MX2008001865A - Albumin fusion proteins. - Google Patents
Albumin fusion proteins.Info
- Publication number
- MX2008001865A MX2008001865A MX2008001865A MX2008001865A MX2008001865A MX 2008001865 A MX2008001865 A MX 2008001865A MX 2008001865 A MX2008001865 A MX 2008001865A MX 2008001865 A MX2008001865 A MX 2008001865A MX 2008001865 A MX2008001865 A MX 2008001865A
- Authority
- MX
- Mexico
- Prior art keywords
- fusion proteins
- albumin fusion
- nucleic acids
- vectors
- host cells
- Prior art date
Links
- 102000009027 Albumins Human genes 0.000 title abstract 6
- 108010088751 Albumins Proteins 0.000 title abstract 6
- 102000037865 fusion proteins Human genes 0.000 title abstract 6
- 108020001507 fusion proteins Proteins 0.000 title abstract 6
- 102000039446 nucleic acids Human genes 0.000 abstract 4
- 108020004707 nucleic acids Proteins 0.000 abstract 4
- 150000007523 nucleic acids Chemical class 0.000 abstract 4
- 239000013598 vector Substances 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/765—Serum albumin, e.g. HSA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Pulmonology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70752105P | 2005-08-12 | 2005-08-12 | |
| US71238605P | 2005-08-31 | 2005-08-31 | |
| US73272405P | 2005-11-03 | 2005-11-03 | |
| US77691406P | 2006-02-28 | 2006-02-28 | |
| US78136106P | 2006-03-13 | 2006-03-13 | |
| US81018206P | 2006-06-02 | 2006-06-02 | |
| US81368206P | 2006-06-15 | 2006-06-15 | |
| PCT/US2006/029391 WO2007021494A2 (en) | 2005-08-12 | 2006-07-31 | Albumin fusion proteins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2008001865A true MX2008001865A (en) | 2008-04-15 |
Family
ID=37758042
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2008001865A MX2008001865A (en) | 2005-08-12 | 2006-07-31 | Albumin fusion proteins. |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP1924596A4 (en) |
| JP (1) | JP2009504157A (en) |
| KR (1) | KR20080071119A (en) |
| AU (1) | AU2006280312A1 (en) |
| BR (1) | BRPI0614761A2 (en) |
| CA (1) | CA2618476A1 (en) |
| EC (1) | ECSP088262A (en) |
| IL (1) | IL189246A0 (en) |
| MA (1) | MA29836B1 (en) |
| MX (1) | MX2008001865A (en) |
| NO (1) | NO20081233L (en) |
| TN (1) | TNSN08064A1 (en) |
| WO (1) | WO2007021494A2 (en) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9526733D0 (en) | 1995-12-30 | 1996-02-28 | Delta Biotechnology Ltd | Fusion proteins |
| CA2405550A1 (en) | 2000-04-12 | 2001-10-25 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| AU2002364586A1 (en) | 2001-12-21 | 2003-07-30 | Delta Biotechnology Limited | Albumin fusion proteins |
| US20080194481A1 (en) * | 2001-12-21 | 2008-08-14 | Human Genome Sciences, Inc. | Albumin Fusion Proteins |
| SI1729795T1 (en) | 2004-02-09 | 2016-04-29 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| EP1816201A1 (en) | 2006-02-06 | 2007-08-08 | CSL Behring GmbH | Modified coagulation factor VIIa with extended half-life |
| EP2046367A4 (en) | 2006-06-07 | 2009-11-11 | Human Genome Sciences Inc | Albumin fusion proteins |
| AU2007294805A1 (en) * | 2006-09-14 | 2008-03-20 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| CA2915168C (en) | 2007-01-30 | 2017-05-23 | Epivax, Inc. | Regulatory t cell epitopes, compositions and uses thereof |
