ag Phenyl or heteroaryl amino alkane derivatives as ip receptor antagonist
US20080124275A1 (en) 2002-11-14 2008-05-29 The Scripps Research Institute Crystalline Form of Fatty Acid Amide Hydrolase (Faah)
WO2004048357A1 (de) 2002-11-27 2004-06-10 Merck Patent Gmbh Tetrahydropyran-derivate
US6924269B2 (en) * 2002-12-04 2005-08-02 Vdf Futureceuticals, Inc. Enzyme inhibitors and methods therefor
US7390806B2 (en) 2002-12-18 2008-06-24 Anacor Pharmaceuticals, Inc. Antibiotics containing borinic acid complexes and methods of use
BRPI0407662B8 (pt) * 2003-02-21 2021-05-25 Chiesi Farm Spa derivados do ácido 1-fenilalcanocarboxílico para o tratamento de doenças neurodegenerativas
EP2295433A3 (en) * 2003-03-06 2011-07-06 Eisai R&D Management Co., Ltd. JNK inhibitors
WO2004080989A1 (ja) 2003-03-10 2004-09-23 Sumitomo Chemical Company Limited フラン化合物の製造方法
MXPA05009885A (es) * 2003-03-14 2005-12-05 Astrazeneca Ab Nuevas triazolonas fusionadas y los usos de las mismas.
DE10325438A1 (de) * 2003-05-21 2004-12-09 Bayer Cropscience Ag Difluormethylbenzanilide
TWI378092B (en) * 2003-06-03 2012-12-01 Rib X Pharmaceuticals Inc Biaryl heterocyclic compounds and methods of making and using the same
JP2007505950A (ja) * 2003-06-10 2007-03-15 フルクラム・ファーマシューティカルズ・インコーポレーテッド β−ラクタマーゼ阻害剤およびその使用方法
US7017590B2 (en) * 2003-06-10 2006-03-28 Vivienne Joyce Mackinder Microwavable hair curling device
CA2529792A1 (en) 2003-06-16 2005-02-17 Anacor Pharmaceuticals, Inc. Hydrolytically-resistant boron-containing therapeutics and methods of use
US20070001055A1 (en) * 2003-06-25 2007-01-04 Smetannikov Vallery I Device for cargo disposition in an aircraft and for jettison said cargo therefrom
DE10337497A1 (de) * 2003-08-14 2005-03-10 Bayer Cropscience Ag 4-Biphenylsubstituierte-Pyrazolidin-3,5-dion-Derivate
US20070293542A1 (en) 2003-10-16 2007-12-20 Cali Brian M Selective Cox-2 Inhibitors
JP2007512244A (ja) * 2003-10-31 2007-05-17 フルクラム・ファーマシューティカルズ・インコーポレーテッド コロナウイルスプロテアーゼの阻害剤およびその使用方法
DE602004008100T2 (de) 2003-11-10 2008-04-30 Microbia Inc., Cambridge 4-biarylyl-1-phenylazetidin-2-one
WO2005051908A1 (en) * 2003-11-25 2005-06-09 Novo Nordisk A/S Indole derivatives for use as chemical uncoupler
US20070010559A1 (en) 2003-11-25 2007-01-11 Novo Nordisk A/S Indole derivatives for use as chemical uncoupler
JP4491666B2 (ja) 2003-12-02 2010-06-30 東ソー株式会社 フルオレン骨格を有するアリールアミン誘導体の製造方法とその合成中間体
GB2410745B (en) 2004-02-06 2007-07-25 Merck Patent Gmbh Cholestanyl derivatives
UA83416C2 (en) * 2004-02-13 2008-07-10 Баниу Фармасьютикал Ко., Лтд. Fused ring 4-oxopyrimidine derivative
GB0403744D0 (en) 2004-02-20 2004-03-24 Astrazeneca Ab Chemical process
KR200349335Y1 (ko) 2004-02-21 2004-05-06 김노석 절수용 밸브
DE502005000317D1 (de) * 2004-03-19 2007-03-08 Alfmeier Praez Ag Fahrzeugsitz mit einer schwenkbar gelagerten kopfstütze
WO2006015123A1 (en) * 2004-07-27 2006-02-09 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
TWM265652U (en) * 2004-08-03 2005-05-21 Premier Image Technology Corp Solid integration rod for DLP
DE102004041530A1 (de) 2004-08-27 2006-03-02 Bayer Cropscience Ag Biphenylthiazolcarboxamide
