[go: up one dir, main page]

MX2007005073A - Conjugados con actividad antiinflamtoria. - Google Patents

Conjugados con actividad antiinflamtoria.

Info

Publication number
MX2007005073A
MX2007005073A MX2007005073A MX2007005073A MX2007005073A MX 2007005073 A MX2007005073 A MX 2007005073A MX 2007005073 A MX2007005073 A MX 2007005073A MX 2007005073 A MX2007005073 A MX 2007005073A MX 2007005073 A MX2007005073 A MX 2007005073A
Authority
MX
Mexico
Prior art keywords
inflammatory activity
steroid
nonsteroidal
substructure
conjugates
Prior art date
Application number
MX2007005073A
Other languages
English (en)
Inventor
Mladen Mercep
Milan Mesic
Linda Tomaskovic
Stribor Markovic
Visnja Poljak
Gordana Sijan
Selvira Selmani
Original Assignee
Glaxosmithkline Zagreb
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Zagreb filed Critical Glaxosmithkline Zagreb
Publication of MX2007005073A publication Critical patent/MX2007005073A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invencion se refiere a nuevos compuestos representados por la formula I (ver formula I): en donde M representa una subunidad macrolida de la subestructura VIII; L representa la cadena de la subestructura IX o XIII; Z representa al subunidad esferoidal o no esferoidal derivada de farmacos esferoidales o no esferoidales (NSAID) con actividad antiinflamatoria; la presente invencion se refiere tambien a sales y solvatos farmaceuticamente aceptables de dichos compuestos preparados, a procedimientos e intermedios para su preparacion, asi como a la accion terapeutica mejorada y al uso en el tratamiento de enfermedades y condiciones inflamatorias en humanos y animales.
MX2007005073A 2004-10-27 2005-10-27 Conjugados con actividad antiinflamtoria. MX2007005073A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62315404P 2004-10-27 2004-10-27
PCT/IB2005/003213 WO2006046123A2 (en) 2004-10-27 2005-10-27 Conjugates with anti-inflammatory activity

Publications (1)

Publication Number Publication Date
MX2007005073A true MX2007005073A (es) 2007-06-25

Family

ID=36097295

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007005073A MX2007005073A (es) 2004-10-27 2005-10-27 Conjugados con actividad antiinflamtoria.

Country Status (17)

Country Link
US (1) US20090048221A1 (es)
EP (2) EP1805202B1 (es)
JP (1) JP2008517993A (es)
KR (1) KR20070083811A (es)
CN (1) CN101090908A (es)
AT (1) ATE453658T1 (es)
AU (1) AU2005298312A1 (es)
BR (1) BRPI0517024A (es)
CA (1) CA2585711A1 (es)
DE (1) DE602005018672D1 (es)
ES (1) ES2337915T3 (es)
IL (1) IL182694A0 (es)
MX (1) MX2007005073A (es)
NO (1) NO20072684L (es)
RU (1) RU2007119577A (es)
WO (1) WO2006046123A2 (es)
ZA (1) ZA200702579B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2337915T3 (es) * 2004-10-27 2010-04-30 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. Conjugados con adtividad antiinflamatoria.
FR2909876A1 (fr) * 2006-12-19 2008-06-20 Galderma Res & Dev S N C Snc Utilisation du nepafenac ou ses derives pour le traitement de desordres dermatologiques
CN101708338B (zh) * 2008-12-26 2014-06-04 中国人民解放军军事医学科学院放射与辐射医学研究所 含甾体结构的前药及其高度分散制剂
KR101245078B1 (ko) * 2010-11-11 2013-03-18 부산대학교 산학협력단 대장 선택성 셀레콕시브 전구체 화합물 및 이를 유효성분으로 함유하는 대장성 질환 치료 또는 예방용 약학조성물
EP2984087A1 (en) 2013-04-10 2016-02-17 Probiotic Pharmaceuticals APS Azithromycin antimicrobial derivatives with non-antibiotic pharmaceutical effect
JP2020517748A (ja) 2017-04-20 2020-06-18 ライジング タイド ファウンデーション 抗がん剤としてホスホニウムイオンを含むアジスロマイシン誘導体
CA3060892A1 (en) 2017-04-20 2018-10-25 Rising Tide Foundation Azithromycin derivatives containing a phosphonium ion as anticancer agents
WO2020052677A1 (en) 2018-09-14 2020-03-19 Jiangyin Usun Pharmaceutical Co., Ltd. New conjugates of montelukast and peptides
CN111170959A (zh) * 2019-12-30 2020-05-19 南开大学 一种大环内酯化合物的晶型及其制备方法与用途
CN112521398B (zh) * 2020-07-30 2022-03-15 上海交通大学医学院附属仁济医院 一种海绵共附生菌来源开环重排甾体化合物及其制备方法与应用

