MX2008009357A - Una composicion solida de taxano liofilizada, un procedimiento para preparar dicha composicion solida, una formulacion farmaceuctica y un conjunto (kit) de dicha formulacion. - Google Patents
Una composicion solida de taxano liofilizada, un procedimiento para preparar dicha composicion solida, una formulacion farmaceuctica y un conjunto (kit) de dicha formulacion.Info
- Publication number
- MX2008009357A MX2008009357A MX2008009357A MX2008009357A MX2008009357A MX 2008009357 A MX2008009357 A MX 2008009357A MX 2008009357 A MX2008009357 A MX 2008009357A MX 2008009357 A MX2008009357 A MX 2008009357A MX 2008009357 A MX2008009357 A MX 2008009357A
- Authority
- MX
- Mexico
- Prior art keywords
- composition
- solid
- taxane
- formulation
- kit
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 7
- 229940123237 Taxane Drugs 0.000 title abstract 6
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 title abstract 6
- 239000007787 solid Substances 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 239000008247 solid mixture Substances 0.000 title abstract 2
- 238000009472 formulation Methods 0.000 title 1
- 238000004108 freeze drying Methods 0.000 abstract 2
- 239000003960 organic solvent Substances 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 abstract 1
- 229930012538 Paclitaxel Natural products 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 239000004359 castor oil Substances 0.000 abstract 1
- 235000019438 castor oil Nutrition 0.000 abstract 1
- 229960003668 docetaxel Drugs 0.000 abstract 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 abstract 1
- 229960001592 paclitaxel Drugs 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 abstract 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 abstract 1
- 229920000053 polysorbate 80 Polymers 0.000 abstract 1
- 229940068968 polysorbate 80 Drugs 0.000 abstract 1
- 230000003381 solubilizing effect Effects 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Epoxy Compounds (AREA)
Abstract
Una composición sólida de taxano (preferentemente docetaxel y paclitaxel) liofilizada, apta para preparar formulaciones farmacéuticas para mamíferos, en particular humanos, que comprende dicho taxano, tensoactivo, excipiente de liofilización y ácido; y además es esencialmente libre de solvente orgánico. Donde dicha composición sólida es libre de polisorbato 80 y de aceite de castor polioxietilado; es estéril; es soluble en soluciones acuosas en ausencia de solvente orgánico; y tienen una densidad aparente de entre 0,05 g/ml y 0,45 g/ml. Un procedimiento de doble liofilización para obtener dicha composición sólida de taxano. Una Formulación farmacéutica de un taxano que comprende dicha composición sólida de taxano liofilizada y una composición solubilizante. Un conjunto que comprende dichas composiciones y una jeringa.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AR20060100208A AR054215A1 (es) | 2006-01-20 | 2006-01-20 | Una formulacion farmaceutica de un taxano, una composicion solida de un taxano liofilizado a partir de una solucion de acido acetico, un procedimiento para la preparacion de dicha composicion solida de un taxano, una composicion solubilizante de un taxano liofilizado, y un conjunto de elementos (kit |
| PCT/ES2007/070013 WO2007082979A1 (es) | 2006-01-20 | 2007-01-19 | Una composición sólida de taxano liofilizada, un procedimiento para preparar dicha composición sólida, una formulación farmacéutica y un conjunto (kit) de dicha formulación |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2008009357A true MX2008009357A (es) | 2008-09-10 |
Family
ID=38134453
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2008009358A MX2008009358A (es) | 2006-01-20 | 2007-01-18 | Una formulacion farmaceutica de taxano, una composicion solida de taxano, un procedimiento para la preparacion de dicha composicion solida de taxano, una composicion solubllizante de dicha composicion solida de taxano, y un conjunto de elementos (kit |
| MX2008009357A MX2008009357A (es) | 2006-01-20 | 2007-01-19 | Una composicion solida de taxano liofilizada, un procedimiento para preparar dicha composicion solida, una formulacion farmaceuctica y un conjunto (kit) de dicha formulacion. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2008009358A MX2008009358A (es) | 2006-01-20 | 2007-01-18 | Una formulacion farmaceutica de taxano, una composicion solida de taxano, un procedimiento para la preparacion de dicha composicion solida de taxano, una composicion solubllizante de dicha composicion solida de taxano, y un conjunto de elementos (kit |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US20090215883A1 (es) |
| EP (2) | EP1994925A4 (es) |
| JP (2) | JP2009523770A (es) |
| AR (1) | AR054215A1 (es) |
| AU (1) | AU2007206877A1 (es) |
| BR (2) | BRPI0706931A2 (es) |
| CA (2) | CA2637893A1 (es) |
| GT (2) | GT200800146A (es) |
