[go: up one dir, main page]

MA46054A - Procédé de préparation de pyrazolo[1,5-a]pyrimidines et de sels de celles-ci - Google Patents

Procédé de préparation de pyrazolo[1,5-a]pyrimidines et de sels de celles-ci

Info

Publication number
MA46054A
MA46054A MA046054A MA46054A MA46054A MA 46054 A MA46054 A MA 46054A MA 046054 A MA046054 A MA 046054A MA 46054 A MA46054 A MA 46054A MA 46054 A MA46054 A MA 46054A
Authority
MA
Morocco
Prior art keywords
pyrazolo
pyrimidines
salts
preparation
Prior art date
Application number
MA046054A
Other languages
English (en)
Inventor
Charles Todd Eary
Julia Haas
Yutong Jiang
Stacey Spencer
Qian Zhao
Original Assignee
Array Biopharma Inc
Loxo Oncology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=62023982&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA46054(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from PCT/US2016/058951 external-priority patent/WO2017075107A1/fr
Application filed by Array Biopharma Inc, Loxo Oncology Inc filed Critical Array Biopharma Inc
Publication of MA46054A publication Critical patent/MA46054A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
MA046054A 2016-10-26 2017-10-26 Procédé de préparation de pyrazolo[1,5-a]pyrimidines et de sels de celles-ci MA46054A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US2016/058951 WO2017075107A1 (fr) 2015-10-26 2016-10-26 Mutations ponctuelles dans le cancer résistant aux inhibiteurs de trk et méthodes associées
US201762524801P 2017-06-26 2017-06-26

Publications (1)

Publication Number Publication Date
MA46054A true MA46054A (fr) 2019-07-03

Family

ID=62023982

Family Applications (2)

Application Number Title Priority Date Filing Date
MA046054A MA46054A (fr) 2016-10-26 2017-10-26 Procédé de préparation de pyrazolo[1,5-a]pyrimidines et de sels de celles-ci
MA45802A MA45802A1 (fr) 2017-06-26 2017-10-26 Procédé de préparation de pyrazolo[1,5-a]pyrimidines et de sels de celles-ci

Family Applications After (1)

Application Number Title Priority Date Filing Date
MA45802A MA45802A1 (fr) 2017-06-26 2017-10-26 Procédé de préparation de pyrazolo[1,5-a]pyrimidines et de sels de celles-ci

Country Status (28)

Country Link
US (1) US11091486B2 (fr)
EP (1) EP3532475A2 (fr)
JP (1) JP2019532089A (fr)
KR (1) KR20190082808A (fr)
CN (1) CN110267958A (fr)
AR (1) AR112207A1 (fr)
AU (1) AU2017348259B2 (fr)
BR (1) BR112019008341A2 (fr)
CA (1) CA3041316A1 (fr)
CL (2) CL2019001094A1 (fr)
CO (1) CO2019004123A2 (fr)
CR (1) CR20190255A (fr)
DO (1) DOP2019000109A (fr)
EA (1) EA201991055A1 (fr)
EC (1) ECSP19036765A (fr)
IL (1) IL266170A (fr)
JO (1) JOP20190092A1 (fr)
MA (2) MA46054A (fr)
MX (1) MX387902B (fr)
NI (1) NI201900037A (fr)
PE (1) PE20191543A1 (fr)
PH (1) PH12019500930A1 (fr)
SG (1) SG11201903487SA (fr)
TN (2) TN2020000195A1 (fr)
TW (1) TW201906840A (fr)
UA (1) UA124271C2 (fr)
UY (1) UY37781A (fr)
WO (2) WO2018081417A2 (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2350075B1 (fr) 2008-09-22 2014-03-05 Array Biopharma, Inc. Composés imidazo[1,2b]pyridazine substitués comme inhibiteurs de kinases trk
KR101853026B1 (ko) 2008-10-22 2018-04-27 어레이 바이오파마 인크. ＴＲＫ 키나아제 억제제로서 치환된 피라졸로［１,５­ａ］ 피리미딘 화합물
AR077468A1 (es) 2009-07-09 2011-08-31 Array Biopharma Inc Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
CN105693720B (zh) 2010-05-20 2019-01-18 阵列生物制药公司 作为trk激酶抑制剂的大环化合物
TWI746426B (zh) 2014-11-16 2021-11-21 美商亞雷生物製藥股份有限公司 (S)-N-(5-((R)-2-(2,5-二氟苯基)-吡咯啶-1-基)-吡唑并[1,5-a]嘧啶-3-基)-3-羥基吡咯啶-1-甲醯胺硫酸氫鹽結晶型
TN2018000138A1 (en) 2015-10-26 2019-10-04 Array Biopharma Inc Point mutations in trk inhibitor-resistant cancer and methods relating to the same
HUE068971T2 (hu) 2016-04-04 2025-02-28 Loxo Oncology Inc (S)-N-(5-((R)-2-(2,5-difluorofenil)-pirrolidin-1-il)-pirazolo[1,5-A]pirimidin-3-il) -3-hidroxipirrolidin-1-karboxamid folyékony készítményei
US10045991B2 (en) 2016-04-04 2018-08-14 Loxo Oncology, Inc. Methods of treating pediatric cancers
SI3458456T1 (sl) 2016-05-18 2021-04-30 Loxo Oncology, Inc. Priprava (S)-N-(5-((R)-2-(2,5-difluorofenil) pirolidin-1-il) pirazolo (1,5-A) pirimidin-3-il)-3-hidroksipirolidin-1-karboksamida
JOP20190092A1 (ar) 2016-10-26 2019-04-25 Array Biopharma Inc عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها
JOP20190213A1 (ar) 2017-03-16 2019-09-16 Array Biopharma Inc مركبات حلقية ضخمة كمثبطات لكيناز ros1
EP3700576A1 (fr) * 2017-10-26 2020-09-02 Array Biopharma Inc. Formulations d'un inhibiteur de kinase trk macrocyclique
WO2019094143A1 (fr) * 2017-11-10 2019-05-16 Angex Pharmaceutical, Inc. Composés macrocycliques en tant qu'inhibiteurs de kinase trk et leurs utilisations
CN110577532B (zh) * 2018-06-08 2022-06-03 江苏威凯尔医药科技有限公司 原肌球蛋白受体激酶抑制剂及其制备方法和应用
WO2019233461A1 (fr) * 2018-06-08 2019-12-12 江苏威凯尔医药科技有限公司 Inhibiteur du récepteur de kinase a lié à la tropomyosine, son procédé de préparation et son utilisation
CN112955453B (zh) * 2018-09-29 2022-04-19 山东绿叶制药有限公司 作为选择性Trk抑制剂的吡唑并嘧啶衍生物
KR102850357B1 (ko) 2018-10-22 2025-08-27 알루미스 인크. Tyk2 억제제 및 이의 용도
AU2019375825B2 (en) * 2018-11-09 2022-09-15 Shandong Xuanzhu Pharma Co., Ltd. Macrocyclic tyrosine kinase inhibitor and uses thereof
CN111253402B (zh) * 2018-11-30 2021-08-03 广州白云山医药集团股份有限公司白云山制药总厂 一种trk激酶抑制剂化合物的中间体化合物及制备方法
AU2020239026B2 (en) * 2019-03-11 2025-10-09 Alumis Inc. TYK2 inhibitors and uses thereof
AR119140A1 (es) 2019-06-13 2021-11-24 Pi Industries Ltd Compuestos heterocíclicos fusionados y su uso como agentes de control de plagas
CN113135938B (zh) * 2020-01-19 2022-06-14 山东轩竹医药科技有限公司 取代的大环类酪氨酸激酶抑制剂及其用途
JP7495035B2 (ja) * 2020-05-08 2024-06-04 シュエンジュウ バイオファーマシューティカル カンパニー リミテッド 大環類チロシンキナーゼ阻害剤の結晶形及びその製造方法
WO2022208370A1 (fr) 2021-03-31 2022-10-06 Pi Industries Ltd. Composés hétérocycliques condensés et leur utilisation en tant qu'agents de lutte antiparasitaire
CN113444070A (zh) * 2021-07-28 2021-09-28 深圳市真味生物科技有限公司 一种由手性叔丁基亚磺酰胺合成手性尼古丁的制备方法
WO2025177310A1 (fr) 2024-02-23 2025-08-28 Pi Industries Ltd. Composés hétérocycliques fusionnés et leurs utilisations
WO2025177312A1 (fr) 2024-02-23 2025-08-28 Pi Industries Ltd. Composés hétérocycliques fusionnés et leurs utilisations

