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MD4659B1 - Polimorf al inhibitorilor SYK - Google Patents

Polimorf al inhibitorilor SYK Download PDF

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Publication number
MD4659B1
MD4659B1 MD20160017A MD20160017A MD4659B1 MD 4659 B1 MD4659 B1 MD 4659B1 MD 20160017 A MD20160017 A MD 20160017A MD 20160017 A MD20160017 A MD 20160017A MD 4659 B1 MD4659 B1 MD 4659B1
Authority
MD
Moldova
Prior art keywords
polymorph
syk inhibitors
methods
relates
monohydrate
Prior art date
Application number
MD20160017A
Other languages
English (en)
Russian (ru)
Other versions
MD20160017A2 (ro
Inventor
Peter Chee-Chu Fung
Dimitrios Stefanidis
Dragos Vizitiu
Tim G Elford
Michael Laird Hurrey
Original Assignee
Gilead Connecticut Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51301367&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MD4659(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gilead Connecticut Inc filed Critical Gilead Connecticut Inc
Publication of MD20160017A2 publication Critical patent/MD20160017A2/ro
Publication of MD4659B1 publication Critical patent/MD4659B1/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Invenţia se referă la un polimorf al unui monohidrat a sării de bis-mesilat a compusului cu formula I:(I).Invenţia se referă, de asemenea, la procedee de preparare a acestuia, la compoziţii farmaceutice şi la metode de tratament al cancerului şi bolilor autoimune.
MD20160017A 2013-07-30 2014-07-29 Polimorf al inhibitorilor SYK MD4659B1 (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361860197P 2013-07-30 2013-07-30
PCT/US2014/048733 WO2015017460A1 (en) 2013-07-30 2014-07-29 Polymorph of syk inhibitors

Publications (2)

Publication Number Publication Date
MD20160017A2 MD20160017A2 (ro) 2016-08-31
MD4659B1 true MD4659B1 (ro) 2019-11-30

Family

ID=51301367

Family Applications (1)

Application Number Title Priority Date Filing Date
MD20160017A MD4659B1 (ro) 2013-07-30 2014-07-29 Polimorf al inhibitorilor SYK

Country Status (32)

Country Link
US (4) US20160168155A1 (ro)
EP (1) EP3027618B1 (ro)
JP (1) JP6230709B2 (ro)
KR (1) KR101810798B1 (ro)
CN (1) CN105452252A (ro)
AP (1) AP2016009008A0 (ro)
AR (1) AR097158A1 (ro)
AU (2) AU2014296308C1 (ro)
CA (1) CA2919661C (ro)
CL (1) CL2016000238A1 (ro)
CR (1) CR20160098A (ro)
DK (1) DK3027618T3 (ro)
EA (2) EA029281B1 (ro)
ES (1) ES2822285T3 (ro)
HK (1) HK1222390A1 (ro)
HR (1) HRP20201582T1 (ro)
HU (1) HUE052090T2 (ro)
IL (1) IL243579A0 (ro)
MD (1) MD4659B1 (ro)
MX (1) MX2016001304A (ro)
MY (1) MY176803A (ro)
NZ (1) NZ715776A (ro)
PE (1) PE20160862A1 (ro)
PH (1) PH12016500169A1 (ro)
PL (1) PL3027618T3 (ro)
PT (1) PT3027618T (ro)
SG (1) SG11201600385TA (ro)
SI (1) SI3027618T1 (ro)
SV (1) SV2016005149A (ro)
TW (1) TW201602108A (ro)
UY (1) UY35683A (ro)
WO (1) WO2015017460A1 (ro)

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PT3027171T (pt) * 2013-07-30 2020-06-18 Gilead Connecticut Inc Formulação de inibidores da syk
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TWI735853B (zh) 2013-12-23 2021-08-11 美商克洛諾斯生技有限公司 脾酪胺酸激酶抑制劑
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TW201639573A (zh) 2015-02-03 2016-11-16 吉李德科學股份有限公司 有關治療癌症之合併治療
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US20170173034A1 (en) 2015-12-17 2017-06-22 Gilead Sciences, Inc. Combination of a jak inhibitor and a syk inhibitor for treating cancers and inflammatory disorders
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TW201822764A (zh) 2016-09-14 2018-07-01 美商基利科學股份有限公司 Syk抑制劑
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PH12016500169A1 (en) 2016-04-25
US9657023B2 (en) 2017-05-23
JP2016527268A (ja) 2016-09-08
PT3027618T (pt) 2020-10-12
MD20160017A2 (ro) 2016-08-31
AU2014296308C1 (en) 2018-09-13
HRP20201582T1 (hr) 2021-02-19
CL2016000238A1 (es) 2016-07-22
NZ715776A (en) 2017-04-28
AR097158A1 (es) 2016-02-24
MX2016001304A (es) 2016-04-07
HUE052090T2 (hu) 2021-04-28
UY35683A (es) 2015-02-27
EA201791873A1 (ru) 2018-09-28
EA029281B1 (ru) 2018-03-30
AU2017225136A1 (en) 2017-10-05
EP3027618B1 (en) 2020-07-08
AP2016009008A0 (en) 2016-01-31
EA201690172A1 (ru) 2016-07-29
WO2015017460A1 (en) 2015-02-05
CR20160098A (es) 2016-07-11
HK1222390A1 (zh) 2017-06-30
CA2919661A1 (en) 2015-02-05
AU2014296308A1 (en) 2016-02-04
ES2822285T3 (es) 2021-04-30
AU2014296308B2 (en) 2017-06-08
JP6230709B2 (ja) 2017-11-15
US20150038505A1 (en) 2015-02-05
PL3027618T3 (pl) 2021-04-19
US20180099971A1 (en) 2018-04-12
US20170217967A1 (en) 2017-08-03
EP3027618A1 (en) 2016-06-08
IL243579A0 (en) 2016-02-29
US20160168155A1 (en) 2016-06-16
SI3027618T1 (sl) 2021-01-29
KR101810798B1 (ko) 2017-12-19
SV2016005149A (es) 2017-04-03
CN105452252A (zh) 2016-03-30
SG11201600385TA (en) 2016-02-26
CA2919661C (en) 2020-08-18
MY176803A (en) 2020-08-21
PE20160862A1 (es) 2016-09-24
TW201602108A (zh) 2016-01-16
KR20160038007A (ko) 2016-04-06
DK3027618T3 (da) 2020-10-12
US10266539B2 (en) 2019-04-23

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