[go: up one dir, main page]

MA54563A - Agents de comblement tissulaire à base de soie-acide hyaluronique et leurs procédés de préparation et d'utilisation - Google Patents

Agents de comblement tissulaire à base de soie-acide hyaluronique et leurs procédés de préparation et d'utilisation

Info

Publication number
MA54563A
MA54563A MA054563A MA54563A MA54563A MA 54563 A MA54563 A MA 54563A MA 054563 A MA054563 A MA 054563A MA 54563 A MA54563 A MA 54563A MA 54563 A MA54563 A MA 54563A
Authority
MA
Morocco
Prior art keywords
silk
preparing
methods
hyaluronic acid
tissue fillers
Prior art date
Application number
MA054563A
Other languages
English (en)
Inventor
Gregory H Altman
Carlos J Bosques
Erlei Jin
Patrik Johansson
Rebecca L Lacouture
Peng Xu
Patrick Yacono
Original Assignee
Evolved By Nature Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evolved By Nature Inc filed Critical Evolved By Nature Inc
Publication of MA54563A publication Critical patent/MA54563A/fr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0059Cosmetic or alloplastic implants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86Polyethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/20Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/26Mixtures of macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52Hydrogels or hydrocolloids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54Biologically active materials, e.g. therapeutic substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58Materials at least partially resorbable by the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/91Injection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/402Anaestetics, analgesics, e.g. lidocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00Materials characterised by their function or physical properties
    • A61L2400/06Flowable or injectable implant compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00Materials or treatment for tissue regeneration
    • A61L2430/34Materials or treatment for tissue regeneration for soft tissue reconstruction

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Birds (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
MA054563A 2018-12-19 2019-12-19 Agents de comblement tissulaire à base de soie-acide hyaluronique et leurs procédés de préparation et d'utilisation MA54563A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862781952P 2018-12-19 2018-12-19
US201962865633P 2019-06-24 2019-06-24

Publications (1)

Publication Number Publication Date
MA54563A true MA54563A (fr) 2022-03-30

Family

ID=71100930

Family Applications (1)

Application Number Title Priority Date Filing Date
MA054563A MA54563A (fr) 2018-12-19 2019-12-19 Agents de comblement tissulaire à base de soie-acide hyaluronique et leurs procédés de préparation et d'utilisation

Country Status (12)

Country Link
US (2) US12296067B2 (fr)
EP (1) EP3897564A4 (fr)
JP (1) JP2022514349A (fr)
KR (1) KR20210144660A (fr)
CN (1) CN113677320A (fr)
AU (1) AU2019405953B2 (fr)
BR (1) BR112021012141A2 (fr)
CA (1) CA3124196A1 (fr)
IL (1) IL284082B2 (fr)
MA (1) MA54563A (fr)
SG (1) SG11202106411QA (fr)
WO (1) WO2020132331A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230190997A1 (en) 2017-06-26 2023-06-22 Evolved By Nature, Inc. Silk-hyaluronic acid based tissue filers and methods of using the same
CN113677320A (zh) 2018-12-19 2021-11-19 自然进化公司 丝-透明质酸组织填充物及其制备和使用方法
US20230108822A1 (en) * 2020-02-06 2023-04-06 Merz Pharma Gmbh & Co. Kgaa Injectable composition for skin and soft tissue augmentation
WO2022155682A1 (fr) * 2021-01-15 2022-07-21 Trustees Of Tufts College Biomatériaux à base de soie accordables avec substitutions de saccharides, et leurs procédés de production
TWI880094B (zh) 2021-06-23 2025-04-11 德商莫茲製藥有限兩合公司 以絲蛋白交聯多醣及所得材料之用途
KR102509832B1 (ko) * 2022-02-23 2023-03-14 주식회사 지씨에스 상이한 구조를 이루는 다분산 펩타이드 기반의 최소 침습 임플란트가 가능한 하이드로겔 조성물 및 그의 용도
EP4633596A1 (fr) 2022-12-15 2025-10-22 Merz Pharma GmbH & Co. KGaA Gel injectable comprenant de la toxine botulique et ses utilisations
KR102684411B1 (ko) 2023-05-02 2024-07-11 (재)씨젠의료재단 설포석신산-가교 히알루론산 및 생체 적합성 미립자를 포함하는 피부 필러 조성물, 및 그 제조방법
KR102684409B1 (ko) 2023-05-02 2024-07-11 (재)씨젠의료재단 석신산-가교 히알루론산을 포함하는 피부 필러 조성물 및 그 제조방법
KR20250079371A (ko) * 2023-11-27 2025-06-04 조은애 친환경 용매를 사용한 생분해성 고분자 마이크로그래뉼이 융합된 히알루론산 겔을 포함하는 조직 수복용 주사제 조성물 및 그 제조 방법