Family Cites Families (266)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ234143A (en) 1989-06-28 1991-10-25 Mcneil Ppc Inc Aqueous pharmaceutical suspension formulation for administering substantially insoluble pharmaceutical agents
RO118291B1 (ro) 1993-11-30 2003-04-30 Searle & Co Derivati de pirazol 1,3,4,5 - tetrasubstituiti si compozitie farmaceutica care ii contine
US5844092A (en) 1994-03-18 1998-12-01 Genentech, Inc. Human TRK receptors and neurotrophic factor inhibitors
US5430021A (en) 1994-03-18 1995-07-04 Pharmavene, Inc. Hydrophobic drug delivery systems
US5877016A (en) 1994-03-18 1999-03-02 Genentech, Inc. Human trk receptors and neurotrophic factor inhibitors
US6458811B1 (en) 1996-03-26 2002-10-01 Eli Lilly And Company Benzothiophenes formulations containing same and methods
CA2206201A1 (fr) 1996-05-29 1997-11-29 Yoshiaki Isobe Derives du pyrazole et leur emploi en pharmacie
JP3898296B2 (ja) 1996-08-28 2007-03-28 ポーラ化成工業株式会社 ピロロピラゾロピリミジン化合物及びこれを有効成分とする医薬
ATE283270T1 (de) 1997-04-25 2004-12-15 Takeda Chemical Industries Ltd Condensierte pyridazine derivate,deren herstellung und verwendung
EE200100382A (et) 1999-01-21 2002-12-16 Bristol-Myers Squibb Company Ras-farnesüültransferaasi inhibiitori ja sulfobutüüleeter-7-ß-tsüklodekstriini või 2-hüdroksüpropüül-ß-tsüklodekstriini kompleks ja selle valmistamise meetod
UA74546C2 (en) 1999-04-06 2006-01-16 Boehringer Ingelheim Ca Ltd Macrocyclic peptides having activity relative to hepatitis c virus, a pharmaceutical composition and use of the pharmaceutical composition
US6534085B1 (en) 1999-09-23 2003-03-18 Bioresponse L.L.C. Phytochemicals for promoting weight loss
DK1292680T3 (da) 2000-06-22 2010-03-08 Genentech Inc Agonist-anti-TrkC monoklonale antistoffer
GB0028575D0 (en) 2000-11-23 2001-01-10 Elan Corp Plc Oral pharmaceutical compositions containing cyclodextrins
TWI312347B (en) 2001-02-08 2009-07-21 Eisai R&D Man Co Ltd Bicyclic nitrogen-containing condensed ring compounds
NZ529612A (en) 2001-05-30 2006-03-31 Genentech Inc Anti-NGF antibodies for the treatment of various disorders
US7101572B2 (en) 2001-12-07 2006-09-05 Unilab Pharmatech, Ltd. Taste masked aqueous liquid pharmaceutical composition
US20030199525A1 (en) 2002-03-21 2003-10-23 Hirst Gavin C. Kinase inhibitors
AU2003227437A1 (en) 2002-04-23 2003-11-10 Shionogi And Co., Ltd. PYRAZOLO(1,5-a)PYRIMIDINE DERIVATIVE AND NAD(P)H OXIDASE INHIBITOR CONTAINING THE SAME
US7449488B2 (en) 2002-06-04 2008-11-11 Schering Corporation Pyrazolopyrimidines as protein kinase inhibitors
US6982253B2 (en) 2002-06-05 2006-01-03 Supergen, Inc. Liquid formulation of decitabine and use of the same
ITMI20021620A1 (it) 2002-07-23 2004-01-23 Novuspharma Spa Composto ad ativita' antitumorale
JP4024624B2 (ja) 2002-08-26 2007-12-19 富士通株式会社 半導体装置の製造方法及び製造装置
EP1537116B1 (fr) 2002-09-04 2010-06-02 Schering Corporation Pyrazolopyrimidines utilisable pour le traitement des maladies cancereuses
US8580782B2 (en) 2002-09-04 2013-11-12 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
US7196078B2 (en) 2002-09-04 2007-03-27 Schering Corpoartion Trisubstituted and tetrasubstituted pyrazolopyrimidines as cyclin dependent kinase inhibitors
US7119200B2 (en) 2002-09-04 2006-10-10 Schering Corporation Pyrazolopyrimidines as cyclin dependent kinase inhibitors
WO2004052286A2 (fr) 2002-12-11 2004-06-24 Merck & Co., Inc. Inhibiteurs de tyrosine kinase
WO2004052315A2 (fr) 2002-12-11 2004-06-24 Merck & Co., Inc. Inhibiteurs des tyrosine kinases
EP1597251B1 (fr) 2003-02-20 2009-06-10 SmithKline Beecham Corporation Composes de pyrimidine
GB0303910D0 (en) 2003-02-20 2003-03-26 Merck Sharp & Dohme Therapeutic agents
US20070037150A1 (en) 2003-02-21 2007-02-15 The Johns Hopkins University Tyrosine kinome
JP2004277337A (ja) 2003-03-14 2004-10-07 Sumitomo Pharmaceut Co Ltd ピラゾロ［１，５−ａ］ピリミジン誘導体
EP1608652A1 (fr) 2003-03-31 2005-12-28 Vernalis (Cambridge) Limited Composes pyrazolopyrimidines et leur utilisation en medecine
EP1615697A2 (fr) 2003-04-11 2006-01-18 Novo Nordisk A/S Utilisation pharmaceutique de pyrazolo 1,5-a]pyrimidines substituees
WO2004089415A2 (fr) 2003-04-11 2004-10-21 Novo Nordisk A/S Therapie combinatoire utilisant un inhibiteur de 11$g(b)-hydroxysteroide deshydrogenase de type 1 et agoniste du recepteur de glucocorticoides pour minimiser les effets secondaires associes a la therapie a base d'agoniste du recepteur de glucocorticoides
US20060094699A1 (en) 2003-04-11 2006-05-04 Kampen Gita Camilla T Combination therapy using an 11beta-hydroxysteroid dehydrogenase type 1 inhibitor and a glucocorticoid receptor agonist to minimize the side effects associated with glucocorticoid receptor agonist therapy
EP1619203A1 (fr) 2003-04-28 2006-01-25 Galpharma Co., Ltd. Facteur d'induction de la galectine 9
PA8603801A1 (es) 2003-05-27 2004-12-16 Janssen Pharmaceutica Nv Derivados de la quinazolina
JP2005008581A (ja) 2003-06-20 2005-01-13 Kissei Pharmaceut Co Ltd 新規なピラゾロ［１，５−ａ］ピリミジン誘導体、それを含有する医薬組成物およびそれらの用途
EA009517B1 (ru) 2003-06-27 2008-02-28 Байер Кропсайенс Аг Пиразолопиримидины
UA115960C2 (uk) 2003-07-15 2018-01-25 Емджен, Інк., Людські анти-ngf нейтралізуючі антитіла як селективні інгібітори метаболічних шляхів фактора росту нервової тканини (ngf)
US7491794B2 (en) 2003-10-14 2009-02-17 Intermune, Inc. Macrocyclic compounds as inhibitors of viral replication
CA2543116A1 (fr) 2003-10-27 2005-05-19 Genelabs Technologies, Inc. Procedes de preparation de derives 7-(2'-.szlig.-d-ribofuranosyl substitue)-4-(nr2r3)-5-(ethyn-1-yl substitue)-pyrrolo[2,3-d]pyrimidine
