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MD3995B1 - Use of di(Á-Ophenoxy)-di{[2-(4-aminobenzenesulfamido)-5-ethyl-1,3,4-thiadiazole]-3,5-dibromosalicylidenethiosemicarbazonato(-1)-copper} as inhibitor of mammary cancer T-47D cell proliferation - Google Patents

Use of di(Á-Ophenoxy)-di{[2-(4-aminobenzenesulfamido)-5-ethyl-1,3,4-thiadiazole]-3,5-dibromosalicylidenethiosemicarbazonato(-1)-copper} as inhibitor of mammary cancer T-47D cell proliferation

Info

Publication number
MD3995B1
MD3995B1 MDA20090050A MD20090050A MD3995B1 MD 3995 B1 MD3995 B1 MD 3995B1 MD A20090050 A MDA20090050 A MD A20090050A MD 20090050 A MD20090050 A MD 20090050A MD 3995 B1 MD3995 B1 MD 3995B1
Authority
MD
Moldova
Prior art keywords
inhibitor
cell proliferation
mammary cancer
dibromosalicylidenethiosemicarbazonato
aminobenzenesulfamido
Prior art date
Application number
MDA20090050A
Other languages
Romanian (ro)
Other versions
MD3995C2 (en
Inventor
Aurelian Gulea
Victor Tapcov
Donald Poirier
Valeriu Rudic
Original Assignee
Universitatea De Stat Din Moldova
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universitatea De Stat Din Moldova filed Critical Universitatea De Stat Din Moldova
Priority to MDA20090050A priority Critical patent/MD3995C2/en
Publication of MD3995B1 publication Critical patent/MD3995B1/en
Publication of MD3995C2 publication Critical patent/MD3995C2/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention relates to chemistry, namely to the use of coordinative compound from the class of thiosemicarbazonates of transition metals as inhibitor of mammary cancer T-47D cell proliferation. Summary of the invention consists in the use as inhibitor of mammary cancer T-47D cell proliferation of di(Á-Ophenoxy)-di{[2-(4-aminobenzenesulfamido)-5-ethyl-1,3,4-thiadiazole]-3,5-dibromosalicylidenethiosemicarbazonato(-1)-copper} of formula:
MDA20090050A 2009-05-11 2009-05-11 Use of di(m-Ophenoxy)-di{[2-(4-aminobenzenesulfamido)-5-ethyl-1,3,4-thiadiazole]-3,5-dibromosalicylidenethiosemicarbazonato(-1)-copper} as inhibitor of mammary cancer T-47D cell proliferation MD3995C2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
MDA20090050A MD3995C2 (en) 2009-05-11 2009-05-11 Use of di(m-Ophenoxy)-di{[2-(4-aminobenzenesulfamido)-5-ethyl-1,3,4-thiadiazole]-3,5-dibromosalicylidenethiosemicarbazonato(-1)-copper} as inhibitor of mammary cancer T-47D cell proliferation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MDA20090050A MD3995C2 (en) 2009-05-11 2009-05-11 Use of di(m-Ophenoxy)-di{[2-(4-aminobenzenesulfamido)-5-ethyl-1,3,4-thiadiazole]-3,5-dibromosalicylidenethiosemicarbazonato(-1)-copper} as inhibitor of mammary cancer T-47D cell proliferation

Publications (2)

Publication Number Publication Date
MD3995B1 true MD3995B1 (en) 2009-12-31
MD3995C2 MD3995C2 (en) 2010-07-31

Family

ID=43568859

Family Applications (1)

Application Number Title Priority Date Filing Date
MDA20090050A MD3995C2 (en) 2009-05-11 2009-05-11 Use of di(m-Ophenoxy)-di{[2-(4-aminobenzenesulfamido)-5-ethyl-1,3,4-thiadiazole]-3,5-dibromosalicylidenethiosemicarbazonato(-1)-copper} as inhibitor of mammary cancer T-47D cell proliferation

Country Status (1)

Country Link
MD (1) MD3995C2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD4132C1 (en) * 2010-12-13 2012-05-31 Государственный Университет Молд0 Di(µ-S)-bis{chloro-[phenyl(pyridine-2-yl)methanone-thiosemicarbazonato(1-)]-copper} manifesting the property of inhibiting the proliferation of mammary cancer T-47D cells
MD4349C1 (en) * 2014-06-23 2015-12-31 Государственный Университет Молд0 N-(3-methoxyphenyl)-2-(pyridine-2-ylmethylene)-hydrazinecarbothioamide compound - inhibitor of human melanoma MeW-164 cell proliferation
MD4520B1 (en) * 2016-12-16 2017-10-31 Государственный Университет Молд0 N-(4-butoxyphenyl)-2-(pyridin-2-ylmethylidene)hydrazinecarbothioamide as T-47D breast cancer cells growth inhibitor

