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MX2007005694A - Novel betulin derivatives, preparation thereof and use thereof. - Google Patents

Novel betulin derivatives, preparation thereof and use thereof.

Info

Publication number
MX2007005694A
MX2007005694A MX2007005694A MX2007005694A MX2007005694A MX 2007005694 A MX2007005694 A MX 2007005694A MX 2007005694 A MX2007005694 A MX 2007005694A MX 2007005694 A MX2007005694 A MX 2007005694A MX 2007005694 A MX2007005694 A MX 2007005694A
Authority
MX
Mexico
Prior art keywords
preparation
betulin derivatives
novel
derivatives
novel betulin
Prior art date
Application number
MX2007005694A
Other languages
Spanish (es)
Inventor
Carl T Wild
Thomas Stephen Coulter
Gary N Robinson
Mark Ashton
Russell Thomas
Christian Montalbetti
Filippo Magaraci
Robert James Townsend
Theodore John Nitz
Original Assignee
Panacos Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Panacos Pharmaceuticals Inc filed Critical Panacos Pharmaceuticals Inc
Publication of MX2007005694A publication Critical patent/MX2007005694A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention relates to novel synthetic derivatives of betulin and the use of such derivatives as pharmaceuticals. The present invention is directed to novel compounds of Formula (I) or a pharmaceutically acceptable salt or prodrug thereof.
MX2007005694A 2004-11-12 2005-11-14 Novel betulin derivatives, preparation thereof and use thereof. MX2007005694A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US62688604P 2004-11-12 2004-11-12
US65308005P 2005-02-16 2005-02-16
PCT/US2005/041043 WO2006053255A2 (en) 2004-11-12 2005-11-14 Novel betulin derivatives, preparation thereof and use thereof

Publications (1)

Publication Number Publication Date
MX2007005694A true MX2007005694A (en) 2007-07-09

Family

ID=36337281

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007005694A MX2007005694A (en) 2004-11-12 2005-11-14 Novel betulin derivatives, preparation thereof and use thereof.

Country Status (14)