MY141220A (en) 2003-11-17 2010-03-31 Astrazeneca Ab Pyrazole derivatives as inhibitors of receptor tyrosine kinases
PE20051046A1 (es) 2003-11-28 2006-01-11 Novartis Ag Derivados de diaril-urea en el tratamiento de enfermedades dependientes de la quinasa de proteina
ES2305887T3 (es) 2003-12-18 2008-11-01 Janssen Pharmaceutica Nv Derivados de pirido y pirimidopirimidinas como agentes antiproliferativos.
ES2527118T3 (es) 2003-12-19 2015-01-20 Plexxikon Inc. Compuestos y procedimientos de desarrollo de moduladores de Ret
WO2005068424A1 (fr) 2004-01-20 2005-07-28 Cell Therapeutics Europe S.R.L. Derives d'indolinone en tant qu'inhibiteurs de tyrosine kinase de recepteurs
US20050222171A1 (en) 2004-01-22 2005-10-06 Guido Bold Organic compounds
WO2005099363A2 (fr) 2004-03-26 2005-10-27 Whitehead Institute For Biomedical Research Methodes de diagnostic, de prevention et de traitement de metastases cancereuses
UA91677C2 (ru) 2004-03-30 2010-08-25 Интермюн, Инк. Макроциклические соединения как ингибиторы вирусной репликации
GB0512324D0 (en) 2005-06-16 2005-07-27 Novartis Ag Organic compounds
PE20060664A1 (es) 2004-09-15 2006-08-04 Novartis Ag Amidas biciclicas como inhibidores de cinasa
KR20070090172A (ko) 2004-11-04 2007-09-05 버텍스 파마슈티칼스 인코포레이티드 단백질 키나아제의 억제제로서 유용한피라졸로[1,5-ａ]피리미딘
JO3088B1 (ar) 2004-12-08 2017-03-15 Janssen Pharmaceutica Nv مشتقات كوينازولين كبيرة الحلقات و استعمالها بصفتها موانع كينيز متعددة الاهداف
DE102005003687A1 (de) 2005-01-26 2006-07-27 Sphingo Tec Gmbh Immunoassay zur Bestimmung der Freisetzung von Neurotensin in die Zirkulation
CN101119996A (zh) 2005-02-16 2008-02-06 阿斯利康(瑞典)有限公司 化学化合物
WO2006087538A1 (fr) 2005-02-16 2006-08-24 Astrazeneca Ab Composés chimiques
KR20070120963A (ko) 2005-03-21 2007-12-26 일라이 릴리 앤드 캄파니 이미다조피리다진 화합물
JP2008540335A (ja) 2005-04-27 2008-11-20 アストラゼネカ・アクチエボラーグ ピラゾリル・ピリミジン誘導体の疼痛治療における使用
US20080287437A1 (en) 2005-05-16 2008-11-20 Astrazeneca Ab Pyrazolylaminopyrimidine Derivatives Useful as Tyrosine Kinase Inhibitors
CN100406650C (zh) 2005-06-05 2008-07-30 徐斌 一种抗特大变位的模块式梳型桥梁伸缩缝装置
ITRM20050290A1 (it) 2005-06-07 2006-12-08 Lay Line Genomics Spa Uso di molecole in grado di inibire il legame tra ngf e il suo recettore trka come analgesici ad effetto prolungato.
UA95244C2 (ru) 2005-06-22 2011-07-25 Плексикон, Инк. Соединения и способ модулирования активности киназ, и показания для их применения
US20070025540A1 (en) 2005-07-07 2007-02-01 Roger Travis Call center routing based on talkativeness
CN101263156A (zh) 2005-07-25 2008-09-10 因特蒙公司 C型肝炎病毒复制的新颖大环抑制剂
US20100216798A1 (en) 2005-07-29 2010-08-26 Astellas Pharma Inc Fused heterocycles as lck inhibitors
EP1909760A1 (fr) 2005-08-03 2008-04-16 Eastman Chemical Company Poudre de succinate de tocopheryl polyethylene glycol et procede de preparation de celle-ci
CA2619365A1 (fr) 2005-08-22 2007-03-01 Amgen Inc. Composes de pyrazolopyridine et de pyrazolopyrimidine utilises comme modulateurs d'enzymes kinases
HRP20140218T4 (hr) 2005-08-25 2017-06-16 Creabilis Therapeutics S.P.A. Polimerni konjugati k-252a i njihovi derivati
US20070049591A1 (en) 2005-08-25 2007-03-01 Kalypsys, Inc. Inhibitors of MAPK/Erk Kinase
DE102005042742A1 (de) 2005-09-02 2007-03-08 Schering Ag Substituierte Imidazo[1,2b]pyridazine als Kinase-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel
US20070078136A1 (en) 2005-09-22 2007-04-05 Bristol-Myers Squibb Company Fused heterocyclic compounds useful as kinase modulators
TWI421078B (zh) 2005-10-06 2014-01-01 Merck Sharp & Dohme 關卡激酶抑制劑及其用途
TW200745128A (en) 2005-10-06 2007-12-16 Schering Corp Pyrazolopyrimidines as protein kinase inhibitors
WO2007057782A2 (fr) 2005-10-11 2007-05-24 Centre National De La Recherche Scientifique (Cnrs) Composes et trousses pour la detection et la quantification de l'apoptose cellulaire
CN101415705B (zh) 2005-10-11 2011-10-26 因特蒙公司 抑制丙型肝炎病毒复制的化合物和方法
JP5376950B2 (ja) 2005-10-21 2013-12-25 エクセリクシス， インク． カゼインキナーゼｉｉ（ｃｋ２）モジュレーターとしてのピリミジオン類
WO2007057399A2 (fr) 2005-11-15 2007-05-24 Boehringer Ingelheim International Gmbh Traitement du cancer
GB0524436D0 (en) 2005-11-30 2006-01-11 Novartis Ag Organic compounds
WO2007070504A2 (fr) 2005-12-13 2007-06-21 Morton Grove Pharmaceuticals, Inc. Compositions orales liquides de sumatriptan stables et de gout agreable
JP5474354B2 (ja) 2005-12-30 2014-04-16 アステックス、セラピューティックス、リミテッド 医薬化合物
WO2007084815A2 (fr) 2006-01-19 2007-07-26 Janssen Pharmaceutica, N.V. Inhibiteurs de la thienopyrimidine kinase substituee
EP1978958A4 (fr) 2006-01-24 2009-12-02 Merck & Co Inc Inhibition de la tyrosine kinase ret
KR100846988B1 (ko) 2006-03-06 2008-07-16 제일약품주식회사 신규한 티에노피리미딘 유도체 또는 이의 약학적으로허용가능한 염, 이의 제조방법 및 이를 함유하는 약학조성물
JP2009529047A (ja) 2006-03-07 2009-08-13 アレイ バイオファーマ、インコーポレイテッド ヘテロ二環系ピラゾール化合物およびその使用
NZ572202A (en) 2006-03-27 2012-05-25 Nerviano Medical Sciences Srl Pyridyl- and pyrimidinyl-substituted pyrrole-, thiophene- and furane-derivatives as kinase inhibitors
GB0606805D0 (en) 2006-04-04 2006-05-17 Novartis Ag Organic compounds
BRPI0710874A2 (pt) 2006-04-26 2012-02-14 Hoffmann La Roche compostos de tienopirimidina, processos de produção dos referidos compostos, composições farmacêuticas contendo os mesmos, kit, produto, e usos dos compostos
EP2036557B1 (fr) 2006-05-18 2015-10-21 Eisai R&D Management Co., Ltd. Agent antitumoral destiné au cancer de la thyroïde
EP1873157A1 (fr) 2006-06-21 2008-01-02 Bayer Schering Pharma Aktiengesellschaft Pyrazolopyrimidines et sels de ceux-ci, compositions pharmaceutiques contenant ces composes, procedes de preparation associes, et leur utilisation