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SU639252A1 (en) * 1975-07-09 1999-12-27 РќРѕСЃРєРѕРІ Р¤.РЎ. PHOSPHORYLATED THIOSEMICARBAZONES WITH ANTI-VIRUS ACTIVITY
IL87405A0 (en) * 1987-08-12 1989-01-31 Immunomedics Inc Radiolabeled agents and methods and kits for the production thereof
JP3015970B2 (en) * 1988-11-25 2000-03-06 セ・イ・エス・ビオ・アンテルナショナル・ソシエテ・アノニム Radiopharmaceutical product having transition tropism especially containing a nitride complex of transition metal and method for producing the same
US5124351A (en) * 1989-02-27 1992-06-23 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Pharmaceutical compositions for the treatment of cancers susceptible to treatment with the copper complex of S-(methylthio)-DL-homocysteine or the L-enantimorph thereof
MD195C2 (en) * 1994-12-05 1995-11-30 Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова The copper complexes with antistaphylococcus properties
US5767134A (en) * 1997-05-15 1998-06-16 Vion Pharmaceuticals, Inc. Prodrug forms of ribonucleotide reductase inhibitors 3-AP and 3-AMP
US5869676A (en) * 1997-05-15 1999-02-09 Vion Pharmaceuticals, Inc. Process for the synthesis of ribonucleotide reductase inhibitors 3-AP and 3-AMP
EP1193261A1 (en) * 2000-10-02 2002-04-03 Warner-Lambert Company New thiadiazoles and their use as phosphodiesterase-7 inhibitors
WO2002051846A1 (en) * 2000-12-22 2002-07-04 Zee, Ok Pyo Apicidin-derivatives, their synthetic methods, and antitumor compositions containing the same
MD1812C2 (en) * 2000-12-29 2002-06-30 Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова Copper complexes as bacteria and fungi inhibitors
MD2003C2 (en) * 2001-01-10 2003-03-31 Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова Copper chelate compounds (II) with antimicrobial and antimycotic activity
MD2942C2 (en) * 2004-04-27 2006-06-30 Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова Di(µ-O)-bis(3,5-dibromosalicylidene thiosemicarbazonatocopper)
MD3124C2 (en) * 2005-05-25 2007-03-31 Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова Sulfanilamide-containing salicylidenethiosemicarbazidates of copper(II)
CN1891701A (en) * 2005-07-07 2007-01-10 桑迪亚医药技术（上海）有限责任公司 Heteraromatic ring thiosemicarbazone compound, and its derivatives and their use forpreparing antitumour medicine
GB0607899D0 (en) * 2006-04-03 2006-05-31 Glaxo Group Ltd Process for preparing heterocyclic derivatives
MD3655G2 (en) * 2007-09-03 2009-02-28 Государственный Университет Молд0 Inhibitor of human myeloid leukemia on base of bis(2-hydroxy-8-phenyl-tricyclo/7.3.1.0.2,7/-tridecane-13-on-thiosemicarbazonato)copper
MD3890G2 (en) * 2008-09-08 2009-12-31 Государственный Университет Молд0 Inhibitors of human myeloid leukemia on base of coordinative compounds of copper(II) with salicylidene thiocarbazides

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD4132C1 (en) * 2010-12-13 2012-05-31 Государственный Университет Молд0 Di(µ-S)-bis{chloro-[phenyl(pyridine-2-yl)methanone-thiosemicarbazonato(1-)]-copper} manifesting the property of inhibiting the proliferation of mammary cancer T-47D cells
MD4349C1 (en) * 2014-06-23 2015-12-31 Государственный Университет Молд0 N-(3-methoxyphenyl)-2-(pyridine-2-ylmethylene)-hydrazinecarbothioamide compound - inhibitor of human melanoma MeW-164 cell proliferation
MD4520B1 (en) * 2016-12-16 2017-10-31 Государственный Университет Молд0 N-(4-butoxyphenyl)-2-(pyridin-2-ylmethylidene)hydrazinecarbothioamide as T-47D breast cancer cells growth inhibitor

Also Published As

Publication number Publication date
MD3995C2 (en) 2010-07-31

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Legal Events

Date Code Title Description
FG4A Patent for invention issued
KA4A Patent for invention lapsed due to non-payment of fees (with right of restoration)
MM4A Patent for invention definitely lapsed due to non-payment of fees