MA46762A - Procédé amélioré de préparation de nanoparticules lipidiques chargées d'arnm - Google Patents
Procédé amélioré de préparation de nanoparticules lipidiques chargées d'arnmInfo
- Publication number
- MA46762A MA46762A MA046762A MA46762A MA46762A MA 46762 A MA46762 A MA 46762A MA 046762 A MA046762 A MA 046762A MA 46762 A MA46762 A MA 46762A MA 46762 A MA46762 A MA 46762A
- Authority
- MA
- Morocco
- Prior art keywords
- rna
- improved process
- lipid nanoparticles
- nanoparticles loaded
- preparing lipid
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/45—Transferases (2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5192—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1816—Erythropoietin [EPO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/44—Oxidoreductases (1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/53—Ligases (6)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5123—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
- C12Y114/16—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with reduced pteridine as one donor, and incorporation of one atom of oxygen (1.14.16)
- C12Y114/16001—Phenylalanine 4-monooxygenase (1.14.16.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y201/00—Transferases transferring one-carbon groups (2.1)
- C12Y201/03—Carboxy- and carbamoyltransferases (2.1.3)
- C12Y201/03003—Ornithine carbamoyltransferase (2.1.3.3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y603/00—Ligases forming carbon-nitrogen bonds (6.3)
- C12Y603/04—Other carbon-nitrogen ligases (6.3.4)
- C12Y603/04005—Argininosuccinate synthase (6.3.4.5)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biophysics (AREA)
- Optics & Photonics (AREA)
- Nanotechnology (AREA)
- Cell Biology (AREA)
- Dispersion Chemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662420413P | 2016-11-10 | 2016-11-10 | |
| US201762580155P | 2017-11-01 | 2017-11-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA46762A true MA46762A (fr) | 2019-09-18 |
Family
ID=60782328
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA046762A MA46762A (fr) | 2016-11-10 | 2017-11-10 | Procédé amélioré de préparation de nanoparticules lipidiques chargées d'arnm |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20180153822A1 (fr) |
| EP (1) | EP3538073A1 (fr) |
| JP (2) | JP7738979B2 (fr) |
| AU (1) | AU2017357758B2 (fr) |
| CA (1) | CA3041345A1 (fr) |
| MA (1) | MA46762A (fr) |
| WO (1) | WO2018089801A1 (fr) |
Families Citing this family (114)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3198966A1 (fr) | 2011-06-08 | 2012-12-13 | Translate Bio, Inc. | Lipides clivables |
| DK4023249T3 (da) | 2014-04-23 | 2025-01-13 | Modernatx Inc | Nukleinsyrevacciner |
| EP3164112A1 (fr) * | 2014-07-02 | 2017-05-10 | Shire Human Genetic Therapies, Inc. | Encapsulation d'arn messager |
| MX2019010155A (es) * | 2017-02-27 | 2020-12-10 | Translate Bio Inc | Arnm de cftr optimizado por codón novedoso. |
| US11576961B2 (en) | 2017-03-15 | 2023-02-14 | Modernatx, Inc. | Broad spectrum influenza virus vaccine |
| EP3595713A4 (fr) | 2017-03-15 | 2021-01-13 | ModernaTX, Inc. | Vaccin contre le virus respiratoire syncytial |
| US11786607B2 (en) | 2017-06-15 | 2023-10-17 | Modernatx, Inc. | RNA formulations |
| MX2020002348A (es) | 2017-08-31 | 2020-10-08 | Modernatx Inc | Métodos de elaboración de nanopartículas lipídicas. |
