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MX2007014082A - Pirido[2,3-d]pirimidinas utiles como inhibidores del virus de la hepatitis c (hcv), y metodos para la preparacion de las mismas. - Google Patents

Pirido[2,3-d]pirimidinas utiles como inhibidores del virus de la hepatitis c (hcv), y metodos para la preparacion de las mismas.

Info

Publication number
MX2007014082A
MX2007014082A MX2007014082A MX2007014082A MX2007014082A MX 2007014082 A MX2007014082 A MX 2007014082A MX 2007014082 A MX2007014082 A MX 2007014082A MX 2007014082 A MX2007014082 A MX 2007014082A MX 2007014082 A MX2007014082 A MX 2007014082A
Authority
MX
Mexico
Prior art keywords
pyrido
preparation
methods
pyrimidines
hcv
Prior art date
Application number
MX2007014082A
Other languages
English (en)
Inventor
Pierre Jean-Marie Bernard Raboisson
Dominique Louis Nest Surleraux
Kenneth Alan Simmen
Tse-I Lin
Oliver Lenz
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Publication of MX2007014082A publication Critical patent/MX2007014082A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invencion se refiere al uso de pirido[2,3-d]pirimidina s como inhibidores de replicacion de 10 HCV asi como tambien a su empleo en composiciones farmaceuticas destinadas a tratar o combatir infecciones con HCV; ademas, la presente invencion se refiere a los compuestos de prido[2,3-d]pirimidinas en si mismos y a su uso como medicinas; la presente invencion tambien se refiere a procesos para la preparacion de tales compuestos, a composiciones farmaceuticas que los comprenden, y a combinaciones de dichos compuestos 15 con otros agentes anti-HCV.
MX2007014082A 2005-05-12 2006-05-12 Pirido[2,3-d]pirimidinas utiles como inhibidores del virus de la hepatitis c (hcv), y metodos para la preparacion de las mismas. MX2007014082A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US68040505P 2005-05-12 2005-05-12
EP05106214 2005-07-07
EP06075855 2006-04-06
PCT/EP2006/062290 WO2006120252A2 (en) 2005-05-12 2006-05-12 Pyrido[2,3-d]pyrimidines useful as hcv inhibitors, and methods for the preparation thereof

Publications (1)

Publication Number Publication Date
MX2007014082A true MX2007014082A (es) 2008-04-17

Family

ID=37198763

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007014082A MX2007014082A (es) 2005-05-12 2006-05-12 Pirido[2,3-d]pirimidinas utiles como inhibidores del virus de la hepatitis c (hcv), y metodos para la preparacion de las mismas.

Country Status (20)

Country Link
US (1) US8022077B2 (es)
EP (1) EP1888580B1 (es)
JP (1) JP5464686B2 (es)
KR (1) KR20080007268A (es)
CN (1) CN101203515B (es)
AR (1) AR054122A1 (es)
AT (1) ATE459623T1 (es)
AU (1) AU2006245676B2 (es)
BR (1) BRPI0609098A2 (es)
CA (1) CA2608301C (es)
DE (1) DE602006012666D1 (es)
DK (1) DK1888580T3 (es)
ES (1) ES2341572T3 (es)
IL (1) IL186881A (es)
MX (1) MX2007014082A (es)
RU (1) RU2444522C2 (es)
SI (1) SI1888580T1 (es)
TW (1) TW200716631A (es)
WO (1) WO2006120252A2 (es)
ZA (1) ZA200709689B (es)