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6630457B1 (en) 1998-09-18 2003-10-07 Orthogene Llc Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same
ATE420671T1 (de) 2001-10-25 2009-01-15 Univ Connecticut Fibroinzusammensetzungen und verfahren zu deren herstellung
US7901668B2 (en) 2001-11-29 2011-03-08 Eaudelman Co., Ltd. Silk fibroin emulsifier and process for the production thereof
US7632873B2 (en) 2002-12-13 2009-12-15 L'oreal S.A. Cosmetic dermatological composition comprising at least one gradient copolymer, makeup comprising the cosmetic or dermatological composition and cosmetic method using the composition
AU2003303820A1 (en) 2003-01-31 2004-08-23 Biosphere S.P.A. Water soluble and biocompatible gels of hyaluronic acid cross-linked with bi-functional l-aminoacids or l-aminoesters
US7060260B2 (en) 2003-02-20 2006-06-13 E.I. Du Pont De Nemours And Company Water-soluble silk proteins in compositions for skin care, hair care or hair coloring
US7115388B2 (en) 2003-03-14 2006-10-03 National Institute Of Agrobiological Sciences Production of functional polypeptides originating from silk protein and use thereof
EP1660013A4 (fr) 2003-08-26 2011-07-20 Gel Del Technologies Inc Biomateriaux et biocoacervats proteiniques, leurs procedes de fabrication et d'utilisation
WO2007041677A2 (fr) 2005-10-03 2007-04-12 Combinatorx, Incorporated Implants de tissus mous et compositions de médicaments combinés, et leur utilisation
US8318695B2 (en) 2007-07-30 2012-11-27 Allergan, Inc. Tunably crosslinked polysaccharide compositions
US8450475B2 (en) 2008-08-04 2013-05-28 Allergan, Inc. Hyaluronic acid-based gels including lidocaine
JP5123873B2 (ja) 2009-02-20 2013-01-23 出光テクノファイン株式会社 繊維架橋体および繊維架橋体の製造方法
JP2010213984A (ja) 2009-03-18 2010-09-30 Naisemu:Kk 柔軟剤及び/又は保湿剤含有生体埋込用医療材料、該医療材料中の柔軟剤及び/又は保湿剤の含有量を調整する方法及び、該生体内埋込用医療材料の製造方法
US20110189292A1 (en) * 2009-04-20 2011-08-04 Allergan, Inc. Dermal fillers comprising silk fibroin hydrogels and uses thereof
EP2498830B1 (fr) 2009-11-11 2016-09-21 University of Twente, Institute for Biomedical Technology and Technical Medicine (MIRA) Hydrogels à base de dextrane-acide hyaluronique
AU2015275313A1 (en) 2010-11-08 2016-01-21 Allergan Industrie, Sas Hyaluronic acid based formulations
RU2624239C2 (ru) 2011-06-03 2017-07-03 Аллерган, Инк. Составы кожного наполнителя, включая антиоксиданты
US9662422B2 (en) 2011-09-06 2017-05-30 Allergan, Inc. Crosslinked hyaluronic acid-collagen gels for improving tissue graft viability and soft tissue augmentation
WO2013040242A2 (fr) 2011-09-14 2013-03-21 Allergan, Inc. Compositions de comblement dermique pour le traitement des ridules
JP6266525B2 (ja) * 2011-11-09 2018-01-24 トラスティーズ・オブ・タフツ・カレッジTrustees Of Tufts College 注射可能なシルクフィブロイン発泡体およびその使用
WO2013159101A1 (fr) 2012-04-20 2013-10-24 Trustees Of Tufts College Compositions de soins personnels à base de fibroïne de soie
