MD4177C1 - Method for vaccination against hepatitis B of persons with immunodeficiency - Google Patents
Method for vaccination against hepatitis B of persons with immunodeficiency Download PDFInfo
- Publication number
- MD4177C1 MD4177C1 MDA20110006A MD20110006A MD4177C1 MD 4177 C1 MD4177 C1 MD 4177C1 MD A20110006 A MDA20110006 A MD A20110006A MD 20110006 A MD20110006 A MD 20110006A MD 4177 C1 MD4177 C1 MD 4177C1
- Authority
- MD
- Moldova
- Prior art keywords
- persons
- vaccine
- immunodeficiency
- vaccination
- glucopyranosyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 238000002255 vaccination Methods 0.000 title abstract 3
- 206010061598 Immunodeficiency Diseases 0.000 title abstract 2
- 208000029462 Immunodeficiency disease Diseases 0.000 title abstract 2
- 208000002672 hepatitis B Diseases 0.000 title abstract 2
- 230000007813 immunodeficiency Effects 0.000 title abstract 2
- 229960005486 vaccine Drugs 0.000 abstract 2
- 239000013543 active substance Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- SPSXSWRZQFPVTJ-ZQQKUFEYSA-N hepatitis b vaccine Chemical compound C([C@H](NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CCSC)C(=O)N[C@@H](CC1N=CN=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)OC(=O)CNC(=O)CNC(=O)[C@H](C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](N)CCCNC(N)=N)C1=CC=CC=C1 SPSXSWRZQFPVTJ-ZQQKUFEYSA-N 0.000 abstract 1
- 229940124736 hepatitis-B vaccine Drugs 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 235000012054 meals Nutrition 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
- 229930002534 steroid glycoside Natural products 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to medicine and can be used in the prevention of viral hepatitis B to increase the effectiveness of vaccination.The method for vaccination consists in that simultaneously with hepatitis B vaccine is also administered an adaptogenic vegetal preparation with the active substance steroid glycoside 3-O-{[α-L-rhamnopyranosyl(1→3)]-[β-D-glucopyranosyl(1→2)]-β-D-glucopyranosyl}-[(25R)-furost-5-en,3β,22α,26-triol]-26-O-β-D-glucopyranoside (Mestim), in tablets of 50 mg, one tablet in the morning 30 minutes before a meal, within 30 days, beginning with the first day of administration of the vaccine.The result consists in intensifying the process of immunogenesis expressed in an increased titer of protective antibodies, which leads to a reduction in the risk of HBV infection to a minimum for persons with immunodeficiency and a reduction in the number of persons, non-respondent to the vaccine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MDA20110006A MD4177C1 (en) | 2011-01-14 | 2011-01-14 | Method for vaccination against hepatitis B of persons with immunodeficiency |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MDA20110006A MD4177C1 (en) | 2011-01-14 | 2011-01-14 | Method for vaccination against hepatitis B of persons with immunodeficiency |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD4177B1 MD4177B1 (en) | 2012-07-31 |
| MD4177C1 true MD4177C1 (en) | 2013-02-28 |
Family
ID=46582439
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MDA20110006A MD4177C1 (en) | 2011-01-14 | 2011-01-14 | Method for vaccination against hepatitis B of persons with immunodeficiency |
Country Status (1)
| Country | Link |
|---|---|
| MD (1) | MD4177C1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MD667Z (en) * | 2013-03-20 | 2014-03-31 | Национальный Центр Общественного Здоровья Министерства Здравоохранения Республики Молдова | Method for treatment of infectious mononucleosis in children |
| MD782Z (en) * | 2013-07-16 | 2015-01-31 | Национальный Центр Общественного Здоровья Министерства Здравоохранения Республики Молдова | Method for vaccination against influenza |