TW201345908A (zh) 2006-07-05 2013-11-16 Mitsubishi Tanabe Pharma Corp 吡唑并〔１，５-ａ〕嘧啶化合物
AR062207A1 (es) 2006-08-04 2008-10-22 Takeda Pharmaceutical Derivados de imidazopiridazina inhibidores de quinasas utiles para prevenir y/o tratar el cancer.
US20100029619A1 (en) 2006-08-04 2010-02-04 Takeda Pharmaceutical Company Limted Fused heterocyclic compound
US7531539B2 (en) 2006-08-09 2009-05-12 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
WO2008030579A2 (fr) 2006-09-07 2008-03-13 Biogen Idec Ma Inc. Modulateurs de la kinase associée au récepteur de l'interleukine-1
WO2008031551A2 (fr) 2006-09-12 2008-03-20 Novartis Forschungsstiftung, Zweigniederlassung Traitement du cancer non neuroendocrinien
KR20090073121A (ko) 2006-09-29 2009-07-02 노파르티스 아게 Ｐｉ3ｋ 지질 키나제 억제제로서의 피라졸로피리미딘
US20100041662A1 (en) 2006-10-30 2010-02-18 Sandrine Ferrand Heterocyclic compounds as antiinflammatory agents
MX2009004700A (es) 2006-11-06 2009-05-15 Supergen Inc Derivados de imidazo[1,2-b]piridazin y pirazolo[1,5-a] pirimidina y su uso como inhibidores de proteina cinasa.
WO2008079909A1 (fr) 2006-12-21 2008-07-03 Plexxikon, Inc. Composés et méthodes de modulation des kinases, et indications connexes
PE20081581A1 (es) 2006-12-21 2008-11-12 Plexxikon Inc COMPUESTOS PIRROLO[2,3-b]PIRIDINAS COMO MODULADORES DE QUINASA
RU2009122670A (ru) 2006-12-21 2011-01-27 Плекссикон, Инк. (Us) Соединения и способы для модуляции киназ и показания к их применению
US7820684B2 (en) 2007-03-01 2010-10-26 Supergen, Inc. Pharmaceutical formulations comprising salts of a protein kinase inhibitor and methods of using same
US20080234267A1 (en) 2007-03-20 2008-09-25 Karen Elizabeth Lackey Compounds and Methods of Treatment
US20080234262A1 (en) 2007-03-21 2008-09-25 Wyeth Pyrazolopyrimidine analogs and their use as mtor kinase and pi3 kinase inhibitors
EP2137187A1 (fr) 2007-03-28 2009-12-30 Inovacia AB Pyrazolo [1,5-a]pyrimidines utilisés comme inhibiteurs de la stéaroyl-coa désaturase
EP2137184B1 (fr) 2007-04-03 2013-05-08 Array Biopharma, Inc. Composés imidazo[1,2-a]pyridine utilisés comme inhibiteurs des récepteurs à activité tyrosine kinase
US8338417B2 (en) 2007-05-04 2012-12-25 Irm Llc Compounds and compositions as c-kit and PDGFR kinase inhibitors
AU2008265104B2 (en) 2007-06-21 2013-09-12 Janssen Pharmaceutica Nv Indolin-2-ones and aza-indolin-2-ones
EP2074118A2 (fr) 2007-07-09 2009-07-01 AstraZeneca AB Derives de pyrimidine trisubstitues pour le traitement de maladies proliferatives
SG183036A1 (en) 2007-07-17 2012-08-30 Plexxikon Inc Compounds and methods for kinase modulation, and indications therefor
CA2693967A1 (fr) 2007-07-19 2009-01-29 Schering Corporation Composes heterocycliques d'amide en tant qu'inhibiteurs de proteine kinase
PL2176231T3 (pl) 2007-07-20 2017-04-28 Nerviano Medical Sciences S.R.L. Podstawione pochodne indazolu aktywne jako inhibitory kinazy
WO2009017838A2 (fr) 2007-08-01 2009-02-05 Exelixis, Inc. Combinaisons d'inhibiteurs jak-2 et d'autres agents
US7988967B2 (en) 2007-08-10 2011-08-02 Regeneron Pharmaceuticals, Inc. High affinity human antibodies to human nerve growth factor
AU2008312631A1 (en) 2007-10-16 2009-04-23 Wyeth Llc Thienopyrimidine and pyrazolopyrimidine compounds and their use as mTOR kinase and PI3 kinase inhibitors
JP2011501760A (ja) 2007-10-23 2011-01-13 ノバルティス アーゲー 呼吸器疾患の処置のためのｔｒｋｂ抗体の使用
EP2217601A1 (fr) 2007-11-08 2010-08-18 Centro Nacional de Investigaciones Oncológicas (CNIO) Imidazopyridazines utilisées comme qu'inhibiteurs de protéine kinases
CA2706946A1 (fr) 2007-11-28 2009-06-04 Schering Corporation 2-fluoropyrazolo[1,5-a] pyrimidines en tant qu'inhibiteurs de proteine kinase
JP5400791B2 (ja) 2007-12-04 2014-01-29 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ 置換ジヒドロプテリジン−６−オン誘導体、その製造方法及びキナーゼ阻害剤としてのその使用
CN102015769B (zh) 2008-01-17 2014-12-10 Irm责任有限公司 改进的抗-trkb抗体
US20090227556A1 (en) 2008-01-31 2009-09-10 Eisai R&D Management Co., Ltd. Receptor tyrosine kinase inhibitors comprising pyridine and pyrimidine derivatives
KR100963051B1 (ko) 2008-03-14 2010-06-09 광동제약 주식회사 입자크기가 조절된 술포데히드로아비에트산을 함유한쓴맛이 저감된 경구용 액상 조성물
EP2254886B1 (fr) 2008-03-28 2016-05-25 Nerviano Medical Sciences S.r.l. Dérivés actifs de 3,4-dihydro-2h-pyrazino[1,2-a]indol-1-one en tant qu'inhibiteurs de kinase, procédé pour leur préparation et compositions pharmaceutiques les contenant
US20090275622A1 (en) 2008-04-30 2009-11-05 Prasoona Linga Nizatidine formulations
BRPI0912668A2 (pt) 2008-05-13 2016-01-26 Irm Llc composto e composições como inibidores de quinase
US8158636B2 (en) 2008-05-19 2012-04-17 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
PE20091846A1 (es) 2008-05-19 2009-12-16 Plexxikon Inc DERIVADOS DE PIRROLO[2,3-d]-PIRIMIDINA COMO MODULADORES DE CINASAS
BRPI0913031A2 (pt) 2008-05-23 2019-11-26 Novartis Ag derivados de quinolina e quinoxalinas como inibidores de proteína tirosina quinase, seus usos e processo de fabricação, bem como composições farmacêuticas e combinação que os compreende
EP2313411A1 (fr) 2008-06-10 2011-04-27 Plexxikon, Inc. Dérivés 5h-pyrrolo-[2,3-b]-pyrazine destinés à la modulation de kinases, et des indications pour ceux-ci
CN102105151B (zh) 2008-07-29 2013-12-18 内尔维阿诺医学科学有限公司 Cdk抑制剂在治疗神经胶质瘤中的应用
JP5746032B2 (ja) 2008-09-19 2015-07-08 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ ３，４−ジヒドロ−２Ｈ−ピロロ［１，２−ａ］ピラジン−１−オン誘導体
EP2350075B1 (fr) 2008-09-22 2014-03-05 Array Biopharma, Inc. Composés imidazo[1,2b]pyridazine substitués comme inhibiteurs de kinases trk
KR101853026B1 (ko) 2008-10-22 2018-04-27 어레이 바이오파마 인크. ＴＲＫ 키나아제 억제제로서 치환된 피라졸로［１,５­ａ］ 피리미딘 화합물
