MX2008007298A - Plant growth regulating and fungicidal compositions - Google Patents

Abstract

The present invention provides a composition capable of regulating growth of a plant or propagation material thereof comprising as plant growth regulating active ingredient a mixture of component (A) and component (B) wherein component (A) is Paclobutrazole and component (B) is selected from the group consisting of Difenoconazole, Ipconazole, Metconazole, Tebuconazole, Prothioconazole, Cyproconazole, Propiconazole and Epoxiconazole wherein component (A) and component (B) are present in said composition in amounts which produce a synergistic effect. Preferably the composition comprises Paclobutrazole and Difenoconazole and the composition inhibits growth of the plant upon application thereby increasing yield/quality. The compositions are alsocapable of preventing and/or treating growth and/or infestation of phytopathogenic fungion a plant or propagation material thereof.

Description

FUNGICIDE AND REGULATORY COMPOSITIONS OF PLANT GROWTH FIELD OF THE INVENTION The present invention relates to new compositions for regulating the growth of plants and for controlling phytopathogenic fungi. Additionally refers to the use of the compositions to regulate the growth of plants, in particular to inhibit the growth of plants to increase the yield and for the control of phytopathogenic fungi. BACKGROUND OF THE INVENTION Paclobutrazol ((2RS, 3RS) -1- (4-chlorophenyl) -4,4-dimethyl-2- (1H-1,2,4-triazol-1-yl) -pentan-3-ol ) is a regulator of plant growth. It is used to produce more compact and mechanical strength plants. Therefore, it is used to reduce the housing and increase the yield in useful plants. Examples of other known plant growth regulators include Prohexadione (3,5-dioxo-4- (1-oxopropyl) cyclohexanecarboxylate) and Clomequat (2-chloro-N, N, N-trimethylethanaminium). Triazole fungicides, including Difenoconazole (1- [2- [2-chloro-4- (4-chlorophenoxy) phenyl] -4-methyl-l, 3-dioxolan-2-ylmethyl] -1H-1,2,4-triazole), are inhibitors of Ref. 193544 steroid demethylation (inhibitors of ergosterol biosynthesis) and used as fungicides which are effective against a number of diseases caused by Ascomycetes, Basidiomycetes and Deuteromycetes. It has now been found, surprisingly, that the plant growth regulating property of Paclobutrazol and some other plant growth regulator compounds can be significantly improved when combined with a triazole fungicide selected from Difenoconazole, Ipconazole, Metconazole, Tebuconazole, Protioconazole, Ciproconazole, Propiconazole and Epoxiconazole. Accordingly, the present invention provides a composition capable of regulating the growth of a plant or propagation material thereof comprising as an active ingredient plant growth regulator a mixture of component (A) and component (B) wherein the component (A) is Paclobutrazol and component (B) is selected from the group consisting of Difenoconazole, Ipconazole, Metconazole, Tebuconazole, Protioconazole, Ciproconazole, Propiconazole and Epoxiconazole wherein component (A) and component (B) are present in the composition in quantities which produce a synergistic effect. DETAILED DESCRIPTION OF THE INVENTION The present invention still further provides a composition capable of controlling phytopathogenic fungi in a plant or propagation material thereof comprising as a fungal active ingredient a mixture of component (A) and component (B) wherein component (A) is Paclobutrazol and component (B) ) is selected from the group consisting of Difenoconazole, Ipconazole, Metconazole, Tebuconazole, Protioconazole, Ciproconazole, Propiconazole and Epoxiconazole wherein component (A) and component (B) are present in the composition in amounts which produce a synergistic effect. In a particular embodiment of the invention the composition comprises as a fungal active ingredient and / or plant growth regulator a mixture of (A) Paclobutrazol and (B) Difenoconazole wherein (A) and (B) are present in the composition in quantities which produce a synergistic effect. In a preferred embodiment the composition comprises as an active ingredient plant growth regulator a mixture of Paclobutrazol and Difenoconazole in amounts which produce a synergistic effect. In a still further embodiment of the invention component (A) is Paclobutrazol in free form. In a still further embodiment the composition comprises as a fungal active ingredient and / or plant growth regulator a mixture of (A) Paclobutrazol and (B) Metconazole wherein (A) and (B) are present in the composition in amounts which produce a synergistic effect. In a still further modality the composition comprises as a fungal active ingredient and / or plant growth regulator a mixture of (A) Paclobutrazol and (B) Ipconazole wherein (A) and (B) are present in the composition in amounts which produce a synergistic effect. In a still further embodiment the composition comprises as a physical active ingredient and / or plant growth regulator a mixture of (A) Paclobutrazol and (B) Tebuconazole wherein (A) and (B) are present in the composition in quantities which produce a synergistic effect. In a still further embodiment the composition comprises as a fungal active ingredient and / or plant growth regulator a mixture of (A) Paclobutrazol and (B) Protioconazole wherein (A) and (B) are present in the composition in amounts which produce a synergistic effect. In a still further embodiment the composition comprises as a fungal active ingredient and / or plant growth regulator a mixture of (A) Paclobutrazol and (B) Ciproconazole wherein (A) and (B) are present in the composition in quantities which produce a synergistic effect. In a still further embodiment the composition comprises as fungal active ingredient and / or plant growth regulator a mixture of (A) Paclobutrazol and (B) Propiconazole wherein (A) and (B) are present in the composition in amounts which produce a synergistic effect. In a still further embodiment the composition comprises as a fungal active ingredient and / or plant growth regulator a mixture of (A) Paclobutrazol and (B) Epoxiconazole wherein (A) and (B) are present in the composition in amounts which produce a synergistic effect. The present invention still further provides a composition capable of regulating the growth of a plant or propagation material thereof and / or controlling phytopathogenic fungi in a plant or propagation material thereof which comprises as a fungal active ingredient and / or a host regulator. growth a mixture of component (A) and component - (B) where component (A) is Prohexadione and component (B) is selected from the group consisting of Difenoconazole, Ipconazole, Metconazole, Tebuconazole, Protioconazole, Ciproconazole, Propiconazole and Epoxiconazole where component (A) and component (B) they are present in the composition in amounts which produce a synergistic effect. In a particular embodiment the composition comprises as an active ingredient plant growth regulator a mixture of Prohexadione and Metconazole in amounts which produce a synergistic effect. In a still further embodiment of the invention Prohexadione is used as a calcium salt. The present invention still further provides a composition capable of regulating the growth of a plant or propagation material thereof and / or controlling phytopathogenic fungi in a plant or propagation material thereof which comprises as a fungal active ingredient and / or a host regulator. growth a mixture of component (A) and component (B) wherein component (A) is Clormequat and component (B) is selected from the group consisting of Difenoconazole, Ipconazole, Protioconazole, Ciproconazole, Propiconazole and Epoxiconazole wherein component (A) and component (B) are present in the composition in amounts which produce a synergistic effect. In a still further embodiment of the invention, Clormequat is used as a chloride salt. In a still further embodiment of the invention component (B) is used in the free form. The compositions according to the invention have, inter alia, growth regulating properties pronounced, which can result in an increase in the yield and quality of the cultivated plants and / or harvested crops. The compositions according to the invention are capable of inhibiting the vegetative growth of both monocotyledons and dicotyledons. The inhibition of vegetative growth of cultivated plants allows more plants to be sown in a growing area, so that a higher yield per unit area can be obtained. An additional mechanism of yield increase using regulators resides in the fact that nutrients are able to promote flower formation and bear fruit to a greater degree, while vegetative growth is inhibited. The inhibition of the vegetative growth of monocotyledonous plants, for example grasses or also cultivated plants such as cereals, is sometimes desirable and advantageous. Such inhibition of growth is of economic interest, inter alia, with respect to pastures, when the frequency of cutting in floral gardens, parks, sports fields or verges can be reduced. It is also desirable to inhibit the growth of herbaceous and woody plants on nearby shoulders and transmission lines, or generally in areas where strong growth is undesirable. The use of growth regulators to inhibit the height growth of cereals and rapeseed is also important, since the shortening of the petioles decreases or completely eliminates the danger of lodging before harvesting. In addition, growth regulators are able to cause a strengthening of petioles in cereal crops and this also counteracts lodging. However, in addition to the current surprising synergistic action with respect to the regulation of plant growth, the compositions according to the invention may also have additional surprising advantageous properties which may also be described, in a broader sense, as synergistic activity. . Examples of such advantageous properties that may be mentioned are: a synergistic fungicidal activity, for example the rates of application of the triazole fungicide and the growth regulator are decreased while the fungicidal action remains equally good; a broadening of the spectrum of fungicidal activity to other phytopathogens, for example to resistant strains; a reduction in the speed of application of the active ingredients; more advantageous degradability; improved toxicological and / or ecotoxicological behavior. The components (A) and components (B) are described in the "The Pesticide Manual" [The Pesticide Manual - A World Compendium, Thirteenth Edition; Editor: C. D. S. Tomlin; The British Crop Protection Council]. Paclobutrazol is described herein under the entry number 612, Prohexadione under the entry number 664, Clormequat under the entry number 137, Difenoconazole under the entry number 247, Ipconazole under the entry number 468, Metconazole under the number of entry 525, Tebuconazole under the entry number 761, Protioconazole under the entry number 685, Ciproconazole under the entry number 207, Propiconazole under the entry number 675 and Epoxiconazole under the entry number 298. The components (A) and Components (B) can exist in different stereoisomeric forms. The invention covers mixtures comprising all those stereoisomeric forms or mixtures of those stereoisomeric forms in any ratio. Accordingly, the present invention provides that Paclobutrazol, Difenoconazole, Ipconazole, Metconazole, Tebuconazole, Protioconazole, Ciproconazole, Propiconazole and Epoxiconazole can be used either in their free form or as metal salts or complexes thereof. The mentioned salts of Paclobutrazol and / or Difenoconazole can be prepared by reacting the respective free form of Paclobutrazol and / or Difenoconazole with acids.

