MA43775A - Analogues du ivacaftor conentant des atomes de silicium - Google Patents
Analogues du ivacaftor conentant des atomes de siliciumInfo
- Publication number
- MA43775A MA43775A MA043775A MA43775A MA43775A MA 43775 A MA43775 A MA 43775A MA 043775 A MA043775 A MA 043775A MA 43775 A MA43775 A MA 43775A MA 43775 A MA43775 A MA 43775A
- Authority
- MA
- Morocco
- Prior art keywords
- ivacaftor
- analogues
- containing silicon
- silicon atoms
- atoms
- Prior art date
Links
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical group [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 title 1
- PURKAOJPTOLRMP-UHFFFAOYSA-N ivacaftor Chemical class C1=C(O)C(C(C)(C)C)=CC(C(C)(C)C)=C1NC(=O)C1=CNC2=CC=CC=C2C1=O PURKAOJPTOLRMP-UHFFFAOYSA-N 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/695—Silicon compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychology (AREA)
- Reproductive Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Ophthalmology & Optometry (AREA)
- Otolaryngology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662319439P | 2016-04-07 | 2016-04-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA43775A true MA43775A (fr) | 2021-05-05 |
Family
ID=58549338
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA043775A MA43775A (fr) | 2016-04-07 | 2017-04-07 | Analogues du ivacaftor conentant des atomes de silicium |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US10662207B2 (fr) |
| EP (1) | EP3440057B1 (fr) |
| JP (1) | JP7061076B2 (fr) |
| KR (1) | KR102448404B1 (fr) |
| CN (1) | CN109563047A (fr) |
| AR (1) | AR108203A1 (fr) |
| AU (1) | AU2017248253B2 (fr) |
| BR (1) | BR112018070747B1 (fr) |
| CA (1) | CA3019663C (fr) |
| IL (1) | IL262030B (fr) |
| MA (1) | MA43775A (fr) |
| MX (1) | MX386698B (fr) |
| NZ (1) | NZ746793A (fr) |
| SA (1) | SA518400164B1 (fr) |
| SG (1) | SG11201808682XA (fr) |
| WO (1) | WO2017177124A1 (fr) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT3203840T (pt) | 2014-10-06 | 2020-10-27 | Vertex Pharma | Moduladores do regulador da condutância transmembranar da fibrose quística |
| EP3325474A1 (fr) | 2015-07-24 | 2018-05-30 | Proteostasis Therapeutics, Inc. | Composés, compositions et procédés pour augmenter l'activité du cftr |
| KR20250136942A (ko) | 2015-10-06 | 2025-09-16 | 프로테오스타시스 테라퓨틱스, 인크. | Cftr 조절용 화합물, 조성물, 및 방법 |
| SG11201808682XA (en) * | 2016-04-07 | 2018-11-29 | Proteostasis Therapeutics Inc | Silicone atoms containing ivacaftor analogues |
| CA3028966A1 (fr) | 2016-06-21 | 2017-12-28 | Proteostasis Therapeutics, Inc. | Composes de phenyle-isoxazole-carboxamide substitues et utilisation connexe pour accroitre l'activite de regulateurs de la conductance transmembranaire de la fibrose kystique |
| LT3519401T (lt) * | 2016-09-30 | 2021-11-25 | Vertex Pharmaceuticals Incorporated | Cistinės fibrozės transmembraninio laidumo reguliavimo moduliatorius, farmacinės kompozicijos, gydymo būdai ir moduliatoriaus gamybos būdas |
| MX2021013639A (es) * | 2016-12-09 | 2022-09-30 | Vertex Pharma | Forma cristalina del compuesto 1, un modulador del regulador de conductancia transmembrana de fibrosis quística, procesos para su preparación, composiciones farmacéuticas del compuesto 1, y su uso en el tratamiento de fibrosis quística. |
| CA3066084A1 (fr) | 2017-06-08 | 2018-12-13 | Vertex Pharmaceuticals Incorporated | Methodes de traitement de la fibrose kystique |
| WO2018237174A2 (fr) * | 2017-06-21 | 2018-12-27 | The Johns Hopkins University | Modulateurs de régulateur de conductance transmembranaire de fibrose kystique pour le traitement d'une polykystose rénale autosomique dominante |
| AU2018304168B2 (en) | 2017-07-17 | 2023-05-04 | Vertex Pharmaceuticals Incorporated | Methods of treatment for cystic fibrosis |
