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MA54550A - Inhibiteurs de kif18a - Google Patents

Inhibiteurs de kif18a

Info

Publication number
MA54550A
MA54550A MA054550A MA54550A MA54550A MA 54550 A MA54550 A MA 54550A MA 054550 A MA054550 A MA 054550A MA 54550 A MA54550 A MA 54550A MA 54550 A MA54550 A MA 54550A
Authority
MA
Morocco
Prior art keywords
kif18a
inhibitors
kif18a inhibitors
Prior art date
Application number
MA054550A
Other languages
English (en)
Inventor
John Gordon Allen
Abhisek Banerjee
Matthew Paul Bourbeau
James Alexander Brown
Jian Jeffrey Chen
Michael J Frohn
Lei Jia
Kexue Li
Qingyian Liu
Jonathan Dante Low
Vu Ma
Ana Elena Minatti
Thomas T Nguyen
Nobuko Nishimura
Liping H Pettus
Nuria A Tamayo
Mary Catherine Walton
Qiufen May Xue
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MA54550A publication Critical patent/MA54550A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Treating Waste Gases (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
MA054550A 2018-12-20 2019-12-20 Inhibiteurs de kif18a MA54550A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201862783069P 2018-12-20 2018-12-20

Publications (1)

Publication Number Publication Date
MA54550A true MA54550A (fr) 2022-03-30

Family

ID=69411509

Family Applications (1)

Application Number Title Priority Date Filing Date
MA054550A MA54550A (fr) 2018-12-20 2019-12-20 Inhibiteurs de kif18a

Country Status (9)