Of the acids that can be used for the preparation of Paclobutrazol and / or Difenoconazole salts, the following may be mentioned: hydrolic acids, such as hydrofluoric acid, hydrochloric acid, hydrobromic acid or hydroiodic acid; sulfuric acid, phosphoric acid, nitric acid, and organic acids, such as acetic acid, trifluoroacetic acid, trichloroacetic acid, propionic acid, glycolic acid, thiocyanic acid, lactic acid, succinic acid, citric acid, benzoic acid, cinnamic acid, oxalic acid , formic acid, benzenesulfonic acid, p-toluenesulfonic acid, methanesulfonic acid, salicylic acid, p-aminosalicylic acid, 2-phenoxybenzoic acid, 2-acetoxybenzoic acid and 1,2-naphthalene disulfonic acid. The metal complexes consist of the basic organic molecule and an inorganic or organic metal salt, for example, a halide, nitrate, sulfate, phosphate, acetate, trifluoroacetate, trichloroacetate, propionate, tartrate, sulfonate, salicylate, benzoate, etc., of an element of the main group II, such as calcium and magnesium, and of major groups III and IV, such as aluminum, tin or lead and subgroups I to VIII such as chromium, manganese, iron, cobalt, nickel, copper, zinc, etc. Preference is given to the elements of the 4th period subgroup. Metals can have any of the different valences in which they occur. The metal complexes can be mono- or poly-nuclear, ie they may contain one or more organic molecule components as ligands. The present invention still further provides a composition as described above wherein the composition regulates the growth of plants by inhibiting the growth of the plant or propagation material thereof. Throughout this specification, the term "composition" represents the various mixtures or combinations of component (A) and component (B), for example in a single "ready mix" form, in a combined spray mixture composed of separate formulations of the single active ingredient components, such as a "tank mixture", and in a combined use of the unique active ingredients when applied in a consecutive manner, ie one after the other with reasonably short period, such as a few hours or days. The order of application of the component (A) and component (B) is not essential to work the present invention. The compositions according to the invention may also comprise additional pesticides. The compositions according to the invention are effective against harmful microorganisms, such as microorganisms, which cause phytopathogenic diseases, in particular against phytopathogenic bacteria or fungi.