| BRPI0915093A2 (en) | 2008-06-13 | 2015-10-27 | Proyecto Biomedicina Cima Sl | conjugates for the administration of biologically active compounds |
| UA103221C2 (en) * | 2009-01-16 | 2013-09-25 | Тева Фармасьютікал Індастріз Лтд. | Stable formulation of recombinant human albumin-human granulocyte colony stimulating factor |
| KR101722961B1 (en) | 2009-02-11 | 2017-04-04 | 알부메딕스 에이/에스 | Albumin variants and conjugates |
| KR20100100254A (en) * | 2009-03-05 | 2010-09-15 | (주)바이오큐어팜 | Composition for preventing or treating cancer comprising human serum albumin-timp-2 fusion protein and anti-cancer agent |
| BR112012004094A2 (en) | 2009-08-24 | 2016-03-08 | Amunix Operating Inc | coagulation factor vii compositions and methods for making and using them |
| MX2012004793A (en) | 2009-10-30 | 2012-07-20 | Novozymes Biopharma Dk As | Albumin variants. |
| JP5969458B2 (en) | 2010-04-09 | 2016-08-17 | アルブミディクス アクティーゼルスカブ | Albumin derivatives and variants |
| JP6200806B2 (en) | 2010-05-21 | 2017-09-20 | メリマック ファーマシューティカルズ インコーポレーティッド | Bispecific fusion protein |
| CN107261119A (en) * | 2011-02-28 | 2017-10-20 | 独立行政法人国立循环器病研究中心 | Malignant tumor of bonal metastasis suppression medicine |
| CA2830660A1 (en) | 2011-05-05 | 2012-11-08 | Novozymes Biopharma Dk A/S | Albumin variants |
| US10201584B1 (en) | 2011-05-17 | 2019-02-12 | Abbvie Inc. | Compositions and methods for treating HCV |
| DK2717898T3 (en) | 2011-06-10 | 2019-03-25 | Bioverativ Therapeutics Inc | COAGULATING COMPOUNDS AND PROCEDURES FOR USE THEREOF |
| US8492386B2 (en) | 2011-10-21 | 2013-07-23 | Abbvie Inc. | Methods for treating HCV |
| GB2515942A (en) | 2011-10-21 | 2015-01-07 | Abbvie Inc | Combination treatment (e.g. with ABT-072 or ABT-333) of DAAs for use in treating HCV |
| US8466159B2 (en) | 2011-10-21 | 2013-06-18 | Abbvie Inc. | Methods for treating HCV |
| PT107894A (en) | 2011-10-21 | 2014-10-31 | Abbvie Inc | METHODS FOR THE TREATMENT OF HCV COMPREHENDING AT LEAST TWO ANTIVIRAL AGENTS OF DIRECT ACTIVITY, RIBAVIRIN, BUT NOT INTERFERED. |
| US20140315817A1 (en) | 2011-11-18 | 2014-10-23 | Eleven Biotherapeutics, Inc. | Variant serum albumin with improved half-life and other properties |
| EA035323B1 (en) | 2012-01-12 | 2020-05-28 | Биовератив Терапьютикс Инк. | CHEMICAL FACTOR VIII POLYPEPTIDES AND THEIR APPLICATION |
| LT2822577T (en) | 2012-02-15 | 2019-03-25 | Bioverativ Therapeutics Inc. | Recombinant factor viii proteins |
| HRP20221531T1 (en) | 2012-02-15 | 2023-02-17 | Bioverativ Therapeutics Inc. | Factor viii compositions and methods of making and using same |
| DK2825556T3 (en) | 2012-03-16 | 2018-04-16 | Albumedix As | albumin Variants |
| AU2013270683A1 (en) | 2012-06-08 | 2014-12-11 | Biogen Ma Inc. | Chimeric clotting factors |
| CA2875246A1 (en) | 2012-06-08 | 2013-12-12 | Biogen Idec Ma Inc. | Procoagulant compounds |
| CN103525695B (en) * | 2012-07-04 | 2015-05-20 | 长沙中生众捷生物技术有限公司 | Portable kidney function detecting system |
| US10138291B2 (en) | 2012-07-11 | 2018-11-27 | Bioverativ Therapeutics Inc. | Factor VIII complex with XTEN and von Willebrand Factor protein, and uses thereof |
| CA2888806A1 (en) | 2012-10-18 | 2014-04-24 | Biogen Idec Ma Inc. | Methods of using a fixed dose of a clotting factor |
| KR20150082422A (en) | 2012-11-08 | 2015-07-15 | 노보자임스 바이오파마 디케이 에이/에스 | Albumin variants |