| CN111051280B (zh) | 2017-08-02 | 2023-12-22 | 弗特克斯药品有限公司 | 制备吡咯烷化合物的方法 |
| WO2019071078A1 (fr) * | 2017-10-06 | 2019-04-11 | Proteostasis Therapeutics, Inc. | Composés, compositions et méthodes pour augmenter l'activité de cftr |
| TWI719349B (zh) | 2017-10-19 | 2021-02-21 | 美商維泰克斯製藥公司 | Cftr調節劑之結晶形式及組合物 |
| MA51039A (fr) | 2017-12-08 | 2020-10-14 | Vertex Pharma | Procédés pour préparer des modulateurs du régulateur de la conductance transmembranaire de la mucoviscidose |
| TWI810243B (zh) | 2018-02-05 | 2023-08-01 | 美商維泰克斯製藥公司 | 用於治療囊腫纖化症之醫藥組合物 |
| SI3752510T1 (sl) | 2018-02-15 | 2023-03-31 | Vertex Pharmaceuticals Incorporated | Makrocikli kot modulatorji regulatorja transmembranske prevodnosti pri cistični fibrozi, farmacevtski sestavki iz le-teh, njihova uporaba pri zdravljenju cistične fibroze in postopek za njihovo proizvodnjo |
| WO2019195739A1 (fr) | 2018-04-05 | 2019-10-10 | Alexander Russell Abela | Modulateurs du régulateur de la conductance transmembranaire de la fibrose kystique |
| EP3774825A1 (fr) | 2018-04-13 | 2021-02-17 | Vertex Pharmaceuticals Incorporated | Modulateurs du régulateur de la conductance transmembranaire de la fibrose kystique, compositions pharmaceutiques, procédés de traitement et procédé de fabrication du modulateur |
| EP3814336A1 (fr) | 2018-06-27 | 2021-05-05 | Proteostasis Therapeutics, Inc. | Composés améliorant l'activité du protéasome |
| CN109663129B (zh) * | 2019-02-27 | 2021-05-11 | 四川大学华西第二医院 | 扩张型心肌病治疗药物及其应用 |
| AR118555A1 (es) | 2019-04-03 | 2021-10-20 | Vertex Pharma | Agentes moduladores del regulador de la conductancia transmembrana de la fibrosis quística |
| TWI867024B (zh) | 2019-08-14 | 2024-12-21 | 美商維泰克斯製藥公司 | 囊腫纖維化跨膜傳導調節蛋白之調節劑 |
| SI4013741T1 (sl) | 2019-08-14 | 2024-06-28 | Vertex Pharmaceuticals Incorporated | Postopek za izdelavo cftr-modulatorjev |
| CA3150162A1 (fr) | 2019-08-14 | 2021-02-18 | Vertex Pharmaceuticals Incorporated | Formes cristallines de modulateurs de cftr |
| EP4259139A1 (fr) | 2020-12-10 | 2023-10-18 | Vertex Pharmaceuticals Incorporated | Méthodes de traitement de la mucoviscidose |
| CN116425642B (zh) * | 2023-04-06 | 2025-06-10 | 浙江科聚生物医药有限公司 | 2-甲氧基-4-氟-5-胺基苯酚的制备方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3812225A1 (de) | 1988-04-13 | 1989-10-26 | Basf Ag | Isoxazol(isothiazol)-5-carbonsaeureamide |
| JPH10507205A (ja) | 1995-08-02 | 1998-07-14 | ホータ.ウリアッヒ イ シイア.エセ.アー. | 抗真菌活性を有する新規カルボンアミド |
| ATE243204T1 (de) | 1995-08-24 | 2003-07-15 | Basf Ag | Isoxazole- und isothiazole-5-carboxamid derivate, deren herstellung und deren verwendung als herbizide |
| ES2188095T3 (es) | 1998-04-15 | 2003-06-16 | Pfizer Prod Inc | Carboxamidas heterociclicas. |
| AU2001273040A1 (en) | 2000-06-27 | 2002-01-08 | Du Pont Pharmaceuticals Company | Factor xa inhibitors |
| JP4901102B2 (ja) | 2002-05-03 | 2012-03-21 | エクセリクシス, インク. | プロテインキナーゼモジュレーターおよびその使用方法 |
| EP1680411A2 (fr) | 2003-10-08 | 2006-07-19 | Vertex Pharmaceuticals Incorporated | Modulateurs des transporteurs des cassettes de fixation de l'atp contenant des groupes cycloalkyle ou pyranyle |
| CA2545719A1 (fr) | 2003-11-14 | 2005-06-02 | Vertex Pharmaceuticals Incorporated | Thiazoles et oxazoles utiles en tant que modulateurs de transporteurs de type cassette de liaison a l'atp |
| WO2005077345A1 (fr) | 2004-02-03 | 2005-08-25 | Astrazeneca Ab | Composes pour le traitement de la maladie du reflux gastro-oesophagien |
| WO2005077373A2 (fr) | 2004-02-03 | 2005-08-25 | Astrazeneca Ab | Nouveau traitement du reflux gastro-oesophagien pathologique ii |
| EP1742627A4 (fr) | 2004-05-06 | 2009-08-26 | Plexxikon Inc | Inhibiteurs de pde4b et leurs utulisations |
| SE0401969D0 (sv) | 2004-08-02 | 2004-08-02 | Astrazeneca Ab | Piperidine derivatives |