The compositions according to the invention are especially effective against phytopathogenic fungi belonging to the following classes: Ascomycetes (for example, Venturia, Podosphaera, Eryeiphe, Monilinia, Mycosphaerella, Uncinula); Basidiomycetes (for example, the genus Hemil eia, Rhi zoctonia, Phakopsora, Puccinia, Us tilago (such as Us ti lago nuda), Tiiietia); Fungi imperfecti (also known as Deu teromycetes, for example Botrytis, Helrnin thosporium, Rhynchosporium, Fusarium, Septoria, Cercospora, Al ternarce, Pyri cularia and Pseudocercosporella); Oo ycetes (for example Phytoph thora, Peronospora, Pseudoperonospora, Albugo, Bremia, Pythi um, Peeudoscl erospora, Plasmopara). In all this specification, the term "plant" / "plants" includes plants of the following species: vine of the grape; cereals, such as wheat, barley, rye or oats; beet such as sugar beet or fodder beet; fruits, such as pomes, stone fruits or berry fruits, for example apples, pears, plums, peaches, almonds, cherries, strawberries, raspberries or blackberries; leguminous plants, such as beans, lentils, peas or soybeans; oil plants, such as rapeseed, mustard, poppy, olives, sunflowers, cone, castor oil plants, cocoa beans or peanuts; cucumber plants, such as pumpkins, cucumbers or melons; fibrous plants, such as cotton, linen, hemp or jute; citric fruits, such as oranges, lemons, grapefruit or tangerines; vegetables, such as spinach, lettuce, asparagus, cabbage, carrots, onions, tomatoes, potatoes, cucurbit or paprika; lauraceae, such as avocados, cinnamon or camphor; corn; tobacco; nuts; coffee; sugar cane; tea; vine; hops; durian; bananas natural rubber plants; lawn or ornamentals, such as flowers, shrubs, broadleaf trees or evergreen trees, for example conifers. More specifically, the "plant" / "plants" of particular interest in connection with the present invention are cereals; soy; rice; rapeseed oil; pip fruits; stone fruits; peanuts; coffee; tea; strawberries; grass; vine and vegetables, such as tomatoes, potatoes, cucurbit and lettuce. The term "plant" / "plants" also includes genetically modified plants including those plants which have become resistant to herbicides, insecticides, fungicides or have been modified in some other way such as to improve yield, drought tolerance or quality . Such genetically modified plants may have been modified via recombinant nucleic acid techniques well known to the person skilled in the art. The term "site" of a plant as used herein is intended to encompass the place where the plants are growing, where the propagation materials Plant plants are planted or where the plant propagation materials of the flat ones will be placed on the ground. An example of such a site is a field, in which crop plants are growing. The term "plant propagation material" is understood to denote generating parts of a plant, such as seeds, which may be used for the multiplication of the latter, and vegetative material, such as cuttings or tubers, for example potatoes. For example, seeds (in the strict sense), roots, fruits, tubers, bulbs, rhizomes and parts of plants can be mentioned. Germinated plants and young plants which will be transplanted after germination or after emerging from the earth, can also be mentioned. These young plants can be protected before transplantation by a total or partial immersion treatment. In a particular embodiment "plant propagation material" means seeds. The compositions according to the invention are particularly effective against mildew; oxidation; species of leaf spots: blight and early molds; especially against Septoria, Puccinia, Erysiphe, Pyrenophora, Fusari um and / or Tapesia in cereals, - Phakopsora in soy; Hemil was in coffee; Phragmidi um in roses; Al ternaría in potatoes, tomatoes and cucurbit; Scl erotinia on grass, vegetables, sunflower and rapeseed; black root, red thunder, mildew, gray mold and vine necrosis disease; Botrytis cinerea in fruits; Monilinia spp. in fruits. The compositions according to the invention are particularly useful for controlling the following plant diseases: Al ternarla species in fruit and vegetables, Ascochyta species in pod-bearing vegetables, Botrytis cinerea in strawberries, tomatoes, sunflower, pod-bearing vegetables, vegetables and grapes, Cercospora arachidi cola in peanuts, Cochl i obol us sa tivus in cereals, species Coll etotrichu in legumes with pod, species Erysiphe in cereals, Erysiphe ci choracearum and Sphaerotheca fuliginea in cucurbita, species Fusari um in cereals and corn, Gaumannomyces graminis in cereals and turf, species Helminthospori um in corn, rice and potatoes, Hemil eia vas ta trix in coffee, My crodochi um in wheat and rye species, Phakopsora in soybean species, Puccinia species in cereals, broadleaf crops and perrenial plants, Pseudocercosporella species in cereals, Phragmidium mucronatum in roses, Podosphaera species in fruits, Pyrenophora species in barley, Pyhcularia oryzae in rice, Ramularia eolio-cygni in barley, Rhi zoctonia species in cotton, soybean, cereals, corn, potatoes, rice and grass, Rhynchospori um secalis in barley and rye, species Scl erotinia on grass, lettuce, vegetables and rapeseed, species Septoria in cereals, soybeans and vegetates, Sphacelotheca reilliana in corn, species Ti l letia in cereals, Uncinula neca tor, Guignardia bidwellii and Phomopsis vi tí cola in vine, Urocystis oceans in rye, Species Ustilago (such as Us tilago nuda) in cereals and corn, species Fruit in fruits, Monilinia species in fruits, Mycosphaerella fijiensis in banana. The compositions according to the invention have a systemic fungicidal action and can be used as foliar, soil and seed treatment fungicides. Via the use of compositions according to the invention, it is possible to inhibit or destroy the phytopathogenic microorganisms which occur in plants or in parts of plants (fruit, flowers, leaves, stems, tubers, roots) in different useful plants, while at the same time the parts of plants which grow later are also protected from attack by phytopathogenic microorganisms. The compositions according to the invention are of particular interest to control a large number of fungi in several useful plants or their seeds, especially in grape vines; cereals, such as wheat, barley, rye or oats; beet, such as sugar beet or fodder beet; fruits, such as knobs, stone fruits; leguminous plants, such as beans, lentils, peas or soybeans; oil plants, such as rapeseed, mustard, poppy, olives, sunflowers; fibrous plants, such as cotton; vegetables, such as lettuce, cabbages, tomatoes, potatoes; lauraceae, such as avocados; bananas lawn or ornamental. The compounds according to the invention can be applied by treating the fungi, the plants, the site thereof or the propagation material thereof with a composition according to the invention. The request can be made to the land before the plants emerge, either pre-planting or post-planting. The application can be done as a foliar spray at different times during the development of the crop, either with one or two applications before or after the post-emergence.

