MEP0808A - Karbonilamino pirolopirayoli, snažni inhibitori kinaza - Google Patents

Karbonilamino pirolopirayoli, snažni inhibitori kinaza

Info

Publication number: MEP0808A
Authority: ME; Montenegro
Prior art keywords: carbonylamino; kinase inhibitors; pyrrolopyrazoles; potent kinase; compounds
Prior art date: 2005-12-21

Application number

MEP-08/08A

Other languages

Bosnian (bs)

English (en)

Inventor

Liming Dong

Chuangxing Guo

Yufeng Hong

Mary Catherine Johnson

Susan Elizabeth Kephart

Haitao Li

Indrawan James Mcalpine

Jayashree Girish Tikhe

Anle Yang

Junhu Zhang

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-12-21

Filing date

2006-12-12

Publication date

2010-02-10

2006-12-12 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2010-02-10 Publication of MEP0808A publication Critical patent/MEP0808A/xx

2010-02-10 Publication of ME00006B publication Critical patent/ME00006B/me

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Oncology (AREA)
Dermatology (AREA)
Urology & Nephrology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

MEP-2008-8A 2005-12-21 2006-12-12 Karbonilamino pirolopirazoli, snažni inhibitori kinaza ME00006B (me)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US75334905P	2005-12-21	2005-12-21
US86493206P	2006-11-08	2006-11-08
PCT/IB2006/003646 WO2007072153A2 (en)	2005-12-21	2006-12-12	Carbonylamino pyrrolopyrazoles, potent kinase inhibitors

Publications (2)

Publication Number	Publication Date
MEP0808A true MEP0808A (xx)	2010-02-10
ME00006B ME00006B (me)	2010-02-10

Family

ID=38189022

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MEP-2008-8A ME00006B (me)	2005-12-21	2006-12-12	Karbonilamino pirolopirazoli, snažni inhibitori kinaza

Country Status (26)

Country	Link
US (1)	US7884117B2 (sr)
EP (1)	EP1979356B1 (sr)
JP (1)	JP4635089B2 (sr)
KR (1)	KR101029167B1 (sr)
AP (1)	AP2369A (sr)
AU (1)	AU2006327866B2 (sr)
BR (1)	BRPI0620354A2 (sr)
CA (1)	CA2634381C (sr)
CR (1)	CR10094A (sr)
CU (1)	CU23751B7 (sr)
DK (1)	DK1979356T3 (sr)
EA (1)	EA015513B1 (sr)
EC (1)	ECSP088558A (sr)
ES (1)	ES2435405T3 (sr)
GE (1)	GEP20104974B (sr)
HR (1)	HRP20130976T1 (sr)
IL (1)	IL191776A (sr)
MA (1)	MA30076B1 (sr)
ME (1)	ME00006B (sr)
MY (1)	MY151455A (sr)
NO (1)	NO20082482L (sr)
NZ (1)	NZ568692A (sr)
PL (1)	PL1979356T3 (sr)
PT (1)	PT1979356E (sr)
RS (2)	RS20080281A (sr)
WO (1)	WO2007072153A2 (sr)

