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MD4258B1 - The use of biologically active coordinative compounds of copper(II) with 4-(methoxyphenyl)thiosemicarbazones of 2-benzoylpyridine as inhibitors of Candida albicans - Google Patents

The use of biologically active coordinative compounds of copper(II) with 4-(methoxyphenyl)thiosemicarbazones of 2-benzoylpyridine as inhibitors of Candida albicans Download PDF

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Publication number
MD4258B1
MD4258B1 MD20120045A MD20120045A MD4258B1 MD 4258 B1 MD4258 B1 MD 4258B1 MD 20120045 A MD20120045 A MD 20120045A MD 20120045 A MD20120045 A MD 20120045A MD 4258 B1 MD4258 B1 MD 4258B1
Authority
MD
Moldova
Prior art keywords
inhibitors
copper
candida albicans
benzoylpyridine
thiosemicarbazones
Prior art date
Application number
MD20120045A
Other languages
Moldavian (mo)
Romanian (ro)
Other versions
MD4258C1 (en
Inventor
Aurelian Gulea
Angela Jalba
Victor Tapcov
Ecaterina Buzatu-Balachin
Aliona Cotovaia
Valeriu Rudic
Original Assignee
Univ De Stat Din Moldova
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ De Stat Din Moldova filed Critical Univ De Stat Din Moldova
Priority to MDA20120045A priority Critical patent/MD4258C1/en
Publication of MD4258B1 publication Critical patent/MD4258B1/en
Publication of MD4258C1 publication Critical patent/MD4258C1/en

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Abstract

The invention relates to medicine, namely to the use of biologically active coordinative compounds of copper from the class of thiosemicarbazonates of transition metals as inhibitors of Candida albicans fungi.Summary of the invention consists in the use as inhibitors of Candida albicans fungi of coordinative compounds of copper(II) with 4-(methoxyphenyl)thiosemicarbazones of 2-benzoylpyridine of general formula:I-IIII: R1 = OCH3, R2 = R3 = H; II: R1 = R3 = H, R2 = OCH3; III: R1 = R2 = H, R3 = OCH3.
MDA20120045A 2012-05-31 2012-05-31 The use of biologically active coordinative compounds of copper(II) with 4-(methoxyphenyl)thiosemicarbazones of 2-benzoylpyridine as inhibitors of Candida albicans MD4258C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
MDA20120045A MD4258C1 (en) 2012-05-31 2012-05-31 The use of biologically active coordinative compounds of copper(II) with 4-(methoxyphenyl)thiosemicarbazones of 2-benzoylpyridine as inhibitors of Candida albicans

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MDA20120045A MD4258C1 (en) 2012-05-31 2012-05-31 The use of biologically active coordinative compounds of copper(II) with 4-(methoxyphenyl)thiosemicarbazones of 2-benzoylpyridine as inhibitors of Candida albicans

Publications (2)

Publication Number Publication Date
MD4258B1 true MD4258B1 (en) 2013-11-30
MD4258C1 MD4258C1 (en) 2014-06-30

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MDA20120045A MD4258C1 (en) 2012-05-31 2012-05-31 The use of biologically active coordinative compounds of copper(II) with 4-(methoxyphenyl)thiosemicarbazones of 2-benzoylpyridine as inhibitors of Candida albicans

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD4383C1 (en) * 2015-03-06 2016-06-30 Государственный Университет Молд0 Acetato-(8-formylquinolinethiosemicarbazono)copper(II) compound, exhibiting antibacterial activity
MD4402C1 (en) * 2015-09-04 2016-09-30 Государственный Университет Молд0 Methyl-N'-[(2-hydroxynaphthalene-1-il)methylidene]-N-prop-2-en-1-ylhydrazonothioate, exhibiting antifungal activity against Candida albicans

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3824276A (en) * 1963-03-14 1974-07-16 Upjohn Co Substituted-2-oxobutyraldehyde bis(thiosemicarbazones)
US6329378B1 (en) * 1999-02-10 2001-12-11 Anadys Pharmaceuticals, Inc. Hydrazone, hydrazine and thiosemicarbazone derivatives as antifungal agents
MD1812C2 (en) * 2000-12-29 2002-06-30 Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова Copper complexes as bacteria and fungi inhibitors
MD2003C2 (en) * 2001-01-10 2003-03-31 Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова Copper chelate compounds (II) with antimicrobial and antimycotic activity
WO2002085358A2 (en) * 2001-04-20 2002-10-31 Vion Pharmaceuticals, Inc. Antiviral agents and methods of treating viral infections
MD2325G2 (en) * 2002-07-10 2004-06-30 Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова Chelate copper(II) complexes - growth and multiplication inhibitors of the yeast and mycelium fungi.
MD2861G2 (en) * 2004-09-20 2006-04-30 Государственный Университет Молд0 (µ-Imidazole-N,N')-bis{4-bromo-2-[2-(oxyethylimino)-methyl]-phenolato(2-)-copper}, manifesting antimycotic activity
MD3484G2 (en) * 2007-02-12 2008-08-31 Государственный Университет Молд0 Di-{µ-[N-(2-hydroxyethyl)-(5-chlorosalicylideneiminato)(-1))]-(O,N,O,Cl)}-bis-(nitrato-imidazolecopper) manifesting antimycotic activity

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD4383C1 (en) * 2015-03-06 2016-06-30 Государственный Университет Молд0 Acetato-(8-formylquinolinethiosemicarbazono)copper(II) compound, exhibiting antibacterial activity
MD4402C1 (en) * 2015-09-04 2016-09-30 Государственный Университет Молд0 Methyl-N'-[(2-hydroxynaphthalene-1-il)methylidene]-N-prop-2-en-1-ylhydrazonothioate, exhibiting antifungal activity against Candida albicans

Also Published As

Publication number Publication date
MD4258C1 (en) 2014-06-30

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FG4A Patent for invention issued
KA4A Patent for invention lapsed due to non-payment of fees (with right of restoration)
MM4A Patent for invention definitely lapsed due to non-payment of fees