MD115C2 - Procedeu de obţinere a fenilalchilaminelor sau ale sărurilor lor farmacologic acceptabile - Google Patents
Procedeu de obţinere a fenilalchilaminelor sau ale sărurilor lor farmacologic acceptabileInfo
- Publication number
- MD115C2 MD115C2 MD94-0332A MD940332A MD115C2 MD 115 C2 MD115 C2 MD 115C2 MD 940332 A MD940332 A MD 940332A MD 115 C2 MD115 C2 MD 115C2
- Authority
- MD
- Moldova
- Prior art keywords
- phenylalkylamines
- alkyl
- new
- cycloalkyl
- phenyl
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 2
- 125000006701 (C1-C7) alkyl group Chemical group 0.000 abstract 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
- 229910000761 Aluminium amalgam Inorganic materials 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- UORVGPXVDQYIDP-UHFFFAOYSA-N borane Chemical compound B UORVGPXVDQYIDP-UHFFFAOYSA-N 0.000 abstract 1
- 229910010277 boron hydride Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 238000005984 hydrogenation reaction Methods 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 229910052751 metal Inorganic materials 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Invenţia se referă la un procedeu de obţinere a fenilalchilaminelor noi cu activitate biologică şi care pot fi utilizate ca agenţi-efectori activi în preparatele farmaceutice ce stimulează sistemul nervos central.Sarcina invenţiei constă în prepararea unor noi stimulatori cu un mecanism nou de acţiune. Fenilalchilaminele cu formula generală 1:în care R1 reprezintă C1-C6-alchilul cu o catenă dreaptă sau ramificată, C7-C10 - fenilalchilul; fenilul sau C3-C8-cicloalchilul;:R2 reprezintă grupa :în care R3 reprezintă H sau C1-C7-alchilul, care poate fi substituit cu halogen, cu OH, cu C1-C4-alcoxigrupa sau cu fenilalchil,R4 reprezintă H sau împreună cu grupa :înseamnă nucleul C3-C8-cicloalchilic, cu condiţia că grupele R1 şi R2 împreună conţin cel puţin 5 atomi de carbon, şi când R1 reprezintă etilul, R2 nu poate fi izobutil, sau sărurile lor farmacologic acceptabile se obţin prin tratarea aminei cu formula IIîn care R1 are valorile sus-menţionate, cu un compus cu formula III:în care R3 şi R4 au valorile sus-menţionate, în prezenţa unui dezoxidant, ca amalgamul de aluminiu, H gazos şi un catalizator metalic de hidrogenare, borhidrura unui metal alcalin. Produsul cu destinaţie specială se separă sub formă de bază liberă sau sare farmacologic acceptabilă
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU864101A HU207280B (en) | 1986-09-25 | 1986-09-25 | Process for producing new phenyl-alkyl-amines and pharmaceutical compositions containing them |
| PCT/HU1987/000040 WO1988002254A1 (en) | 1986-09-25 | 1987-09-25 | New psychostimulant agent |
| SU894742460A RU2007384C1 (ru) | 1986-09-25 | 1989-11-23 | Способ получения фенилалкиламинов или их фармакологически приемлемых солей |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD115B1 MD115B1 (ro) | 1994-12-31 |
| MD115C2 true MD115C2 (ro) | 1995-12-31 |
Family
ID=26317737
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MD94-0332A MD115C2 (ro) | 1986-09-25 | 1994-08-25 | Procedeu de obţinere a fenilalchilaminelor sau ale sărurilor lor farmacologic acceptabile |
Country Status (1)
| Country | Link |
|---|---|
| MD (1) | MD115C2 (ro) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4025624A (en) * | 1975-11-18 | 1977-05-24 | A. H. Robins Company, Incorporated | Phenylalkylamines and phenylalkylureas in combinations to suppress gastric bleeding in aspirin therapy |
-
1994
- 1994-08-25 MD MD94-0332A patent/MD115C2/ro not_active IP Right Cessation
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4025624A (en) * | 1975-11-18 | 1977-05-24 | A. H. Robins Company, Incorporated | Phenylalkylamines and phenylalkylureas in combinations to suppress gastric bleeding in aspirin therapy |
Non-Patent Citations (1)
| Title |
|---|
| Вейганд-Хильгутаг "Методы эксперимента в органической химии", 1968, Химия, М., р.378, 470, 480. * |
Also Published As
| Publication number | Publication date |
|---|---|
| MD115B1 (ro) | 1994-12-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 1M4A | Expiration of terms |