MA46905A - Compositions et procédés de synthèse de phosphoramidites et d'oligonucléotides - Google Patents
Compositions et procédés de synthèse de phosphoramidites et d'oligonucléotidesInfo
- Publication number
- MA46905A MA46905A MA046905A MA46905A MA46905A MA 46905 A MA46905 A MA 46905A MA 046905 A MA046905 A MA 046905A MA 46905 A MA46905 A MA 46905A MA 46905 A MA46905 A MA 46905A
- Authority
- MA
- Morocco
- Prior art keywords
- phosphoramidites
- oligonucleotides
- synthesis
- compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
- C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
- C07F9/65844—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring the phosphorus atom being part of a five-membered ring which may be condensed with another ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/06—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662426079P | 2016-11-23 | 2016-11-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA46905A true MA46905A (fr) | 2019-10-02 |
Family
ID=62195630
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA046905A MA46905A (fr) | 2016-11-23 | 2017-11-22 | Compositions et procédés de synthèse de phosphoramidites et d'oligonucléotides |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US11873316B2 (fr) |
| EP (1) | EP3544987A4 (fr) |
| JP (2) | JP7296882B2 (fr) |
| CN (1) | CN110088113A (fr) |
| MA (1) | MA46905A (fr) |
| WO (1) | WO2018098264A1 (fr) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2767253A1 (fr) | 2009-07-06 | 2011-01-13 | Ontorii, Inc. | Nouveaux precurseurs d'acide nucleique et leurs methodes d'utilisation |
| WO2012039448A1 (fr) | 2010-09-24 | 2012-03-29 | 株式会社キラルジェン | Groupe auxiliaire asymétrique |
| WO2013012758A1 (fr) | 2011-07-19 | 2013-01-24 | Ontorii, Inc. | Procédés pour la synthèse d'acides nucléiques fonctionnalisés |
| JP6268157B2 (ja) | 2012-07-13 | 2018-01-24 | 株式会社Ｗａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｊａｐａｎ | 不斉補助基 |
| KR102712879B1 (ko) | 2012-07-13 | 2024-10-04 | 웨이브 라이프 사이언시스 리미티드 | 키랄 제어 |
| EP4137572A1 (fr) | 2014-01-16 | 2023-02-22 | Wave Life Sciences Ltd. | Conception chirale |
| MA43072A (fr) | 2015-07-22 | 2018-05-30 | Wave Life Sciences Ltd | Compositions d'oligonucléotides et procédés associés |
| SG10201912902TA (en) | 2015-10-09 | 2020-02-27 | Wave Life Sciences Ltd | Oligonucleotide compositions and methods thereof |
| MA43822A (fr) | 2016-03-13 | 2018-11-28 | Wave Life Sciences Ltd | Compositions et procédés de synthèse de phosphoramidite et d'oligonucléotides |
| MA45270A (fr) | 2016-05-04 | 2017-11-09 | Wave Life Sciences Ltd | Compositions d'oligonucléotides et procédés associés |
| EP3463386A4 (fr) | 2016-06-03 | 2020-03-04 | Wave Life Sciences Ltd. | Oligonucléotides, compositions et méthodes associées |
| US10988763B2 (en) | 2016-06-22 | 2021-04-27 | Proqr Therapeutics Ii B.V. | Single-stranded RNA-editing oligonucleotides |
| PL3507366T3 (pl) | 2016-09-01 | 2021-05-04 | Proqr Therapeutics Ii B.V. | Chemicznie modyfikowane jednoniciowe oligonukleotydy edytujące rna |
| US11873316B2 (en) | 2016-11-23 | 2024-01-16 | Wave Life Sciences Ltd. | Compositions and methods for phosphoramidite and oligonucleotide synthesis |
| US11597927B2 (en) | 2017-06-02 | 2023-03-07 | Wave Life Sciences Ltd. | Oligonucleotide compositions and methods of use thereof |
| JP2020522510A (ja) | 2017-06-02 | 2020-07-30 | ウェイブ ライフ サイエンシズ リミテッドＷａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｌｔｄ． | オリゴヌクレオチド組成物及びその使用方法 |
| EP3642182A4 (fr) | 2017-06-21 | 2020-12-09 | Wave Life Sciences Ltd. | Composés, compositions et procédés de synthèse |