Citations (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4189471A (en) * | 1978-07-11 | 1980-02-19 | Merck & Co., Inc. | Immunologic glycolipid adjuvants |
| SU1162817A1 (en) * | 1983-07-06 | 1985-06-23 | Отдел Генетики Растений Ан Мсср | Method of isolating trioside of /(25r)-furost-5-en-3beta-22alpha,26 triol/-26-0-beta-d-glucopyranoside |
| WO1988009336A1 (en) * | 1987-05-29 | 1988-12-01 | Cambridge Bioscience Corporation | Saponin adjuvant |
| WO1993005789A1 (en) * | 1991-09-18 | 1993-04-01 | Cambridge Biotech Corporation | Saponin-antigen conjugates and the use thereof |
| US5846964A (en) * | 1993-07-19 | 1998-12-08 | Tokyo Tanabe Company Limited | Hepatitis C virus proliferation inhibitor |
| RU2127605C1 (en) * | 1996-05-22 | 1999-03-20 | Юрий Леонидович Криворутченко | Method of stimulation of humoral and cellular immunity response to target antigen |
| MD1473G2 (en) * | 1998-06-02 | 2001-05-31 | Национальный Научно-Практический Центр Превентивной Медицины Министерства Здравоохранения Республики Молдова | Antiherpetic remedy |
| WO2001097749A2 (en) * | 2000-06-23 | 2001-12-27 | Kotze, Gavin, Salomon | The use of synthetic, non-hormonal 21-aminosteroids and thereof |
| MD1875G2 (en) * | 1999-11-01 | 2002-09-30 | Национальный Научно-Практический Центр Превентивной Медицины Министерства Здравоохранения Республики Молдова | Method of treatment of the acute viral hepatitis B |
| MD2026G2 (en) * | 2001-12-05 | 2003-05-31 | Институт Физиологии Растений Академии Наук Республики Молдова | Process for increasing the vine crop resistance to drought |
| US6905712B2 (en) * | 1999-12-08 | 2005-06-14 | Statens Veterinarmedicinska Anstalt | Vaccine adjuvants comprising ginseng plant extract and added aluminum salt |
| MD3121G2 (en) * | 2005-09-15 | 2007-03-31 | Национальный Научно-Практический Центр Превентивной Медицины Министерства Здравоохранения Республики Молдова | Method of viral hepatitis B prophylaxis |
| RU2311926C2 (en) * | 2006-02-15 | 2007-12-10 | Федеральное Агентство По Образованию Государственное Образовательное Учреждение Высшего Профессионального Образования "Дальневосточный Государственный Университет" | Antigen carrier and adjuvant |
| TW200808354A (en) * | 2006-08-08 | 2008-02-16 | Lotus Pharmaceutical Co Ltd | Furost-5-ene-3,22,26-triol glucoside compounds for cancer prevention and treatment |
| US20100317637A1 (en) * | 2009-06-16 | 2010-12-16 | Industrial Technology Research Institute | Anti-hepatitis c composition and method for preparing drug for inhibiting hepatitis c viruses or treating hepatitis c |
| JP2011001345A (en) * | 2009-06-16 | 2011-01-06 | Ind Technol Res Inst | Anti-hepatitis c composition, method for preparing agent for inhibiting hepatitis c virus or treating hepatitis c, and use of limonoid compound |
| US20110218162A1 (en) * | 1998-11-24 | 2011-09-08 | Frincke James M | 15-thia steroid compounds and compositions |
| UA98631C2 (en) * | 2006-12-05 | 2012-06-11 | Зентива, К.С. | Method of purification of (s)-n-methy]-3-(1-naphtyloxy)-3-(2-thienyl) propylamine hydrochloride |
-
2011
- 2011-01-14 MD MDA20110006A patent/MD4177C1/en not_active IP Right Cessation
Patent Citations (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4189471A (en) * | 1978-07-11 | 1980-02-19 | Merck & Co., Inc. | Immunologic glycolipid adjuvants |
| SU1162817A1 (en) * | 1983-07-06 | 1985-06-23 | Отдел Генетики Растений Ан Мсср | Method of isolating trioside of /(25r)-furost-5-en-3beta-22alpha,26 triol/-26-0-beta-d-glucopyranoside |
| WO1988009336A1 (en) * | 1987-05-29 | 1988-12-01 | Cambridge Bioscience Corporation | Saponin adjuvant |
