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MX2008008120A - Nuevos compuestos y metodos para formar taxanos y uso de los mismos. - Google Patents

Nuevos compuestos y metodos para formar taxanos y uso de los mismos.

Info

Publication number
MX2008008120A
MX2008008120A MX2008008120A MX2008008120A MX2008008120A MX 2008008120 A MX2008008120 A MX 2008008120A MX 2008008120 A MX2008008120 A MX 2008008120A MX 2008008120 A MX2008008120 A MX 2008008120A MX 2008008120 A MX2008008120 A MX 2008008120A
Authority
MX
Mexico
Prior art keywords
taxanes
useful
methods
forming
novel compounds
Prior art date
Application number
MX2008008120A
Other languages
English (en)
Inventor
Donald G Walker
John T Henri
James D Micchesney
Sylesh Venkataraman
Christian Sumner
George Petros Yiannikouros
Aaron Michael Stemphoski
Original Assignee
Tapestry Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tapestry Pharmaceuticals Inc filed Critical Tapestry Pharmaceuticals Inc
Publication of MX2008008120A publication Critical patent/MX2008008120A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

La presente invención se refiere en general a nuevos compuestos útiles para la síntesis de compuestos biológicamente activos. De manera más particular, las presentes modalidades descritas en la presente se refieren a nuevas cadenas laterales, que cuando se acoplan a un taxano, son útiles para la síntesis de taxanos farmacéuticamente útiles. También se describen métodos para formar las nuevas cadenas laterales y acoplarlas a alcoholes impedidos, específicamente taxanos que dan por resultado esteres útiles. Se conoce que varios compuestos de taxanos exhiben actividad anti-tumoral.
MX2008008120A 2005-12-21 2005-12-21 Nuevos compuestos y metodos para formar taxanos y uso de los mismos. MX2008008120A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2005/046887 WO2007073383A1 (en) 2005-12-21 2005-12-21 Novel compounds and methods for forming taxanes and using the same

Publications (1)

Publication Number Publication Date
MX2008008120A true MX2008008120A (es) 2008-09-24

Family

ID=38188982

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2008008120A MX2008008120A (es) 2005-12-21 2005-12-21 Nuevos compuestos y metodos para formar taxanos y uso de los mismos.

Country Status (8)

Country Link
US (1) US20090156828A1 (es)
EP (1) EP1973892A1 (es)
JP (1) JP2009521435A (es)
CN (2) CN101370798A (es)
AU (1) AU2005339274A1 (es)
CA (1) CA2634453A1 (es)
MX (1) MX2008008120A (es)
WO (1) WO2007073383A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7745650B2 (en) 2003-09-25 2010-06-29 Tapestry Pharmaceuticals, Inc 9,10-α,α-OH-taxane analogs and methods for production thereof
WO2007075870A2 (en) * 2005-12-21 2007-07-05 Tapestry Pharmaceuticals, Inc. Processes for taxane derivatives and intermediates useful therein
US20090306400A1 (en) * 2006-03-27 2009-12-10 Henri John T Convergent process for the synthesis of taxane derivatives.
US7847111B2 (en) 2006-06-19 2010-12-07 Canada Inc. Semi-synthetic route for the preparation of paclitaxel, docetaxel, and 10-deacetylbaccatin III from 9-dihydro-13-acetylbaccatin III
WO2007143839A1 (en) * 2006-06-12 2007-12-21 6570763 Canada Inc. Semi-synthetic route for the preparation of paclitaxel, docetaxel and 10-deacetylbaccatin iii from 9-dihydro-13-acetylbaccatin iii
US11786504B2 (en) 2006-09-28 2023-10-17 Tapestry Pharmaceuticals, Inc. Taxane analogs for the treatment of brain cancer
WO2008121476A1 (en) 2007-03-28 2008-10-09 Tapestry Pharmaceuticals, Inc. Biologically active taxane analogs and methods of treatment by oral administration
US11873308B2 (en) 2006-11-06 2024-01-16 Tapestry Pharmaceuticals, Inc. Biologically active taxane analogs and methods of treatment by oral administration
US20080207743A1 (en) * 2007-02-28 2008-08-28 Rodger Lamb Biologically Active Taxane Analogs and Methods of Treatment
WO2008109360A1 (en) 2007-02-28 2008-09-12 Tapestry Pharmaceuticals, Inc Taxane analogs for the treatment of brain cancer
CN101735179B (zh) * 2008-11-19 2012-09-12 上海百灵医药科技有限公司 一种多烯紫杉醇的制备方法，其中间体及制备方法
MX341082B (es) 2010-05-03 2016-08-08 Teikoku Pharma Usa Inc Formulaciones de pro-emulsion de taxano no acuosas y metodos para hacer y usar las mismas.
JO3685B1 (ar) 2012-10-01 2020-08-27 Teikoku Pharma Usa Inc صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها
JP6637069B2 (ja) * 2015-01-20 2020-01-29 オロン ソシエタ ペル アチオニＯｌｏｎ Ｓｐａ インダンアミン誘導体の製法及び新規な合成中間体
CN106831664B (zh) * 2017-02-06 2019-08-13 重庆泰润制药有限公司 一种紫杉烷类化合物及其中间体的制备方法
CN109748891B (zh) * 2017-11-01 2023-07-28 中国医学科学院药物研究所 多西他赛衍生物和其药物组合物与用途

