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MA52284A - Anticorps anti-hla-g et leur utilisation - Google Patents

Anticorps anti-hla-g et leur utilisation

Info

Publication number
MA52284A
MA52284A MA052284A MA52284A MA52284A MA 52284 A MA52284 A MA 52284A MA 052284 A MA052284 A MA 052284A MA 52284 A MA52284 A MA 52284A MA 52284 A MA52284 A MA 52284A
Authority
MA
Morocco
Prior art keywords
hla
antibodies
Prior art date
Application number
MA052284A
Other languages
English (en)
Inventor
Alexander Bujotzek
Stefan Dengl
Sebastian Fenn
Jens Fischer
Andreas Hinz
Sabine Hoves
Claudia Kirstenpfad
Stefan Klostermann
Meher Majety
Joerg Moelleken
Georg Tiefenthaler
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA52284A publication Critical patent/MA52284A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
MA052284A 2018-04-18 2019-04-17 Anticorps anti-hla-g et leur utilisation MA52284A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP18168011 2018-04-18

Publications (1)

Publication Number Publication Date
MA52284A true MA52284A (fr) 2021-02-24

Family

ID=62025723

Family Applications (1)

Application Number Title Priority Date Filing Date
MA052284A MA52284A (fr) 2018-04-18 2019-04-17 Anticorps anti-hla-g et leur utilisation

Country Status (21)

Country Link
US (2) US12157770B2 (fr)
EP (1) EP3781593A1 (fr)
JP (1) JP7186239B2 (fr)
KR (1) KR102608672B1 (fr)
CN (1) CN112004831B (fr)
AR (1) AR114789A1 (fr)
AU (1) AU2019254596B2 (fr)
BR (1) BR112020020588A2 (fr)
CA (1) CA3094895A1 (fr)
CL (1) CL2020002540A1 (fr)
CO (1) CO2020012347A2 (fr)
CR (1) CR20200483A (fr)
IL (1) IL277308A (fr)
MA (1) MA52284A (fr)
MX (1) MX2020010951A (fr)
PE (1) PE20201419A1 (fr)
PH (1) PH12020551710A1 (fr)
SG (1) SG11202009695QA (fr)
TW (1) TW201945395A (fr)
WO (1) WO2019202040A1 (fr)
ZA (1) ZA202006066B (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201829463A (zh) 2016-11-18 2018-08-16 瑞士商赫孚孟拉羅股份公司 抗hla-g抗體及其用途
AR114789A1 (es) 2018-04-18 2020-10-14 Hoffmann La Roche Anticuerpos anti-hla-g y uso de los mismos
CN113056483B (zh) 2018-07-09 2025-08-01 戊瑞治疗有限公司 结合到ilt4的抗体
CN115057932A (zh) 2018-09-27 2022-09-16 提泽纳治疗公司 抗hla-g抗体、包含抗hla-g抗体的组合物和使用抗hla-g抗体的方法
CN113528448B (zh) * 2020-04-14 2023-01-24 同济大学 一种人胚胎干细胞的构建方法
CR20230263A (es) 2020-12-17 2023-08-21 Hoffmann La Roche Anticuerpos anti-hla-g y uso de estos
US12012454B2 (en) * 2021-03-24 2024-06-18 China Medical University Hospital Anti-tumor antigen nanobody and nucleic acid encoding sequence thereof, and uses of the same
GB202111905D0 (en) 2021-08-19 2021-10-06 UCB Biopharma SRL Antibodies
US20250213692A1 (en) * 2022-03-25 2025-07-03 Hk Inno.N Corporation Anti-hla-g chimeric antigen receptor, and use thereof
JP2025514619A (ja) * 2022-03-25 2025-05-09 エイチケー イノ．エヌ コーポレーション Ｈｌａ－ｇ特異的抗体及びその用途
CN115894687B (zh) * 2022-03-31 2024-06-07 台州恩泽医疗中心(集团) 一种抗hla-g1，-g2，-g5及hla-g6异构体分子的单克隆抗体及其用途
WO2024108568A1 (fr) * 2022-11-25 2024-05-30 深圳先进技术研究院 Nanocorps anti-antigène leucocytaire humain g, son procédé de préparation et son utilisation
CN120835901A (zh) 2023-03-13 2025-10-24 豪夫迈·罗氏有限公司 采用pd1-lag3双特异性抗体和hla-g t细胞双特异性抗体的组合疗法
WO2024188966A1 (fr) 2023-03-13 2024-09-19 F. Hoffmann-La Roche Ag Traitement du cancer à l'aide d'un anticorps bispécifique anti-hla-g/anti-cd3 et d'un agoniste de 4-1bb (cd137)
WO2025054312A1 (fr) * 2023-09-05 2025-03-13 Tizona Therapeutics Anticorps hla-g dans des conjugués anticorps-médicament
WO2025160427A1 (fr) * 2024-01-26 2025-07-31 The Uab Research Foundation Identification d'épitopes hla ciblés par le système immunitaire

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