DE102004041532A1 (de) 2004-08-27 2006-03-02 Bayer Cropscience Ag Biphenylthiazolcarboxamide
EP1812451A4 (en) * 2004-11-01 2009-10-21 Nuada Llc COMPOUNDS AND METHODS OF USE THEREOF
WO2006050054A2 (en) * 2004-11-01 2006-05-11 Nuada, Llc Compounds and methods of use thereof
WO2006050236A2 (en) * 2004-11-01 2006-05-11 Nuada, Llc Compounds and methods of use thereof
JP2008519853A (ja) * 2004-11-12 2008-06-12 トラスティーズ オブ タフツ カレッジ リパーゼ阻害物質
DE102005023834A1 (de) * 2004-11-20 2006-05-24 Bayer Healthcare Ag Substituierte[(Phenylethanoyl)amino]benzamide
US7425281B2 (en) * 2004-12-02 2008-09-16 Displaytech, Inc. Liquid crystal compositions comprising an organogermanium compound and methods for using the same
US7553496B2 (en) * 2004-12-21 2009-06-30 University Of Kentucky Research Foundation VEGF-A as an inhibitor of angiogenesis and methods of using same
US20060211698A1 (en) * 2005-01-14 2006-09-21 Genelabs, Inc. Bicyclic heteroaryl derivatives for treating viruses
EP1851197A2 (en) 2005-02-09 2007-11-07 Microbia, Inc. Phenylazetidinone derivatives
JP5038912B2 (ja) 2005-02-16 2012-10-03 アナコール ファーマシューティカルズ，インコーポレイテッド ホウ素含有小分子
DE112006000379T5 (de) 2005-02-22 2008-02-07 Sumation Co. Ltd. Arylenpolymere mit grosser Bandlücke
US7589066B2 (en) * 2005-03-11 2009-09-15 The University Of North Carolina At Chapel Hill Potent and specific immunoproteasome inhibitors
GB2424881B (en) 2005-04-07 2010-11-24 Merck Patent Gmbh Halophenyl derivatives of bisalkylfluorene
JP4792796B2 (ja) 2005-04-08 2011-10-12 東ソー株式会社 ２，３−ジハロビフェニレン誘導体、その前駆化合物及び製造方法
WO2006122186A2 (en) 2005-05-10 2006-11-16 Microbia, Inc. 1,4-diphenyl-3-hydroxyalkyl-2-azetidinone derivatives for treating hypercholestrolemia
JP2008540573A (ja) 2005-05-13 2008-11-20 マイクロビア インコーポレーテッド ４−ビアリーリル−１−フェニラゼチジン−２−オン類
EP1726581A1 (en) 2005-05-25 2006-11-29 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Synthesis of novel monomers containing the Trifluorovinylidene-group and the Cyanato-group and polymers thereof
JP2008546651A (ja) 2005-06-14 2008-12-25 メルク フロスト カナダ リミテツド モノアミンオキシダーゼａ及びｂの可逆的阻害剤
KR100659088B1 (ko) 2005-07-15 2006-12-21 삼성에스디아이 주식회사 디플루오로피리딘계 화합물 및 이를 이용한 유기 발광 소자
KR100730140B1 (ko) 2005-07-15 2007-06-19 삼성에스디아이 주식회사 트리아진계 화합물 및 이를 이용한 유기 발광 소자
DE102005037925A1 (de) 2005-08-11 2007-02-15 Merck Patent Gmbh Hydro-cyclopenta[a]naphthaline
WO2007028104A2 (en) * 2005-09-02 2007-03-08 Auspex Pharmaceuticals, Inc. Novel therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders
KR20080045749A (ko) 2005-09-13 2008-05-23 바이엘 크롭사이언스 아게 살충성 비-페닐-아미딘 유도체
AU2006319247B2 (en) * 2005-12-01 2010-03-11 F. Hoffmann-La Roche Ag Heteroaryl substituted piperidine derivatives as L-CPT1 inhibitors
KR101408026B1 (ko) 2005-12-02 2014-06-20 사켐,인코포레이티드 음이온-교환 치환 크로마토그래피 공정 및 음이온-교환치환 크로마토그래피 공정에서 디스플레이서 화합물들로서사용하기 위한 음이온성 유기 화합물들
CN106008571A (zh) 2005-12-30 2016-10-12 安纳考尔医药公司 含硼的小分子
US20100048713A1 (en) 2006-01-06 2010-02-25 Aarhus Universitet Compounds acting on the serotonin transporter
GB0602046D0 (en) 2006-02-01 2006-03-15 Smithkline Beecham Corp Compounds
DK1988779T5 (en) 2006-02-16 2016-10-10 Anacor Pharmaceuticals Inc SMALL boron MOLECULES AS ANTI-INFLAMMATORY AGENTS