| RU2022103533A (ru) * | 2017-10-20 | 2022-03-10 | Бионтек Рна Фармасьютикалс Гмбх (Biontech Rna Pharmaceuticals Gmbh) | Приготовление и хранение липосомальных РНК-составов, подходящих для терапии |
| US11939601B2 (en) | 2017-11-22 | 2024-03-26 | Modernatx, Inc. | Polynucleotides encoding phenylalanine hydroxylase for the treatment of phenylketonuria |
| US11911453B2 (en) | 2018-01-29 | 2024-02-27 | Modernatx, Inc. | RSV RNA vaccines |
| BR112020021037A2 (pt) | 2018-04-25 | 2021-01-19 | Ethris Gmbh | Composição, composição sólida, processo para a preparação de uma composição, método para preservar uma formulação de nano ou micropartícula de um agente terapeuticamente ativo, uso de um composto selecionado de alcanos c3-c5 substituídos com um ou dois grupos hidróxi, e, dispositivo |
| JP7448488B2 (ja) * | 2018-05-15 | 2024-03-12 | トランスレイト バイオ， インコーポレイテッド | メッセンジャーｒｎａの皮下送達 |
| AU2019271215B2 (en) | 2018-05-16 | 2024-09-12 | Translate Bio, Inc. | Ribose cationic lipids |
| JP7488193B2 (ja) | 2018-05-24 | 2024-05-21 | トランスレイト バイオ， インコーポレイテッド | チオエステルカチオン性脂質 |
| CN112384205B (zh) | 2018-05-30 | 2024-05-03 | 川斯勒佰尔公司 | 信使rna疫苗及其用途 |
| MA52762A (fr) | 2018-05-30 | 2021-04-14 | Translate Bio Inc | Lipides cationiques comprenant une fraction stéroïdienne |
| JP2021525743A (ja) | 2018-05-30 | 2021-09-27 | トランスレイト バイオ， インコーポレイテッド | リン酸エステルカチオン性脂質 |
| MA52766A (fr) | 2018-05-30 | 2021-04-14 | Translate Bio Inc | Lipides cationiques vitaminiques |
| CN120514877A (zh) | 2018-07-23 | 2025-08-22 | 川斯勒佰尔公司 | 信使rna的干粉制剂 |
| CA3109548A1 (fr) * | 2018-08-14 | 2020-02-20 | Ethris Gmbh | Formulations a base de lipides contenant des sels pour l'administration d'arn |
| EP3840728A4 (fr) * | 2018-08-24 | 2022-06-08 | Flagship Pioneering Innovations VI, LLC | Paquets de messagers végétaux modifiés et utilisations associées |
| CA3108920A1 (fr) | 2018-08-29 | 2020-03-05 | Translate Bio, Inc. | Procede ameliore de preparation de nanoparticules lipidiques chargees d'arnm |
| US20230145188A1 (en) | 2018-09-14 | 2023-05-11 | Translate Bio, Inc. | Composition and methods for treatment of methylmalonic acidemia |
| CA3113025A1 (fr) * | 2018-09-19 | 2020-03-26 | Modernatx, Inc. | Lipides peg et leurs utilisations |
| EP4509118A3 (fr) | 2018-09-19 | 2025-05-14 | ModernaTX, Inc. | Lipides peg de haute pureté et leurs utilisations |
| US12090235B2 (en) | 2018-09-20 | 2024-09-17 | Modernatx, Inc. | Preparation of lipid nanoparticles and methods of administration thereof |
| KR20210093232A (ko) | 2018-10-09 | 2021-07-27 | 더 유니버시티 오브 브리티시 콜롬비아 | 유기용매와 세제가 없는 형질감염 적격 소포를 포함하는 조성물과 시스템 및 관련 방법 |
| AU2019362031A1 (en) | 2018-10-19 | 2021-04-08 | Translate Bio, Inc. | Pumpless encapsulation of messenger RNA |
| WO2020097511A2 (fr) | 2018-11-09 | 2020-05-14 | Translate Bio, Inc. | Thérapie par l'arn messager pour le traitement des maladies oculaires |
| MX2021005482A (es) | 2018-11-09 | 2021-09-08 | Translate Bio Inc | Lípidos de 2,5-dioxopiperazina con porciones éster, tioéster, disulfuro y anhidrido intercaladas. |
| AU2019378763B2 (en) * | 2018-11-12 | 2025-06-26 | Translate Bio, Inc. | Methods for inducing immune tolerance |
| CN113412273B (zh) | 2019-01-07 | 2025-08-22 | 川斯勒佰尔公司 | 用于治疗原发性纤毛运动障碍的组合物和方法 |
| WO2020150320A1 (fr) * | 2019-01-17 | 2020-07-23 | Georgia Tech Research Corporation | Systèmes d'administration de médicament contenant des cholestérols oxydés |