EP2348860B1 (fr) 2008-10-31 2015-05-27 Genentech, Inc. Composés inhibiteurs de jak à la pyrazolopyrimidine et procédés
WO2010058006A1 (fr) 2008-11-24 2010-05-27 Nerviano Medical Sciences S.R.L. Inhibiteur de cdk (kinase cycline-dépendante) pour le traitement d'un mésothéliome
JO3265B1 (ar) 2008-12-09 2018-09-16 Novartis Ag مثبطات بيريديلوكسى اندولات vegf-r2 واستخدامها لعلاج المرض
DK2881402T3 (en) 2009-02-12 2017-08-28 Cell Signaling Technology Inc Mutant ROS expression in human liver cancer
WO2010111527A1 (fr) 2009-03-26 2010-09-30 Plexxikon, Inc. Pyrazolo [ 3, 4 -b] pyridines en tant qu'inhibiteurs de la kinase et leur utilisation médicale
ES2570756T3 (es) 2009-06-15 2016-05-20 Nerviano Medical Sciences Srl Derivados pirimidinilpirrolopiridinona sustituidos, proceso para su preparación y su uso como inhibidores de cinasa
AR077468A1 (es) 2009-07-09 2011-08-31 Array Biopharma Inc Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
WO2011092120A1 (fr) 2010-01-29 2011-08-04 Nerviano Medical Sciences S.R.L. Dérivés de 6,7-dihydroimidazo[1,5-a]pyrazin-8(5h)-one comme modulateurs de protéines kinases
ES2594927T3 (es) 2010-02-18 2016-12-23 INSERM (Institut National de la Santé et de la Recherche Médicale) Métodos para prevenir las metástasis cancerosas
KR20130043104A (ko) 2010-04-06 2013-04-29 카리스 라이프 사이언스 룩셈부르크 홀딩스 질병용 순환 생물학적 지표들
US8383793B2 (en) 2010-04-15 2013-02-26 St. Jude Children's Research Hospital Methods and compositions for the diagnosis and treatment of cancer resistant to anaplastic lymphoma kinase (ALK) kinase inhibitors
TWI510487B (zh) 2010-04-21 2015-12-01 Plexxikon Inc 用於激酶調節的化合物和方法及其適應症
CN105693720B (zh) 2010-05-20 2019-01-18 阵列生物制药公司 作为trk激酶抑制剂的大环化合物
PL2580322T3 (pl) 2010-06-09 2018-09-28 Dana-Farber Cancer Institute, Inc. Mutacja mek1 wykazująca odporność na inhibitory raf i mek
ES2910305T3 (es) 2010-08-19 2022-05-12 Zoetis Belgium S A Anticuerpos anti-NGF y su uso
WO2012034095A1 (fr) 2010-09-09 2012-03-15 Irm Llc Composés et compositions comme inhibiteurs de trk
UY33597A (es) 2010-09-09 2012-04-30 Irm Llc Compuestos y composiciones como inhibidores de la trk
JP2014005206A (ja) 2010-10-22 2014-01-16 Astellas Pharma Inc アリールアミノヘテロ環カルボキサミド化合物
NZ611076A (en) 2010-12-01 2015-09-25 Alderbio Holdings Llc Anti-ngf compositions and use thereof
CN103339134B (zh) 2011-01-26 2015-12-23 内尔维阿诺医学科学有限公司 三环吡咯并衍生物、它们的制备方法和它们作为激酶抑制剂的应用
US8916577B2 (en) 2011-01-26 2014-12-23 Nerviano Medical Sciences S.R.L. Tricyclic derivatives, process for their preparation and their use as kinase inhibitors
JP5941069B2 (ja) 2011-02-07 2016-06-29 プレキシコン インコーポレーテッドＰｌｅｘｘｉｋｏｎ Ｉｎｃ． キナーゼ調節のための化合物および方法、ならびにそれに対する適応症
JP6013375B2 (ja) 2011-02-24 2016-10-25 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ キナーゼ阻害剤としてのチアゾリルフェニル−ベンゼンスルホンアミド誘導体
JP5959541B2 (ja) 2011-02-25 2016-08-02 ノバルティス アーゲー Ｔｒｋ阻害剤としてのピラゾロ［１，５−ａ］ピリジン
US9284298B2 (en) 2011-04-11 2016-03-15 Nerviano Medical Sciences S.R.L. Pyrazolyl-pyrimidine derivatives as kinase inhibitors
BR112013026137B1 (pt) 2011-04-19 2020-12-01 Nerviano Medical Sciences S.R.L pirimidinil-pirróis substituídos ativos como inibidores da quinase
CA2835478C (fr) 2011-05-12 2019-02-05 Nerviano Medical Sciences S.R.L. Derives d'indazole substitues actifs en tant qu'inhibiteurs de kinases
CN105130967B (zh) 2011-05-13 2018-04-17 阵列生物制药公司 作为trka激酶抑制剂的吡咯烷基脲和吡咯烷基硫脲化合物
JP6016915B2 (ja) 2011-07-28 2016-10-26 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ キナーゼ阻害剤として活性なアルキニル置換ピリミジニルピロール
JP6063945B2 (ja) 2011-10-07 2017-01-18 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ キナーゼ阻害剤としての４−アルキル置換３，４−ジヒドロピロロ［１，２−ａ］ピラジン−１（２Ｈ）−オン誘導体
EP2788351B1 (fr) 2011-10-07 2017-06-28 Nerviano Medical Sciences S.r.l. DÉRIVÉS DE LA 3,4-DIHYDROPYRROLO[1,2-a]PYRAZIN-1(2H)-ONE EN TANT QU'INHIBITEURS DE KINASES
WO2013059740A1 (fr) 2011-10-21 2013-04-25 Foundation Medicine, Inc. Nouvelles molécules de fusion alk et ntrk1 et leurs utilisations
BR112014011465A2 (pt) 2011-11-14 2017-05-09 Tesaro Inc modulação de determinadas quinases de tirosina
CA2858958C (fr) 2011-12-12 2016-10-04 Dr. Reddy's Laboratories Ltd. Pyrazolo[1,5-a]pyridines substituees en tant qu'inhibiteurs du recepteur kinase lie a la tropomyosine (trk)
US8377946B1 (en) 2011-12-30 2013-02-19 Pharmacyclics, Inc. Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors
WO2013161919A1 (fr) 2012-04-26 2013-10-31 小野薬品工業株式会社 COMPOSÉ INHIBITEUR DE Trk
JP2013226108A (ja) 2012-04-27 2013-11-07 Astellas Pharma Inc 新規ｎｔｒｋ２活性化変異の検出法
MX355409B (es) 2012-05-23 2018-04-18 Nerviano Medical Sciences Srl Proceso para la preparacion de n- [5- (3,5-difluoro-bencil) -1h-indazol-3-il] -4- (4-metil-piperazin-1-il) -2- (tetrahidro-piran-4-ilamino) -benzamida.
TWI585088B (zh) 2012-06-04 2017-06-01 第一三共股份有限公司 作爲激酶抑制劑之咪唑并［１，２－ｂ］嗒衍生物
NZ702930A (en) 2012-06-28 2017-05-26 Mcneil Ppc Inc Racecadotril liquid compositions
RU2019102203A (ru) 2012-07-11 2019-03-05 Блюпринт Медсинс Корпорейшн Ингибиторы рецептора фактора роста фибробластов
WO2014018567A1 (fr) 2012-07-24 2014-01-30 Pharmacyclics, Inc. Mutations associées à la résistance à des inhibiteurs de la tyrosine kinase de bruton (btk)
EP2689778A1 (fr) 2012-07-27 2014-01-29 Pierre Fabre Medicament Dérivés de type azaindazole ou diazaindazole pour le traitement de la douleur
RU2666538C2 (ru) 2012-08-02 2018-09-11 НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л. Замещенные пирролы, активные в качестве ингибиторов киназ
US20150218652A1 (en) 2012-08-31 2015-08-06 The Regents Of The Unversity Of Colorado, A Body Corporate Methods for diagnosis and treatment of cancer