DE102007009944B4 (de) 2006-03-15 2016-04-28 Merck Patent Gmbh Flüssigkristallines Medium und seine Verwendung
AR059898A1 (es) * 2006-03-15 2008-05-07 Janssen Pharmaceutica Nv Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2
US20090170845A1 (en) 2006-04-13 2009-07-02 Aegera Therapeutics Inc. USE OF IMIDAZO[2,1-b]-1,3,4-THIADIAZOLE-2-SULFONAMIDE COMPOUNDS TO TREAT NEUROPATHIC PAIN
JP5145753B2 (ja) 2006-04-20 2013-02-20 Ｊｎｃ株式会社 フルオロイソプロピル基を側鎖として有する化合物およびこれを用いた液晶組成物
EP2044091A4 (en) * 2006-06-12 2010-08-04 Anacor Pharmaceuticals Inc COMPOUNDS FOR THE TREATMENT OF PARODONTAL DISEASE
US7838542B2 (en) 2006-06-29 2010-11-23 Kinex Pharmaceuticals, Llc Bicyclic compositions and methods for modulating a kinase cascade
US20080032995A1 (en) 2006-07-27 2008-02-07 Jeff Zablocki Aldh-2 inhibitors in the treatment of drug addiction
JP4881095B2 (ja) * 2006-07-28 2012-02-22 株式会社東海理化電機製作所 キーシステム
WO2008020920A1 (en) 2006-08-15 2008-02-21 Duke University Ros-sensitive iron chelators and methods of using the same
ATE515553T1 (de) 2006-08-16 2011-07-15 Merck Patent Gmbh Cyclohexen-verbindungen für flüssigkristalline mischungen
ATE476489T1 (de) * 2006-09-13 2010-08-15 Merck Patent Gmbh Fluorphenyl-verbindungen für flüssigkristalline mischungen
EP2059227A2 (en) * 2006-09-26 2009-05-20 Aeris Therapeutics, Inc. Polymer systems for lung volume reduction therapy
WO2008039829A2 (en) 2006-09-26 2008-04-03 Ironwood Pharmaceuticals, Inc. Diphenylheterocycle cholesterol absorption inhibitors
JO3598B1 (ar) 2006-10-10 2020-07-05 Infinity Discovery Inc الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني
BRPI0717596B8 (pt) 2006-10-18 2021-05-25 Pfizer Prod Inc compostos de éter biarílico uréia, seu uso e composição farmacêutica que os compreende
US7846514B2 (en) 2007-01-24 2010-12-07 Chisso Corporation Liquid crystal compound, liquid crystal composition and, liquid crystal display device
US7951433B2 (en) 2007-02-28 2011-05-31 Chisso Corporation Five-ring liquid crystal compound having CF2O bonding group, liquid crystal composition, and liquid crystal display device
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
US20080280991A1 (en) 2007-05-08 2008-11-13 Auspex Pharmaceuticals, Inc. Substituted naphthalenes
DE102007030269B4 (de) * 2007-06-28 2014-07-17 Mitsubishi Hitachi Power Systems Europe Gmbh Kohlenstaubbrenner zur Verfeuerung von in Dichtstromförderung zugeführtem Brennstoff
WO2009011904A1 (en) 2007-07-19 2009-01-22 Renovis, Inc. Compounds useful as faah modulators and uses thereof
WO2009126691A1 (en) 2008-04-09 2009-10-15 Infinity Pharmaceuticals, Inc Inhibitors of fatty acid amide hydrolase
CN102015585B (zh) 2008-05-08 2013-06-19 住友化学株式会社 不饱和有机化合物的制造方法
DE102008023801A1 (de) 2008-05-15 2009-11-19 Bayer Schering Pharma Aktiengesellschaft Substituierte Imidazo- und Triazolopyrimidine, Imidazo- und Pyrazolopyrazine und Imidazotriazine
EP2417115A4 (en) 2009-04-07 2012-10-31 Infinity Pharmaceuticals Inc FATTY ACID AMIDE HYDROLASE INHIBITORS
MX336742B (es) 2010-02-03 2016-01-29 Infinity Pharmaceuticals Inc Inhibidores de amida hidrolasa de acido graso.