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| DE102004051277A1 (de) | 2004-10-21 | 2006-04-27 | Merck Patent Gmbh | Heterocyclische Carbonylverbindungen |
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| WO2006136924A1 (fr) | 2005-06-22 | 2006-12-28 | Pfizer Products Inc. | Antagonistes du recepteur 3 de l'histamine |
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| US8193225B2 (en) | 2006-10-13 | 2012-06-05 | The Board Of Regents Of The University Of Texas System | Isoxazole amides, derivatives and methods of chemical induction of neurogenesis |
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| JP2011511756A (ja) | 2007-08-02 | 2011-04-14 | ナームローゼ・フエンノートチヤツプ・オルガノン | Trpv1モジュレータとしての5−フェニル−イソオキサゾール−3−カルボキサミド誘導体 |
| CA2709784A1 (fr) | 2007-12-21 | 2009-07-09 | University Of Rochester | Procede permettant de modifier la duree de vie d'organismes eucaryotes |
| WO2009131951A2 (fr) | 2008-04-21 | 2009-10-29 | Institute For Oneworld Health | Composés, compositions et procédés comprenant des dérivés isoxazole |
| US20090318429A1 (en) | 2008-04-28 | 2009-12-24 | Institute For Oneworld Health | Compounds, Compositions and Methods Comprising Heteroaromatic Derivatives |
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-
2017
- 2017-04-07 SG SG11201808682XA patent/SG11201808682XA/en unknown
- 2017-04-07 CN CN201780031083.2A patent/CN109563047A/zh active Pending
- 2017-04-07 KR KR1020187031895A patent/KR102448404B1/ko active Active
- 2017-04-07 CA CA3019663A patent/CA3019663C/fr active Active
- 2017-04-07 EP EP17718318.3A patent/EP3440057B1/fr active Active
- 2017-04-07 AU AU2017248253A patent/AU2017248253B2/en active Active
- 2017-04-07 JP JP2018552693A patent/JP7061076B2/ja active Active
- 2017-04-07 AR ARP170100899A patent/AR108203A1/es active IP Right Grant
- 2017-04-07 MA MA043775A patent/MA43775A/fr unknown
- 2017-04-07 US US16/091,401 patent/US10662207B2/en active Active
- 2017-04-07 WO PCT/US2017/026579 patent/WO2017177124A1/fr not_active Ceased
- 2017-04-07 NZ NZ746793A patent/NZ746793A/en unknown
- 2017-04-07 MX MX2018012331A patent/MX386698B/es unknown
- 2017-04-07 BR BR112018070747-3A patent/BR112018070747B1/pt active IP Right Grant
-
2018
- 2018-10-02 IL IL262030A patent/IL262030B/en unknown
- 2018-10-04 SA SA518400164A patent/SA518400164B1/ar unknown
-
2020
- 2020-04-14 US US16/848,345 patent/US11248010B2/en active Active
-
2023
- 2023-12-04 US US18/527,973 patent/US20240109922A1/en not_active Abandoned
-
2024
- 2024-07-19 US US18/778,363 patent/US20240368198A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| SG11201808682XA (en) | 2018-11-29 |
| SA518400164B1 (ar) | 2022-05-08 |
| EP3440057B1 (fr) | 2021-09-22 |
| JP2019513741A (ja) | 2019-05-30 |
| JP7061076B2 (ja) | 2022-04-27 |
| BR112018070747B1 (pt) | 2024-01-09 |
| US20210061823A1 (en) | 2021-03-04 |
| MX386698B (es) | 2025-03-19 |
| AU2017248253B2 (en) | 2021-07-29 |
| WO2017177124A1 (fr) | 2017-10-12 |
| AU2017248253A1 (en) | 2018-10-18 |
| EP3440057A1 (fr) | 2019-02-13 |
| US10662207B2 (en) | 2020-05-26 |
| IL262030A (en) | 2018-11-29 |
| CA3019663C (fr) | 2024-09-24 |
| BR112018070747A2 (pt) | 2019-06-18 |
| US11248010B2 (en) | 2022-02-15 |
| US20240368198A1 (en) | 2024-11-07 |
| RU2018137683A3 (fr) | 2020-05-18 |
| CA3019663A1 (fr) | 2017-10-12 |
| US20240109922A1 (en) | 2024-04-04 |
| AR108203A1 (es) | 2018-07-25 |
| NZ746793A (en) | 2022-10-28 |
| KR20180132803A (ko) | 2018-12-12 |
| CN109563047A (zh) | 2019-04-02 |
| RU2018137683A (ru) | 2020-05-12 |
| US20190153000A1 (en) | 2019-05-23 |
| KR102448404B1 (ko) | 2022-09-27 |
| IL262030B (en) | 2021-10-31 |
| MX2018012331A (es) | 2019-05-23 |
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