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PL385265A1 (pl) *	2008-05-23	2009-12-07	Zakłady Farmaceutyczne POLPHARMA Spółka Akcyjna	Sposób wytwarzania solifenacyny i/lub jej soli o wysokiej czystości farmaceutycznej
CA2744987C (en)	2008-12-02	2018-01-16	Chiralgen, Ltd.	Method for the synthesis of phosphorus atom modified nucleic acids
CA2767253A1 (en)	2009-07-06	2011-01-13	Ontorii, Inc.	Novel nucleic acid prodrugs and methods of use thereof
US9180127B2 (en)	2009-12-29	2015-11-10	Dana-Farber Cancer Institute, Inc.	Type II Raf kinase inhibitors
WO2012039448A1 (ja) *	2010-09-24	2012-03-29	株式会社キラルジェン	不斉補助基
JP2013542965A (ja)	2010-11-17	2013-11-28	エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト	腫瘍の治療方法
US8771682B2 (en)	2011-04-26	2014-07-08	Technische Universtität Dresden	Methods and compositions for reducing interleukin-4 or interleukin-13 signaling
WO2013012758A1 (en)	2011-07-19	2013-01-24	Ontorii, Inc.	Methods for the synthesis of functionalized nucleic acids
EP3569598A1 (en)	2011-11-17	2019-11-20	Dana Farber Cancer Institute, Inc.	Inhibitors of c-jun-n-terminal kinase (jnk)
CN104168898A (zh)	2012-03-16	2014-11-26	霍夫曼-拉罗奇有限公司	以pak1抑制剂治疗黑色素瘤的方法
JP6268157B2 (ja)	2012-07-13	2018-01-24	株式会社ＷａｖｅＬｉｆｅＳｃｉｅｎｃｅｓＪａｐａｎ	不斉補助基
KR102712879B1 (ko)	2012-07-13	2024-10-04	웨이브 라이프 사이언시스 리미티드	키랄 제어
CN104684923B (zh)	2012-07-13	2018-09-28	株式会社新日本科学	手性核酸佐剂
EP2909194A1 (en)	2012-10-18	2015-08-26	Dana-Farber Cancer Institute, Inc.	Inhibitors of cyclin-dependent kinase 7 (cdk7)
US9758522B2 (en)	2012-10-19	2017-09-12	Dana-Farber Cancer Institute, Inc.	Hydrophobically tagged small molecules as inducers of protein degradation
WO2014063054A1 (en)	2012-10-19	2014-04-24	Dana-Farber Cancer Institute, Inc.	Bone marrow on x chromosome kinase (bmx) inhibitors and uses thereof
WO2015058126A1 (en)	2013-10-18	2015-04-23	Syros Pharmaceuticals, Inc.	Heteroaromatic compounds useful for the treatment of prolferative diseases
JP6491202B2 (ja)	2013-10-18	2019-03-27	デイナファーバーキャンサーインスティチュート，インコーポレイテッド	サイクリン依存性キナーゼ７（ｃｄｋ７）の多環阻害剤
US10144933B2 (en)	2014-01-15	2018-12-04	Shin Nippon Biomedical Laboratories, Ltd.	Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator
JPWO2015108048A1 (ja)	2014-01-15	2017-03-23	株式会社新日本科学	抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
JPWO2015108046A1 (ja)	2014-01-15	2017-03-23	株式会社新日本科学	抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤
EP4137572A1 (en)	2014-01-16	2023-02-22	Wave Life Sciences Ltd.	Chiral design
US10017477B2 (en)	2014-04-23	2018-07-10	Dana-Farber Cancer Institute, Inc.	Janus kinase inhibitors and uses thereof
US9862688B2 (en)	2014-04-23	2018-01-09	Dana-Farber Cancer Institute, Inc.	Hydrophobically tagged janus kinase inhibitors and uses thereof
US10131679B2 (en)	2014-10-31	2018-11-20	Ube Industries, Ltd.	Substituted dihydropyrrolopyrazole compound
HK1245260A1 (zh)	2014-12-23	2018-08-24	Dana-Farber Cancer Institute, Inc.	细胞周期蛋白依赖性激酶7(cdk7)的抑制剂
JP6861166B2 (ja)	2015-03-27	2021-04-21	ダナ−ファーバーキャンサーインスティテュート，インコーポレイテッド	サイクリン依存性キナーゼの阻害剤
CA2986441A1 (en)	2015-06-12	2016-12-15	Dana-Farber Cancer Institute, Inc.	Combination therapy of transcription inhibitors and kinase inhibitors
RU2765718C1 (ru) *	2015-06-15	2022-02-02	Убе Индастриз, Лтд.	Замещенное производное дигидропирролопиразола
US11142507B2 (en)	2015-09-09	2021-10-12	Dana-Farber Cancer Institute, Inc.	Inhibitors of cyclin-dependent kinases
WO2017144546A1 (en)	2016-02-23	2017-08-31	INSERM (Institut National de la Santé et de la Recherche Médicale)	Methods and pharmaceutical compositions for the treatment of nasopharyngeal carcinoma
EP3810132A4 (en)	2018-06-25	2022-06-22	Dana-Farber Cancer Institute, Inc.	TAIRE FAMILY KINASE INHIBITORS AND RELATED USES
EP3885347B1 (en)	2018-11-14	2023-11-22	UBE Corporation	Dihydropyrrolopyrazole derivative
CA3124422A1 (en)	2018-12-28	2020-07-02	Dana-Farber Cancer Institute, Inc.	Inhibitors of cyclin-dependent kinase 7 and uses thereof
WO2020212484A1 (en)	2019-04-17	2020-10-22	INSERM (Institut National de la Santé et de la Recherche Médicale)	Methods and compositions for treatment of nlrp3 inflammasome mediated il-1beta dependent disorders
WO2021118924A2 (en)	2019-12-12	2021-06-17	Ting Therapeutics Llc	Compositions and methods for the prevention and treatment of hearing loss
WO2021198511A1 (en)	2020-04-03	2021-10-07	INSERM (Institut National de la Santé et de la Recherche Médicale)	Methods and compositions for treatment of sars-cov-2 infection
WO2022008597A1 (en)	2020-07-08	2022-01-13	INSERM (Institut National de la Santé et de la Recherche Médicale)	Methods and pharmaceutical composition for the treatment of infectious diseases
WO2024261302A1 (en)	2023-06-22	2024-12-26	Institut National de la Santé et de la Recherche Médicale	Nlrp3 inhibitors, pak1/2 inhibitors and/or caspase 1 inhibitors for use in the treatment of rac2 monogenic disorders
WO2025078334A1 (en)	2023-10-09	2025-04-17	Institut National de la Santé et de la Recherche Médicale	Combination of pak1 inhibitors and clk inhibitors for preventing resistance to chemotherapy in patients suffering from acute myeloid leukemia

