MA47290A - Combinaison d'un agoniste sélectif de l'il-2rbeta et d'un agoniste de l'il-15 à action prolongée - Google Patents
Combinaison d'un agoniste sélectif de l'il-2rbeta et d'un agoniste de l'il-15 à action prolongéeInfo
- Publication number
- MA47290A MA47290A MA047290A MA47290A MA47290A MA 47290 A MA47290 A MA 47290A MA 047290 A MA047290 A MA 047290A MA 47290 A MA47290 A MA 47290A MA 47290 A MA47290 A MA 47290A
- Authority
- MA
- Morocco
- Prior art keywords
- agonist
- 2rbeta
- selective
- action
- combination
- Prior art date
Links
- 239000000556 agonist Substances 0.000 title 2
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2086—IL-13 to IL-16
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2013—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562239207P | 2015-10-08 | 2015-10-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA47290A true MA47290A (fr) | 2019-11-27 |
Family
ID=57249859
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA047290A MA47290A (fr) | 2015-10-08 | 2016-10-07 | Combinaison d'un agoniste sélectif de l'il-2rbeta et d'un agoniste de l'il-15 à action prolongée |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US12233104B2 (fr) |
| EP (1) | EP3359182B1 (fr) |
| JP (3) | JP7407511B2 (fr) |
| KR (1) | KR102861230B1 (fr) |
| CN (1) | CN108135978A (fr) |
| AU (1) | AU2016335860B2 (fr) |
| IL (1) | IL258456B (fr) |
| MA (1) | MA47290A (fr) |
| MX (1) | MX2018004296A (fr) |
| WO (1) | WO2017062832A1 (fr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12036283B2 (en) | 2017-05-15 | 2024-07-16 | Nektar Therapeutics | Long-acting interleukin-15 receptor agonists and related immunotherapeutic compositions and methods |
| WO2020247388A2 (fr) | 2019-06-03 | 2020-12-10 | Medikine, Inc. | Composés de liaison de sous-unité de récepteur il-2alpha |
| EP4463135A2 (fr) | 2022-01-10 | 2024-11-20 | Sana Biotechnology, Inc. | Méthodes de dosage et d'administration ex vivo de particules lipidiques ou de vecteurs viraux ainsi que systèmes et utilisations associés |
| WO2023193015A1 (fr) | 2022-04-01 | 2023-10-05 | Sana Biotechnology, Inc. | Polythérapies d'agoniste de récepteur de cytokine et de vecteur viral |
Family Cites Families (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4401756A (en) | 1981-04-14 | 1983-08-30 | Immunex Corporation | Process for preparing human interleukin 2 |
| US4569790A (en) | 1984-03-28 | 1986-02-11 | Cetus Corporation | Process for recovering microbially produced interleukin-2 and purified recombinant interleukin-2 compositions |
| US5116943A (en) | 1985-01-18 | 1992-05-26 | Cetus Corporation | Oxidation-resistant muteins of Il-2 and other protein |
| JP2524586B2 (ja) | 1985-06-26 | 1996-08-14 | シタス コーポレイション | ポリマ−接合を利用する医薬組成物用蛋白質の可溶化 |
| US4766106A (en) | 1985-06-26 | 1988-08-23 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
| US5206344A (en) | 1985-06-26 | 1993-04-27 | Cetus Oncology Corporation | Interleukin-2 muteins and polymer conjugation thereof |
| US4705848A (en) | 1986-06-02 | 1987-11-10 | International Minerals & Chemical Corp. | Isolation of bioactive, monomeric growth hormone |