| WO2019032612A1 (fr) | 2017-08-08 | 2019-02-14 | Wave Life Sciences Ltd. | Compositions oligonucléotidiques et méthodes associées |
| KR20250123934A (ko) | 2017-09-18 | 2025-08-18 | 웨이브 라이프 사이언시스 리미티드 | 올리고뉴클레오티드 제조 기술 |
| EP3694530A4 (fr) | 2017-10-12 | 2021-06-30 | Wave Life Sciences Ltd. | Compositions d'oligonucléotides et procédés associés |
| CA3098624A1 (fr) | 2018-05-11 | 2019-11-14 | Wave Life Sciences Ltd. | Compositions d'oligonucleotides et leurs procedes d'utilisation |
| GB201808146D0 (en) | 2018-05-18 | 2018-07-11 | Proqr Therapeutics Ii Bv | Stereospecific Linkages in RNA Editing Oligonucleotides |
| US20230203484A1 (en) | 2020-05-22 | 2023-06-29 | Wave Life Sciences Ltd. | Double stranded oligonucleotide compositions and methods relating thereto |
| EP4479535A1 (fr) | 2022-02-14 | 2024-12-25 | ProQR Therapeutics II B.V. | Oligonucléotides guides pour l'édition d'acides nucléiques dans le traitement de l'hypercholestérolémie |
| EP4555085A1 (fr) | 2022-07-15 | 2025-05-21 | ProQR Therapeutics II B.V. | Oligonucléotides chimiquement modifiés pour édition d'arn médiée par adar |
| WO2024013361A1 (fr) | 2022-07-15 | 2024-01-18 | Proqr Therapeutics Ii B.V. | Oligonucléotides pour édition d'arn médiée par adar et leur utilisation |
| GB202215614D0 (en) | 2022-10-21 | 2022-12-07 | Proqr Therapeutics Ii Bv | Heteroduplex rna editing oligonucleotide complexes |
| CN120476207A (zh) | 2022-11-24 | 2025-08-12 | ProQR治疗上市公司Ⅱ | 反义寡核苷酸治疗遗传性hfe血色素沉着症 |
| GB202218090D0 (en) | 2022-12-01 | 2023-01-18 | Proqr Therapeutics Ii Bv | Antisense oligonucleotides for the treatment of aldehyde dehydrogenase 2 deficiency |
| EP4630553A1 (fr) | 2022-12-09 | 2025-10-15 | ProQR Therapeutics II B.V. | Oligonucléotides antisens pour le traitement d'une maladie cardiovasculaire |
| GB202300865D0 (en) | 2023-01-20 | 2023-03-08 | Proqr Therapeutics Ii Bv | Delivery of oligonucleotides |
| WO2024175550A1 (fr) | 2023-02-20 | 2024-08-29 | Proqr Therapeutics Ii B.V. | Oligonucléotides antisens pour le traitement d'une maladie cardiovasculaire athérosclérotique |
| GB202304363D0 (en) | 2023-03-24 | 2023-05-10 | Proqr Therapeutics Ii Bv | Chemically modified antisense oligonucleotides for use in RNA editing |
| WO2024206175A1 (fr) | 2023-03-24 | 2024-10-03 | Proqr Therapeutics Ii B.V. | Oligonucléotides antisens pour le traitement de troubles neurologiques |
| WO2024200472A1 (fr) | 2023-03-27 | 2024-10-03 | Proqr Therapeutics Ii B.V. | Oligonucléotides antisens pour traitement des maladies du foie |
| AR132964A1 (es) | 2023-06-16 | 2025-08-13 | Proqr Therapeutics Ii Bv | Oligonucleótidos antisentido para el tratamiento de enfermedades neurodegenerativas |
| WO2025015335A1 (fr) | 2023-07-13 | 2025-01-16 | Korro Bio, Inc. | Oligonucléotides d'édition d'arn et leurs utilisations |
| WO2025051946A1 (fr) | 2023-09-07 | 2025-03-13 | Proqr Therapeutics Ii B.V. | Oligonucléotides antisens pour le traitement de troubles métaboliques |
| WO2025096809A1 (fr) | 2023-10-31 | 2025-05-08 | Korro Bio, Inc. | Oligonucléotides comprenant des liaisons internucléotidiques de phosphoramidate |
| WO2025104239A1 (fr) | 2023-11-16 | 2025-05-22 | Proqr Therapeutics Ii B.V. | Oligonucléotides antisens pour le traitement de galactosémie classique |
| WO2025128799A1 (fr) | 2023-12-12 | 2025-06-19 | Korro Bio, Inc. | Oligonucléotides d'édition d'arn double brin et leurs utilisations |
| WO2025132708A1 (fr) | 2023-12-20 | 2025-06-26 | Proqr Therapeutics Ii B.V. | Oligonucléotides antisens pour traitement de maladie de huntington |
| GB202404661D0 (en) | 2024-04-02 | 2024-05-15 | Proqr Therapeutics Ii Bv | Antisense oligoncleotides for the treatment of liver disease |