CN104703600A (zh) 2012-09-07 2015-06-10 埃克塞里艾克西斯公司 用于治疗肺腺癌的met、vegfr和ret的抑制剂
US20140084039A1 (en) 2012-09-24 2014-03-27 Electro Scientific Industries, Inc. Method and apparatus for separating workpieces
JP2014082984A (ja) 2012-10-23 2014-05-12 Astellas Pharma Inc 新規ｎｔｒｋ２活性化変異の検出法
AU2013337264B2 (en) 2012-11-05 2018-03-08 Foundation Medicine, Inc. Novel fusion molecules and uses thereof
WO2014071358A2 (fr) 2012-11-05 2014-05-08 Foundation Medicine, Inc. Nouvelles molécules de fusion de ntrk1 et leurs utilisations
US9604980B2 (en) 2012-11-07 2017-03-28 Nerviano Medical Sciences S.R.L. Substituted pyrimidinyl and pyridinyl-pyrrolopyridinones, process for their preparation and their use as kinase inhibitors
WO2014078328A1 (fr) 2012-11-13 2014-05-22 Array Biopharma Inc. Composés de n-pyrrolidinyle, n'-pyrazolyl-urée, thio-urée,guanidine et cyanoguanidine en tant qu'inhibiteurs de la kinase trka
WO2014078322A1 (fr) 2012-11-13 2014-05-22 Array Biopharma Inc. Composés de thiazolyl-urée, oxazolyl-urée, thio-urée, guanidine et cyanoguanidine en tant qu'inhibiteurs de la kinase trka
US9790210B2 (en) 2012-11-13 2017-10-17 Array Biopharma Inc. N-(monocyclic aryl),N'-pyrazolyl-urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors
WO2014078378A1 (fr) 2012-11-13 2014-05-22 Array Biopharma Inc. Composés de n-pyrrolidinyle urée, thio-urée,guanidine et cyanoguanidine en tant qu'inhibiteurs de la kinase trka
MX365733B (es) 2012-11-13 2019-06-12 Array Biopharma Inc Compuestos de n-pirrolidinil, n' -pirazolil-urea, tiourea, guanidina y cianoguanidina como inhibidores de trka cinasa.
WO2014078372A1 (fr) 2012-11-13 2014-05-22 Array Biopharma Inc. Composés de n-pyrrolidinyle urée, thio-urée,guanidine et cyanoguanidine en tant qu'inhibiteurs de la kinase trka
US9822118B2 (en) 2012-11-13 2017-11-21 Array Biopharma Inc. Bicyclic heteroaryl urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors
US9809578B2 (en) 2012-11-13 2017-11-07 Array Biopharma Inc. Pyrazolyl urea, thiourea, guanidine and cyanoguanidine compounds as trkA kinase inhibitors
US9969694B2 (en) 2012-11-13 2018-05-15 Array Biopharma Inc. N-(arylalkyl)-N′-pyrazolyl-urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors
RU2664541C2 (ru) 2012-11-13 2018-08-20 Эррэй Биофарма Инк. Бициклические соединения мочевины, тиомочевины, гуанидина и цианогуанидина, пригодные для лечения боли
US20150290233A1 (en) 2012-11-29 2015-10-15 Yeda Research And Development Co.Ltd. At The Weizmann Institute Of Science Methods of preventing tumor metastasis, treating and prognosing cancer and identifying agents which are putative metastasis inhibitors
US9447135B2 (en) 2012-12-14 2016-09-20 University Of Kentucky Research Foundation Semi-synthetic mithramycin derivatives with anti-cancer activity
US9127055B2 (en) 2013-02-08 2015-09-08 Astellas Pharma Inc. Method of treating pain with anti-human NGF antibody
BR122017003181A2 (pt) 2013-02-19 2019-09-10 Ono Pharmaceutical Co composto inibidor de trk, composição farmacêutica e medicamento compreendendo dito composto e seu uso para profilaxia e/ou terapia de doença relacionada à trk e/ou para inibir trk
WO2014130975A1 (fr) 2013-02-22 2014-08-28 Bastian Boris C Polynucléotides de fusion et polypeptides de fusion associés au cancer, en particulier au mélanome, et leurs utilisations en tant que cibles thérapeutiques et diagnostiques
WO2014134096A1 (fr) 2013-02-27 2014-09-04 Oregon Health & Science University Méthodes de traitement de cancers caractérisés par une activité aberrante de ros1
EP2968551B1 (fr) 2013-03-15 2021-05-05 The Trustees of Columbia University in the City of New York Protéines de fusion et procédés correspondants
WO2014152777A2 (fr) 2013-03-15 2014-09-25 Insight Genetics, Inc. Procédés et compositions pour le diagnostic et le traitement de cancers résistants aux inhibiteurs de ros1
US9499522B2 (en) 2013-03-15 2016-11-22 Blueprint Medicines Corporation Compositions useful for treating disorders related to kit
EP3421613B1 (fr) 2013-03-15 2020-08-19 The Board of Trustees of the Leland Stanford Junior University Identification et utilisation de marqueurs tumoraux d'acides nucléiques circulants
WO2014150751A2 (fr) 2013-03-15 2014-09-25 Novartis Ag Biomarqueurs associés à l'inhibition de brm
AR095308A1 (es) 2013-03-15 2015-10-07 Glaxosmithkline Ip Dev Ltd Compuesto de 2-piridona, composición farmacéutica que lo comprende y su uso para preparar un medicamento
CN118910253A (zh) 2013-04-17 2024-11-08 生命技术公司 与癌症相关的基因融合体和基因变异体
US10072298B2 (en) 2013-04-17 2018-09-11 Life Technologies Corporation Gene fusions and gene variants associated with cancer
ES2646019T3 (es) 2013-05-14 2017-12-11 Nerviano Medical Sciences S.R.L. Derivados de 6-amino-7-deaza-purina, proceso para su preparación y su uso como inhibidores de cinasa
BR112015028845A2 (pt) 2013-05-30 2017-07-25 Plexxikon Inc compostos para a modulação da quinase e indicações da mesma
TWI610923B (zh) 2013-07-11 2018-01-11 Betta Pharmaceuticals Co Ltd 酪氨酸蛋白激酶調節劑及其應用方法
JP6534930B2 (ja) 2013-07-26 2019-06-26 公益財団法人がん研究会 Ｎｔｒｋ３融合体の検出法
US10875930B2 (en) 2013-07-30 2020-12-29 Blueprint Medicines Corporation PIK3C2G fusions
WO2015017533A1 (fr) 2013-07-30 2015-02-05 Blueprint Medicines Corporation Fusions de ntrk2
WO2015039006A1 (fr) 2013-09-16 2015-03-19 The General Hospital Corporation Procédés de traitement du cancer
US9334263B2 (en) 2013-10-17 2016-05-10 Blueprint Medicines Corporation Compositions useful for treating disorders related to kit
WO2015057873A1 (fr) 2013-10-17 2015-04-23 Blueprint Medicines Corporation Compositions utiles pour le traitement de troubles associés à l'enzyme kit
