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MD4407B1 - Inhibitor of human myeloid leukemia HL-60 cells based on bis[N-(prop-2-en-1-yl)-2-(pyridine-2-ylmethylidene)hydrazinecarbothioamide]nickel(II) chloride hydrate - Google Patents

Inhibitor of human myeloid leukemia HL-60 cells based on bis[N-(prop-2-en-1-yl)-2-(pyridine-2-ylmethylidene)hydrazinecarbothioamide]nickel(II) chloride hydrate Download PDF

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Publication number
MD4407B1
MD4407B1 MDA20150041A MD20150041A MD4407B1 MD 4407 B1 MD4407 B1 MD 4407B1 MD A20150041 A MDA20150041 A MD A20150041A MD 20150041 A MD20150041 A MD 20150041A MD 4407 B1 MD4407 B1 MD 4407B1
Authority
MD
Moldova
Prior art keywords
myeloid leukemia
human myeloid
ylmethylidene
hydrazinecarbothioamide
prop
Prior art date
Application number
MDA20150041A
Other languages
Romanian (ro)
Russian (ru)
Other versions
MD4407C1 (en
Inventor
Aurelian Gulea
Vasilii Graur
Victor Ţapcov
Original Assignee
Universitatea De Stat Din Moldova
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universitatea De Stat Din Moldova filed Critical Universitatea De Stat Din Moldova
Priority to MDA20150041A priority Critical patent/MD4407C1/en
Publication of MD4407B1 publication Critical patent/MD4407B1/en
Publication of MD4407C1 publication Critical patent/MD4407C1/en

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Abstract

The invention relates to chemistry, namely to a coordinative compound from the class of thiosemicarbazonates of transition metals and may find application in medicine for the prevention and treatment of human myeloid leukemia.Summary of the invention consists in that as an inhibitor of human myeloid leukemia HL-60 cells is proposed the new bis[N-(prop-2-en-1-yl)-2-(pyridine-2-ylmethylidene)hydrazinecarbothioamide]nickel(II) chloride hydrate compound of formula:The claimed compound expands the range of highly active inhibitors of human myeloid leukemia cells.
MDA20150041A 2015-04-29 2015-04-29 Inhibitor of human myeloid leukemia HL-60 cells based on bis[N-(prop-2-en-1-yl)-2-(pyridine-2-ylmethylidene)hydrazinecarbothioamide]nickel(II) chloride hydrate MD4407C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
MDA20150041A MD4407C1 (en) 2015-04-29 2015-04-29 Inhibitor of human myeloid leukemia HL-60 cells based on bis[N-(prop-2-en-1-yl)-2-(pyridine-2-ylmethylidene)hydrazinecarbothioamide]nickel(II) chloride hydrate

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MDA20150041A MD4407C1 (en) 2015-04-29 2015-04-29 Inhibitor of human myeloid leukemia HL-60 cells based on bis[N-(prop-2-en-1-yl)-2-(pyridine-2-ylmethylidene)hydrazinecarbothioamide]nickel(II) chloride hydrate

Publications (2)

Publication Number Publication Date
MD4407B1 true MD4407B1 (en) 2016-03-31
MD4407C1 MD4407C1 (en) 2016-10-31

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MDA20150041A MD4407C1 (en) 2015-04-29 2015-04-29 Inhibitor of human myeloid leukemia HL-60 cells based on bis[N-(prop-2-en-1-yl)-2-(pyridine-2-ylmethylidene)hydrazinecarbothioamide]nickel(II) chloride hydrate

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD4434C1 (en) * 2015-10-09 2017-04-30 Государственный Университет Молд0 Use of N'-[1-(2-pyridyl)ethylidene]morpholin-4-carbothiohydrazide as a human myeloid leukemia HL-60 cell proliferation inhibitor
MD4520B1 (en) * 2016-12-16 2017-10-31 Государственный Университет Молд0 N-(4-butoxyphenyl)-2-(pyridin-2-ylmethylidene)hydrazinecarbothioamide as T-47D breast cancer cells growth inhibitor