| WO1993005789A1 (en) * | 1991-09-18 | 1993-04-01 | Cambridge Biotech Corporation | Saponin-antigen conjugates and the use thereof |
| US5846964A (en) * | 1993-07-19 | 1998-12-08 | Tokyo Tanabe Company Limited | Hepatitis C virus proliferation inhibitor |
| RU2127605C1 (en) * | 1996-05-22 | 1999-03-20 | Юрий Леонидович Криворутченко | Method of stimulation of humoral and cellular immunity response to target antigen |
| MD1473G2 (en) * | 1998-06-02 | 2001-05-31 | Национальный Научно-Практический Центр Превентивной Медицины Министерства Здравоохранения Республики Молдова | Antiherpetic remedy |
| US20110218162A1 (en) * | 1998-11-24 | 2011-09-08 | Frincke James M | 15-thia steroid compounds and compositions |
| MD1875G2 (en) * | 1999-11-01 | 2002-09-30 | Национальный Научно-Практический Центр Превентивной Медицины Министерства Здравоохранения Республики Молдова | Method of treatment of the acute viral hepatitis B |
| US6905712B2 (en) * | 1999-12-08 | 2005-06-14 | Statens Veterinarmedicinska Anstalt | Vaccine adjuvants comprising ginseng plant extract and added aluminum salt |
| WO2001097749A2 (en) * | 2000-06-23 | 2001-12-27 | Kotze, Gavin, Salomon | The use of synthetic, non-hormonal 21-aminosteroids and thereof |
| MD2026G2 (en) * | 2001-12-05 | 2003-05-31 | Институт Физиологии Растений Академии Наук Республики Молдова | Process for increasing the vine crop resistance to drought |
| MD3121G2 (en) * | 2005-09-15 | 2007-03-31 | Национальный Научно-Практический Центр Превентивной Медицины Министерства Здравоохранения Республики Молдова | Method of viral hepatitis B prophylaxis |
| RU2311926C2 (en) * | 2006-02-15 | 2007-12-10 | Федеральное Агентство По Образованию Государственное Образовательное Учреждение Высшего Профессионального Образования "Дальневосточный Государственный Университет" | Antigen carrier and adjuvant |
| TW200808354A (en) * | 2006-08-08 | 2008-02-16 | Lotus Pharmaceutical Co Ltd | Furost-5-ene-3,22,26-triol glucoside compounds for cancer prevention and treatment |
| UA98631C2 (en) * | 2006-12-05 | 2012-06-11 | Зентива, К.С. | Method of purification of (s)-n-methy]-3-(1-naphtyloxy)-3-(2-thienyl) propylamine hydrochloride |
| US20100317637A1 (en) * | 2009-06-16 | 2010-12-16 | Industrial Technology Research Institute | Anti-hepatitis c composition and method for preparing drug for inhibiting hepatitis c viruses or treating hepatitis c |
| JP2011001345A (en) * | 2009-06-16 | 2011-01-06 | Ind Technol Res Inst | Anti-hepatitis c composition, method for preparing agent for inhibiting hepatitis c virus or treating hepatitis c, and use of limonoid compound |
Non-Patent Citations (2)
| Title |
|---|
| Euvax-B. Instrucţiune de utilizare a vaccinului contra hepatitei virale B, CNSP, Chişinău, 2005 * |
| Types of adjuvants, Plant derivatives. Patent Landscape on Adjuvants, Patent Lens DataBase of Cambia of independent non-profit Institute, (regăsit în Internet la 2012.05.14 url: http://www.patentlens.net/daisy/adjuvants/Introduction.html ). * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MD667Z (en) * | 2013-03-20 | 2014-03-31 | Национальный Центр Общественного Здоровья Министерства Здравоохранения Республики Молдова | Method for treatment of infectious mononucleosis in children |
| MD782Z (en) * | 2013-07-16 | 2015-01-31 | Национальный Центр Общественного Здоровья Министерства Здравоохранения Республики Молдова | Method for vaccination against influenza |
Also Published As
| Publication number | Publication date |
|---|---|
| MD4177B1 (en) | 2012-07-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG4A | Patent for invention issued | ||
| KA4A | Patent for invention lapsed due to non-payment of fees (with right of restoration) | ||
| MM4A | Patent for invention definitely lapsed due to non-payment of fees |