| LT2956477T (en) | 2013-02-15 | 2021-02-10 | Bioverativ Therapeutics Inc. | Optimized factor viii gene |
| CN105007722A (en) | 2013-02-16 | 2015-10-28 | 诺维信生物制药丹麦公司 | Pharmacokinetic animal model |
| EA037906B1 (en) | 2013-03-15 | 2021-06-04 | Биовератив Терапьютикс Инк. | Factor ix polypeptide formulations |
| WO2014210558A1 (en) | 2013-06-28 | 2014-12-31 | Biogen Idec Ma Inc. | Thrombin cleavable linker with xten and its uses thereof |
| EP3033097B1 (en) | 2013-08-14 | 2021-03-10 | Bioverativ Therapeutics Inc. | Factor viii-xten fusions and uses thereof |
| HUE057005T2 (en) | 2013-09-25 | 2022-04-28 | Bioverativ Therapeutics Inc | On-column viral inactivation methods |
| WO2015070014A1 (en) | 2013-11-08 | 2015-05-14 | Biogen Idec Ma Inc. | Procoagulant fusion compound |
| DK3091997T5 (en) | 2014-01-10 | 2024-10-14 | Bioverativ Therapeutics Inc | CHIMERIC FACTOR VIII PROTEINS AND USES THEREOF |
| EP3160478A4 (en) | 2014-06-30 | 2018-05-16 | Bioverativ Therapeutics Inc. | Optimized factor ix gene |
| EP3207130B1 (en) | 2014-10-14 | 2019-08-07 | Halozyme, Inc. | Compositions of adenosine deaminase-2 (ada2), variants thereof and methods of using same |
| MA40835A (en) | 2014-10-23 | 2017-08-29 | Biogen Ma Inc | ANTI-GPIIB / IIIA ANTIBODIES AND THEIR USES |
| MA40861A (en) | 2014-10-31 | 2017-09-05 | Biogen Ma Inc | ANTI-GLYCOPROTEIN IIB / IIIA ANTIBODIES |
| MX2018001497A (en) | 2015-08-03 | 2018-05-15 | Bioverativ Therapeutics Inc | Factor ix fusion proteins and methods of making and using same. |
| EP3337816B1 (en) | 2015-08-20 | 2024-02-14 | Albumedix Ltd | Albumin variants and conjugates |
| US10040840B2 (en) | 2015-10-02 | 2018-08-07 | Silver Creek Pharmaceuticals, Inc. | Bi-specific annexin A5/IGF-1 proteins and methods of use thereof to promote regeneration and survival of tissue |
| CN105254766B (en) * | 2015-10-26 | 2018-10-16 | 中国航天员科研训练中心 | Application of the Mecano growth factor MGF E domain peptides in regulation and control memory related gene and miRNA expression |
| PL3411478T3 (en) | 2016-02-01 | 2022-10-03 | Bioverativ Therapeutics Inc. | Optimized factor VIII genes |
| US11192914B2 (en) | 2016-04-28 | 2021-12-07 | Emory University | Alkyne containing nucleotide and nucleoside therapeutic compositions and uses related thereto |
| JP2020500306A (en) | 2016-11-04 | 2020-01-09 | オーフス ウニベルシテット | Identification and treatment of tumors characterized by neonatal Fc receptor overexpression |
| WO2018102743A1 (en) | 2016-12-02 | 2018-06-07 | Bioverativ Therapeutics Inc. | Methods of treating hemophilic arthropathy using chimeric clotting factors |
| BR112019011198A2 (en) | 2016-12-02 | 2019-12-17 | Bioverativ Therapeutics Inc | methods of inducing immune tolerance to coagulation factors |
| MA47163A (en) | 2016-12-16 | 2019-11-06 | Biogen Ma Inc | PROTEOLYTICALLY STABILIZED ACTIVATED GROWTH DIFFERENTIATION FACTOR 11 |
| EA201991768A1 (en) | 2017-01-31 | 2020-01-22 | Байоверетив Терапьютикс Инк. | FUSIONED PROTEINS BASED ON FACTOR IX AND METHODS OF PRODUCING THEM AND WAYS OF APPLICATION |
| WO2018193033A1 (en) * | 2017-04-20 | 2018-10-25 | Novo Nordisk A/S | Methods of purification of albumin fusion proteins |
| JP7374883B2 (en) | 2017-08-09 | 2023-11-07 | バイオベラティブ セラピューティクス インコーポレイテッド | Nucleic acid molecules and their uses |
| WO2019152692A1 (en) | 2018-02-01 | 2019-08-08 | Bioverativ Therapeutics, Inc. | Use of lentiviral vectors expressing factor viii |