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1448295A (en) * 1974-05-01 1976-09-02 Farmaceutici Italia Thiosemicarbazones
US4657903A (en) * 1982-03-31 1987-04-14 The United States Of America As Represented By The Secretary Of The Army Transition metal complexes of the selenium analogs of 2-acetyl- and 2-propionylpyridine thiosemicarbazones useful for treating malarial infections and leukemia
DK383183A (en) * 1983-08-22 1985-02-23 Cheminova As BIOCID, NON-FUNGICID AND / OR BACTERICID, AGENT AND THIOSEMIC CARBONZONE AND METAL COMPLEXES THEREOF FOR USE IN THE AGENT
US5281715A (en) * 1992-05-13 1994-01-25 Yale University 2-formylpyridine thiosemicarbazone compounds
JP2006516979A (en) * 2003-02-05 2006-07-13 ニューサウス イノベーションズ ピーティーワイ リミテッド Metal ion chelating agents and their therapeutic use
MD3098G2 (en) * 2006-01-03 2007-02-28 Государственный Университет Молд0 Dihydrate of di( -Ophenoxy)-di[N-(2-oxy-1-benzal)-N1- -oxyfuralhydrazine(2-)copper] with properties of inhibitor of the human myeloid leukemia
MD3655G2 (en) * 2007-09-03 2009-02-28 Государственный Университет Молд0 Inhibitor of human myeloid leukemia on base of bis(2-hydroxy-8-phenyl-tricyclo/7.3.1.0.2,7/-tridecane-13-on-thiosemicarbazonato)copper
MD3890G2 (en) * 2008-09-08 2009-12-31 Государственный Университет Молд0 Inhibitors of human myeloid leukemia on base of coordinative compounds of copper(II) with salicylidene thiocarbazides
MD20110040A1 (en) * 2011-05-10 2012-11-30 Государственный Университет Молд0 Inhibitors of human myeloid leukemia based on 2-[2-(pyridine-2-ilmethylidene)hydrazine]-1,3-benzothiazole and 2-[2-(1-pyridine-2-ilethylidene)hydrazine]-1,3-benzothiazole dihydrate
MD4190C1 (en) * 2011-06-16 2013-07-31 Государственный Университет Молд0 Inhibitor of human myeloid leukemia based on {bis[2-(3,5-dibrom-2-hydroxyphenyl)-2-oxoethyl-piperidin-1-carbodithioato(1-)-O,O′]copper}
MD4215C1 (en) * 2012-07-09 2013-11-30 Государственный Университет Молд0 Inhibitor of human myeloid leukemia based on N-(4-(5-(pyridin-2-yl)-4,5-dihydro-1H-pyrazol-3-yl)phenyl)-2-(pyridin-2-ylmethylen)-hydrazinecarbothioamide
MD4300C1 (en) * 2012-12-28 2015-03-31 Государственный Университет Молд0 Inhibitor of HepG2 cell proliferation in liver cancer based on chloro-[2-phenyl(pyridine-2-yl)methanone-4-(3-methoxyphenyl)thiosemicarbazono]nickel
CN103951602B (en) * 2014-03-19 2016-06-15 河南理工大学 There is the synthetic method of pyrroles's thiosemicarbazones copper of anti-tumor activity, nickel complex

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD4434C1 (en) * 2015-10-09 2017-04-30 Государственный Университет Молд0 Use of N'-[1-(2-pyridyl)ethylidene]morpholin-4-carbothiohydrazide as a human myeloid leukemia HL-60 cell proliferation inhibitor
MD4520B1 (en) * 2016-12-16 2017-10-31 Государственный Университет Молд0 N-(4-butoxyphenyl)-2-(pyridin-2-ylmethylidene)hydrazinecarbothioamide as T-47D breast cancer cells growth inhibitor

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Publication number Publication date
MD4407C1 (en) 2016-10-31

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FG4A Patent for invention issued
KA4A Patent for invention lapsed due to non-payment of fees (with right of restoration)
MM4A Patent for invention definitely lapsed due to non-payment of fees