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MA40071A - Comprimés probiotiques bi-couche à double libération - Google Patents

Comprimés probiotiques bi-couche à double libération

Info

Publication number
MA40071A
MA40071A MA040071A MA40071A MA40071A MA 40071 A MA40071 A MA 40071A MA 040071 A MA040071 A MA 040071A MA 40071 A MA40071 A MA 40071A MA 40071 A MA40071 A MA 40071A
Authority
MA
Morocco
Prior art keywords
different
probiotic
probiotics
gastrointestinal tract
dual release
Prior art date
Application number
MA040071A
Other languages
English (en)
Inventor
Anthony Blanch
Timothy Gamble
Original Assignee
Probi Usa Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Probi Usa Inc filed Critical Probi Usa Inc
Publication of MA40071A publication Critical patent/MA40071A/fr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/74Bacteria
    • A61K35/741Probiotics
    • A61K35/744Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/745Bifidobacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44Oxidoreductases (1)
    • A61K38/446Superoxide dismutase (1.15)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2072Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/74Bacteria
    • A61K35/741Probiotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/74Bacteria
    • A61K35/741Probiotics
    • A61K35/744Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/74Bacteria
    • A61K35/741Probiotics
    • A61K35/744Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747Lactobacilli, e.g. L. acidophilus or L. brevis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2072Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2095Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y115/00Oxidoreductases acting on superoxide as acceptor (1.15)
    • C12Y115/01Oxidoreductases acting on superoxide as acceptor (1.15) with NAD or NADP as acceptor (1.15.1)
    • C12Y115/01001Superoxide dismutase (1.15.1.1)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne d'une manière générale un supplément diététique et des formulations pharmaceutiques comprenant des formulations à usage oral de formes galéniques résistantes à l'acidité disposées en couches, comprenant des probiotiques et fournies sous forme d'unités individuelles de la forme galénique, unifiée ou cohésive. Chaque couche individuelle résistante à l'acidité de la forme galénique cohésive correspond à l'une des différentes charges probiotiques et profil de libération différent permettant une administration ciblée du probiotique au niveau d'une région donnée du tractus gastro-intestinal, ou aux deux charges probiotiques différentes et profils de libération différents afin de permettre une administration ciblée de différents probiotiques au niveau de régions distinctes du tractus gastro-intestinal.
MA040071A 2014-07-01 2015-06-29 Comprimés probiotiques bi-couche à double libération MA40071A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462019717P 2014-07-01 2014-07-01

Publications (1)

Publication Number Publication Date
MA40071A true MA40071A (fr) 2016-01-07

Family

ID=55019868

Family Applications (1)

Application Number Title Priority Date Filing Date
MA040071A MA40071A (fr) 2014-07-01 2015-06-29 Comprimés probiotiques bi-couche à double libération

Country Status (17)

Country Link
US (1) US10799541B2 (fr)
EP (1) EP3164145A4 (fr)
JP (1) JP2017520577A (fr)
KR (1) KR20170021350A (fr)
CN (1) CN106535909A (fr)
AP (1) AP2016009641A0 (fr)
AU (1) AU2015284425B2 (fr)
BR (1) BR112016031000B1 (fr)
CA (1) CA2951739C (fr)
CL (1) CL2016003306A1 (fr)
MA (1) MA40071A (fr)
MX (1) MX383492B (fr)
PH (1) PH12016502463A1 (fr)
RU (1) RU2736823C2 (fr)
SG (1) SG11201610250WA (fr)
WO (1) WO2016003870A1 (fr)
ZA (1) ZA201608433B (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3048361B1 (fr) * 2016-03-01 2020-12-18 Biose Compositions pour le traitement des candidoses
CN108066296B (zh) * 2016-11-11 2020-11-17 南京益恒寿生命科技有限公司 一种生物学活性组分结肠靶向组合物及其应用
EP3501503A1 (fr) * 2017-12-22 2019-06-26 Cosmo Technologies Ltd. Composition pour administration solide
AU2019205296B2 (en) * 2018-01-05 2021-12-23 Nubiyota Llc Compositions comprising co-selected microbiota and methods for use thereof
EP3556226B1 (fr) * 2018-04-20 2021-01-20 Raab Vitalfood GmbH Synbiotiques complexes destinés au développement d'un microbiote saine
MX2020013439A (es) 2018-06-18 2021-05-12 Probi Ab Composiciones probioticas y usos de las mismas.
KR102770563B1 (ko) 2018-06-18 2025-02-21 프로비 에이비 락토바실러스 플란타룸 조성물 및 이의 용도
US12144834B2 (en) 2018-09-13 2024-11-19 Xbiome Inc. Methods and compositions for treating gastrointestinal and inflammatory disorders
WO2020181096A1 (fr) * 2019-03-05 2020-09-10 The Texas A&M University System Combinaisons de tannase et de formulations probiotiques et procédés d'utilisation pour améliorer le métabolisme des tanins
GB201905386D0 (en) 2019-04-16 2019-05-29 Probi Ab Probiotic compositions and uses thereof
GB201908154D0 (en) 2019-06-07 2019-07-24 Probi Ab Lactobacillus compositions and uses thereof
GB201908706D0 (en) 2019-06-18 2019-07-31 Probi Ab Lactobacillus compositions and uses thereof
CN110251474B (zh) * 2019-07-15 2022-01-07 北京工商大学 一种淀粉基大肠靶向双层益生菌片的制备方法
CN117159485A (zh) * 2023-08-11 2023-12-05 江中药业股份有限公司 一种益生菌香口丸及其制备方法

