MX2007003112A - Sustancias polimorfas del inhibidor de cisteina-proteasa, n-(1-cianociclopropil)-3-ciclopropilmetanosulfonil-2 (r)-(2,2,2-trifluoro-1(s)-(4-fluorofenil) etilamino)- propionamida. - Google Patents
Sustancias polimorfas del inhibidor de cisteina-proteasa, n-(1-cianociclopropil)-3-ciclopropilmetanosulfonil-2 (r)-(2,2,2-trifluoro-1(s)-(4-fluorofenil) etilamino)- propionamida.Info
- Publication number
- MX2007003112A MX2007003112A MX2007003112A MX2007003112A MX2007003112A MX 2007003112 A MX2007003112 A MX 2007003112A MX 2007003112 A MX2007003112 A MX 2007003112A MX 2007003112 A MX2007003112 A MX 2007003112A MX 2007003112 A MX2007003112 A MX 2007003112A
- Authority
- MX
- Mexico
- Prior art keywords
- polymorphs
- cyanocyclopropyl
- propionamide
- trifluoro
- cyclopropylmethansulfonyl
- Prior art date
Links
- 101000749287 Clitocybe nebularis Clitocypin Proteins 0.000 title 1
- 101000767029 Clitocybe nebularis Clitocypin-1 Proteins 0.000 title 1
- 229940094664 Cysteine protease inhibitor Drugs 0.000 title 1
- NOTSCKFHTQJLMM-HOTGVXAUSA-N (2r)-n-(1-cyanocyclopropyl)-3-(cyclopropylmethylsulfonyl)-2-[[(1s)-2,2,2-trifluoro-1-(4-fluorophenyl)ethyl]amino]propanamide Chemical compound C1=CC(F)=CC=C1[C@@H](C(F)(F)F)N[C@H](C(=O)NC1(CC1)C#N)CS(=O)(=O)CC1CC1 NOTSCKFHTQJLMM-HOTGVXAUSA-N 0.000 abstract 1
- 108090000613 Cathepsin S Proteins 0.000 abstract 1
- 102100035654 Cathepsin S Human genes 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La presente invencion se refiere a sustancias polimorfas de N-(1-cianociclopropil)-3-ciclopropilmetansulfonil-2-(R)-(2, 2, 2-trifluoro-1(S)-(4-fluorofeniletilamino)-propionamida, metodos para usarlas para tratar una enfermedad mediada por catepsina S, composiciones farmaceuticas que comprenden estas sustancias polimorfas y procesos para prepararlas.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/943,768 US7547701B2 (en) | 2003-09-18 | 2004-09-17 | Haloalkyl containing compounds as cysteine protease inhibitors |
| PCT/US2004/030442 WO2005028429A2 (en) | 2003-09-18 | 2004-09-17 | Haloalkyl containing compounds as cysteine protease inhibitors |
| US66424405P | 2005-03-21 | 2005-03-21 | |
| PCT/US2005/033074 WO2006034006A1 (en) | 2004-09-17 | 2005-09-16 | Polymorphs of the cysteine protease inhibitor n- (1-cyanocyclopropyl)-3-cyclopropylmethansulfonyl-2 (r) - (2,2,2-trifluoro-1 (s) - (4-fluorophenyl) ethylamino) propionamide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2007003112A true MX2007003112A (es) | 2007-05-21 |
Family
ID=38325575
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2007003112A MX2007003112A (es) | 2004-09-17 | 2005-09-16 | Sustancias polimorfas del inhibidor de cisteina-proteasa, n-(1-cianociclopropil)-3-ciclopropilmetanosulfonil-2 (r)-(2,2,2-trifluoro-1(s)-(4-fluorofenil) etilamino)- propionamida. |
Country Status (5)
| Country | Link |
|---|---|
| BR (1) | BRPI0515449A2 (es) |
| IL (1) | IL181791A0 (es) |
| MX (1) | MX2007003112A (es) |
| NO (1) | NO20071936L (es) |
| ZA (1) | ZA200703104B (es) |
-
2005
- 2005-09-16 MX MX2007003112A patent/MX2007003112A/es unknown
- 2005-09-16 BR BRPI0515449-9A patent/BRPI0515449A2/pt not_active Application Discontinuation
-
2007
- 2007-03-08 IL IL181791A patent/IL181791A0/en unknown
- 2007-04-16 ZA ZA200703104A patent/ZA200703104B/xx unknown
- 2007-04-16 NO NO20071936A patent/NO20071936L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200703104B (en) | 2008-09-25 |
| NO20071936L (no) | 2007-06-12 |
| BRPI0515449A2 (pt) | 2008-12-16 |
| IL181791A0 (en) | 2007-07-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AP1744A (en) | Inhibitors of factor XA and other serine proteases involved in the coagulation cascade | |
| EP1446115A4 (en) | CYANO ALKYLAMINO DERIVATIVES AS PROTEASE INHIBITORS | |
| CY1111212T1 (el) | Θειικες ενωσεις ως αναστολεις της πρωτεασης σερινης ns3 του ιου της ηπατιτιδας γ | |
| WO2007022459A3 (en) | Processes and intermediates | |
| NO20083958L (no) | Prodrugs av GABA-analoger, sammensetninger og anvendelse derav | |
| TWI265927B (en) | Novel compounds as NS3-serine protease inhibitors of hepatitis C virus | |
| MA29135B1 (fr) | Potentialisateurs de recepteurs du glutamate | |
| IS7925A (is) | Hýdroxýetýlamínafleiður til að meðhöndla Alzheimers-sjúkdóm | |
| SE0201976D0 (sv) | Novel compounds | |
| MY140710A (en) | Novel peptides as ns3-serine protease inhibitors of hepatitis c virus | |
| EP1613368A4 (en) | Carboxamide-spiro hydantoin-CGRP Receptor Antagonists | |
| NO20061627L (no) | Haloalkyl inneholdende forbindelser som cysteinproteaseinhibitorer | |
| BR0316723A (pt) | Derivados de anilinopirazol úteis para o tratamento de diabetes | |
| DK1532124T3 (da) | Anvendelse af nitriderivater som medikament | |
| WO2006078576A3 (en) | Aminomethyl beta-secretase inhibitors for the treatment of alzheimer's disease | |
| DE602005010421D1 (de) | Neue Cysteine Protease Hemmers und ihre therapeutische Anwendungen | |
| WO2005051318A3 (en) | Compounds, compositions and methods for treatment and prophylaxis of hepatitis c viral infections and associated diseases | |
| WO2005063742A3 (en) | Amidino compounds as cysteine protease inhibitors | |
| WO2006055434A3 (en) | Macrocyclic tertiary amine beta-secretase inhibitors for the treatment of alzheimer's disease | |
| WO2006102243A3 (en) | Alpha ketoamide compounds as cysteine protease inhibitors | |
| EA200501802A1 (ru) | Сочетание аналептина модафинила и антидепрессанта для лечения депресии | |
| EA200900510A1 (ru) | Дифторосодержащие соединения в качестве ингибиторов цистеиновых протеаз | |
| WO2006102535A3 (en) | Sulfonyl containing compounds as cysteine protease inhibitors | |
| MX2007003112A (es) | Sustancias polimorfas del inhibidor de cisteina-proteasa, n-(1-cianociclopropil)-3-ciclopropilmetanosulfonil-2 (r)-(2,2,2-trifluoro-1(s)-(4-fluorofenil) etilamino)- propionamida. | |
| WO2007017758A3 (en) | Novel cysteine protease inhibitors and their therapeutic applications |