MA47381A - Procédés et micro-organismes de fabrication de 2,3-butanediol et ses dérivés à partir de composés carbonés en c1 - Google Patents

Procédés et micro-organismes de fabrication de 2,3-butanediol et ses dérivés à partir de composés carbonés en c1

Info

Publication number: MA47381A
Authority: MA; Morocco
Prior art keywords: butanediol; organisms; derivatives; micro; manufacture
Prior art date: 2017-01-30

Application number

MA047381A

Other languages

English (en)

Inventor

Lily Yuin Chao

Kevin Lee Dietzel

Mark Anton Held

Tina Huynh

James Kealey

Matthias Helmut Schamlisch

Na Trinh

Bryan Yeh

Xinhua Zhao

Original Assignee

Intrexon Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2017-01-30

Filing date

2018-01-30

Publication date

2021-04-14

2018-01-30 Application filed by Intrexon Corp filed Critical Intrexon Corp

2021-04-14 Publication of MA47381A publication Critical patent/MA47381A/fr

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C11/00—Aliphatic unsaturated hydrocarbons
- C07C11/12—Alkadienes
- C07C11/16—Alkadienes with four carbon atoms
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1022—Transferases (2.) transferring aldehyde or ketonic groups (2.2)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
- C12P5/02—Preparation of hydrocarbons or halogenated hydrocarbons acyclic
- C12P5/023—Methane
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/16—Butanols
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01076—(S,S)-Butanediol dehydrogenase (1.1.1.76)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01304—Diacetyl reductase, (S)-acetoin forming (1.1.1.304)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y401/00—Carbon-carbon lyases (4.1)
- C12Y401/01—Carboxy-lyases (4.1.1)
- C12Y401/01004—Acetoacetate decarboxylase (4.1.1.4)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y401/00—Carbon-carbon lyases (4.1)
- C12Y401/01—Carboxy-lyases (4.1.1)
- C12Y401/01005—Acetolactate decarboxylase (4.1.1.5)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01004—R,R-butanediol dehydrogenase (1.1.1.4)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y202/00—Transferases transferring aldehyde or ketonic groups (2.2)
- C12Y202/01—Transketolases and transaldolases (2.2.1)
- C12Y202/01006—Acetolactate synthase (2.2.1.6)
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/30—Fuel from waste, e.g. synthetic alcohol or diesel

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
Microbiology (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Biophysics (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Virology (AREA)
Tropical Medicine & Parasitology (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

MA047381A 2017-01-30 2018-01-30 Procédés et micro-organismes de fabrication de 2,3-butanediol et ses dérivés à partir de composés carbonés en c1 MA47381A (fr)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date
US201762451819P	2017-01-30	2017-01-30
US201762504626P	2017-05-11	2017-05-11
US201762512312P	2017-05-30	2017-05-30
US201762588985P	2017-11-21	2017-11-21

Publications (1)

Publication Number	Publication Date
MA47381A true MA47381A (fr)	2021-04-14

Family

ID=62978733

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MA047381A MA47381A (fr)	2017-01-30	2018-01-30	Procédés et micro-organismes de fabrication de 2,3-butanediol et ses dérivés à partir de composés carbonés en c1

Country Status (14)