Country Link
US (1) US20060205697A1 (en)
EP (1) EP1828223A4 (en)
JP (1) JP2008519857A (en)
KR (1) KR20070101851A (en)
AR (1) AR051768A1 (en)
AU (1) AU2005304323A1 (en)
BR (1) BRPI0517343A (en)
CA (1) CA2587498A1 (en)
IL (1) IL183102A0 (en)
MX (1) MX2007005694A (en)
NO (1) NO20072978L (en)
RU (1) RU2007121729A (en)
TW (1) TW200628161A (en)
WO (1) WO2006053255A2 (en)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006105356A2 (en) * 2005-03-29 2006-10-05 Regents Of The University Of Minnesota Methods of manufacturing bioactive 3-esters of betulinic aldehyde and betulinic acid
JP2008535923A (en) * 2005-04-12 2008-09-04 パナコス ファーマシューティカルズ インコーポレーティッド Polymorph of 3-O- (3 ', 3'-dimethylsuccinyl) betulinate di-N-methyl-D-glucamine
US20090149429A1 (en) * 2005-06-22 2009-06-11 Myriad Genetics, Incorporated Antiviral compounds
FI121468B (en) * 2006-06-07 2010-11-30 Valtion Teknillinen Compounds derived from betulin as antimicrobial agents
US20080039428A1 (en) * 2006-06-29 2008-02-14 Panacos Pharmaceuticals, Inc. Antiretroviral combination therapy
WO2008097341A2 (en) * 2006-07-26 2008-08-14 Myriad Genetics, Inc. Antiviral compounds and use thereof
CZ300722B6 (en) * 2006-09-27 2009-07-22 Univerzita Karlova v Praze, Prírodovedecká fakulta Process for preparing inclusion complex of pentacyclic and tetracyclic terpenoids, process for preparing pharmaceutical composition containing this inclusion complex, inclusion complex of pentacyclic or tetracyclic terpenoid and pharmaceutical compos
WO2008127364A2 (en) * 2006-10-13 2008-10-23 Myriad Genetics, Inc. Antiviral compounds and use thereof
US20110144069A1 (en) * 2006-10-16 2011-06-16 Myriad Genetics, Incorporated Compounds for treating viral infections
AR063546A1 (en) 2006-11-03 2009-01-28 Panacos Pharmaceuticals Inc TRITERPEN DERIVATIVES, METHODS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT INCLUDE THEM AND THEIR USE IN THE MANUFACTURE OF MEDICINES FOR THE TREATMENT OF INFECTION WITH HIV VIRUS.
US20110152229A1 (en) * 2006-11-22 2011-06-23 Duke University Betulinic acid derivatives as anti-hiv agents
EP2231163A4 (en) * 2007-12-04 2012-10-31 Myriad Pharmaceuticals Inc Compounds and therapeutic use thereof
WO2009082819A1 (en) * 2008-01-03 2009-07-09 Virochem Pharma Inc. Novel lupane derivatives
US8269026B2 (en) * 2008-01-03 2012-09-18 Vertex Pharmaceuticals Incorporated Lupane derivatives useful for treating HIV
EP2257567A1 (en) * 2008-02-14 2010-12-08 Virochem Pharma Inc. Novel 17 beta lupane derivatives
MD4009C2 (en) * 2008-07-15 2010-08-31 Институт Химии Академии Наук Молдовы Use of 1-methyl-4-(N-methylaminobutyl-4)-b-carboline as antituberculous remedy
KR101027217B1 (en) * 2009-03-11 2011-04-06 주식회사 바이오폴리메드 Novel water-soluble betulin derivatives, preparation method thereof and cosmetic composition for improving wrinkles
KR101061911B1 (en) * 2009-04-01 2011-09-02 주식회사 페라온 PEGylated betulin derivatives and cosmetic compositions comprising the same
US20120101098A1 (en) * 2009-05-15 2012-04-26 Kuo-Hsiung Lee 3,28-disubstituted betulinic acid derivatives as anti-hiv agents
US8802727B2 (en) * 2009-07-14 2014-08-12 Hetero Research Foundation, Hetero Drugs Limited Pharmaceutically acceptable salts of betulinic acid derivatives
US9067966B2 (en) 2009-07-14 2015-06-30 Hetero Research Foundation, Hetero Drugs Ltd. Lupeol-type triterpene derivatives as antivirals
EA201290632A1 (en) * 2010-02-11 2013-03-29 ГЛАКСОСМИТКЛАЙН ЭлЭлСи DERIVATIVES OF BETULINA
MX2012013628A (en) * 2010-06-04 2012-12-17 Bristol Myers Squibb Co C-28 amides of modified c-3 betulinic acid derivatives as hiv maturation inhibitors.
CN103038245B (en) * 2010-06-04 2015-03-25 百时美施贵宝公司 Modified c-3 betulinic acid derivatives as HIV maturation inhibitors
RU2448115C1 (en) * 2010-12-20 2012-04-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Новосибирский национальный исследовательский государственный университет" (Новосибирский государственный университет (НГУ) Hydrogenated betulonic acid and amides thereof as triterpene anti-tumour agents
US8846647B2 (en) 2011-01-31 2014-09-30 Bristol-Myers Squibb Company C-17 and C-3 modified triterpenoids with HIV maturation inhibitory activity
RS54352B1 (en) 2011-01-31 2016-02-29 Bristol-Myers Squibb Company C-28 AMINES OF C-3 MODIFIED BETULINIC ACID DERIVATIVES AS HIV INVESTIGATION INHIBITORS
EP2567965B1 (en) * 2011-09-12 2015-09-02 Centre National de la Recherche Scientifique (CNRS) Derivatives of 3-O-(3',3'-dimethylsuccinyl)-betulinic acid
BR112014006559A2 (en) 2011-09-21 2017-03-28 Bristol Myers Squibb Co betulinic acid derivatives with antiviral activity
ES2584684T3 (en) 2011-12-14 2016-09-28 Glaxosmithkline Llc Betulin propenoate derivatives
JO3387B1 (en) 2011-12-16 2019-03-13 Glaxosmithkline Llc Derivatives of betulin
US8906889B2 (en) 2012-02-15 2014-12-09 Bristol-Myers Squibb Company C-3 cycloalkenyl triterpenoids with HIV maturation inhibitory activity
US8889854B2 (en) 2012-05-07 2014-11-18 Bristol-Myers Squibb Company C-17 bicyclic amines of triterpenoids with HIV maturation inhibitory activity
MA38182A1 (en) 2012-12-14 2018-04-30 Glaxosmithkline Llc Long-acting pharmaceutical compositions for use in the treatment or prevention of human immunodeficiency virus (hiv) infections
US9637516B2 (en) 2012-12-31 2017-05-02 Hetero Research Foundation Betulinic acid proline derivatives as HIV inhibitors
SG11201505639SA (en) 2013-02-06 2015-08-28 Bristol Myers Squibb Co C-19 modified triterpenoids with hiv maturation inhibitory activity
MX2015010354A (en) 2013-02-25 2015-10-09 Squibb Bristol Myers Co C-3 alkyl and alkenyl modified betulinic acid derivatives useful in the treatment of hiv.
PL3129392T3 (en) 2014-04-11 2021-04-06 VIIV Healthcare UK(No.4) Limited Triterpenoids with hiv maturation inhibitory activity, substituted in position 3 by a non-aromatic ring carrying a haloalkyl substituent
WO2015195776A1 (en) 2014-06-19 2015-12-23 Bristol-Myers Squibb Company Betulinic acid derivatives with hiv maturation inhibitory activity
US20170129916A1 (en) 2014-06-26 2017-05-11 Hetero Research Foundation Novel betulinic proline imidazole derivatives as hiv inhibitors
WO2015198263A2 (en) * 2014-06-26 2015-12-30 Hetero Research Foundation Novel betulinic proline substituted derivatives as hiv inhibitors
SG11201702379TA (en) 2014-09-26 2017-04-27 Glaxosmithkline Ip No 2 Ltd Long acting pharmaceutical compositions
US10047118B2 (en) 2014-11-14 2018-08-14 VIIV Healthcare UK (No.5) Limited C17-aryl substituted betulinic acid analogs
US9969767B2 (en) 2014-11-14 2018-05-15 VIIV Healthcare UK (No.5) Limited Oxolupene derivatives
KR102467681B1 (en) * 2014-11-24 2022-11-16 주식회사 클랩 Mono-azide compound for photo-induced cross-linking polymer strands
MA40886B1 (en) 2015-02-09 2020-03-31 Hetero Research Foundation Novel c-3 triterpenone with c-28 reverse amide derivatives as hiv inhibitors
US10370405B2 (en) 2015-03-16 2019-08-06 Hetero Labs Limited C-3 novel triterpenone with C-28 amide derivatives as HIV inhibitors
WO2017017630A1 (en) * 2015-07-28 2017-02-02 Hetero Research Foundation Novel betulinic substituted amide derivatives as hiv inhibitors
US10669305B2 (en) 2015-10-13 2020-06-02 Hetero Labs Limited C-3 novel triterpenone with C-28 urea derivatives as HIV inhibitors
AR107512A1 (en) 2016-02-04 2018-05-09 VIIV HEALTHCARE UK Nº 5 LTD TRITERPENOIDS MODIFIED IN C-3 AND C-17 AS HIV-1 INHIBITORS
HRP20231582T1 (en) 2019-02-11 2024-03-15 Hetero Labs Limited NEW TRITERPENE DERIVATIVES AS HIV INHIBITORS