The compositions according to the invention can be applied before or after the infection of the useful plants or the propagation material thereof by the fungi. The amount of a composition according to the invention to be applied will depend on several factors, such as the object of the treatment, such as, for example, plants, soil or seeds; the type of treatment, such as, for example, spraying, dusting or disinfecting seeds; the purpose of the treatment, such as, for example, therapeutic or prophylactic control of the disease; in the case of disease control the type of fungi to be controlled or the time of application. The weight ratio of component (A) to component (B) is thus selected as one which provides synergistic activity. In general, the weight ratio of component (A) to component (B) is from 1000: 1 to 1: 1000, preferably from 100: 1 to 1: 100, more preferably from 10: 1 to 1:10, more preferably from 6: 1 to 1: 6, for example Paclobutrazol: Difenoconazole equals 1: 2. The synergistic activity of the compositions according to the invention is evident from the fact that the growth regulating property of the composition of the component (A) and component (B) is greater than the sum of the regulatory growth properties of component (A) component (B). When applied to plants component (A) is applied at a rate of 5 to 2000 g a. i. / ha, particularly 10 to 1000 g a. i. / ha, for example 37.5, 50, 62.5, 75, 100 or 200 a. i. / ha, in association with 1 to 5000 a. i. / ha, particularly 2 to 2000 a. i. / ha, for example 75, 100, 125, 250, 500, 800, 1000, 1500 a. i. / ha of component (B). In agricultural practice the application rates of the compositions according to the invention depend on the type of effect desired, and typically vary from 20 to 4000 g of total composition per hectare, preferably 20 to 1000 g of total composition per hectare. When the compositions according to the invention are used to treat seeds, the speeds of 0.001 to 50 g of component (A) per kg of seed, preferably from 0.01 to 10 g per kg of seed, and 0.001 to 50 g of component ( B), per kg of seed, preferably 0.01 to 10 g per kg of seed, are generally sufficient. The composition of the invention can be used in any conventional form, for example in the form of a double pack, a powder for dry seed treatment.

