MX2008015918A - Compuestos para el tratamiento de enfermedad periodontal. - Google Patents

Info

Publication number

MX2008015918A

MX2008015918A MX2008015918A MX2008015918A MX2008015918A MX 2008015918 A MX2008015918 A MX 2008015918A MX 2008015918 A MX2008015918 A MX 2008015918A MX 2008015918 A MX2008015918 A MX 2008015918A MX 2008015918 A MX2008015918 A MX 2008015918A

Authority

MX

Mexico

Prior art keywords

substituted

alkyl

unsubstituted

compound

species

Prior art date

2006-06-12

Links

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• 238000011282 treatment Methods 0.000 title abstract description 19
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• 238000000034 method Methods 0.000 claims abstract description 106
• -1 2- (morpholino) ethoxy Chemical group 0.000 claims description 428
• 125000000217 alkyl group Chemical group 0.000 claims description 130
• 229910052736 halogen Inorganic materials 0.000 claims description 47
• 125000001072 heteroaryl group Chemical group 0.000 claims description 47
• 229910052739 hydrogen Inorganic materials 0.000 claims description 47
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 44
• 150000002367 halogens Chemical class 0.000 claims description 42
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 40
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 40
• 150000003839 salts Chemical class 0.000 claims description 34
• 229910052796 boron Inorganic materials 0.000 claims description 33
• ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical group [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 claims description 30
• 125000003710 aryl alkyl group Chemical group 0.000 claims description 28
• 125000003545 alkoxy group Chemical group 0.000 claims description 27
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• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 24
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• 230000002829 reductive effect Effects 0.000 description 58
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• 239000000047 product Substances 0.000 description 53
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• 238000004128 high performance liquid chromatography Methods 0.000 description 49
• 150000002148 esters Chemical class 0.000 description 46
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• 125000001424 substituent group Chemical group 0.000 description 33
• 125000000592 heterocycloalkyl group Chemical group 0.000 description 32
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• 229910052757 nitrogen Inorganic materials 0.000 description 31
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