Country	Link
US (6)	US11111496B2 (fr)
EP (2)	EP3574081A4 (fr)
KR (2)	KR102525517B1 (fr)
CN (1)	CN110475850B (fr)
AU (2)	AU2018213387B2 (fr)
BR (1)	BR112019015754A2 (fr)
CA (2)	CA3052046A1 (fr)
IL (2)	IL268337B2 (fr)
MA (1)	MA47381A (fr)
MX (1)	MX2019009032A (fr)
PH (2)	PH12019501767A1 (fr)
SG (3)	SG11201907008RA (fr)
WO (2)	WO2018140936A1 (fr)
ZA (3)	ZA201905094B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP3615676A4 (fr) *	2017-04-28	2021-07-07	Intrexon Corporation	Procédés et micro-organismes pour la fermentation de méthane en composés multi-carbonés
CN112154207B (zh) *	2018-08-24	2022-03-22	江苏省农业科学院	油菜抗嘧啶水杨酸类除草剂基因及其应用
KR102481504B1 (ko) *	2019-04-16	2022-12-27	경희대학교 산학협력단	2,3-부탄디올 생산용 메탄자화균 형질전환체
KR20210045752A (ko)	2019-10-17	2021-04-27	경희대학교 산학협력단	1,3-부탄다이올 생산용 형질전환 메탄자화균 및 이의 용도
CN114731793A (zh) *	2022-04-07	2022-07-12	中山大学	一种降低稻田土壤甲烷排放的方法
CN115058374B (zh) *	2022-05-24	2023-08-01	天津大学前沿技术研究院有限公司	一种利用丙酮酸合成乙偶姻的重组运动发酵单胞菌及其构建方法与应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2404046C (fr) *	2000-03-24	2008-06-03	Xoma Technology Ltd.	Procedes ameliores et cellules servant a exprimer des produits de proteine de recombinaison
EP2284185A3 (fr)	2004-01-09	2011-05-18	Novozymes A/S	Inactivation de protéine de Bacillus licheniformis
US8206970B2 (en) *	2006-05-02	2012-06-26	Butamax(Tm) Advanced Biofuels Llc	Production of 2-butanol and 2-butanone employing aminobutanol phosphate phospholyase
US20080014619A1 (en) *	2006-07-12	2008-01-17	Lixuan Lisa Huang	Method of production of para-hydroxycinnamic acid
CN102015995B (zh) *	2008-03-03	2014-10-22	焦耳无限科技公司	产生碳基目的产物的二氧化碳固定工程微生物
AU2012362144A1 (en) *	2011-12-30	2014-07-03	Butamax (Tm) Advanced Biofuels Llc	Genetic switches for butanol production
WO2014089436A1 (fr)	2012-12-07	2014-06-12	Ginkgo Bioworks, Inc.	Procédés et systèmes de production méthylotrophique de composés organiques
WO2014092562A1 (fr) *	2012-12-11	2014-06-19	Photanol B.V.	Synthèse d'acétoïne, de 2,3-butanediol et de 2-butanol par des cyanobactéries par expression hétérologue d'une voie catabolique
US9267158B2 (en)	2013-03-14	2016-02-23	Intrexon Corporation	Biological production of multi-carbon compounds from methane
DK3158065T3 (en) *	2014-06-18	2019-04-08	Calysta Inc	NUCLEIC ACIDS AND VECTORS FOR USE WITH METHANOTROPHIC BACTERIES
EA035950B1 (ru) *	2014-12-08	2020-09-04	Ланцатек Нью Зилэнд Лимитед	Рекомбинантные микроорганизмы, проявляющие повышенный поток при ферментационном пути
US10858661B2 (en) *	2017-01-10	2020-12-08	University-Industry Cooperation Group Of Kyung Hee University	Use of Methylomonas sp. DH-1 strain and its transformants
EP3615676A4 (fr) *	2017-04-28	2021-07-07	Intrexon Corporation	Procédés et micro-organismes pour la fermentation de méthane en composés multi-carbonés

2018
- 2018-01-30 KR KR1020197024829A patent/KR102525517B1/ko active Active
- 2018-01-30 EP EP18744512.7A patent/EP3574081A4/fr active Pending
- 2018-01-30 MA MA047381A patent/MA47381A/fr unknown
- 2018-01-30 US US16/481,799 patent/US11111496B2/en active Active
- 2018-01-30 EP EP18745386.5A patent/EP3574092A4/fr active Pending
- 2018-01-30 SG SG11201907008RA patent/SG11201907008RA/en unknown
- 2018-01-30 CA CA3052046A patent/CA3052046A1/fr active Pending
- 2018-01-30 SG SG10202107750TA patent/SG10202107750TA/en unknown
- 2018-01-30 US US16/481,811 patent/US11198877B2/en active Active
- 2018-01-30 CA CA3052072A patent/CA3052072A1/fr active Pending
- 2018-01-30 KR KR1020237013483A patent/KR20230142696A/ko not_active Ceased
- 2018-01-30 CN CN201880023046.1A patent/CN110475850B/zh active Active
- 2018-01-30 MX MX2019009032A patent/MX2019009032A/es unknown
- 2018-01-30 AU AU2018213387A patent/AU2018213387B2/en active Active
- 2018-01-30 BR BR112019015754A patent/BR112019015754A2/pt not_active Application Discontinuation
- 2018-01-30 IL IL268337A patent/IL268337B2/en unknown
- 2018-01-30 AU AU2018213395A patent/AU2018213395B2/en active Active
- 2018-01-30 WO PCT/US2018/015925 patent/WO2018140936A1/fr not_active Ceased
- 2018-01-30 SG SG11201907012VA patent/SG11201907012VA/en unknown
- 2018-01-30 WO PCT/US2018/015909 patent/WO2018140928A1/fr not_active Ceased
2019
- 2019-07-29 IL IL268339A patent/IL268339A/en unknown
- 2019-07-30 PH PH12019501767A patent/PH12019501767A1/en unknown
- 2019-07-30 PH PH12019501768A patent/PH12019501768A1/en unknown
- 2019-07-31 ZA ZA2019/05094A patent/ZA201905094B/en unknown
- 2019-07-31 ZA ZA2019/05095A patent/ZA201905095B/en unknown
2021
- 2021-07-30 ZA ZA2021/05423A patent/ZA202105423B/en unknown
- 2021-07-31 US US17/444,188 patent/US11939584B2/en active Active
- 2021-11-08 US US17/454,060 patent/US12091667B2/en active Active
2024
- 2024-02-20 US US18/582,362 patent/US20240263182A1/en active Pending
- 2024-08-14 US US18/805,099 patent/US20250027093A1/en active Pending