(DS), an emulsion for seed treatment (ES), a flowable concentrate for seed treatment (FS), a solution for seed treatment (LS), a water dispersible powder for seed treatment (WS), a capsule suspension for seed treatment (CF), a seed treatment gel (GF), an emulsion concentrate (EC) ), a suspension concentrate (SC), a suspo-emulsion (SE), a capsule suspension (CS), a water-dispersible granule (WG), an emulsifiable granule (EG), an emulsion, water-in-oil (EO) ), an emulsion, oil in water (EW), a micro-emulsion (ME), an oil dispersion (OD), an oil miscible flowable (OF), an oil miscible liquid (OL), a soluble concentrate ( SL), an ultra-low volume suspension (SU), an ultra-low volume liquid (UL), a technical concentrate (TK), a dispersible concentrate (DC), a wettable powder (WP) or any technically feasible formulation in combination with agriculturally acceptable adjuvants. Such compositions can be produced in conventional manner, for example by mixing the active ingredients with appropriate inert formulation aids (diluents, solvents, fillers and optionally other formulation ingredients such as surfactants, biocides, antifreezes, tackifiers, thickeners and compounds that provide adjuvant effects. ). It is also possible to use conventional slow-release formulations where long-term efficacy is proposed. Particularly formulations to be applied in spray forms, such as water dispersible concentrates (eg, EC, SC, DC, OD, SE, EW, EO and the like), wettable powders and granules, may contain surfactants such as wetting agents and dispersion and other compounds that provide adjuvant effects, for example the condensation product of formaldehyde with naphthalene sulfonate, an alkylarylsulfonate, a lignin sulfonate, a fatty alkyl sulfate, an ethoxylated alkylphenol and an ethoxylated fatty alcohol. A seed disinfectant formulation is applied in a manner known per se to the seeds using the compositions according to the invention and a diluent in the form of a suitable seed disinfecting formulation, for example as an aqueous suspension in or in a dry powder form which It has good adhesion to the seeds. Such seed disinfectant formulations are known in the art. The seed disinfectant formulations may contain the unique active ingredients or the combination of active ingredients in encapsulated form, for example as microcapsules or slow release capsules. In general, the formulations include from 0.01 to 90% by weight of active agent, from 0 to 20% of agriculturally acceptable surfactant and 10 to 99.99% of adjuvants and inerts of solid or liquid formulation, the active agent consists of at least component (A) together with component (B), and optionally other active agents, particularly microbiocides or preservatives or the like. The concentrated forms of compositions generally contain between about 2 and 80%, preferably between about 5 and 70% by weight of active agent. Formulation application forms for example may contain from 0.01 to 20% by weight, preferably from 0.01 to 5% by weight of active agent. While commercial products will preferably be formulated as concentrates, the end user will usually employ diluted formulations. The present invention still further provides a method of regulating growth of a plant or propagation material thereof which comprises applying to the plant, the site thereof or propagation material thereof a composition as described above. In a particular embodiment of the invention the composition comprises as an active ingredient plant growth regulator a mixture of Paclobutrazol and Difenoconazole in amounts which produce a synergistic effect. The present invention still further provides a method for regulating the growth of a plant to obtain an increase in yield, which comprises applying to the plant, the site thereof or propagating material thereof a composition as described above. Preferably, the composition comprises as an active ingredient plant growth regulator a mixture of Paclobutrazol and Difenoconazole in amounts which produce a synergistic effect. The present invention still further provides a method for controlling phytopathogenic disease in a plant or a propagation material thereof, which comprises applying to the plant, the site thereof or propagation material thereof a composition as described above. In a particular embodiment the composition is applied to the plant or site thereof. In a still further embodiment the composition is applied to the propagation material of the plant. The present invention still further provides a method as described above wherein the plant or propagation material is a cereal or rapeseed plant or material. In a further aspect of the invention there is provided the use of a composition as described above in a method for regulating the growth of a plant or propagation material thereof. In a particular embodiment of the invention the growth of the plant or the propagation material is inhibited. In a Further embodiment of the invention the plant or the propagation material is a plant or propagation material of cereal or rapeseed. In a still further aspect the use of a composition as described above in the prevention and / or treatment of growth and / or infestation of phytopathogenic fungi in a plant or propagation material thereof is provided. In a further embodiment of the invention the plant or propagation material is a cereal or rapeseed plant or material. The examples which follow serve to illustrate the invention, "active ingredient" denotes a mixture of component (A) and component (B) in a specific mixing ratio.

Formulation examples Wettable powders (a) (b) active ingredient A): B) = 1: 3 (a), 1: 2 (b) 25% 50% sodium lignosulfonate 5% 5% sodium lauryl sulfate 3% -diisobutyl naphthanesulfonate sodium - 6% phenol ether polyethylene glycol _ 2% (7-8 mol of ethylene oxide) highly dispersed silicic acid 5% 10% Kaolin 62% 27% The active ingredient is completely mixed with the adjuvants and the mixture is completely crushed in a suitable mill, producing wettable powders that can be diluted with water to produce suspensions of the desired concentration.

Powders for dry seed treatment ((aa)) (b) active ingredient A): B) = 1: 3 (a), 1: 2 (b) 25% 50% light mineral oil 5% 5% highly silicic acid scattered 5% 5% Kaolin 65% 40% Talc The active ingredient is completely mixed with the adjuvants and the mixture is completely crushed in a suitable mill, producing powders that can be used directly for seed treatment.

Emulsifiable concentrate active ingredient (A): B) = 1: 3) 10% octylphenol ether 3% polyethylene glycol (4-5 mole of ethylene oxide) 3% calcium dodecylbenzenesulfonate 4% polyglycol ether of castor oil (35 mole of ethylene oxide) Cyclohexanone 30% xylene blend 50% Emulsions of any required dilution, which can be used in plant protection, can be obtained from this concentrate by dilution with water.

Powders (a) (b) Active ingredient A): B) = 1: 6 (a), 1: 2 (b) 5% 6% Talc 95% Kaolin - 94% mineral filler The ready-to-use powders were obtained by mixing the active ingredient with the carrier and grinding Mix in a suitable mill. Such powders can also be used for dry seed fertilizers.

Extruder granules active ingredient (A): B) = 2: 1) 15% sodium lignosulfonate 2% carboxymethylcellulose 1% Kaolin 82% The active ingredient was mixed and crushed with the adjuvants, and the mixture was wetted with water. The mixture was extruded and then dried in a stream of air.

Coated granules active ingredient (A): B) = 1:10) 8% polyethylene glycol (200 mole weight) 3% Kaolin 89% The finely ground active ingredient was uniformly applied, in a mixer, to the kaolin moistened with polyethylene glycol. The non-powdered coated granules were obtained in this manner.

Suspension concentrate active ingredient (A): B) = 1: 8) 40% propylene glycol 10% nonylphenol polyethylene glycol 6% (15 mol of ethylene oxide) 10% sodium lignosulfonate Carboxymethylcellulose 1% Water 32% The finely ground active ingredient was intimately mixed with the adjuvants, producing a suspension concentrate from which suspensions of any desired dilution can be obtained by dilution with water. Using such dilutions, living plants as well as propagation material can be treated and protected against infestation by microorganisms, by spraying, pouring or immersion.