| WO2025224230A1 (fr) | 2024-04-25 | 2025-10-30 | Proqr Therapeutics Ii B.V. | Oligonucléotides antisens pour traitement de la stéatose hépatique |
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| JP2011184318A (ja) | 2010-03-05 | 2011-09-22 | Univ Of Tokyo | リボヌクレシドｈ−ボラノホスホネート |
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| KR102712879B1 (ko) | 2012-07-13 | 2024-10-04 | 웨이브 라이프 사이언시스 리미티드 | 키랄 제어 |
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| MA43072A (fr) | 2015-07-22 | 2018-05-30 | Wave Life Sciences Ltd | Compositions d'oligonucléotides et procédés associés |
| SG10201912902TA (en) | 2015-10-09 | 2020-02-27 | Wave Life Sciences Ltd | Oligonucleotide compositions and methods thereof |
| MA43822A (fr) | 2016-03-13 | 2018-11-28 | Wave Life Sciences Ltd | Compositions et procédés de synthèse de phosphoramidite et d'oligonucléotides |
| KR102372122B1 (ko) | 2016-03-18 | 2022-03-07 | 로슈 이노베이션 센터 코펜하겐 에이/에스 | 아실-보호된 l-lna-구아노신 단량체 |
| MA45270A (fr) | 2016-05-04 | 2017-11-09 | Wave Life Sciences Ltd | Compositions d'oligonucléotides et procédés associés |
| MA45290A (fr) | 2016-05-04 | 2019-03-13 | Wave Life Sciences Ltd | Procédés et compositions d'agents biologiquement actifs |
| EP3463386A4 (fr) | 2016-06-03 | 2020-03-04 | Wave Life Sciences Ltd. | Oligonucléotides, compositions et méthodes associées |
| US20190264267A1 (en) | 2016-07-25 | 2019-08-29 | Wave Life Sciences Ltd. | Phasing |
| US11873316B2 (en) | 2016-11-23 | 2024-01-16 | Wave Life Sciences Ltd. | Compositions and methods for phosphoramidite and oligonucleotide synthesis |
| US11597927B2 (en) | 2017-06-02 | 2023-03-07 | Wave Life Sciences Ltd. | Oligonucleotide compositions and methods of use thereof |
| US20210198305A1 (en) | 2017-06-02 | 2021-07-01 | Wave Life Sciences Ltd. | Oligonucleotide compositions and methods of use thereof |
| JP2020522510A (ja) | 2017-06-02 | 2020-07-30 | ウェイブ ライフ サイエンシズ リミテッドＷａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｌｔｄ． | オリゴヌクレオチド組成物及びその使用方法 |
| EP3642182A4 (fr) | 2017-06-21 | 2020-12-09 | Wave Life Sciences Ltd. | Composés, compositions et procédés de synthèse |
| CN110831951B (zh) | 2017-06-28 | 2023-10-27 | 罗氏创新中心哥本哈根有限公司 | 多重偶联和氧化方法 |
| WO2019032612A1 (fr) | 2017-08-08 | 2019-02-14 | Wave Life Sciences Ltd. | Compositions oligonucléotidiques et méthodes associées |
| KR20250123934A (ko) | 2017-09-18 | 2025-08-18 | 웨이브 라이프 사이언시스 리미티드 | 올리고뉴클레오티드 제조 기술 |
| EP3694530A4 (fr) | 2017-10-12 | 2021-06-30 | Wave Life Sciences Ltd. | Compositions d'oligonucléotides et procédés associés |
| IL277889B2 (en) | 2018-04-12 | 2025-01-01 | Wave Life Sciences Ltd | Oligonucleotide preparations and methods of using them |
| CA3098624A1 (fr) | 2018-05-11 | 2019-11-14 | Wave Life Sciences Ltd. | Compositions d'oligonucleotides et leurs procedes d'utilisation |
| WO2020118246A1 (fr) | 2018-12-06 | 2020-06-11 | Wave Life Sciences Ltd. | Compositions d'oligonucléotides et procédés associés |
| CN113423385A (zh) | 2019-02-01 | 2021-09-21 | 波涛生命科学有限公司 | 寡核苷酸组合物及其方法 |
| AU2020241559A1 (en) | 2019-03-20 | 2021-11-11 | Wave Life Sciences Ltd. | Technologies useful for oligonucleotide preparation |
| US20220307019A1 (en) | 2019-03-25 | 2022-09-29 | National University Corporation Tokyo Medical And Dental University | Double-stranded nucleic acid complex and use thereof |
| AU2020262485A1 (en) | 2019-04-25 | 2021-11-11 | Wave Life Sciences Ltd. | Oligonucleotide compositions and methods of use thereof |
| AU2020261434A1 (en) | 2019-04-25 | 2021-11-11 | Wave Life Sciences Ltd. | Oligonucleotide compositions and methods of use thereof |