US9511050B2 (en) 2013-10-24 2016-12-06 Georgetown University Methods and compositions for treating cancer
PT3395814T (pt) 2013-10-25 2022-07-27 Blueprint Medicines Corp Inibidores do recetor do fator de crescimento de fibroblastos
WO2015064621A1 (fr) 2013-10-29 2015-05-07 公益財団法人がん研究会 Nouvelles fusions, et procédé pour leur détection
WO2015108992A1 (fr) 2014-01-15 2015-07-23 Blueprint Medicines Corporation Composés hétérobicycliques et leur utilisation en tant qu'inhibiteurs du récepteur fgfr4
WO2015112806A2 (fr) 2014-01-24 2015-07-30 Tp Therapeutics, Inc. Macrocycles de diaryle en tant que modulateurs de protéines kinases
MX375372B (es) 2014-02-05 2025-03-06 VM Oncology LLC COMPOSICIONES DE COMPUESTOS DE MOLÉCULA PEQUEÑA Y USO DE LOS MISMOS COMO INHIBIDORES TrKA.
TWI672141B (zh) 2014-02-20 2019-09-21 美商醫科泰生技 投予ｒｏｓ１突變癌細胞之分子
EP3132054B1 (fr) 2014-04-18 2021-06-30 Blueprint Medicines Corporation Fusions de met
WO2015161274A1 (fr) 2014-04-18 2015-10-22 Blueprint Medicines Corporation Fusions de pik3ca
HUE045340T2 (hu) 2014-05-15 2019-12-30 Array Biopharma Inc 1-((3S,4R)-4-(3-fluorfenil)-1-(2-metoxietil)pirrolidin-3-il)-3-(4-metil-3-(2- metilpirimidin-5-il)-1-fenil-1H-pirazol-5-il)karbamid mint TrkA kináz inhibitor
WO2015183837A1 (fr) 2014-05-27 2015-12-03 Brian Haynes Compositions, procedes, et utilisations associees a des fusions ntrk2-tert
WO2015183836A1 (fr) 2014-05-27 2015-12-03 Brian Haynes Compositions, procédés et utilisations relatifs à des fusions ntrk2-tert
US20170114415A1 (en) 2014-05-30 2017-04-27 The Regents Of The University Of Colorado, A Body Corporate Activating ntrk1 gene fusions predictive of kinase inhibitor therapy
WO2015191667A1 (fr) 2014-06-10 2015-12-17 Blueprint Medicines Corporation Fusions de pkn1
US10378063B2 (en) 2014-06-10 2019-08-13 Blueprint Medicines Corporation RAF1 fusions
WO2016011141A1 (fr) 2014-07-17 2016-01-21 Blueprint Medicines Corporation Fusions de fgr
US10370724B2 (en) 2014-07-17 2019-08-06 Blueprint Medicines Corporation PRKC fusions
EP3169808B1 (fr) 2014-07-17 2019-05-22 Blueprint Medicines Corporation Fusion trio:tert dans le cancer
BR112017001677A2 (pt) 2014-08-01 2018-07-17 Pharmacyclics Llc biomarcadores para predizer resposta de dlbcl ao tratamento com um inibidor de btk
US9688680B2 (en) 2014-08-04 2017-06-27 Blueprint Medicines Corporation Compositions useful for treating disorders related to kit
TWI560185B (en) 2014-08-18 2016-12-01 Ono Pharmaceutical Co Acid addition salt of trk inhibitor compound
CN114920840A (zh) 2014-10-14 2022-08-19 诺华股份有限公司 针对pd-l1的抗体分子及其用途
CA2967125C (fr) 2014-11-14 2022-10-25 Nerviano Medical Sciences S.R.L. Derives 6-amino -7-bicyclo -7-deazapurine utiles en tant qu'inhibiteurs de proteine kinase
TWI746426B (zh) 2014-11-16 2021-11-21 美商亞雷生物製藥股份有限公司 (S)-N-(5-((R)-2-(2,5-二氟苯基)-吡咯啶-1-基)-吡唑并[1,5-a]嘧啶-3-基)-3-羥基吡咯啶-1-甲醯胺硫酸氫鹽結晶型
EP3221700B1 (fr) 2014-11-18 2022-06-22 Blueprint Medicines Corporation Fusions de prkacb
PL3233863T3 (pl) 2014-12-15 2024-11-12 Cmg Pharmaceutical Co., Ltd. Związki heteroarylowe ze skondensowanymi pierścieniami i ich zastosowanie jako inhibitorów trk
WO2016187508A2 (fr) 2015-05-20 2016-11-24 The Broad Institute Inc. Néo-antigènes partagés
MA43943A (fr) 2015-05-29 2018-12-12 Ignyta Inc Compositions et procédés pour traiter des patients avec des cellules mutantes rtk
KR20180021745A (ko) 2015-06-01 2018-03-05 록쏘 온콜로지, 인코포레이티드 암을 진단하고 치료하는 방법
AU2015101722A4 (en) 2015-06-19 2016-05-19 Macau University Of Science And Technology Oncogenic ros1 and alk kinase inhibitor
US9782400B2 (en) 2015-06-19 2017-10-10 Macau University Of Science And Technology Oncogenic ROS1 and ALK kinase inhibitor
GB201511546D0 (en) 2015-07-01 2015-08-12 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against ovarian cancer and other cancers
ES2864839T3 (es) 2015-07-02 2021-10-14 Turning Point Therapeutics Inc Macrociclos de diarilo quirales como moduladores de proteína quinasas
TN2018000138A1 (en) 2015-10-26 2019-10-04 Array Biopharma Inc Point mutations in trk inhibitor-resistant cancer and methods relating to the same
WO2017127835A2 (fr) 2016-01-22 2017-07-27 The Medicines Company Formulations aqueuses, et procédés de préparation et d'utilisation de celles-ci
TW201733580A (zh) 2016-03-11 2017-10-01 小野藥品工業股份有限公司 Ｔｒｋ抑制劑抵抗性的癌治療劑
HUE068971T2 (hu) 2016-04-04 2025-02-28 Loxo Oncology Inc (S)-N-(5-((R)-2-(2,5-difluorofenil)-pirrolidin-1-il)-pirazolo[1,5-A]pirimidin-3-il) -3-hidroxipirrolidin-1-karboxamid folyékony készítményei
US10045991B2 (en) 2016-04-04 2018-08-14 Loxo Oncology, Inc. Methods of treating pediatric cancers
RS65988B1 (sr) 2016-04-04 2024-10-31 Loxo Oncology Inc Postupak lečenja pedijatrijskih karcinoma
CN109475545A (zh) 2016-04-19 2019-03-15 埃克塞里艾克西斯公司 三阴性乳腺癌治疗方法
SI3458456T1 (sl) 2016-05-18 2021-04-30 Loxo Oncology, Inc. Priprava (S)-N-(5-((R)-2-(2,5-difluorofenil) pirolidin-1-il) pirazolo (1,5-A) pirimidin-3-il)-3-hidroksipirolidin-1-karboksamida
WO2017201156A1 (fr) 2016-05-18 2017-11-23 Duke University Méthode de traitement du cancer colorectal métastatique kras sauvage au moyen de cabozantinib et de panitumumab
JOP20190092A1 (ar) 2016-10-26 2019-04-25 Array Biopharma Inc عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها
JOP20190213A1 (ar) 2017-03-16 2019-09-16 Array Biopharma Inc مركبات حلقية ضخمة كمثبطات لكيناز ros1
EP3700576A1 (fr) * 2017-10-26 2020-09-02 Array Biopharma Inc. Formulations d'un inhibiteur de kinase trk macrocyclique
CA3095366A1 (fr) 2018-03-29 2019-10-03 Loxo Oncology, Inc. Traitement de cancers associes a trk