| MX (2) | MX2008009358A (es) |
| NZ (2) | NZ569783A (es) |
| PE (2) | PE20070945A1 (es) |
| RU (1) | RU2429837C2 (es) |
| UY (2) | UY30100A1 (es) |
| WO (2) | WO2007082978A1 (es) |
| ZA (2) | ZA200805704B (es) |
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| KR100573289B1 (ko) | 2002-07-20 | 2006-04-24 | 대화제약 주식회사 | 방광내 투여를 통한 방광암치료용 파클리탁셀 조성물 및그의 제조 방법 |
| KR100508518B1 (ko) | 2002-11-13 | 2005-08-17 | 한미약품 주식회사 | 초임계유체 공정을 이용한 파클리탁셀 고체분산체의 제조방법 및 이 방법으로 제조된 파클리탁셀 고체분산체 |
| US6759539B1 (en) * | 2003-02-27 | 2004-07-06 | Chaichem Pharmaceuticals International | Process for isolation and purification of paclitaxel from natural sources |
| US20040247624A1 (en) | 2003-06-05 | 2004-12-09 | Unger Evan Charles | Methods of making pharmaceutical formulations for the delivery of drugs having low aqueous solubility |
| US20050152979A1 (en) | 2003-09-05 | 2005-07-14 | Cell Therapeutics, Inc. | Hydrophobic drug compositions containing reconstitution enhancer |
| KR20050099311A (ko) * | 2004-04-09 | 2005-10-13 | 에이엔에이치 케어연구소(주) | 주사제용 항암제 조성물 |
| US7345093B2 (en) * | 2004-04-27 | 2008-03-18 | Formatech, Inc. | Methods of enhancing solubility of compounds |
| US8158152B2 (en) * | 2005-11-18 | 2012-04-17 | Scidose Llc | Lyophilization process and products obtained thereby |
| BRPI0600194A (pt) * | 2006-01-30 | 2007-10-23 | Quiral Quimica Do Brasil S A | composições farmacêuticas contendo docetaxel e um inibidor de degradação e processo de obtenção das mesmas |
| CN1850056A (zh) * | 2006-03-06 | 2006-10-25 | 杨典忠 | 多西他赛冻干粉针及其制备方法 |
| AR063111A1 (es) * | 2007-10-03 | 2008-12-30 | Eriochem Sa | Una formulacion farmaceutica de taxano |
-
2006
- 2006-01-20 AR AR20060100208A patent/AR054215A1/es unknown
-
2007
- 2007-01-18 WO PCT/ES2007/070012 patent/WO2007082978A1/es not_active Ceased
- 2007-01-18 JP JP2008550785A patent/JP2009523770A/ja active Pending
- 2007-01-18 BR BRPI0706931-6A patent/BRPI0706931A2/pt not_active IP Right Cessation
- 2007-01-18 CA CA002637893A patent/CA2637893A1/en not_active Abandoned
- 2007-01-18 US US12/161,625 patent/US20090215883A1/en not_active Abandoned
- 2007-01-18 NZ NZ569783A patent/NZ569783A/en not_active IP Right Cessation
- 2007-01-18 MX MX2008009358A patent/MX2008009358A/es unknown
- 2007-01-18 RU RU2008133761/15A patent/RU2429837C2/ru not_active IP Right Cessation
- 2007-01-18 EP EP07712569A patent/EP1994925A4/en not_active Withdrawn
- 2007-01-19 UY UY30100A patent/UY30100A1/es not_active Application Discontinuation
- 2007-01-19 WO PCT/ES2007/070013 patent/WO2007082979A1/es not_active Ceased
- 2007-01-19 ZA ZA200805704A patent/ZA200805704B/xx unknown
- 2007-01-19 JP JP2008550786A patent/JP2009523771A/ja not_active Abandoned
- 2007-01-19 PE PE2007000062A patent/PE20070945A1/es not_active Application Discontinuation
- 2007-01-19 NZ NZ569968A patent/NZ569968A/en not_active IP Right Cessation
- 2007-01-19 MX MX2008009357A patent/MX2008009357A/es not_active Application Discontinuation
- 2007-01-19 AU AU2007206877A patent/AU2007206877A1/en not_active Abandoned
- 2007-01-19 EP EP07712570A patent/EP1982699A1/en not_active Withdrawn
- 2007-01-19 BR BRPI0706932-4A patent/BRPI0706932A2/pt not_active IP Right Cessation
- 2007-01-19 UY UY30099A patent/UY30099A1/es not_active Application Discontinuation
- 2007-01-19 US US12/161,609 patent/US20090215882A1/en not_active Abandoned
- 2007-01-19 CA CA002638034A patent/CA2638034A1/en not_active Abandoned
- 2007-01-19 PE PE2007000063A patent/PE20071243A1/es not_active Application Discontinuation
-
2008
- 2008-07-09 ZA ZA200805989A patent/ZA200805989B/xx unknown
- 2008-07-18 GT GT200800146A patent/GT200800146A/es unknown
- 2008-07-18 GT GT200800145A patent/GT200800145A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2637893A1 (en) | 2007-07-26 |
| JP2009523771A (ja) | 2009-06-25 |
| WO2007082979A1 (es) | 2007-07-26 |
| CA2638034A1 (en) | 2007-07-26 |
| UY30100A1 (es) | 2008-09-02 |
| EP1994925A1 (en) | 2008-11-26 |
| ZA200805989B (en) | 2009-05-27 |
| BRPI0706931A2 (pt) | 2011-04-19 |
| PE20070945A1 (es) | 2007-10-07 |
| GT200800146A (es) | 2008-12-15 |
| BRPI0706932A2 (pt) | 2011-04-19 |
| WO2007082978A1 (es) | 2007-07-26 |
| ZA200805704B (en) | 2009-11-25 |
| GT200800145A (es) | 2009-07-21 |
| NZ569968A (en) | 2011-07-29 |
| WO2007082978B1 (es) | 2007-09-07 |
| AR054215A1 (es) | 2007-06-13 |
| AU2007206876A1 (en) | 2007-07-26 |
| US20090215883A1 (en) | 2009-08-27 |
| EP1994925A4 (en) | 2013-01-23 |
| JP2009523770A (ja) | 2009-06-25 |
| MX2008009358A (es) | 2008-09-10 |
| UY30099A1 (es) | 2008-09-02 |
| RU2008133761A (ru) | 2010-02-27 |
| NZ569783A (en) | 2011-04-29 |
| PE20071243A1 (es) | 2008-02-03 |
| EP1982699A1 (en) | 2008-10-22 |
| US20090215882A1 (en) | 2009-08-27 |
| RU2429837C2 (ru) | 2011-09-27 |
| AU2007206877A1 (en) | 2007-07-26 |
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| FA | Abandonment or withdrawal |