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6448392B1 (en) * 1985-03-06 2002-09-10 Chimerix, Inc. Lipid derivatives of antiviral nucleosides: liposomal incorporation and method of use
US6599887B2 (en) * 1988-07-07 2003-07-29 Chimerix, Inc. Methods of treating viral infections using antiviral liponucleotides
FR2683531B1 (en) * 1991-11-13 1993-12-31 Rhone Poulenc Rorer Sa NEW LUPANE DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
US5643884A (en) * 1993-08-09 1997-07-01 Glycomed Incorporated Lupane triterpenoid derivatives
US6787527B1 (en) * 1994-11-10 2004-09-07 Duke University Methods of preventing and treating HIV infection
US5696277A (en) * 1994-11-15 1997-12-09 Karl Y. Hostetler Antiviral prodrugs
US5679828A (en) * 1995-06-05 1997-10-21 Biotech Research Labs, Inc. Betulinic acid and dihydrobetulinic acid derivatives and uses therefor
US6730679B1 (en) * 1996-03-22 2004-05-04 Smithkline Beecham Corporation Pharmaceutical formulations
WO1998055497A1 (en) * 1997-06-04 1998-12-10 Cornell Research Foundation, Inc. Betulinol derivatives
PT1068219E (en) * 1998-03-02 2007-03-30 Univ North Carolina Acylated betulin and dihydrobetulin derivatives, preparation thereof and use thereof
WO2002026762A1 (en) * 2000-09-29 2002-04-04 Regents Of The University Of Minnesota Triterpenes having antibacterial activity
WO2004072092A1 (en) * 2003-02-11 2004-08-26 Novelix Pharmaceuticals, Inc. Medicament for inhibiting tumour growth
US7026305B2 (en) * 2003-04-14 2006-04-11 Meharry Medical College Anti-HIV agents with dual sites of action
WO2006105356A2 (en) * 2005-03-29 2006-10-05 Regents Of The University Of Minnesota Methods of manufacturing bioactive 3-esters of betulinic aldehyde and betulinic acid

Also Published As

Publication number Publication date
AU2005304323A1 (en) 2006-05-18
BRPI0517343A (en) 2008-10-07
JP2008519857A (en) 2008-06-12
WO2006053255A2 (en) 2006-05-18
RU2007121729A (en) 2008-12-20
EP1828223A2 (en) 2007-09-05
US20060205697A1 (en) 2006-09-14
NO20072978L (en) 2007-06-27
CA2587498A1 (en) 2006-05-18
TW200628161A (en) 2006-08-16
KR20070101851A (en) 2007-10-17
IL183102A0 (en) 2007-09-20
AR051768A1 (en) 2007-02-07
EP1828223A4 (en) 2009-03-11
WO2006053255A3 (en) 2007-01-18

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Legal Events

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FA Abandonment or withdrawal