| RS66972B1 (en) | 2018-05-18 | 2025-07-31 | Bioverativ Therapeutics Inc | Methods of treating hemophilia a |
| KR20210027426A (en) | 2018-07-03 | 2021-03-10 | 브리스톨-마이어스 스큅 컴퍼니 | FGF21 formulation |
| CN119955796A (en) | 2018-08-09 | 2025-05-09 | 比奥维拉迪维治疗股份有限公司 | Nucleic acid molecules and their use in non-viral gene therapy |
| BR112021010047A2 (en) | 2018-12-06 | 2021-08-24 | Bioverativ Therapeutics Inc. | Use of lentiviral vectors expressing factor ix |
| CN115279896A (en) | 2019-09-30 | 2022-11-01 | 比奥维拉迪维治疗股份有限公司 | Lentiviral vector formulations |
| MX2023000156A (en) | 2020-06-24 | 2023-02-16 | Bioverativ Therapeutics Inc | METHODS FOR THE ELIMINATION OF FREE FACTOR VIII FROM PREPARATIONS OF LENTIVIRAL VECTORS MODIFIED TO EXPRESS SAID PROTEIN. |
| WO2022030580A1 (en) * | 2020-08-06 | 2022-02-10 | 国立大学法人宮崎大学 | Novel long-acting adrenomedullin derivative, method for producing same and pharmaceutical use thereof |
| US12487299B2 (en) | 2022-06-20 | 2025-12-02 | Shanghai United Imaging Healthcare Co., Ltd. | Magnetic resonance imaging devices and radiation therapy systems including the magnetic resonance imaging devices |
| JP2024056667A (en) * | 2022-10-11 | 2024-04-23 | Jcrファーマ株式会社 | Fusion protein of serum albumin and a biologically active protein |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002364586A1 (en) * | 2001-12-21 | 2003-07-30 | Delta Biotechnology Limited | Albumin fusion proteins |
| CA2513213C (en) * | 2003-01-22 | 2013-07-30 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| SI1729795T1 (en) * | 2004-02-09 | 2016-04-29 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| US20060051859A1 (en) * | 2004-09-09 | 2006-03-09 | Yan Fu | Long acting human interferon analogs |
-
2006
- 2006-07-31 KR KR1020087006077A patent/KR20080071119A/en not_active Withdrawn
- 2006-07-31 MX MX2008001865A patent/MX2008001865A/en not_active Application Discontinuation
- 2006-07-31 WO PCT/US2006/029391 patent/WO2007021494A2/en not_active Ceased
- 2006-07-31 AU AU2006280312A patent/AU2006280312A1/en not_active Abandoned
- 2006-07-31 EP EP06813242A patent/EP1924596A4/en not_active Withdrawn
- 2006-07-31 CA CA002618476A patent/CA2618476A1/en not_active Abandoned
- 2006-07-31 JP JP2008526056A patent/JP2009504157A/en not_active Withdrawn
- 2006-07-31 BR BRPI0614761-5A patent/BRPI0614761A2/en not_active IP Right Cessation
-
2008
- 2008-02-04 IL IL189246A patent/IL189246A0/en unknown
- 2008-02-11 TN TNP2008000064A patent/TNSN08064A1/en unknown
- 2008-03-07 MA MA30727A patent/MA29836B1/en unknown
- 2008-03-10 NO NO20081233A patent/NO20081233L/en not_active Application Discontinuation
- 2008-03-12 EC EC2008008262A patent/ECSP088262A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1924596A2 (en) | 2008-05-28 |
| IL189246A0 (en) | 2008-08-07 |
| ECSP088262A (en) | 2008-05-30 |
| NO20081233L (en) | 2008-05-09 |
| TNSN08064A1 (en) | 2009-07-14 |
| AU2006280312A1 (en) | 2007-02-22 |
| KR20080071119A (en) | 2008-08-01 |
| JP2009504157A (en) | 2009-02-05 |
| WO2007021494A2 (en) | 2007-02-22 |
| EP1924596A4 (en) | 2009-07-29 |
| MA29836B1 (en) | 2008-10-03 |
| BRPI0614761A2 (en) | 2009-05-19 |
| WO2007021494A3 (en) | 2007-07-26 |
| CA2618476A1 (en) | 2007-02-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |