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MX2009002010A - Derivados de heteroarilo como inhibidores de la proteina cinasa. - Google Patents

Derivados de heteroarilo como inhibidores de la proteina cinasa.

Info

Publication number
MX2009002010A
MX2009002010A MX2009002010A MX2009002010A MX2009002010A MX 2009002010 A MX2009002010 A MX 2009002010A MX 2009002010 A MX2009002010 A MX 2009002010A MX 2009002010 A MX2009002010 A MX 2009002010A MX 2009002010 A MX2009002010 A MX 2009002010A
Authority
MX
Mexico
Prior art keywords
protein kinase
kinase inhibitors
heteroaryl derivatives
compounds
mentioned compounds
Prior art date
Application number
MX2009002010A
Other languages
English (en)
Inventor
Stefan Scheiblich
Konrad Honold
Wolfgang Schaefer
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2009002010A publication Critical patent/MX2009002010A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se relaciona con los compuestos de la fórmula I sus sales farmacéuticamente aceptables, formas enantioméricas, diastereoisómeros y racetamos, la preparación de los compuestos mencionados anteriormente, medicamentos que los contienen y su manufactura, así como el uso de los compuestos mencionados anteriormente en el control o prevención de enfermedades, tal como cáncer.
MX2009002010A 2006-09-06 2007-09-04 Derivados de heteroarilo como inhibidores de la proteina cinasa. MX2009002010A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06018627 2006-09-06
PCT/EP2007/007691 WO2008028617A1 (en) 2006-09-06 2007-09-04 Heteroaryl derivatives as protein kinase inhibitors

Publications (1)

Publication Number Publication Date
MX2009002010A true MX2009002010A (es) 2009-03-05

Family

ID=37668072

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009002010A MX2009002010A (es) 2006-09-06 2007-09-04 Derivados de heteroarilo como inhibidores de la proteina cinasa.

Country Status (11)

Country Link
US (1) US8067599B2 (es)
EP (1) EP2064213A1 (es)
JP (1) JP2010502660A (es)
KR (1) KR101104666B1 (es)
CN (1) CN101511828A (es)
AU (1) AU2007294149A1 (es)
BR (1) BRPI0716477A2 (es)
CA (1) CA2662031A1 (es)
IL (1) IL196554A0 (es)
MX (1) MX2009002010A (es)
WO (1) WO2008028617A1 (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2064213A1 (en) 2006-09-06 2009-06-03 F. Hoffmann-La Roche AG Heteroaryl derivatives as protein kinase inhibitors
WO2008144253A1 (en) * 2007-05-14 2008-11-27 Irm Llc Protein kinase inhibitors and methods for using thereof
CA2716949A1 (en) * 2008-02-29 2009-09-11 Array Biopharma Inc. N- (6-aminopyridin-3-yl) -3- (sulfonamido) benzamide derivatives as b-raf inhibitors for the treatment of cancer
CA2716947A1 (en) * 2008-02-29 2009-09-11 Array Biopharma Inc. Imidazo [4,5-b] pyridine derivatives used as raf inhibitors
US8394795B2 (en) 2008-02-29 2013-03-12 Array Biopharma Inc. Pyrazole [3, 4-B] pyridine Raf inhibitors
WO2009111278A2 (en) 2008-02-29 2009-09-11 Array Biopharma Inc. Raf inhibitor compounds and methods of use thereof
KR100970670B1 (ko) 2008-04-22 2010-07-15 계명대학교 산학협력단 세포증식 억제제로서 유용한 벤즈아미드 유도체 및 그제조방법
FR2941948B1 (fr) * 2009-02-12 2013-04-05 Nova Decision Derives d'azaindoles en tant qu'inhibiteur des proteines kinases abl et src
EP2470539A1 (en) 2009-08-28 2012-07-04 Array Biopharma, Inc. Raf inhibitor compounds and methods of use thereof
US20120157452A1 (en) * 2009-08-28 2012-06-21 Genentech, Inc. 1h-pyrazolo[3,4-b] pyridine compounds for inhibiting raf kinase
US20120214811A1 (en) 2009-08-28 2012-08-23 Ignacio Aliagas Raf inhibitor compounds and methods of use thereof
EP2470538A1 (en) 2009-08-28 2012-07-04 Array Biopharma, Inc. Raf inhibitor compounds and methods of use thereof
JP2013503187A (ja) 2009-08-28 2013-01-31 アレイ バイオファーマ、インコーポレイテッド Ｒａｆ阻害化合物およびその使用方法
WO2011025947A1 (en) 2009-08-28 2011-03-03 Array Biopharma Inc. Raf inhibitor compounds and methods of use thereof
US8883819B2 (en) * 2011-09-01 2014-11-11 Irm Llc Bicyclic heterocycle derivatives for the treatment of pulmonary arterial hypertension
US10138235B2 (en) 2011-12-14 2018-11-27 Sanofi Pyrazolopyridine derivatives, preparation process therefor and therapeutic use thereof
FR2984325A1 (fr) * 2011-12-14 2013-06-21 Sanofi Sa Derives de pyrazolopyridine, leur procede de preparation et leur application en therapeutique
DK2797888T3 (en) 2011-12-31 2016-09-19 Beigene Ltd Fused tricyclic compounds as RAF kinase inhibitors
CN102659778A (zh) * 2012-03-22 2012-09-12 盛世泰科生物医药技术(苏州)有限公司 6-氨基-2-甲基-3H-咪唑并[4,5-b]吡啶的合成新工艺
FR3000492B1 (fr) * 2012-12-28 2015-09-11 Oribase Pharma Nouveaux derives azaindole en tant qu'inhibiteurs multikinases
FR3000494B1 (fr) 2012-12-28 2015-08-21 Oribase Pharma Nouveaux derives d'azaindoles en tant qu'inhibiteurs de proteines kinases
FR3000493A1 (fr) * 2012-12-28 2014-07-04 Oribase Pharma Nouveaux inhibiteurs de proteines kinases
JP6423372B2 (ja) 2013-02-28 2018-11-14 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ 強力なｒｏｃｋ１およびｒｏｃｋ２阻害剤としてのフェニルピラゾール誘導体
TW201444798A (zh) 2013-02-28 2014-12-01 必治妥美雅史谷比公司 作爲強效ｒｏｃｋ１及ｒｏｃｋ２抑制劑之苯基吡唑衍生物
EP3013797B1 (en) 2013-06-28 2018-01-03 BeiGene, Ltd. Fused tricyclic amide compounds as multiple kinase inhibitors
EA029412B1 (ru) 2013-06-28 2018-03-30 Бейджин, Лтд. Конденсированные трициклические соединения мочевины в качестве ингибиторов киназы raf и/или димера киназы raf
US9795140B2 (en) 2015-04-17 2017-10-24 Dow Agrosciences Llc Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto
CN108701171B (zh) * 2015-10-22 2022-06-10 马古苏托科技大学 在通过抑制cyp17a1和cyp19a1治疗癌症中具有应用的药效团、化合物和方法
BR122020018163B8 (pt) 2016-10-12 2022-09-06 Dow Agrosciences Llc Moléculas tendo utilidade pesticida, e intermediários, composições, processos relacionados às mesmas e sementes resistentes a pragas
TWI758313B (zh) 2016-10-12 2022-03-21 美商陶氏農業科學公司 一種用於製備(1r,3r)-及(1s,3s)-2,2-二鹵基-3-(經取代之苯基)環丙烷甲酸的方法
AU2019223215B2 (en) * 2018-02-23 2022-09-15 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Novel inhibitors of bacterial glutaminyl cyclases for use in the treatment of periodontal and related diseases

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA02012271A (es) * 2000-06-27 2004-09-06 Genelabs Tech Inc Nuevos compuestos que poseen actividad antibacteriana, antifungal o antitumor.
TWI276631B (en) 2002-09-12 2007-03-21 Avanir Pharmaceuticals Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation
GB0330043D0 (en) 2003-12-24 2004-01-28 Pharmacia Italia Spa Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions comprising them
WO2006066914A2 (en) * 2004-12-23 2006-06-29 F. Hoffmann-La Roche Ag Carbamate substituted imidazo- and pyrrolo-pyridines as protein kinase inhibitors
EP1833829A2 (en) * 2004-12-23 2007-09-19 F. Hoffmann-Roche AG Benzamide substituted imidazo- and pyrrolo-pyridines as protein kinase inhibitors
DE602006020295D1 (de) 2005-07-29 2011-04-07 Hoffmann La Roche Azabenzimidalzolderivate, ihre herstellung und ihre verwendung als antikrebsmittel
EP2064213A1 (en) 2006-09-06 2009-06-03 F. Hoffmann-La Roche AG Heteroaryl derivatives as protein kinase inhibitors

Also Published As

Publication number Publication date
CA2662031A1 (en) 2008-03-13
CN101511828A (zh) 2009-08-19
BRPI0716477A2 (pt) 2014-03-18
AU2007294149A1 (en) 2008-03-13
EP2064213A1 (en) 2009-06-03
KR101104666B1 (ko) 2012-01-13
JP2010502660A (ja) 2010-01-28
WO2008028617A1 (en) 2008-03-13
US20090318428A1 (en) 2009-12-24
KR20090038487A (ko) 2009-04-20
US8067599B2 (en) 2011-11-29
IL196554A0 (en) 2009-11-18

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