Family Cites Families (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6037953A (ja) * 1983-08-11 1985-02-27 Herusu Eido:Kk カルシウムを主成分とする栄養補助食品
US6004534A (en) 1993-07-23 1999-12-21 Massachusetts Institute Of Technology Targeted polymerized liposomes for improved drug delivery
GB9402203D0 (en) * 1994-02-04 1994-03-30 Smithkline Beecham Plc Pharmaceutical formulation
US6241983B1 (en) 1994-10-28 2001-06-05 Metagenics, Inc. Bacteria-and fiber-containing composition for human gastrointestinal health
US5531989A (en) 1994-10-28 1996-07-02 Metagenics, Inc. Immunoglobulin and fiber-containing composition for human gastrointestinal health
US7048906B2 (en) 1995-05-17 2006-05-23 Cedars-Sinai Medical Center Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions
ES2173372T3 (es) * 1997-12-19 2002-10-16 Merck Patent Gmbh Comprimidos multicapa que contienen microorganismos probioticos, como por ejemplo latobacilos o bifidobacterias.
JP2000302694A (ja) 1999-04-16 2000-10-31 Fuyuki Mitsuyama 医食兼用物質
US6696057B1 (en) 1999-09-22 2004-02-24 Lacpro Industries, Inc. Composition and method for treatment of gastrointestinal disorders and hyperlipidemia
US20020044926A1 (en) 1999-12-10 2002-04-18 Gregor Reid Oral administration of lactobacillus for the treatment and prevention of urogenital infection
US20030118547A1 (en) * 2000-01-27 2003-06-26 Vandenberg Grant William Composition for intestinal delivery
MXPA02007254A (es) * 2000-02-04 2002-12-09 Depomed Inc Forma de dosis de cubierta-y-nucleo que se aproxima a liberacion de droga de orden cero.
EP1151673A3 (fr) 2000-05-03 2002-01-02 Societe Des Produits Nestle S.A. Confiserié avec remplissage
CA2442602A1 (fr) 2000-12-18 2002-08-01 Probio Health, Llc Composes probiotiques obtenus a partir d'une souche de lactobacillus casei (ke01)
AUPR272901A0 (en) 2001-01-25 2001-02-22 Gainful Plan Limited Method of preparing biological materials and preparations produced using same
EP1228769A1 (fr) 2001-02-02 2002-08-07 Jörg-Peter Prof. Schür Preparation symbiotique regénératrice
EP1392245A2 (fr) 2001-04-05 2004-03-03 Universite Laval Procede de fabrication d'une matrice d'administration et utilisations
US6627220B2 (en) 2001-07-13 2003-09-30 Scolr, Inc. Tablets containing heat sensitive materials and method for forming thereof
US8048924B2 (en) 2001-08-29 2011-11-01 Biocon Limited Methods and compositions employing 4-aminophenylacetic acid compounds
US20070098784A1 (en) * 2001-09-28 2007-05-03 Nutraceutix, Inc. Delivery system for biological component
JP5041651B2 (ja) * 2001-09-28 2012-10-03 ティーエヌティーギャンブル・インコーポレーテッド 生物体成分の送達系
US7101565B2 (en) 2002-02-05 2006-09-05 Corpak Medsystems, Inc. Probiotic/prebiotic composition and delivery method
EP1344458A1 (fr) 2002-03-12 2003-09-17 Société des Produits Nestlé S.A. Système d'administration de composés probiotiques
US20030175295A1 (en) 2002-03-15 2003-09-18 Richard Ticktin Composition and method for reducing odors from metabolic processes
US7670612B2 (en) 2002-04-10 2010-03-02 Innercap Technologies, Inc. Multi-phase, multi-compartment capsular delivery apparatus and methods for using same
GB0212975D0 (en) 2002-06-06 2002-07-17 Mars Uk Ltd Mammalian animal composition
TW200404544A (en) 2002-06-17 2004-04-01 Kowa Co Controlled release pharmaceutical composition
US20050266069A1 (en) 2002-09-06 2005-12-01 Simmons Donald L Stable probiotic microsphere compositions and their methods of preparation