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AR052771A1 (es) * 2004-09-30 2007-04-04 Tibotec Pharm Ltd Pirimidinas biciclicas inhibidoras del vhc
BRPI0609650A2 (pt) * 2005-03-25 2010-04-20 Tibotec Pharm Ltd inibidores heterobicìlicos de hvc
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WO2008133753A2 (en) 2006-12-20 2008-11-06 Abbott Laboratories Anti-viral compounds
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
EP2376514A2 (en) 2008-12-23 2011-10-19 Pharmasset, Inc. Nucleoside analogs
BRPI0923815A2 (pt) 2008-12-23 2015-07-14 Pharmasset Inc Síntese de nucleosídeos de purina
EA019341B1 (ru) 2008-12-23 2014-02-28 Джилид Фармассет, Ллс. Фосфорамидаты нуклеозидов
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BR112012022774A2 (pt) * 2010-03-10 2017-09-12 Abbott Lab Composição sólida compreendendo primeira e segunda dispersões sólidas amorfas
LT2609923T (lt) 2010-03-31 2017-09-11 Gilead Pharmasset Llc (s)-izopropilo 2-(((s)-(perfluorfenoksi)(fenoksi)fosforil)amino)-propanoato kristalinimo būdas
PL3290428T3 (pl) 2010-03-31 2022-02-07 Gilead Pharmasset Llc Tabletka zawierająca krystaliczny (S)-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-diokso-3,4-dihydropirymidyn-1(2H)-ylo)-4-fluoro-3-hydroksy-4-metylotetrahydrofuran-2-ylo)metoksy)(fenoksy)fosforylo)amino)propanian izopropylu
TW201136945A (en) 2010-03-31 2011-11-01 Pharmasset Inc Purine nucleoside phosphoramidate
US8841275B2 (en) 2010-11-30 2014-09-23 Gilead Pharmasset Llc 2′-spiro-nucleosides and derivatives thereof useful for treating hepatitis C virus and dengue virus infections
TR201815062T4 (tr) 2011-04-08 2018-11-21 Janssen Sciences Ireland Uc Viral enfeksiyonların tedavisine yönelik pirimidin deriveleri.
KR102025276B1 (ko) 2011-11-09 2019-09-25 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 바이러스 감염 치료를 위한 퓨린 유도체
US8889159B2 (en) 2011-11-29 2014-11-18 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
PL2872515T3 (pl) 2012-07-13 2017-05-31 Janssen Sciences Ireland Uc Puryny makrocykliczne do leczenia infekcji wirusowych
MX386924B (es) 2012-10-10 2025-03-19 Janssen Sciences Ireland Uc Derivados pirrolo[3,2-d]pirimidínicos para el tratamiento de infecciones víricas y otras enfermedades.
EA035431B1 (ru) 2012-11-16 2020-06-15 Янссен Сайенсиз Айрлэнд Юси Гетероциклические замещенные производные 2-амино-хиназолина в качестве модуляторов tlr7 и/или tlr8 для лечения вирусных инфекций
SG11201506639XA (en) 2013-02-21 2015-09-29 Janssen Sciences Ireland Uc 2-aminopyrimidine derivatives for the treatment of viral infections
AU2014242954B2 (en) 2013-03-29 2018-03-15 Janssen Sciences Ireland Uc Macrocyclic deaza-purinones for the treatment of viral infections
KR102280559B1 (ko) 2013-05-24 2021-07-22 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 바이러스 감염 및 추가적인 질환의 치료를 위한 피리돈 유도체
HRP20171720T1 (hr) 2013-06-27 2017-12-29 Janssen Sciences Ireland Uc Derivati pirolo [3,2-d] pirimidina za liječenje virusnih infekcija i drugih bolesti
CN105492446B (zh) 2013-07-30 2018-08-03 爱尔兰詹森科学公司 用于治疗病毒性感染的噻吩并[3,2-d]嘧啶衍生物
SI3038601T1 (sl) 2013-08-27 2020-07-31 Gilead Pharmasset Llc Formulacija kombinacije dveh protivirusnih spojin
ES2813875T3 (es) 2014-01-01 2021-03-25 Medivation Tech Llc Compuestos y procedimientos de uso
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Also Published As

Publication number Publication date
KR20080007268A (ko) 2008-01-17
DE602006012666D1 (de) 2010-04-15
TW200716631A (en) 2007-05-01
EP1888580A2 (en) 2008-02-20
RU2444522C2 (ru) 2012-03-10
ZA200709689B (en) 2009-07-29
WO2006120252A3 (en) 2007-02-22
CA2608301C (en) 2014-04-22
AU2006245676B2 (en) 2012-08-02
AR054122A1 (es) 2007-06-06
WO2006120252A2 (en) 2006-11-16
ES2341572T3 (es) 2010-06-22
JP2008540494A (ja) 2008-11-20
IL186881A0 (en) 2008-02-09
US20090131460A1 (en) 2009-05-21
CN101203515B (zh) 2014-02-26
AU2006245676A1 (en) 2006-11-16
EP1888580B1 (en) 2010-03-03
JP5464686B2 (ja) 2014-04-09
CN101203515A (zh) 2008-06-18
IL186881A (en) 2015-06-30
DK1888580T3 (da) 2010-06-14
CA2608301A1 (en) 2006-11-16
US8022077B2 (en) 2011-09-20
SI1888580T1 (sl) 2010-06-30
RU2007146173A (ru) 2009-06-20
ATE459623T1 (de) 2010-03-15
BRPI0609098A2 (pt) 2010-02-17

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