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MXPA03001169A (es)	2000-08-10	2003-06-30	Pharmacia Italia Spa	Biciclo-pirazoles activos como inhibidores de quinasa, proceso para su preparacion y composiciones farmaceuticas que comprenden los mismos.
JP2005537290A (ja)	2002-07-25	2005-12-08	ファルマシア・イタリア・エス・ピー・エー	キナーゼ阻害剤として活性なビシクロピラゾール類、その製造方法、およびそれを含有する薬学的組成物
UA81790C2 (uk) *	2002-12-19	2008-02-11	Фармация Италия С.П.А.	Заміщені піролопіразольні похідні як інгібітори кінази
GB0229526D0 (en)	2002-12-19	2003-01-22	Astrazeneca Ab	Chemical compounds
WO2005030776A1 (en) *	2003-09-23	2005-04-07	Vertex Pharmaceuticals Incorporated	Pyrazolopyrrole derivatives as protein kinase inhibitors
BRPI0518509A2 (pt) *	2005-01-10	2008-11-25	Pfizer	pirrolopirazàis, inibidores de cinase potentes

2006
- 2006-12-12 RS RSP-2008/0281A patent/RS20080281A/sr unknown
- 2006-12-12 PL PL06831731T patent/PL1979356T3/pl unknown
- 2006-12-12 PT PT68317312T patent/PT1979356E/pt unknown
- 2006-12-12 ME MEP-2008-8A patent/ME00006B/me unknown
- 2006-12-12 NZ NZ568692A patent/NZ568692A/en not_active IP Right Cessation
- 2006-12-12 WO PCT/IB2006/003646 patent/WO2007072153A2/en not_active Ceased
- 2006-12-12 HR HRP20130976TT patent/HRP20130976T1/hr unknown
- 2006-12-12 GE GEAP200610777A patent/GEP20104974B/en unknown
- 2006-12-12 EA EA200801291A patent/EA015513B1/ru not_active IP Right Cessation
- 2006-12-12 DK DK06831731.2T patent/DK1979356T3/da active
- 2006-12-12 ES ES06831731T patent/ES2435405T3/es active Active
- 2006-12-12 KR KR1020087014963A patent/KR101029167B1/ko not_active Expired - Fee Related
- 2006-12-12 RS RS20130498A patent/RS53029B/sr unknown
- 2006-12-12 AP AP2008004506A patent/AP2369A/xx active
- 2006-12-12 MY MYPI20082267 patent/MY151455A/en unknown
- 2006-12-12 EP EP06831731.2A patent/EP1979356B1/en active Active
- 2006-12-12 CA CA2634381A patent/CA2634381C/en not_active Expired - Fee Related
- 2006-12-12 JP JP2008546667A patent/JP4635089B2/ja not_active Expired - Fee Related
- 2006-12-12 BR BRPI0620354-0A patent/BRPI0620354A2/pt not_active IP Right Cessation
- 2006-12-12 US US12/158,241 patent/US7884117B2/en not_active Expired - Fee Related
- 2006-12-12 AU AU2006327866A patent/AU2006327866B2/en not_active Ceased
2008
- 2008-05-27 IL IL191776A patent/IL191776A/en not_active IP Right Cessation
- 2008-06-02 NO NO20082482A patent/NO20082482L/no not_active Application Discontinuation
- 2008-06-18 EC EC2008008558A patent/ECSP088558A/es unknown
- 2008-06-19 CU CU20080115A patent/CU23751B7/es active IP Right Grant
- 2008-06-20 MA MA31060A patent/MA30076B1/fr unknown
- 2008-06-20 CR CR10094A patent/CR10094A/es unknown