US8168170B2 (en) 2002-10-03 2012-05-01 The Procter And Gamble Company Compositions having an inner core and at least three surrounding layers
US7105336B2 (en) 2002-10-07 2006-09-12 Biogaia Ab Selection and use of lactic acid bacteria for reducing inflammation caused by Helicobacter
CA2504610C (fr) * 2002-11-12 2012-02-21 Elan Pharma International Ltd. Formes posologiques solides a desintegration rapide non friables et comprenant du pullulane
WO2004087109A1 (fr) 2003-03-27 2004-10-14 Hisamitsu Pharmaceutical Co., Inc. Preparations medicamenteuses orales liberees au niveau du colon, preparations medicamenteuses orales pour traiter le cancer du colon et preparations medicamenteuses orales pour traiter la colite
US7025998B2 (en) 2003-05-30 2006-04-11 Rotta Research Laboratorium S.P.A. Phytoestrogens and probiotic for women's health
JP3818319B2 (ja) 2003-08-21 2006-09-06 大塚製薬株式会社 粘膜免疫賦活作用を有する乳酸菌
GB0330009D0 (en) * 2003-12-24 2004-01-28 Ferrosan As Probiotic tablet formulations
CA2547843A1 (fr) 2004-02-09 2005-08-18 Transfert Plus Societe En Commandite Composition contenant un materiau polymere et utilisations associees
US20050260181A1 (en) 2004-03-05 2005-11-24 Immunopath Profile, Inc. Compositions and methods for tissue repair
US7854927B2 (en) 2004-05-11 2010-12-21 Ganeden Biotech, Inc. Methods and compositions for the dietary management of autoimmune disorders
GB0410785D0 (en) 2004-05-14 2004-06-16 Glycologic Ltd Improved prebiotic
WO2005115341A2 (fr) 2004-05-27 2005-12-08 Advanced Bionutrition Corporation Microparticules pour administration orale
DE102004026706A1 (de) 2004-05-28 2005-12-15 Merck Patent Gmbh Orale Darreichungsform enthaltend probiotische Bakterien
US20060062742A1 (en) 2004-09-21 2006-03-23 The Procter & Gamble Company Compositions for reduction of human malodor
US20060115465A1 (en) 2004-10-29 2006-06-01 Macfarlane George Treatment of gastrointestinal disorders
ES2368344T3 (es) 2005-05-18 2011-11-16 Dsm Ip Assets B.V. Composiciones para aplicación parenteral de microorganismos.
EA014825B1 (ru) 2005-09-29 2011-02-28 Мерк Патент Гмбх Способ стабилизации фармацевтических форм для введения, включающих микроорганизмы
US7982066B2 (en) 2005-12-09 2011-07-19 Novalife, Inc. High protein supplement
SI1962873T1 (sl) 2005-12-14 2013-10-30 Oxthera Intellectual Property Ab Farmacevtski sestavki, ki vsebujejo bakterijo za zmanjšanje oksalata
US20070184111A1 (en) 2006-02-03 2007-08-09 Pharmavite Llc Hybrid tablet
CA2673120C (fr) 2006-12-18 2012-08-07 Advanced Bionutrition Corporation Produit alimentaire sec contenant un probiotique vivant
DE102006062250A1 (de) 2006-12-22 2008-06-26 Roland Saur-Brosch Verwendung einer Zusammensetzung aus Mineralstoffen und/oder Vitaminen und gegebenenfalls acetogenen und/oder butyrogenen Bakterien zur oralen oder rektalen Verabreichung für die Behandlung und Vorbeugung von abdominalen Beschwerden
US20080171085A1 (en) 2007-01-11 2008-07-17 Natrol, Inc. Novel biphasic delivery system for a pharmaceutical or nutraceutical composition and method of administration
US8066986B2 (en) * 2007-02-01 2011-11-29 Master Supplements, Inc. Formulations including digestive enzymes and polysorbate surfactants that enhance the colonization of administered probiotics microoganisms
CN103120653B (zh) 2007-04-04 2015-09-30 希格默伊德药业有限公司 一种口服药物组合物
MX2010001260A (es) * 2007-08-03 2010-04-07 Shaklee Corp Sistema de suplemento nutricional.
WO2009037264A2 (fr) 2007-09-17 2009-03-26 Da Volterra Administration d'agents antimicrobiens par le colon