| US5078997A (en) | 1988-07-13 | 1992-01-07 | Cetus Corporation | Pharmaceutical composition for interleukin-2 containing physiologically compatible stabilizers |
| US5089261A (en) | 1989-01-23 | 1992-02-18 | Cetus Corporation | Preparation of a polymer/interleukin-2 conjugate |
| US4902502A (en) | 1989-01-23 | 1990-02-20 | Cetus Corporation | Preparation of a polymer/interleukin-2 conjugate |
| US5153310A (en) | 1989-02-28 | 1992-10-06 | Du Pont Merck Pharmaceutical Company | Il-2 analogs containing n-linked glycosylation sites |
| US5166322A (en) | 1989-04-21 | 1992-11-24 | Genetics Institute | Cysteine added variants of interleukin-3 and chemical modifications thereof |
| IE912365A1 (en) | 1990-07-23 | 1992-01-29 | Zeneca Ltd | Continuous release pharmaceutical compositions |
| US5595732A (en) | 1991-03-25 | 1997-01-21 | Hoffmann-La Roche Inc. | Polyethylene-protein conjugates |
| US6077519A (en) * | 1993-01-29 | 2000-06-20 | University Of Pittsburgh | Methods for isolation and use of T cell epitopes eluted from viable cells in vaccines for treating cancer patients |
| AU1096595A (en) * | 1993-11-12 | 1995-05-29 | Gilead Sciences, Inc. | Thrombin mutants |
| US5446090A (en) | 1993-11-12 | 1995-08-29 | Shearwater Polymers, Inc. | Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules |
| US5635597A (en) | 1994-05-27 | 1997-06-03 | Affymax Technologies, N.V. | Peptides that bind IL-2 receptors |
| US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
| US7008624B1 (en) | 1995-02-22 | 2006-03-07 | Immunex Corporation | Antagonists of interleukin-15 |
| US5795966A (en) | 1995-02-22 | 1998-08-18 | Immunex Corp | Antagonists of interleukin-15 |
| US6034072A (en) | 1997-02-10 | 2000-03-07 | Genemedicine, Inc. | IL-2 gene expression and delivery systems and uses |
| US6180095B1 (en) | 1997-12-17 | 2001-01-30 | Enzon, Inc. | Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents |
| CA2323048C (fr) | 1998-03-12 | 2006-10-10 | Shearwater Polymers, Inc. | Derives de poly(ethylene glycol) avec groupes reactifs proximaux |
| DZ2788A1 (fr) | 1998-05-15 | 2003-12-01 | Bayer Ag | Agonistes et antagonistes selectifs à IL-2. |
| US6168785B1 (en) | 1998-07-16 | 2001-01-02 | Institut Pasteur | Biological applications of new peptides of IL-2 and derivatives and use as therapeutic agents |
| AU2001238595A1 (en) | 2000-02-22 | 2001-09-03 | Shearwater Corporation | N-maleimidyl polymer derivatives |
| US6689353B1 (en) | 2000-06-28 | 2004-02-10 | Bayer Pharmaceuticals Corporation | Stabilized interleukin 2 |
| CA2422294C (fr) | 2000-09-14 | 2012-12-04 | Beth Israel Deaconess Medical Center, Inc. | Modulation de reactions de cellules t induites par il-15 et il-2 |
| CN101584867A (zh) | 2000-10-31 | 2009-11-25 | 瑟莫迪克斯药品公司 | 提高生物活性分子传递的方法和组合物 |
| FR2826365B1 (fr) | 2001-06-20 | 2003-09-26 | Oreal | Compositions cosmetiques photoprotectrices contenant des derives amides, sulfonamides ou carbamates aromatiques d'acrylonitrile et nouveaux derives amides, sulfonamides ou carbamates d'acrylonitrile |
| EA200500475A1 (ru) | 2002-09-09 | 2005-10-27 | Нектар Терапеутикс Ал, Корпорейшн | Водорастворимые полимерные алканалы |