Also Published As

Publication number	Publication date
CU20080115A7 (es)	2010-08-30
AP2008004506A0 (en)	2008-06-30
DK1979356T3 (da)	2013-11-18
AU2006327866B2 (en)	2012-06-14
WO2007072153A2 (en)	2007-06-28
MY151455A (en)	2014-05-30
PL1979356T3 (pl)	2014-01-31
WO2007072153A3 (en)	2007-10-25
JP4635089B2 (ja)	2011-02-16
ECSP088558A (es)	2008-07-30
PT1979356E (pt)	2013-11-21
RS20080281A (sr)	2009-09-08
CR10094A (es)	2008-08-01
EP1979356A2 (en)	2008-10-15
KR20080080567A (ko)	2008-09-04
US20090318440A1 (en)	2009-12-24
KR101029167B1 (ko)	2011-04-12
BRPI0620354A2 (pt)	2011-11-08
HK1128290A1 (en)	2009-10-23
MA30076B1 (fr)	2008-12-01
HRP20130976T1 (hr)	2013-11-22
WO2007072153A8 (en)	2008-08-14
EP1979356B1 (en)	2013-09-18
CA2634381A1 (en)	2007-06-28
US7884117B2 (en)	2011-02-08
GEP20104974B (en)	2010-04-26
CU23751B7 (es)	2012-01-31
EA200801291A1 (ru)	2008-12-30
EA015513B1 (ru)	2011-08-30
AP2369A (en)	2012-02-29
NZ568692A (en)	2011-07-29
CA2634381C (en)	2011-03-08
RS53029B (sr)	2014-04-30
AU2006327866A1 (en)	2007-06-28
NO20082482L (no)	2008-07-02
JP2009520805A (ja)	2009-05-28
ME00006B (me)	2010-02-10
IL191776A0 (en)	2008-12-29
ES2435405T3 (es)	2013-12-19
IL191776A (en)	2013-03-24

Publication	Publication Date	Title
MY151455A (en)	2014-05-30	Carbonylamino pyrrolopyrazoles, potent kinase inhibitors
EA200701257A1 (ru)	2007-12-28	Пирролопиразолы в качестве сильнодействующих ингибиторов киназы
MX2009011211A (es)	2009-10-30	Indoles sustituidos en la posicion 7 inhibidores de mci-1.
MXPA05012026A (es)	2006-02-03	Compuestos de azaindol como inhibidores de cinasa.
MXPA05012025A (es)	2006-02-03	Imidazo y tiazolopiridinas como inhibidores de cinasa jak3.
PH12015501484A1 (en)	2017-06-05	Heteroaryl compounds and uses thereof
WO2007079164A3 (en)	2007-09-27	Protein kinase inhibitors
MXPA06011327A (es)	2006-12-15	Azaindoles utiles como inhibidores de jak y otras proteinas cinasas.
MY148634A (en)	2013-05-15	Pyridazinone derivatives
JO3181B1 (ar)	2018-03-08	مشتقات كمحول ثاني الكيل البايردينيل - أحادي الفينيل كأنزيم ثنائي استرات الفوسفود
SG154433A1 (en)	2009-08-28	Phthalazine derivatives as parp inhibitors
MX340714B (es)	2016-07-22	Inhibidores de hsp90.
GB0400895D0 (en)	2004-02-18	Chemical compounds
MX2008001538A (es)	2008-04-04	Aril piridinas y metodos para su uso.
EA200800357A1 (ru)	2008-06-30	Новые фармацевтические соединения
TW200628153A (en)	2006-08-16	Novel compounds
UA87494C2 (en)	2009-07-27	Azaindoles useful as inhibitors of jak and other protein kinases
MX2009012079A (es)	2009-11-19	Compuestos heterociclicos condensados como inhibidores de proteina cinasas.
TW200624429A (en)	2006-07-16	Novel cysteine protease inhibitors
UA92047C2 (uk)	2010-09-27	Карбоніламінопіролпіразоли - потужні інгібітори кінази
WO2006097809A3 (en)	2007-04-26	Novel tyrosine derivatives
UA88794C2 (en)	2009-11-25	Pyrrolopyrazoles, potent kinase inhibitors
DE602006016430D1 (de)	2010-10-07	Phosphodiesteraseinhibitoren auf azolbasis
MXPA05011594A (es)	2005-12-15	Intermediarios de imidazopiridina.
CY1114511T1 (el)	2016-10-05	Καρβονυλαμινο πυρρολοπυραζολες, ικανοι αναστολεις κινασων