| AU2020267775A1 (en) | 2019-05-09 | 2021-12-02 | Wave Life Sciences Ltd. | Oligonucleotide compositions and methods of use thereof |
| MX2022004101A (es) | 2019-10-06 | 2022-04-26 | Wave Life Sciences Ltd | Composiciones de oligonucleotidos y metodos de uso de las mismas. |
| MX2022004102A (es) | 2019-10-06 | 2022-04-26 | Wave Life Sciences Ltd | Composiciones de oligonucleotidos y metodos de uso de las mismas. |
| CN115210377A (zh) | 2020-03-01 | 2022-10-18 | 波涛生命科学有限公司 | 寡核苷酸组合物及其方法 |
| US20230203484A1 (en) | 2020-05-22 | 2023-06-29 | Wave Life Sciences Ltd. | Double stranded oligonucleotide compositions and methods relating thereto |
| EP4153604A4 (fr) | 2020-05-22 | 2024-11-27 | Wave Life Sciences Ltd. | Compositions d'oligonucléotides et procédés associés |
| EP4200616A1 (fr) | 2020-08-24 | 2023-06-28 | Wave Life Sciences Ltd. | Dosages immunologiques pour détecter une protéine de huntingtine de type sauvage et procédés de traitement utilisant de tels dosages immunologiques |
| CN115989041A (zh) | 2020-08-24 | 2023-04-18 | 波涛生命科学有限公司 | 经工程化为表达adar1的细胞和非人动物及其用途 |
| WO2022067023A1 (fr) | 2020-09-24 | 2022-03-31 | Mayo Foundation For Medical Education And Research | Plates-formes de criblage |
| KR20230118716A (ko) | 2020-11-08 | 2023-08-11 | 웨이브 라이프 사이언시스 리미티드 | 올리고뉴클레오티드 조성물 및 이의 방법 |
| CN116507724A (zh) | 2020-11-08 | 2023-07-28 | 波涛生命科学有限公司 | 寡核苷酸组合物及其方法 |
| IL311625A (en) | 2021-09-26 | 2024-05-01 | Wave Life Sciences Ltd | Oligonucleotide compositions and methods thereof |
| EP4404942A2 (fr) | 2021-09-26 | 2024-07-31 | Wave Life Sciences Ltd. | Compositions pour l'édition de transcrits mecp2 et procédés associés |
| AU2021471586A1 (en) | 2021-10-27 | 2024-05-09 | Wave Life Sciences Ltd. | Oligonucleotide compositions and methods of use thereof |
| EP4422645A4 (fr) | 2021-10-27 | 2025-12-03 | Wave Life Sciences Ltd | Compositions oligonucléotidiques et leurs procédés d'utilisation |
| WO2023154528A1 (fr) | 2022-02-11 | 2023-08-17 | Wave Life Sciences Ltd. | Technologies stéréosélectives pour composés chiraux |
| IL315089A (en) | 2022-03-02 | 2024-10-01 | Wave Life Sciences Ltd | Oligonucleotide compositions and methods thereof for exon skipping |
| IL316178A (en) | 2022-04-15 | 2024-12-01 | Wave Life Sciences Ltd | Oligonucleotide compositions and methods related thereto |
| JP2025516659A (ja) | 2022-05-12 | 2025-05-30 | ウェイブ ライフ サイエンシズ リミテッド | オリゴヌクレオチド組成物及びその方法 |
| EP4569115A1 (fr) | 2022-08-11 | 2025-06-18 | Wave Life Sciences Ltd. | Compositions oligonucléotidiques et procédés associés |
| WO2025030155A1 (fr) | 2023-08-03 | 2025-02-06 | Wave Life Sciences Ltd. | Compositions d'oligonucléotides et procédés associés |
-
2017
- 2017-11-22 US US16/463,328 patent/US11873316B2/en active Active
- 2017-11-22 MA MA046905A patent/MA46905A/fr unknown
- 2017-11-22 CN CN201780072663.6A patent/CN110088113A/zh active Pending
- 2017-11-22 JP JP2019547600A patent/JP7296882B2/ja active Active
- 2017-11-22 EP EP17874211.0A patent/EP3544987A4/fr active Pending
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2023
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| JP7296882B2 (ja) | 2023-06-23 |
| US11873316B2 (en) | 2024-01-16 |
| CN110088113A (zh) | 2019-08-02 |
| EP3544987A4 (fr) | 2020-11-18 |
| US20190375774A1 (en) | 2019-12-12 |
| JP2023062180A (ja) | 2023-05-02 |
| JP2019535831A (ja) | 2019-12-12 |
| WO2018098264A1 (fr) | 2018-05-31 |
| US12473321B2 (en) | 2025-11-18 |
| US20240368207A1 (en) | 2024-11-07 |
| EP3544987A1 (fr) | 2019-10-02 |
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