| JP2006519170A (ja) | 2002-12-26 | 2006-08-24 | マウンテン ビュー ファーマシューティカルズ，インコーポレイテッド | サイトカイン、ケモカイン、増殖因子、ポリペプチドホルモン、およびレセプター結合活性が保存されたそのアンタゴニストのポリマー結合体 |
| KR101025143B1 (ko) | 2002-12-31 | 2011-04-01 | 넥타르 테라퓨틱스 | 가수분해상으로 안정한 말레이미드－종결 중합체 |
| MXPA05007348A (es) | 2003-01-06 | 2005-10-05 | Nektar Therapeutics Al Corp | Derivados de polimeros solubles en agua tiol-selectivos. |
| PL1620118T3 (pl) | 2003-04-08 | 2014-11-28 | Yeda Res & Dev | Leki odwracalnie pegylowane |
| CN1747748B (zh) | 2003-05-23 | 2011-01-19 | 尼克塔治疗公司 | 具有特定原子排列的聚合物衍生物 |
| WO2005007121A2 (fr) | 2003-07-18 | 2005-01-27 | Massachusetts Institute Of Technology | Polypeptides de l'interleukine-2(il-2) mutante |
| US20050069521A1 (en) * | 2003-08-28 | 2005-03-31 | Emd Lexigen Research Center Corp. | Enhancing the circulating half-life of interleukin-2 proteins |
| JP2007506789A (ja) | 2003-09-25 | 2007-03-22 | ザイモジェネティクス， インコーポレイテッド | Ｉｌ−２１を用いた自己免疫疾患の治療方法 |
| EP1691841B1 (fr) | 2003-12-10 | 2020-09-09 | Nektar Therapeutics | Compositions contenant deux populations diffferentes de conjugues polymeres-agents actifs |
| WO2006020849A2 (fr) | 2004-08-11 | 2006-02-23 | Beth Israel Deaconess Medical Center, Inc. | Polypeptides d'interleukine-15 mutants |
| CA2583274A1 (fr) | 2004-10-05 | 2007-02-15 | Ochsner Clinic Foundation | Amelioration de la proliferation des lymphocytes b par il-15 |
| DE602005001688T2 (de) | 2005-02-07 | 2008-04-10 | Novartis Vaccines and Diagnostics, Inc., Emeryville | Aufbereitung von Aldesleukin zur pharmazeutischen Verwendung |
| JP4560629B2 (ja) * | 2005-03-31 | 2010-10-13 | 国立大学法人 筑波大学 | 腫瘍壊死誘導療法の抗腫瘍効果増強剤 |
| US20060257361A1 (en) * | 2005-04-12 | 2006-11-16 | Government Of The Us, As Represented By The Secretary, Department Of Health And Human Services | Novel form of interleukin-15, Fc-IL-15, and methods of use |
| RS52861B (sr) | 2005-06-07 | 2013-12-31 | Esbatech - A Novartis Company Llc | Stabilna i rastvorljiva antitela koja inhibiraju tnf (alfa) |
| WO2006138572A2 (fr) | 2005-06-16 | 2006-12-28 | Nektar Therapeutics Al, Corporation | Conjugues a liaison degradable et reactifs polymeres utilises dans la preparation de ces conjugues |
| WO2007075534A2 (fr) | 2005-12-16 | 2007-07-05 | Nektar Therapeutics Al, Corporation | Conjugues polymeres de glp-1 |
| EP1966369B1 (fr) * | 2005-12-21 | 2010-10-06 | Sentoclone AB | Methode pour la proliferation de lymphocytes t reactifs a une tumeur a des fins d'immunotherapie pour des patients atteints de cancer |
| US9101670B2 (en) | 2006-04-07 | 2015-08-11 | Nektar Therapeutics | Conjugates of an anti-TNF-α antibody |
| CN101104077A (zh) | 2006-07-12 | 2008-01-16 | 北京紫辰医药生物技术研究所 | 重组人白介素-2与聚乙二醇的偶合物 |
| AU2007340382B2 (en) | 2006-12-27 | 2013-06-27 | Nektar Therapeutics | Von Willebrand Factor- and Factor VIII-polymer conjugates having a releasable linkage |
| BRPI0720619B1 (pt) * | 2006-12-27 | 2022-04-05 | Nektar Therapeutics | Composto de fator ix-poli(etileno glicol) com uma ligação liberável, método para preparar o mesmo e composição |
| WO2008106186A2 (fr) | 2007-02-28 | 2008-09-04 | Serina Therapeutics, Inc. | Polyoxazolines activées et composition comprenant celles-ci |
| EP2237799B1 (fr) | 2008-02-01 | 2019-04-10 | Ascendis Pharma A/S | Promédicament comprenant un linker auto-clivable |