Country Link
US (1) US12459932B2 (fr)
EP (1) EP3897855B1 (fr)
JP (1) JP7686559B2 (fr)
AU (1) AU2019403488B2 (fr)
CA (1) CA3123042A1 (fr)
ES (1) ES2953821T3 (fr)
MA (1) MA54550A (fr)
MX (1) MX2021007104A (fr)
WO (1) WO2020132651A1 (fr)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
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IL283639B2 (en) 2018-12-20 2024-06-01 Amgen Inc Kif18a inhibitors
WO2020132653A1 (fr) * 2018-12-20 2020-06-25 Amgen Inc. Amides d'hétéroaryle utiles en tant qu'inhibiteurs de kif18a
CA3123227A1 (fr) 2018-12-20 2020-06-25 Amgen Inc. Amides d'heteroaryle utiles en tant qu'inhibiteurs de kif18a
US12459932B2 (en) 2018-12-20 2025-11-04 Amgen Inc. KIF18A inhibitors
CN114401953A (zh) 2019-08-02 2022-04-26 美国安进公司 Kif18a抑制剂
WO2021231413A1 (fr) * 2020-05-11 2021-11-18 University Of Vermont Approche de traitement impliquant l'inhibition de kif18a pour des tumeurs instables du point de vue chromosomique
CA3198809A1 (fr) 2020-10-20 2022-04-28 Amgen Inc. Composes spiro heterocycliques et methodes d'utilisation
CA3199082A1 (fr) 2020-10-27 2022-05-05 Amgen Inc. Composes spiro heterocycliques et procedes d'utilisation
MX2023012725A (es) 2021-04-29 2024-09-23 Amgen Inc Compuestos de 2-aminobenzotiazol y metodos de uso de los mismos.
KR20240040742A (ko) 2021-06-25 2024-03-28 항저우 인노게이트 파마 컴퍼니 리미티드 Kif18a 억제제로서의 화합물
JP2024534840A (ja) * 2021-08-26 2024-09-26 ヴォラストラ セラピューティクス，インコーポレーテッド Ｋｉｆ１８ａのスピロインドリン阻害剤
CN118076586A (zh) * 2021-09-16 2024-05-24 微境生物医药科技(上海)有限公司 Kif18a抑制剂
CA3237625A1 (fr) * 2021-11-19 2023-05-25 Yuli Xie Inhibiteur de kif18a
CN118715215A (zh) 2022-02-16 2024-09-27 美国安进公司 作为突变kras蛋白抑制剂的喹唑啉化合物及其用途
JP2025508702A (ja) 2022-02-16 2025-04-10 アムジエン・インコーポレーテツド キナゾリン化合物、及び変異ｋｒａｓタンパク質の阻害剤としてのその使用
WO2023174175A1 (fr) * 2022-03-17 2023-09-21 微境生物医药科技(上海)有限公司 Inhibiteur de kif18a
CN116514777B (zh) * 2022-05-13 2024-07-19 上海湃隆生物科技有限公司 驱动蛋白kif18a抑制剂及其应用
WO2023217232A1 (fr) * 2022-05-13 2023-11-16 上海湃隆生物科技有限公司 Inhibiteur de kinésine kif18a et son utilisation
EP4549437A4 (fr) * 2022-06-30 2025-10-15 Suzhou Genhouse Bio Co Ltd Composé contenant de l'azote et son utilisation
WO2024022508A1 (fr) * 2022-07-29 2024-02-01 武汉人福创新药物研发中心有限公司 Inhibiteur de la kif18a et utilisation
CN117510463A (zh) * 2022-08-05 2024-02-06 长春金赛药业有限责任公司 Kif18a抑制剂化合物、药物组合物及其制备方法和应用
WO2024035950A1 (fr) * 2022-08-12 2024-02-15 Accent Therapeutics, Inc. Inhibiteurs de kif18a et leurs utilisations
JP2025529821A (ja) 2022-08-18 2025-09-09 アクセント・セラピューティクス・インコーポレイテッド Ｋｉｆ１８ａ阻害剤及びその使用
CN119907796A (zh) * 2022-09-09 2025-04-29 海南先声再明医药股份有限公司 酰胺类化合物、其组合物及用途
TW202415648A (zh) * 2022-09-30 2024-04-16 大陸商長春金賽藥業有限責任公司 稠環類kif18a抑制劑化合物、藥物組合物及其製備方法和用途
WO2024078569A1 (fr) * 2022-10-13 2024-04-18 浙江海正药业股份有限公司 Dérivé d'amide aromatique, son procédé de préparation et son utilisation
WO2024083208A1 (fr) * 2022-10-21 2024-04-25 杭州邦顺制药有限公司 Inhibiteur de protéine kif18a
WO2024099398A1 (fr) * 2022-11-10 2024-05-16 南京明德新药研发有限公司 Classe de composés sulfonamide contenant un hétérocycle ortho-condensé et leur utilisation
CN120265620A (zh) * 2022-11-24 2025-07-04 益方生物科技(上海)股份有限公司 杂环化合物、其制备方法和用途
WO2024114730A1 (fr) * 2022-11-30 2024-06-06 微境生物医药科技(上海)有限公司 Composition pharmaceutique pour le traitement du cancer
WO2024114787A1 (fr) * 2022-12-02 2024-06-06 深圳众格生物科技有限公司 Composé amide ou urée
CN120265626A (zh) * 2022-12-14 2025-07-04 浙江海正药业股份有限公司 芳香酰胺类衍生物、其制备方法和其在医药上的应用
CN120752230A (zh) * 2022-12-28 2025-10-03 英矽智能科技知识产权有限公司 Kif18a的抑制剂及其用途
CN120569373A (zh) * 2023-01-05 2025-08-29 浙江海正药业股份有限公司 芳香酰胺类衍生物及其制备方法和医药上的用途
WO2024153217A1 (fr) * 2023-01-20 2024-07-25 Insilico Medicine Ip Limited Inhibiteurs de kif18a et leurs utilisations
WO2024156288A1 (fr) * 2023-01-29 2024-08-02 Shanghai Kygent Pharmaceutical Co., Ltd Inhibiteurs de dnmt1, compositions pharmaceutiques et applications thérapeutiques
CN118598855A (zh) * 2023-03-06 2024-09-06 武汉人福创新药物研发中心有限公司 抑制kif18a的化合物及其用途
WO2024216145A1 (fr) * 2023-04-13 2024-10-17 Ideaya Biosciences, Inc. Polythérapie comprenant un inhibiteur de mat2a et un inhibiteur de topoisomérase, un inhibiteur d'épissage sulfonamide ou un inhibiteur de kif18
WO2025067239A1 (fr) * 2023-09-26 2025-04-03 上海湃隆生物科技有限公司 Inhibiteur de kinésine kif18a et son application
WO2025194057A1 (fr) 2024-03-14 2025-09-18 Amgen Inc. Composés macrocycliques utilisés en tant que modulateurs de kras et leurs utilisations
WO2025194054A1 (fr) 2024-03-14 2025-09-18 Amgen Inc. Composés spirocycliques utilisés en tant que modulateurs de kras et leurs utilisations
WO2025217247A1 (fr) 2024-04-10 2025-10-16 Amgen Inc. Inhibiteurs spiro-hétérocycliques ancrés de protéines mutantes kras g12c et leurs utilisations
WO2025230862A1 (fr) 2024-04-29 2025-11-06 Amgen Inc. Composés aminés macrocycliques utilisés en tant que modulateurs de kras et leurs utilisations
WO2025230878A1 (fr) 2024-04-29 2025-11-06 Amgen Inc. Composés macrocycliques utilisés en tant que modulateurs de kras et leurs utilisations
WO2025240582A1 (fr) 2024-05-14 2025-11-20 Amgen Inc. Composés macrocycliques utilisés en tant que modulateurs de kras et leurs utilisations
WO2025242166A1 (fr) * 2024-05-22 2025-11-27 InventisBio Co., Ltd. Composés hétérocycliques, leurs procédés de préparation et leurs utilisations
CN120665073B (zh) * 2025-08-18 2025-10-28 山东绿叶制药有限公司 作为kif18a抑制剂的化合物及其用途

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