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE76311T1 (de) 1986-08-19 1992-06-15 Genentech Inc Einrichtung und dispersion zum intrapulmonalen eingeben von polypeptidwuchsstoffen und zytokinen.
HU198913B (en) 1987-09-03 1989-12-28 Pliva Pharm & Chem Works Process for producing 10-dihydro-10-deoxo-11-aza-erythronolide a-derivatives and pharmaceutical compositions containing them as active components
SE9100342D0 (sv) 1991-02-04 1991-02-04 Astra Ab Novel steroid esters
SE9100341D0 (sv) 1991-02-04 1991-02-04 Astra Ab Novel steroids
GB9225923D0 (en) 1992-12-11 1993-02-03 Rhone Poulenc Rorer Ltd New compositions of matter
JP2657982B2 (ja) 1992-12-24 1997-09-30 ローン−プーラン・ロレ・リミテツド 新規ステロイド
EP0775489A4 (en) 1994-08-12 1998-05-06 Taisho Pharmaceutical Co Ltd INTERLEUKIN-5 PRODUCTION INHIBITOR
CA2196879A1 (en) 1994-08-12 1996-02-22 Akihiko Hoshino Interleukin-5 production inhibitor
DE19616573C2 (de) 1996-04-25 1999-03-04 Pari Gmbh Verwendung unterkritischer Treibmittelmischungen und Aerosole für die Mikronisierung von Arzneimitteln mit Hilfe dichter Gase
JP3530004B2 (ja) 1998-02-06 2004-05-24 株式会社日立ユニシアオートモティブ 吸入式投薬器
WO2000025776A1 (en) 1998-10-30 2000-05-11 Nitromed, Inc. Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use
IT1306205B1 (it) 1999-01-15 2001-05-30 Zambon Spa Macrolidi ad attivita' antiinfiammatoria.
HRP20000310A2 (en) 2000-05-17 2002-02-28 Pliva Farmaceutska Ind Dioniko New dibenzoazulene compounds as tumor necrosis factor inhibitors
FI110835B (fi) 2000-07-11 2003-03-31 Radiolinja Ab Menetelmä palvelunumeropuhelun tarjoamiseksi matkaviestintilaajalle ennalta määrätyllä taksalla
HRP20010018A2 (en) 2001-01-09 2002-12-31 Pliva D D Novel anti-inflammatory compounds
EP1483277A4 (en) 2002-02-15 2007-10-03 Merckle Gmbh CONJUGATES OF BIOLOGICALLY ACTIVE COMPOUNDS, METHODS OF PREPARATION AND USE, AND FORMULATION AND PHARMACEUTICAL APPLICATIONS
ATE429441T1 (de) 2002-07-08 2009-05-15 Glaxosmithkline Zagreb Hybridmoleküle von makroliden mit steroidalen/nicht-steroidalen antientzündlich aktiven molekülen
WO2004005310A2 (en) * 2002-07-08 2004-01-15 Pliva-Istrazivacki Institut D.O.O. New compounds, compositions and methods for treatment of inflammatory diseases and conditions
RS20050007A (sr) 2002-07-08 2007-09-21 Glaxo Smith Kline Istraživački Centar Zagreb D.O.O., NOVE NESTEROIDNE-ANTI- INFLAMATORNE SUPSTANCE, KOMPOZICIJE I POSTUPCI ZA NjIHOVU UPOTREBU
HRP20030324A2 (en) * 2003-04-24 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. Compounds of antiinflammatory effect
MX2007001669A (es) * 2004-08-12 2007-04-10 Glaxosmithkline Zagreb Uso de conjugados especificos celulares para el tratamiento de enfermedades inflamatorias del tracto gastrointestinal.
ES2337915T3 (es) * 2004-10-27 2010-04-30 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. Conjugados con adtividad antiinflamatoria.