Flowable concentrate for seed treatment Active ingredient (A): B) = 1.8) 40% Propylene glycol 5% Copolymer of PO / EO 2% tristyrenphenol with 10-20 moles EO 2% 1, 2-benzisothiazolin-3-one (in the form of a 0.5% to 20% solution in water) calcium salt monoazo-pigment 5% silicone oil (in the form of a 0.2% water emulsion 45.3% The finely ground active ingredient is intimately mixed with the equivalents, producing a suspension concentrate from which suspensions of any desired dilution can be obtained by dilution with water. Using such dilutions, living plants as well as plant propagation material can be treated to protect against infestation by microorganisms, by spraying, pouring or immersion.

Suspension in Slow Capsule Release 28 parts of a combination of a compound of component (A) and a compound of component (B), or of each of these compounds separately, were mixed with 2 parts of an aromatic solvent and 7 parts of toluene diisocyanate / polymethylene-polyphenyldiisocyanate mixture (8: 1).

This mixture was emulsified in a mixture of 1.2 parts of polyvinylalcohol, 0.05 parts of a defoamer and 51.6 parts of water until the desired particle size was achieved. To this emulsion was added a mixture of 2.8 parts of 1,6-diaminohexane in 5.3 parts of water. The mixture was stirred until the polymerization reaction was complete. The capsule suspension obtained was stabilized by adding 0.25 parts of a thickener and 3 parts of a dispersing agent. The capsule suspension formulation contains 28% of the active ingredients. The diameter of the middle capsule is 8-15 microns. The resulting formulation was applied to seeds as an aqueous suspension in an apparatus suitable for this purpose.

Biological Examples There is a synergistic effect each time that the action of a combination of active ingredient, such as, for example, the plant growth regulating property or the fungal activity, is greater than the sum of the actions of the individual components. The action to be expected E for a given active ingredient combination obeys the so-called COLBY formula and can be calculated as follows (COLBY, S.R. "Calculating synergistic and antagonistic responses of herbicide combination. "Weeds, Vol. 15, pages 20-22, 1967): X =% action per active ingredient A) at a given amount of active ingredient Y =% action per active ingredient B) at a given amount of active ingredient According to COLBY, the expected combined action of active ingredients A) + B) is E = x +? __X 100 if the currently observed activity (O) is greater than the expected combined action (E), then the activity of the combination is super-additive, ie there is a synergistic effect. In mathematical terms, the synergy factor SF corresponds to the O / E ratio.

Example B-l: Regulation of Plant Growth ("PGR"); Pre-emergence The compounds are sprayed with a vertical low-crop sprayer at the mentioned speeds (ref. tables), pre-planted in the pure soil, then incorporated into the soil and the plants are sown.

After 14 days the plant growth was evaluated against an untreated control.

Example B-2: Regulation of Plant Growth ("PGR"); post-emergence The plants were planted and grown in a greenhouse until Growth Stage 12 (2 leaves not folded). Then the compounds / mixture of the compounds are sprayed with a vertical crop sprayer on the leaves. Plant growth was evaluated against an untreated control, 14 days after application.

Example C-1: Fungicidal action against Botytis cinerea - Fungal growth assay Conidia of the cryogenic storage fungus were directly mixed in nutrient broth (PBD broth of potato dextrose). After placing a solution (DMSO) of the test compounds in a micro-titration plate (96-well format) the nutrient broth containing the fungal spores was added. The test plates were incubated at 24 ° C and the inhibition of growth was determined photometrically after 48-72 hrs.

Example C-2: Fungicidal action against Septoria tritici in wheat a) Fungal growth assay Conidia of the cryogenic storage fungus were directly mixed in nutrient broth (PBD broth of potato dextrose). After placing a solution (DMSO) of the test compounds in a micro-titration plate (96 cavity format) the nutrient broth containing the fungal spores was added. The test plates were incubated at 24 ° C and the inhibition of growth was determined photometrically after 72 hrs. b) Protective treatment Plants of wheat of 2 weeks of age cv. Riband were treated with the formulated test compound (0.2% active ingredient) in a spray chamber. One day after the application, the wheat plants were inoculated by spraying a spore suspension (lOxlO5 conidia / ml) into the test plants. After an incubation period of 1 day at 23 ° C and 95% relative humidity, the plants were maintained for 16 days at 23 ° C and 60% relative humidity in a greenhouse. The incidence of disease was assessed 18 days after inoculation.

Example C-2: Fungicidal action against Pyricularia in rice a) Fungal growth assay Conidia of the cryogenic storage fungus were directly mixed in nutrient broth (PBD broth of potato dextrose). After placing a solution (DMSO) of the test compounds in a micro-titration plate (96 cavity format) the nutrient broth containing the fungal spores was added. The test plates were incubated at 24 ° C and the inhibition of growth was determined photometrically after 72 hrs. b) Protective Treatment Segments of rice leaf were placed on agar in multiple cavity plates (24 cavity format) and sprayed with test solutions. After drying, the leaf discs were inoculated with a spore suspension of the fungus. After the appropriate incubation the activity of a compound was evaluated 96 hrs after the inoculation as a preventive fungicidal activity.