| BR112021014845A2 (pt) * | 2019-01-31 | 2021-11-03 | Modernatx Inc | Métodos de preparação de nanopartículas lipídicas |
| EP3956303A1 (fr) | 2019-04-18 | 2022-02-23 | Translate Bio, Inc. | Lipides cationiques de cystine |
| EP3959195B1 (fr) | 2019-04-22 | 2023-11-08 | Translate Bio, Inc. | Lipides cationiques de thioester |
| EP3962902A1 (fr) | 2019-05-03 | 2022-03-09 | Translate Bio, Inc. | Lipides cationiques di-thioesters |
| WO2020232276A1 (fr) * | 2019-05-14 | 2020-11-19 | Translate Bio, Inc. | Procédé amélioré de préparation de nanoparticules lipidiques chargées d'arnm |
| EP3976593A1 (fr) | 2019-05-31 | 2022-04-06 | Translate Bio, Inc. | Lipides macrocycliques |
| CN114401942B (zh) | 2019-06-21 | 2024-01-26 | 川斯勒佰尔公司 | 三(羟甲基)甲基甘氨酸和柠檬酸脂质 |
| WO2020257611A1 (fr) | 2019-06-21 | 2020-12-24 | Translate Bio, Inc. | Lipides cationiques comprenant une fraction hydroxy |
| EP4467653A3 (fr) | 2019-07-08 | 2024-12-18 | Translate Bio, Inc. | Nanoparticules lipidiques chargées d'arn messager améliorées et leurs procédés de fabrication |
| KR20220038365A (ko) | 2019-07-23 | 2022-03-28 | 트랜슬레이트 바이오 인코포레이티드 | Mrna-로딩된 지질 나노입자의 안정한 조성물 및 제조 방법 |
| US12378560B2 (en) | 2019-10-29 | 2025-08-05 | Northwestern University | Sequence multiplicity within spherical nucleic acids |
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| WO2021127394A2 (fr) | 2019-12-20 | 2021-06-24 | Translate Bio, Inc. | Administration par voie rectale d'arn messager |
| WO2021142245A1 (fr) | 2020-01-10 | 2021-07-15 | Translate Bio, Inc. | Composés, compositions pharmaceutiques et méthodes pour moduler l'expression de la muc5b dans des cellules et des tissus pulmonaires |
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| CN118591398A (zh) | 2021-11-10 | 2024-09-03 | 翻译生物公司 | 用于治疗原发性纤毛运动不良症的组合物和方法 |
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| WO2023111262A1 (fr) | 2021-12-17 | 2023-06-22 | Sanofi | Vaccin à base d'arn contre la maladie de lyme |
| US20250099614A1 (en) | 2022-01-28 | 2025-03-27 | CureVac SE | Nucleic acid encoded transcription factor inhibitors |
| CN118922409A (zh) | 2022-03-16 | 2024-11-08 | 翻译生物公司 | 非对称的基于哌嗪的阳离子脂质 |
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-
2017
- 2017-11-10 JP JP2019524194A patent/JP7738979B2/ja active Active
- 2017-11-10 MA MA046762A patent/MA46762A/fr unknown
- 2017-11-10 AU AU2017357758A patent/AU2017357758B2/en active Active
- 2017-11-10 US US15/809,680 patent/US20180153822A1/en not_active Abandoned
- 2017-11-10 CA CA3041345A patent/CA3041345A1/fr active Pending
- 2017-11-10 WO PCT/US2017/061113 patent/WO2018089801A1/fr not_active Ceased
- 2017-11-10 EP EP17818338.0A patent/EP3538073A1/fr active Pending
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- 2023-06-02 US US18/328,206 patent/US20240041789A1/en active Pending
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|---|---|
| AU2017357758B2 (en) | 2023-11-16 |
| JP2019533707A (ja) | 2019-11-21 |
| WO2018089801A1 (fr) | 2018-05-17 |
| JP7738979B2 (ja) | 2025-09-16 |
| JP2023166489A (ja) | 2023-11-21 |
| CA3041345A1 (fr) | 2018-05-17 |
| AU2017357758A1 (en) | 2019-05-16 |
| US20180153822A1 (en) | 2018-06-07 |
| EP3538073A1 (fr) | 2019-09-18 |
| US20240041789A1 (en) | 2024-02-08 |
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