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MX2007004769A - Derivado de pirimidina condensado con un anillo no aromatico. - Google Patents

Derivado de pirimidina condensado con un anillo no aromatico.

Info

Publication number
MX2007004769A
MX2007004769A MX2007004769A MX2007004769A MX2007004769A MX 2007004769 A MX2007004769 A MX 2007004769A MX 2007004769 A MX2007004769 A MX 2007004769A MX 2007004769 A MX2007004769 A MX 2007004769A MX 2007004769 A MX2007004769 A MX 2007004769A
Authority
MX
Mexico
Prior art keywords
insulin
pyrimidine derivative
action
nonaromatic ring
diabetes
Prior art date
Application number
MX2007004769A
Other languages
English (en)
Inventor
Yasuhiro Yonetoku
Kenji Negoro
Kenichi Onda
Masahiko Hayakawa
Daisuke Sasuga
Takahiro Nigawara
Kazuhiko Iikubo
Hiroyuki Moritomo
Shigeru Yoshida
Takahide Ohishi
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Publication of MX2007004769A publication Critical patent/MX2007004769A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Se proporcionan nuevos derivados de pirimidina condensados con un anillo no aromatico seleccionado de dihidrotiofeno, dihidrofuran, porcion de cicloalcano, y lo similar o sales farmaceuticamente aceptables de los mismos; y una composicion farmaceutica comprendiendo dicho compuesto como un ingrediente activo. Estos compuestos muestran excelente actividad de promocion en secrecion de insulina y actividad contra hiperglicemia. Por lo tanto, las composiciones farmaceuticas comprendiendo tales compuestos como ingredientes activos, en base a estas acciones, son utiles para tratar y/o prevenir diabetes dependiente de insulina (diabetes tipo 1), diabetes no dependiente de insulina (diabetes tipo 2), enfermedades resistentes a insulina, obesidad y lo similar.
MX2007004769A 2004-10-20 2005-10-17 Derivado de pirimidina condensado con un anillo no aromatico. MX2007004769A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2004305374 2004-10-20
PCT/JP2005/019000 WO2006043490A1 (ja) 2004-10-20 2005-10-17 非芳香環縮合ピリミジン誘導体

Publications (1)

Publication Number Publication Date
MX2007004769A true MX2007004769A (es) 2007-06-25

Family

ID=36202906

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007004769A MX2007004769A (es) 2004-10-20 2005-10-17 Derivado de pirimidina condensado con un anillo no aromatico.

Country Status (15)

Country Link
US (1) US7947690B2 (es)
EP (1) EP1803710A4 (es)
JP (1) JP4775767B2 (es)
KR (1) KR20070084035A (es)
CN (1) CN101044123B (es)
AU (1) AU2005297743A1 (es)
BR (1) BRPI0516237A (es)
CA (1) CA2584666C (es)
IL (1) IL182641A0 (es)
MX (1) MX2007004769A (es)
NO (1) NO20072542L (es)
RU (1) RU2007118653A (es)
TW (1) TW200621257A (es)
WO (1) WO2006043490A1 (es)
ZA (1) ZA200703947B (es)

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Also Published As

Publication number Publication date
TW200621257A (en) 2006-07-01
JP4775767B2 (ja) 2011-09-21
CN101044123B (zh) 2010-09-08
EP1803710A4 (en) 2009-08-26
CA2584666C (en) 2011-12-06
NO20072542L (no) 2007-07-18
WO2006043490A1 (ja) 2006-04-27
AU2005297743A1 (en) 2006-04-27
US20080070896A1 (en) 2008-03-20
IL182641A0 (en) 2007-07-24
BRPI0516237A (pt) 2008-08-26
KR20070084035A (ko) 2007-08-24
JPWO2006043490A1 (ja) 2008-05-22
ZA200703947B (en) 2008-08-27
CA2584666A1 (en) 2006-04-27
US7947690B2 (en) 2011-05-24
EP1803710A1 (en) 2007-07-04
RU2007118653A (ru) 2008-11-27
CN101044123A (zh) 2007-09-26

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