Example C-4: Fungicidal action against Alternaria spp. a) Fungal growth assay al) Alternaria solani (early blight) Conidia collected from a colony of recent growth of the fungus were mixed directly into nutrient broth (potato dextrose broth). After placing a solution (DMSO) of the test compounds in a micro-titration plate (96 cavity format) the nutrient broth containing the fungal spores was added. The test plates were incubated at 24 ° C and the inhibition of growth was determined photometrically after 48 hrs. a2) Alternating brassicae (black rapeseed spot): Conidia collected from a colony of recent growth of the fungus were mixed directly in nutrient broth (potato dextrose broth). After placing a solution (DMSO) of the test compounds in a micro-titration plate (96 cavity format) the nutrient broth containing the fungal spores was added. The test plates were incubated at 24 ° C and the inhibition of growth was determined photometrically after 72 hrs. a3) Alternating brassicicola (rapeseed silicone): Conidia collected from a colony of recent growth of the fungus were mixed directly in broth from nutrient (potato dextrose broth). After placing a solution (DMSO) of the test compounds in a micro-titration plate (96 cavity format) the nutrient broth containing the fungal spores was added. The test plates were incubated at 24 ° C and the inhibition of growth was determined photometrically after 48 hrs. b) Protective Treatment Alternarla solari (early blight) Tomato plants 4 weeks old cv. Roter Gnom were treated with the formulated test compound (0.2% active ingredient) in a spray chamber. Two days after the application, the tomato plants were inoculated by spraying a spore suspension (2xl05 conidia / ml) into the test plants. After an incubation period of 3 days at 20 ° C and 95% relative humidity in a growth chamber the incidence of disease was assessed.

Example C-5: Fungicidal action against Pyrenopeziza brassicae (syn.Cylindrosporium concentricum, clear rapeseed spot) - Fungal growth assay Conidia collected from a colony of recent growth of the fungus were mixed directly into nutrient broth (dextrose broth from dad) . After placing a solution (DMSO) of the test compounds on a plate of micro-titration (96 cavity format) the nutrient broth containing the fungal spores was added. The test plates were incubated at 24 ° C and the inhibition of growth was determined photometrically after 48 hrs.

Example C-6: Fungicidal action against Venturia inae ualis in apple a) Fungal growth assay Conidia of the cryogenic storage fungus were directly mixed in nutrient broth (PBD dextrose broth of potato). After placing a solution (DMSO) of the test compounds in a micro-titration plate (96 cavity format) the nutrient broth containing the fungal spores was added. The test plates were incubated at 24 ° C and the inhibition of growth was determined photometrically after 144 hrs. b) Protective treatment Apple seedlings of 4 weeks of age cv. Mcintosh were treated with the formulated test compound (0.2% active ingredient) in a spray chamber. One day after the application, the apple plants were inoculated by spraying a suspension of spores (4xl05 conidia / ml) into the test plants. After an incubation period of 4 days at 21 ° C and 95% relative humidity the Plants were placed for 4 days at 21 ° C and 60% relative humidity in a greenhouse. After another period of 4 days of incubation at 21 ° C and 95% relative humidity the incidence of disease was assessed.

Example C-7: Fungicidal action against Pythium ultimum (rot) - fungal growth assay Mycelial fragments of the fungus, prepared from a fresh liquid culture, were directly mixed in nutrient broth (PBD broth of potato dextrose). After placing a solution (DMSO) of the test compounds in a micro-titration plate (96-well format) the nutrient broth containing the fungal spores was added. The test plates were incubated at 24 ° C and the inhibition of growth was determined photometrically after 48 hrs.

Example C-8: Fungicidal action against Leptosphaeria ssp. fungal growth assay a) Leptosphaeria nodorum (wheat septoria) Conidia of the cryogenic storage fungus were mixed directly in nutrient broth (PBD broth of potato dextrose). After placing a solution (DMSO) of the test compounds in a micro-titration plate (96 cavity format) the nutrient broth containing Fungal spores were added. The test plates were incubated at 24 ° C and the inhibition of growth was determined photometrically after 48 hrs. a2) Leptosphaeria maculans (syn Phoma linga, black foot of cruciferae): Conidia collected from a colony of recent growth of the fungus were directly mixed in nutrient broth (potato dextrose broth). After placing a solution (DMSO) of the test compounds in a micro-titration plate (96 cavity format) the nutrient broth containing the fungal spores was added. The test plates were incubated at 24 ° C and the inhibition of growth was determined photometrically after 48 hrs.

Example C-9: Fungicidal action against Pseudocercosporella herpotrichoides var. Acufrmis (cercosporelosis / cereals) fungal growth assay Conidia of the cryogenic storage fungus were mixed directly in nutrient broth (PBD broth of potato dextrose). After placing a solution (DMSO) of the test compounds in a micro-titration plate (96 cavity format) the nutrient broth containing the fungal spores was added. The test plates were incubated at 24 ° C and the inhibition of growth was determined photometrically after 72 hrs.

Example C-10: Fungicidal action against recondite Puccinia (brown roy) in wheat Wheat leaf segments were placed on agar in multiple cavity plates (24-cavity format) and sprayed with test solutions. After drying, the leaf discs were inoculated with a spore suspension of the fungus. After the appropriate incubation the activity of a compound was assessed 9 days after the inoculation as a preventive fungicidal activity. b) Protective treatment of plants Wheat plants of 1 week of age cv. Arina were treated with the formulated test compound (0.02% active ingredient) in a spray chamber. One day after the application, the wheat plants were inoculated by spraying a spore suspension (1 x 105 uredospore / ml) into the test plants. After an incubation period of 2 days at 20 ° C and 95% relative humidity the plants were kept in a greenhouse for 8 days at 20 ° C and 60% relative humidity. The incidence of disease was assessed 10 days after inoculation.