US20140023688A1 (en) 2012-07-13 2014-01-23 Firmenich Sa Encapsulated oils
CN102836465B (zh) * 2012-08-30 2014-06-04 浙江星月生物科技股份有限公司 一种注射用丝素蛋白透明质酸复合凝胶及其制备与应用
US9987367B2 (en) * 2012-09-06 2018-06-05 Nanyang Technological University Hyaluronic acid-based drug delivery systems
WO2014055895A1 (fr) 2012-10-05 2014-04-10 Allergan, Inc. Dispositif injectable et méthode de modelage, d'augmentation ou de correction de traits faciaux tels que du menton
WO2014056722A2 (fr) 2012-10-08 2014-04-17 Anteis S.A. Formulation aqueuse stérile injectable à base d'acide hyaluronique réticulé et d'hydroxyapatite pour usage esthétique
US20140235554A1 (en) 2013-02-12 2014-08-21 Brian Lawrence Ophthalmic formulation derived from silk protein
US11376329B2 (en) 2013-03-15 2022-07-05 Trustees Of Tufts College Low molecular weight silk compositions and stabilizing silk compositions
US20140315828A1 (en) 2013-04-22 2014-10-23 Allergan, Inc. Cross-linked silk-hyaluronic acid compositions
WO2014189780A2 (fr) 2013-05-20 2014-11-27 Tufts University Appareil et procédé de formation d'un composite hydrogel à base de nanofibres
EP3033117A4 (fr) 2013-08-20 2017-04-19 Wake Forest University Health Sciences Dispositifs de réparation tissulaire faisant appel à des matériaux auto-assemblés
SG10201907426UA (en) 2013-09-30 2019-09-27 Evolved By Nature Inc Silk protein fragment compositions and articles manufactured therefrom
JP6369783B2 (ja) 2014-06-12 2018-08-08 株式会社アーダン 加水分解フィブロインを含む軟膏及びその製造方法
US11260012B2 (en) 2015-01-12 2022-03-01 Evolved By Nature, Inc. Preserved silk protein fragment compositions and articles manufactured therefrom
CN114886796A (zh) 2015-04-29 2022-08-12 丝绸医疗公司 基于丝的保湿剂组合物及其方法
FR3036035B1 (fr) 2015-05-11 2018-10-05 Laboratoires Vivacy Compositions comprenant au moins un polyol et au moins un anesthesique
CN104998302B (zh) 2015-08-31 2017-11-24 中原工学院 一种以取向纳米纤维毡为骨架的纳米软骨修复材料及其制备方法
TWI727014B (zh) 2016-03-24 2021-05-11 德商梅茲製藥有限兩合公司 修飾透明質酸與其製造方法及其用途
EP3503841A4 (fr) * 2016-08-24 2020-04-22 Allergan, Inc. Hydrogels co-réticulés d'acide hyaluronique-fibroïne pour améliorer la viabilité des greffes tissulaires et pour l'augmentation des tissus mous
WO2018081815A2 (fr) 2016-10-31 2018-05-03 Sofregen Medical, Inc. Compositions comprenant des particules de fibroïne de soie et leurs utilisations
CN106492279A (zh) * 2016-11-04 2017-03-15 武汉纺织大学 一种丝素蛋白‑透明质酸复合凝胶的快速制备方法
CN107880282B (zh) 2016-12-29 2020-09-29 北京键凯科技股份有限公司 一种注射用多元甘醇环氧衍生物交联的透明质酸钠凝胶及其制备方法
US20230190997A1 (en) 2017-06-26 2023-06-22 Evolved By Nature, Inc. Silk-hyaluronic acid based tissue filers and methods of using the same
KR20200032103A (ko) 2017-06-26 2020-03-25 이발브드 바이 네이처, 인크. 실크-히알루론산 기초 조직 충전제 및 이를 사용하는 방법
CN107619481B (zh) 2017-08-09 2020-08-14 浙江理工大学 一种利用桑蚕丝制备粘性丝素蛋白水凝胶的方法
CN108392680B (zh) 2018-02-09 2020-12-18 珠海睿展生物材料有限公司 一种可塑形全降解硬组织填充生物材料
CN113677320A (zh) 2018-12-19 2021-11-19 自然进化公司 丝-透明质酸组织填充物及其制备和使用方法