| KR20090103209A (ko) | 2008-03-27 | 2009-10-01 | (주)한국비엠아이 | 사람 인터루킨-2 동종체 |
| WO2009135031A1 (fr) * | 2008-04-30 | 2009-11-05 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Servic | Il-15 substitué |
| MX2010012430A (es) | 2008-05-16 | 2010-12-21 | Nektar Therapeutics | Conjugados de una porcion de colinesterasa y un polimero. |
| WO2010014258A2 (fr) | 2008-08-01 | 2010-02-04 | Nektar Therapeutics Al, Corporation | Conjugués possédant une liaison libérable |
| MX2011003117A (es) | 2008-09-19 | 2011-04-21 | Nektar Therapeutics | Conjugados polimericos de peptidos terapeuticos. |
| DK2431741T3 (da) | 2008-10-21 | 2013-10-21 | Baxter Int | Fremgangsmåde til bestemmelse af virksomme bestanddele i profarmaka-PEG-proteinkonjugat |
| KR102325780B1 (ko) | 2010-07-30 | 2021-11-12 | 박스알타 인코퍼레이티드 | 옥심 결합용 친핵성 촉매 |
| RS61854B1 (sr) * | 2010-11-12 | 2021-06-30 | Nektar Therapeutics | Konjugati il-2 dela i polimera |
| WO2013020079A2 (fr) * | 2011-08-04 | 2013-02-07 | Nektar Therapeutics | Conjugués d'une fraction il-11 et d'un polymère |
| WO2014201378A1 (fr) | 2013-06-13 | 2014-12-18 | Massachusetts Institute Of Technology | Traitement synergique de tumeur avec il-2 à pk prolongée et thérapie cellulaire adoptive |
| SMT202100191T1 (it) | 2014-02-21 | 2021-05-07 | Nektar Therapeutics | Agonisti selettivi per il-2rbeta in combinazione con un anticorpo anti.ctla-4 o un anticorpo anti-pd-1 |
| MA39711A (fr) * | 2014-04-03 | 2015-10-08 | Nektar Therapeutics | Conjugués d'une fraction d'il-15 et d'un polymère |
-
2016
- 2016-10-07 US US15/765,207 patent/US12233104B2/en active Active
- 2016-10-07 KR KR1020187011922A patent/KR102861230B1/ko active Active
- 2016-10-07 MX MX2018004296A patent/MX2018004296A/es unknown
- 2016-10-07 CN CN201680058497.XA patent/CN108135978A/zh active Pending
- 2016-10-07 AU AU2016335860A patent/AU2016335860B2/en active Active
- 2016-10-07 MA MA047290A patent/MA47290A/fr unknown
- 2016-10-07 EP EP16791713.7A patent/EP3359182B1/fr active Active
- 2016-10-07 WO PCT/US2016/056088 patent/WO2017062832A1/fr not_active Ceased
- 2016-10-07 JP JP2018517898A patent/JP7407511B2/ja active Active
-
2018
- 2018-03-29 IL IL258456A patent/IL258456B/en unknown
-
2021
- 2021-02-04 JP JP2021016606A patent/JP2021066748A/ja not_active Withdrawn
-
2023
- 2023-05-24 JP JP2023085387A patent/JP2023099731A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CN108135978A (zh) | 2018-06-08 |
| EP3359182A1 (fr) | 2018-08-15 |
| KR102861230B1 (ko) | 2025-09-17 |
| US12233104B2 (en) | 2025-02-25 |
| EP3359182B1 (fr) | 2023-04-19 |
| JP2018530568A (ja) | 2018-10-18 |
| WO2017062832A1 (fr) | 2017-04-13 |
| HK1253347A1 (en) | 2019-06-14 |
| CA3000211A1 (fr) | 2017-04-13 |
| JP2023099731A (ja) | 2023-07-13 |
| JP7407511B2 (ja) | 2024-01-04 |
| KR20180063184A (ko) | 2018-06-11 |
| AU2016335860B2 (en) | 2023-08-10 |
| IL258456A (en) | 2018-06-28 |
| AU2016335860A1 (en) | 2018-04-12 |
| JP2021066748A (ja) | 2021-04-30 |
| US20180296645A1 (en) | 2018-10-18 |
| IL258456B (en) | 2021-07-29 |
| MX2018004296A (es) | 2018-08-01 |
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