Example C-ll: Fungicidal action against Septoria nodorum in wheat a) Protective treatment of leaf segments Wheat leaf segments were placed on agar in multi-cavity plates (24-cavity format) and sprayed with test solutions. After drying, the leaf discs were inoculated with a spore suspension of the fungus. After the appropriate incubation the activity of a compound was evaluated 96 hrs after the inoculation as a preventive fungicidal activity. b) Protective treatment of plants Wheat plants of 1 week of age cv. Arina were treated with the formulated test compound (0.02% active ingredient) in a spray chamber. One day after the application, the wheat plants were inoculated by spraying a spore suspension (5 x 105 conidia / ml) into the test plants. After an incubation period of 1 day at 20 ° C and 95% relative humidity the plants were kept for 10 days at 20 ° C and 60% relative humidity in a greenhouse. The incidence of disease was assessed 11 days after inoculation.

Example C-12: Fungicidal action against Uncinula necator (mildew) on grapes protective treatment Seedlings of grape of 5 weeks of age cv. Gutedel were treated with the formulated test compound (0.2% active ingredient) in a spray chamber. One day after the application, the grape plants were inoculated by shaking the plants infested with grape mildew on top of the test plants. After an incubation period of 7 days at 26 ° C and 60% relative humidity under a light regime of 14/10 hours (light / dark) the incidence of disease was assessed.

Example C-13: Fungicidal action against Sclerotinia sclerotiorum (cottony rot) - fungal growth assay Mycelial fragments of the fungus, prepared fresh liquid culture, were directly mixed into nutrient broth (PBD potato dextrose broth). After placing a solution (DMSO) of the test compounds in a micro-titration plate (96 cavity format) the nutrient broth containing the fungal spores was added. The test plates were incubated at 24 ° C and the inhibition of growth was determined photometrically after 48 hrs.

Example C-14: Fungicidal action against Rhi zoctonia solani (gummosis, rot) - fungal growth test Mycelial fragments of the cryogenic storage fungus were mixed directly in nutrient broth (PBD broth of potato dextrose). After placing a solution (DMSO) of the test compounds in a microtiter plate (96 cavity format) the nutrient broth containing the fungal spores was added. The test plates were incubated at 24 ° C and the inhibition of growth was determined photometrically after 48 hrs.

Example C-15: Fungicidal action against Phakopsora pachyrhi zi (soybean rust) - protective treatment The treatment of soy leaves with the active ingredients mentioned was conducted 4 weeks after planting in a spray chamber. Before or after spraying, discs of leaves were cut from the first trifoliate leaf and placed in plates of multiple cavities in agar. Leaf discs were then inoculated with Phakopsora pachyrhizi (Asian soybean oxidation (ASR)) one day after treatment (curative). The evaluations of the leaves were conducted ten days after the inoculation.

Example C-16: Fungicidal action against Puccinia recondit (brown rust) - protective treatment Wheat leaf segments were placed on agar in Multiple cavity plates (24 cavity format) and sprayed with test solutions (0.02% active ingredient). After drying, the leaf discs were inoculated with a spore suspension of the fungus. After the appropriate incubation the activity of a compound was assessed 9 days after the inoculation - as a preventive fungicidal activity. The compositions according to the invention exhibit good fungicidal activity in Examples C-1 to C-16. It is noted that in relation to this date, the best method known to the applicant to carry out the aforementioned invention, is that which is clear from the present description of the invention.

Claims (13)

1. CLAIMS Having described the invention as above, the content of the following claims is claimed as property: 1. Composition able to regulate the growth of a plant or propagation material thereof, characterized in that it comprises as an active ingredient plant growth regulator a mixture of component (A) and component (B) wherein component (A) is Paclobutrazol and component (B) is selected from the group consisting of Difenoconazole, Ipconazole, Metconazole, Tebuconazole, Prothioconazole, Cyproconazole, Propioconazole and Epoxiconaol wherein the component (A) and component (B) are present in the composition in amounts which produce a synergistic effect.
2. 2. Composition capable of controlling phytopathogenic fungi in a plant or propagation material thereof, characterized in that it comprises as a fungicidal active ingredient a mixture of component (A) and component (B) according to claim 1, wherein the component ( A) and component (B) are present in the composition in amounts which produce a synergistic effect.
3. 3. Composition according to claim 1 or claim 2, characterized in that component (B) is Difenoconazole.
4. 4. Composition according to any of claims 1 to 3, characterized in that the weight ratio of component (A) to component (B) is from 1000: 1 to 1: 1000.
5. 5. Composition according to any of claims 1 to 4, characterized in that it regulates the growth of plants by inhibiting the growth of the plant or propagation material thereof.
6. 6. Method for regulating the growth of a plant or propagation material thereof, characterized in that it comprises applying to the plant, the site thereof or propagation material thereof a composition according to any of claims 1 to 5
7. 7. Method for regulating the growth of a plant to obtain an increase in yield, characterized in that it comprises applying to the plant, the site thereof or propagation material thereof a composition according to any of claims 1 to 5.
8. 8. Method for controlling the phytopathogenic disease in a plant or propagation material thereof, characterized in that it comprises applying to the plant, the site thereof or propagation material thereof a composition according to any of the claims 1 to 5.
9. 9. Method of compliance with any of the claims 6 to 8, characterized in that the composition is applied to the plant or site thereof.
10. 10. Method according to any of claims 6 to 8, characterized in that the composition is applied to the propagation material of the plant. Method according to any of claims 6 to 10, characterized in that the plant or propagation material is a cereal or rapeseed propagation material or plant. 12. Use of a composition according to any of claims 1 to 5 in a method for regulating the growth of a plant or propagation material thereof. 13. Use of a composition according to any of claims 1 to 5 in the prevention and / or treatment of growth and / or infestation of phytopathogenic fungi in a plant or propagation material thereof. 1 . Use according to claim 12 wherein the growth of the plant or propagation material of the mass is inhibited. 15. Use according to claim 13 or claim 14 wherein the plant or propagation material thereof is a cereal or rapeseed plant or material.