Also Published As

Publication number Publication date
EP1805202A2 (en) 2007-07-11
JP2008517993A (ja) 2008-05-29
IL182694A0 (en) 2007-09-20
KR20070083811A (ko) 2007-08-24
EP1805202B1 (en) 2009-12-30
RU2007119577A (ru) 2008-12-10
CN101090908A (zh) 2007-12-19
DE602005018672D1 (de) 2010-02-11
US20090048221A1 (en) 2009-02-19
ATE453658T1 (de) 2010-01-15
WO2006046123A2 (en) 2006-05-04
ES2337915T3 (es) 2010-04-30
WO2006046123A3 (en) 2006-07-06
NO20072684L (no) 2007-07-11
EP2196469A1 (en) 2010-06-16
BRPI0517024A (pt) 2008-03-25
ZA200702579B (en) 2008-08-27
AU2005298312A1 (en) 2006-05-04
CA2585711A1 (en) 2006-05-04

Similar Documents

Publication Publication Date Title
IL182694A0 (en) Conjugates with anti-inflammatory activity
EA017278B9 (ru) Соединения азаиндазола и способы применения
GEP20084527B (en) Benzimidazolone compounds having 5-ht4 receptor agonistic activity
MY148480A (en) Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
UA97351C2 (ru) Производная кумарина, имеющая противоопухолевую активность
TW200635582A (en) Medicaments for the treatment or prevention of fibrotic diseases
NO20082445L (no) Neuropeptid-2 reseptor-agonister
TW200728307A (en) Novel spirochromanone derivatives
RU2011138962A (ru) Производные 4-изопропилфенилглюцита в качестве ингибиторов sglt1
GEP20084417B (en) Imidazopyridine substituted tropane derivatives with ccr5 receptor antagonist activity for the treatment of hiv and inflammation
NO20065904L (no) Terapeutiske forbindelser
WO2004094449A8 (en) Macrolide-conjugates with anti-inflammatory activity
NO20083058L (no) Cykloheksylsulfonamidderivater med H3 reseptor aktivitet
NO20082112L (no) 3-Amino-2-arylpropylazaindoler og deres anvendelse
BRPI0517438A (pt) composto, método para tratar a condição associada com atividade de receptor muscarìnico m4, uso do composto, e, composição farmacêutica
TW200611695A (en) Pyrrolopyridine derivatives
WO2004005309A3 (en) Novel nonsteroidal anti-inflammatory substances, compositions and methods for their use
BR0208027A (pt) Composto de n-fenilarilsulfonamida, droga contendo o composto como ingrediente ativo, intermediário para o composto, e processos para a produção do mesmo
TW200800943A (en) Indane derivatives as MCH receptor antagonists
ATE495159T1 (de) Diaminocyclohexan- und diaminocyclopentanderivate
DE602005021150D1 (de) 3-substituierte pyridinderivate als h3-antagonisten
MX2007004861A (es) Derivados de sulfonamida novedosos como moduladores de receptor glucocorticoide para el tratamiento de enfermedades inflamatorias.
TW200732304A (en) Piperidine derivatives
TW200635592A (en) Pyridyl-substituted spiro-hydantoin compounds and use thereof
UA86873C2 (en) SUBSTITUTED ARYL 1,4-PYRAZlNE DERIVATIVES