Also Published As

Publication number Publication date
AU2019405953A1 (en) 2021-08-05
KR20210144660A (ko) 2021-11-30
BR112021012141A2 (pt) 2021-08-31
IL284082A (en) 2021-08-31
US20230114250A1 (en) 2023-04-13
IL284082B2 (en) 2025-07-01
US20250332322A1 (en) 2025-10-30
WO2020132331A1 (fr) 2020-06-25
CN113677320A (zh) 2021-11-19
EP3897564A4 (fr) 2022-10-19
JP2022514349A (ja) 2022-02-10
EP3897564A1 (fr) 2021-10-27
US12296067B2 (en) 2025-05-13
AU2019405953B2 (en) 2025-09-18
IL284082B1 (en) 2025-03-01
SG11202106411QA (en) 2021-07-29
CA3124196A1 (fr) 2020-06-25

Similar Documents

Publication Publication Date Title
MA54563A (fr) Agents de comblement tissulaire à base de soie-acide hyaluronique et leurs procédés de préparation et d'utilisation
EP3645063A4 (fr) Agents de comblement tissulaire à base de soie-acide hyaluronique et leurs procédés d'utilisation
EP3746785A4 (fr) Organoïdes associés à une immunothérapie et leurs procédés de préparation et d'utilisation
EP4037695A4 (fr) Compositions oligonucléotidiques et leurs procédés d'utilisation
EP3958872A4 (fr) Compositions d'oligonucléotides et leurs procédés d'utilisation
EP3824096A4 (fr) Nouveaux anticorps et leurs procédés de préparation et d'utilisation
EP3775203A4 (fr) Compositions d'oligonucléotides et leurs procédés d'utilisation
EP3840730A4 (fr) Compositions pour l'administration d'agents thérapeutiques et leurs méthodes d'utilisation et leurs procédés de préparation
MA52753A (fr) Anticorps anti-sirpa et leurs procédés d'utilisation
EP3914651A4 (fr) Compositions d'agrégats de carbonate et leurs procédés de préparation et d'utilisation
EP3645742A4 (fr) Anticorps anti-ror1 et leurs procédés de préparation et d'utilisation
EP3493676A4 (fr) Compositions antimicrobiennes à base de polymère et leurs procédés d'utilisation
EP3684423A4 (fr) Virus adéno-associé à variant de capsides et leurs procédés d'utilisation
MA55025A (fr) Anticorps anti-trem2 et leurs procédés d'utilisation
MA56191A (fr) Inhibiteurs de l'autophagie à base d'amide d'aminopyrimidine et leurs procédés d'utilisation
EP3423421A4 (fr) Ciments blancs à base de silicate de calcium carbonatable et leurs procédés de préparation et d'utilisation
EP3821012A4 (fr) Véhicule d'administration à base de rétrotransposon et ses procédés d'utilisation
EP4034605A4 (fr) Compositions de polissage et leurs procédés d'utilisation
EP4048298A4 (fr) Préparation et utilisation d'hydrogels thérapeutiques
EP3893767A4 (fr) Instruments spécifiques à un patient et procédés d'utilisation
EP3994228A4 (fr) Composition de silicone adhésive sensible à la pression et ses procédés de préparation et d'utilisation
MA54148A (fr) Mélanges et compositions comprenant de la 5-fluoro-4-imino-3-méthyl-1-tosyl-3,4-dihydropyrimidin-2-one et leurs procédés d'utilisation
MA53328A (fr) Anticorps anti-siglec-5 et leurs procédés d'utilisation
EP3755723A4 (fr) Anticorps tgf-beta 1 anti-latents inter-espèces et leurs procédés d'utilisation
EP3920905A4 (fr) Composition à base de cannabinoïde, ses procédés de préparation et d'utilisation