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2629818B1 (fr) * 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
US5015744A (en) * 1989-11-14 1991-05-14 Florida State University Method for preparation of taxol using an oxazinone
US5352806A (en) * 1992-04-17 1994-10-04 Abbott Laboratories Taxol derivatives
JP3031715B2 (ja) * 1993-02-05 2000-04-10 ブリン モーアー カレッジ 様々なａ環側鎖を有するタキソール、類似体及び中間体の合成
US6107497A (en) * 1996-02-29 2000-08-22 Napro Biotherapeutics, Inc. Intermediate for use in docetaxel synthesis and production method therefor
US5688977A (en) * 1996-02-29 1997-11-18 Napro Biotherapeutics, Inc. Method for docetaxel synthesis
US5635531A (en) * 1996-07-08 1997-06-03 Bristol-Myers Squibb Company 3'-aminocarbonyloxy paclitaxels
US5750737A (en) * 1996-09-25 1998-05-12 Sisti; Nicholas J. Method for paclitaxel synthesis
JPH11140071A (ja) * 1997-11-04 1999-05-25 Tanabe Seiyaku Co Ltd バッカチン誘導体及びその製法
US6448417B1 (en) * 1998-05-01 2002-09-10 Napro Biotherapeutics, Inc. Methods and useful intermediates for paclitaxel synthesis from C-7, C-10 di-cbz 10-deacetylbaccatin III
US6066749A (en) * 1998-05-01 2000-05-23 Napro Biotherapeutics, Inc. Method for conversion of C-2'-O-protected-10-hydroxy taxol to c-2'-O-protected taxol:useful intermediates in paclitaxel synthesis
US6825166B2 (en) * 2001-03-23 2004-11-30 Tapestry Pharmaceuticals, Inc. Molecular conjugates for use in treatment of cancer
US7745650B2 (en) * 2003-09-25 2010-06-29 Tapestry Pharmaceuticals, Inc 9,10-α,α-OH-taxane analogs and methods for production thereof
EP1888121A2 (en) * 2005-05-12 2008-02-20 Tapestry Pharmaceuticals, Inc. Anticancer targeted conjugates comprising a succinyl or glutaryl linker
WO2007075870A2 (en) * 2005-12-21 2007-07-05 Tapestry Pharmaceuticals, Inc. Processes for taxane derivatives and intermediates useful therein
US20090306400A1 (en) * 2006-03-27 2009-12-10 Henri John T Convergent process for the synthesis of taxane derivatives.
US20080207743A1 (en) * 2007-02-28 2008-08-28 Rodger Lamb Biologically Active Taxane Analogs and Methods of Treatment

Also Published As

Publication number Publication date
WO2007073383A1 (en) 2007-06-28
US20090156828A1 (en) 2009-06-18
EP1973892A1 (en) 2008-10-01
JP2009521435A (ja) 2009-06-04
AU2005339274A1 (en) 2007-06-28
CA2634453A1 (en) 2007-06-28
CN101379046A (zh) 2009-03-04
CN101370798A (zh) 2009-02-18

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