Also Published As

Publication number Publication date
WO2018081417A2 (fr) 2018-05-03
TN2020000195A1 (en) 2022-04-04
ECSP19036765A (es) 2019-07-31
CR20190255A (es) 2019-10-02
SG11201903487SA (en) 2019-05-30
MX2019004951A (es) 2019-08-21
CN110267958A (zh) 2019-09-20
US11091486B2 (en) 2021-08-17
WO2019005796A1 (fr) 2019-01-03
TW201906840A (zh) 2019-02-16
CO2019004123A2 (es) 2019-08-30
AU2017348259B2 (en) 2021-12-02
WO2018081417A3 (fr) 2018-06-07
TN2019000133A1 (en) 2020-10-05
AU2017348259A1 (en) 2019-05-09
IL266170A (en) 2019-06-30
NI201900037A (es) 2019-06-14
EP3532475A2 (fr) 2019-09-04
UA124271C2 (uk) 2021-08-18
CL2019001094A1 (es) 2019-07-26
US20200216451A1 (en) 2020-07-09
BR112019008341A2 (pt) 2019-08-06
CL2019003178A1 (es) 2020-04-03
EA201991055A1 (ru) 2019-10-31
PE20191543A1 (es) 2019-10-24
MA45802A1 (fr) 2019-12-31
CA3041316A1 (fr) 2018-05-03
PH12019500930A1 (en) 2019-08-19
AR112207A1 (es) 2019-10-02
DOP2019000109A (es) 2019-09-30
JP2019532089A (ja) 2019-11-07
KR20190082808A (ko) 2019-07-10
UY37781A (es) 2019-11-29
MX387902B (es) 2025-03-19
JOP20190092A1 (ar) 2019-04-25

Similar Documents

Publication Publication Date Title
MA46054A (fr) Procédé de préparation de pyrazolo[1,5-a]pyrimidines et de sels de celles-ci
EP3321271A4 (fr) Procédé de production de dérivé de 7h-pyrollo[2,3-d]pyrimidine et intermédiaire correspondant
LT3555097T (lt) Imidazo[4,5-d]pirolo[2,3-b]piridino junginiai kaip janus kinazės inhibitoriai
PL3345907T3 (pl) Związki pirazolo[3,4-d]pirymidynowe lub ich sole
IL266305B (en) History of [4,2,1]triazolo[5,1-a]pyrimidine as pde2 inhibitors
LT3429591T (lt) Pakeistojo tieno[2,3-d]pirimidino dariniai kaip menino-mll inhibitoriai ir jų panaudojimo būdai
BR112014028395A2 (pt) derivados 3,4-di-hidro-2h-pirido[1,2-a] pirazina-1,6-diona substituídos úteis para o tratamento de (inter alia) doença de alzheimer
HUE057549T2 (hu) Imidazo[1,2-a]pirimidinszármazékok, eljárás elõállításukra és alkalmazásaik
IL288080A (en) A process for the preparation of h7-pyrrolo[3,2-d]pyrimidine derivatives and their artificial intermediates
HUE053704T2 (hu) 3-szubsztitutált 5-amino-6H-tiazolo[4,5-d]pirimidin-2,7-dion vegyületek vírusfertõzések kezelésére és megelõzésére
PL3107914T3 (pl) Związki pirazolo[1,5-a]pirymidyno-5,7-diaminowe jako inhibitory CDK i ich zastosowanie terapeutyczne
SI3174870T1 (sl) Tieno (3,2-D)pirimidini, furo (3,2,d)pirimidini in pirolo (3,2-d)pirimidini uporabni za zdravljenje okužb z respiratornim sincicijskim virusom
SG10202110927VA (en) Process for the preparation of 4-phenyl-5-alkoxycarbonyl-2-thiazol-2-yl-1,4-dihydropyrimidin-6-yl]methyl]-3-oxo-5,6,8,8a-tetrahydro-1h-imidazo[1,5-a]pyrazin-2-yl]-carboxylic acid
EP3412673A4 (fr) Procédé de préparation d'un composé pyrrolo[3,2-d]pyrimidine, et ses intermédiaires
EP3472169A4 (fr) Procédé de fabrication de 4-chloro -7 h-pyrrolo [2,3-d]pyrimidine
ZA201604415B (en) [1,2,4]triazolo[1,5-a]pyrimidine derivatives as protozoan proteasome inhibitors for the treatment of parasitic diseases such as leishmaniasis
MA46690A (fr) Composés de [1,2,4]triazolo [1,5-a]pyrimidine en tant qu'inhibiteurs de pde2
IL267801A (en) Process for the preparation of 3-disubstituted 5-amino-h6-thiazolo[5,4-d]pyrimidine-7,2-dione compounds
MA46937A (fr) 3-amino-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-ones en tant qu'inhibiteurs de kinases dépendantes des cyclines
ZA201804871B (en) Process for preparing 7h-pyrrolo [2, 3-d] pyrimidine compounds
HUE055530T2 (hu) 7H-pirrolo[2,3-D]pirimidin vegyület kristály formája és só formája, és ezek elkészítési eljárása
EP3533856A4 (fr) Procédé de préparation d'hexadécahydropyrène
PL3277687T3 (pl) Pochodne 7-(morfolin-4-ylo)pirazolo[1,5-a]pirymidyny użyteczne do leczenia chorób immunologicznych lub zapalnych lub nowotworów
EP3406729A4 (fr) Procédé de préparation enzymatique de phosphate de fludarabine
IL253427B (en) The result of pyrazolo[3,4-d]pyrimidine and its use in the treatment of Jericho rose