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MD4201B1 - Process for production of carbonitrile derivatives of spiro[cyclopropane-oxindoles] - Google Patents

Process for production of carbonitrile derivatives of spiro[cyclopropane-oxindoles] Download PDF

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Publication number
MD4201B1
MD4201B1 MDA20120030A MD20120030A MD4201B1 MD 4201 B1 MD4201 B1 MD 4201B1 MD A20120030 A MDA20120030 A MD A20120030A MD 20120030 A MD20120030 A MD 20120030A MD 4201 B1 MD4201 B1 MD 4201B1
Authority
MD
Moldova
Prior art keywords
oxindoles
cyclopropane
spiro
production
carbonitrile derivatives
Prior art date
Application number
MDA20120030A
Other languages
Moldavian (mo)
Romanian (ro)
Other versions
MD4201C1 (en
Inventor
Natalia Sucman
Flyur Makaev
Fliur MACAEV
Original Assignee
Inst De Chimie Al Academiei De Stiinte A Moldovei
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst De Chimie Al Academiei De Stiinte A Moldovei filed Critical Inst De Chimie Al Academiei De Stiinte A Moldovei
Priority to MDA20120030A priority Critical patent/MD4201C1/en
Publication of MD4201B1 publication Critical patent/MD4201B1/en
Publication of MD4201C1 publication Critical patent/MD4201C1/en

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Indole Compounds (AREA)

Abstract

The invention relates to the synthesis of carbonitrile derivatives of spiro[cyclopropane-oxindoles], which can serve as precursors in the synthesis of substances with anti-HIV activity.The process involves the reaction of cyclopropanation of diazoisatins with acrylonitrile, used both as reagent and solvent at its boiling point.The proposed process allows of carrying out the reaction in a shorter time with high yields, without the use of catalysts and inert atmosphere.
MDA20120030A 2012-03-21 2012-03-21 Process for production of carbonitrile derivatives of spiro[cyclopropane-oxindoles] MD4201C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
MDA20120030A MD4201C1 (en) 2012-03-21 2012-03-21 Process for production of carbonitrile derivatives of spiro[cyclopropane-oxindoles]

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MDA20120030A MD4201C1 (en) 2012-03-21 2012-03-21 Process for production of carbonitrile derivatives of spiro[cyclopropane-oxindoles]

Publications (2)

Publication Number Publication Date
MD4201B1 true MD4201B1 (en) 2013-02-28
MD4201C1 MD4201C1 (en) 2013-09-30

Family

ID=47831222

Family Applications (1)

Application Number Title Priority Date Filing Date
MDA20120030A MD4201C1 (en) 2012-03-21 2012-03-21 Process for production of carbonitrile derivatives of spiro[cyclopropane-oxindoles]

Country Status (1)

Country Link
MD (1) MD4201C1 (en)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57102863A (en) * 1980-12-16 1982-06-26 Takeda Chem Ind Ltd Spiroindolinone and its preparation
FR2740136B1 (en) * 1995-10-24 1998-01-09 Sanofi Sa INDOLIN-2-ONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US7205328B2 (en) * 2002-10-21 2007-04-17 Irm Llc Oxindoles with anti-HIV activity
US7370333B2 (en) * 2003-06-02 2008-05-06 Microsoft Corporation Efficient processing of a convoy workflow scenario in a message driven process
US7309787B2 (en) * 2005-07-13 2007-12-18 Allergan, Inc. Kinase inhibitors

Also Published As

Publication number Publication date
MD4201C1 (en) 2013-09-30

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Legal Events

Date Code Title Description
FG4A Patent for invention issued
KA4A Patent for invention lapsed due to non-payment of fees (with right of restoration)
MM4A Patent for invention definitely lapsed due to non-payment of fees