Also Published As

Publication number	Publication date
KR102525517B1 (ko)	2023-04-25
BR112019015754A2 (pt)	2020-06-09
AU2018213387A1 (en)	2019-08-15
SG10202107750TA (en)	2021-09-29
US20220112506A1 (en)	2022-04-14
WO2018140928A1 (fr)	2018-08-02
US11939584B2 (en)	2024-03-26
AU2018213387B2 (en)	2024-06-13
CN110475850B (zh)	2023-11-07
US20200115713A1 (en)	2020-04-16
ZA201905095B (en)	2022-12-21
RU2019124480A3 (fr)	2021-12-15
US12091667B2 (en)	2024-09-17
EP3574081A4 (fr)	2021-04-14
SG11201907008RA (en)	2019-08-27
IL268339A (en)	2019-09-26
US11198877B2 (en)	2021-12-14
CA3052046A1 (fr)	2018-08-02
AU2018213395A1 (en)	2019-08-15
EP3574092A1 (fr)	2019-12-04
WO2018140936A1 (fr)	2018-08-02
IL268337B2 (en)	2024-09-01
AU2018213395B2 (en)	2024-09-05
IL268337B1 (en)	2024-05-01
PH12019501767A1 (en)	2020-06-01
US20200040344A1 (en)	2020-02-06
PH12019501768A1 (en)	2020-03-16
EP3574081A1 (fr)	2019-12-04
KR20230142696A (ko)	2023-10-11
EP3574092A4 (fr)	2021-01-13
RU2019124480A (ru)	2021-03-01
US11111496B2 (en)	2021-09-07
IL268337A (en)	2019-09-26
KR20190112044A (ko)	2019-10-02
ZA202105423B (en)	2023-12-20
SG11201907012VA (en)	2019-08-27
US20250027093A1 (en)	2025-01-23
CA3052072A1 (fr)	2018-08-02
MX2019009032A (es)	2019-09-10
US20240263182A1 (en)	2024-08-08
ZA201905094B (en)	2022-01-26
CN110475850A (zh)	2019-11-19
US20220049259A1 (en)	2022-02-17

Publication	Publication Date	Title
MA47381A (fr)	2021-04-14	Procédés et micro-organismes de fabrication de 2,3-butanediol et ses dérivés à partir de composés carbonés en c1
EP3647310A4 (fr)	2021-03-24	Procédé de préparation de 2,5-furandiméthylcarboxylate à partir d'hydroxyméthylfurfural
EP3376859A4 (fr)	2019-03-06	Micro-organismes destinés à la production de phéromones d'insectes et composés associés
EP3677589A4 (fr)	2021-04-21	Procédé amélioré de production d'un conjugué anticorps-médicament
MA49752A (fr)	2021-04-21	Procédés de préparation de composés de pyrrolidine
DK3728284T3 (da)	2024-10-28	19-homo, 3.alpha.-hydroxy-steroid-20-on forbindelser til behandling af cns-lidelser
EP2989113C0 (fr)	2024-04-10	Micro-organismes et procédés de production du 4-hydroxybutyrate, du 1,4-butanediol, et composés associés
EP3432812A4 (fr)	2019-11-27	Groupe d'instrumentation chirurgicale, ensemble et procédé chirurgical de réparation de l'épaule
GB201910389D0 (en)	2019-09-04	Novel compounds, methods for their manufacture, and uses thereof
MA51629A (fr)	2020-11-18	Procédés de production, purification et formulation de conjugués anticorps-médicaments
EP3504196A4 (fr)	2020-01-22	Procédés de préparation d'olaparib
EP3480334A4 (fr)	2020-02-26	Acier inoxydable ferritique, tôle d'acier de celui-ci et procédés de production associés
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