Also Published As

Publication number Publication date
US20110230440A1 (en) 2011-09-22
JO3598B1 (ar) 2020-07-05
IL219039A (en) 2015-07-30
NZ576851A (en) 2012-09-28
US20130059819A1 (en) 2013-03-07
CN104230971A (zh) 2014-12-24
CA2666224C (en) 2017-07-11
WO2008063300A3 (en) 2008-07-17
JP2010505955A (ja) 2010-02-25
EP2404607A1 (en) 2012-01-11
US7947663B2 (en) 2011-05-24
EP2073816B1 (en) 2011-09-14
AU2007322268A1 (en) 2008-05-29
WO2008063300A8 (en) 2009-06-11
SG10201908757TA (en) 2019-10-30
AR063165A1 (es) 2008-12-30
JP2014114305A (ja) 2014-06-26
SG175608A1 (en) 2011-11-28
BRPI0719218A2 (pt) 2014-03-18
US8349814B2 (en) 2013-01-08
KR20150038363A (ko) 2015-04-08
JP5641600B2 (ja) 2014-12-17
EP2073816A2 (en) 2009-07-01
HK1137137A1 (en) 2010-07-23
ATE524188T1 (de) 2011-09-15
AU2007322268B2 (en) 2013-05-30
CN101563089A (zh) 2009-10-21
TWI451870B (zh) 2014-09-11
IL197932A0 (en) 2009-12-24
US20150344503A1 (en) 2015-12-03
PE20081172A1 (es) 2008-09-30
DK2073816T3 (da) 2011-12-12
TW200820979A (en) 2008-05-16
RU2492174C2 (ru) 2013-09-10
US20140121183A1 (en) 2014-05-01
NO20091620L (no) 2009-07-09
US8329675B2 (en) 2012-12-11
CN104230971B (zh) 2017-11-24
JP5710805B2 (ja) 2015-04-30
IL219039A0 (en) 2012-05-31
UA101601C2 (uk) 2013-04-25
PH12012500765A1 (en) 2014-09-08
WO2008063300A2 (en) 2008-05-29
CL2007002910A1 (es) 2008-07-04
US9108989B2 (en) 2015-08-18
KR20090085623A (ko) 2009-08-07
US20090099131A1 (en) 2009-04-16
EP2399585A1 (en) 2011-12-28
RU2009113830A (ru) 2010-11-20
SG10201502266RA (en) 2015-05-28
US20110224171A1 (en) 2011-09-15
NO342439B1 (no) 2018-05-22
PT2073816E (pt) 2011-12-15
IL197932A (en) 2013-11-28
EP2399584A1 (en) 2011-12-28
CA2666224A1 (en) 2008-05-29
US8629125B2 (en) 2014-01-14
ES2373697T3 (es) 2012-02-07

Similar Documents

Publication Publication Date Title
MX2009003727A (es) Acidos y esteres boronicos como inhibidores de amida hidrolasa de acido graso.
NZ619076A (en) Isoxazolines as inhibitors of fatty acid amide hydrolase
EP2352497A4 (en) COMPOSITIONS WITH DELTA-9-THC-AMINO-ACID ESTERS AND MANUFACTURING METHOD
MY150787A (en) Aminotetrahydropyrans as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of prevention of diabetes
TNSN08367A1 (en) Aminotetrahydropyrans as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes
MY171021A (en) Boronate ester compounds and pharmaceutical compositions thereof
WO2008157537A3 (en) Compositions and methods of use for treating or preventing lipid related disorders
MX2013006598A (es) Inhibidores de la amida hidrolasa de acidos grasos (faah).
WO2007097931A3 (en) Aminotetrahydropyrans as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes
WO2007136603A3 (en) Aminotetrahydropyrans as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes
MY161991A (en) Proteasome inhibitors
IL198979A (en) Enzyme inhibitors diacylglycerol o-acetyltransferase type 1
MX342128B (es) Compuestos farmaceuticos.
WO2007087231A3 (en) Aminocyclohexanes as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes
EA201170061A1 (ru) Новые производные фенилимидазола в качестве ингибиторов фермента pde10a
MX2012002633A (es) Aminotetrahidropiranos como inhibidores de la dipeptidil peptidasa iv para el tratamiento prevencion de la diabetes.
IL193252A0 (en) N-hydroxyacrylamide compounds
MX2012006490A (es) Inhibidores azociclicos de hidrolasa de amidas de acidos grasos.
EA201290516A1 (ru) Гетероароматические производные соединения фенилимидазола в качестве ингибиторов фермента pde10a
UA96156C2 (ru) Эфиры докозагексаеновой кислоты и их применение для лечения и предупреждения сердечнососудистого заболевания
MY143568A (en) 11b-hsd1 inhibitors for the treatment of diabetes
EA200901237A1 (ru) Применение димирацетама при лечении хронической боли
EP2417115A4 (en) FATTY ACID AMIDE HYDROLASE INHIBITORS
MY156278A (en) Disubstituted [4-(5-aminomethyl-phenyl)-piperidin-1-yl]-1h-indol-3-yl]-methanones
WO2007044325A3 (en) Apoe4 domain interaction inhibitors and methods of use thereof

Legal Events

Date Code Title Description
HH Correction or change in general
FG Grant or registration