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MX2008011892A - Nanoparticulas de polilactido. - Google Patents

Nanoparticulas de polilactido.

Info

Publication number
MX2008011892A
MX2008011892A MX2008011892A MX2008011892A MX2008011892A MX 2008011892 A MX2008011892 A MX 2008011892A MX 2008011892 A MX2008011892 A MX 2008011892A MX 2008011892 A MX2008011892 A MX 2008011892A MX 2008011892 A MX2008011892 A MX 2008011892A
Authority
MX
Mexico
Prior art keywords
active substance
nanoparticles
targeted
delivery
poiy
Prior art date
Application number
MX2008011892A
Other languages
English (en)
Inventor
Joerg Kreuter
Svetlana Gelperina
Olga Maksimenko
Alexander Khalanskiy
Original Assignee
Lohmann Therapie Syst Lts
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lohmann Therapie Syst Lts filed Critical Lohmann Therapie Syst Lts
Publication of MX2008011892A publication Critical patent/MX2008011892A/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0085—Brain, e.g. brain implants; Spinal cord
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    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • C08G63/08—Lactones or lactides
    • A—HUMAN NECESSITIES
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

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  • Veterinary Medicine (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Physics & Mathematics (AREA)
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  • Diabetes (AREA)
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  • Emergency Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Communicable Diseases (AREA)

Abstract

La presente invención se refiere a un sistema para la administración dirigida de fármaco para administrar una sustancia farmacológicamente activa al sistema nervioso central de un mamífero a través de su barrera hematoencefálica, en donde el sistema para la administración dirigida del fármaco comprende nanopartículas elaboradas de poli(DL-láctido) (PLA) y/o poli(DL-láctido-co-glicólido) (PLGA), y al menos una sustancia farmacológicamente activa que está absorbida, adsorbida y/o incluida en las nanopartículas, y que contiene TPGS o comprende un recubrimiento del tensoactivo pluronic 188 depositado sobre las nanopartículas cargadas con fármaco, así como a métodos para producir el sistema para la administración dirigida del fármaco y el uso del sistema para la administración dirigida del fármaco para tratar una enfermedad o trastorno del sistema nervioso central.
MX2008011892A 2006-03-24 2007-03-13 Nanoparticulas de polilactido. MX2008011892A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102006013531A DE102006013531A1 (de) 2006-03-24 2006-03-24 Polylactid-Nanopartikel
PCT/EP2007/002198 WO2007110152A2 (de) 2006-03-24 2007-03-13 Polylactid-nanopartikel

Publications (1)

Publication Number Publication Date
MX2008011892A true MX2008011892A (es) 2008-11-14

Family

ID=38110479

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2008011892A MX2008011892A (es) 2006-03-24 2007-03-13 Nanoparticulas de polilactido.

Country Status (14)

Country Link
US (2) US8003128B2 (es)
EP (1) EP1998752A2 (es)
JP (1) JP2009530325A (es)
KR (1) KR20080111079A (es)
CN (1) CN101410099A (es)
AU (1) AU2007229738A1 (es)
BR (1) BRPI0709352A2 (es)
CA (1) CA2644411A1 (es)
DE (1) DE102006013531A1 (es)
IN (1) IN2008DE08036A (es)
MX (1) MX2008011892A (es)
NZ (1) NZ571354A (es)
RU (1) RU2423104C2 (es)
WO (1) WO2007110152A2 (es)

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JP2009530325A (ja) 2009-08-27
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