US9078824B2 (en) 2007-09-24 2015-07-14 The Procter & Gamble Company Composition and method of stabilized sensitive ingredient
US20110223248A1 (en) 2007-12-12 2011-09-15 Ritter Pharmaceuticals, Inc. Methods and compositions for treating lactose intolerance
UA101176C2 (ru) 2008-01-24 2013-03-11 Нестек С.А. Капсула для применения в устройстве для приготовления напитков, которая содержит питательные ингредиенты и способ получения питательной жидкости из капсулы
CA2721981A1 (fr) 2008-05-01 2009-11-05 The Procter & Gamble Company Procedes et kits destines au traitement de troubles inflammatoires de l'intestin
US8586029B2 (en) 2008-06-04 2013-11-19 Trustees Of Dartmouth College Prevention or treatment of immune-relevant disease by modification of microfloral populations
RU2011100746A (ru) * 2008-06-24 2012-07-27 Вм. Ригли Дж. Компани (Us) Композиция жевательной резинки с пробиотиком и способ ее производства
US20100068268A1 (en) 2008-09-15 2010-03-18 Miloud Rahmouni Starch-based microparticles for the release of agents disposed therein
CL2009002073A1 (es) * 2008-11-14 2010-12-24 Portola Pharm Inc Composicion farmaceutica solida para la liberacion controlada de un agente activo activo en el tracto gastrointestinal que comprende al menos un agente acido con solubilidad de menos de 0,3 mg/ml en solucion acuosa a un ph alrededor del pka del agente acido, un polimero hidrofilo, un alcanizador; uso en trastornos cardiovasculares.
GB0900551D0 (en) 2009-01-14 2009-02-11 Horton Richard Ingestible compositions and processes of preparation
LT2381799T (lt) 2009-01-27 2018-10-25 Probiotical S.P.A. Šokoladu aromatizuotas probiotikų papildas
SG10201901259RA (en) 2009-02-24 2019-03-28 Ritter Pharmaceuticals Inc Prebiotic formulations and methods of use
US8785160B2 (en) 2009-02-24 2014-07-22 Ritter Pharmaceuticals, Inc. Prebiotic formulations and methods of use
ZA201107285B (en) 2009-03-06 2012-12-27 Delivtx Inc Microencapsulated bioactive agents for oral delivery and methods of the thereof
WO2010105207A1 (fr) 2009-03-13 2010-09-16 The Regents Of The University Of California Oligosaccharides prébiotiques
US20100330151A1 (en) 2009-06-25 2010-12-30 Mary Elaine Freeland Method of Promoting Gastrointestinal Health Using a Combination of a Probiotic Microorganism and Chocolate
US20120087902A1 (en) * 2009-07-20 2012-04-12 Bracco S.P.A. Therapeutic Use Of Probiotics
BR112012001812B1 (pt) 2009-07-30 2019-04-16 Dupont Nutrition Biosciences Aps Uso de bactéria para o tratamento da endotoxemiametabólica em mamífero
US8313768B2 (en) 2009-09-24 2012-11-20 Mcneil-Ppc, Inc. Manufacture of tablet having immediate release region and sustained release region
EP2519108A4 (fr) 2009-12-31 2013-10-16 Ira Milton Trachtman Compositions et procédés pour traitement et prophylaxie d'une maladie intestinale inflammatoire
US9504750B2 (en) 2010-01-28 2016-11-29 Advanced Bionutrition Corporation Stabilizing composition for biological materials
KR101143997B1 (ko) 2010-03-04 2012-05-09 한미사이언스 주식회사 유산균 제제 및 5-ht4 수용체 효능제를 함유하는 경구 투여용 복합 제제 및 이의 제조방법
US9301982B2 (en) 2010-04-14 2016-04-05 Ganeden Biotech, Inc. Probiotic confection and lipid compositions
CN103221420A (zh) 2010-05-19 2013-07-24 北卡罗莱纳州立大学 用于递送治疗性肽的组合物和方法
US20140154312A1 (en) 2010-09-17 2014-06-05 Monica Gulati Oral targetted drug delivery system
WO2012103411A2 (fr) * 2011-01-28 2012-08-02 Zx Pharma, Llc Composition de mélatonine à libération contrôlée et procédés associés
EP2685994B1 (fr) * 2011-03-17 2015-12-30 Probiotical S.p.A. Bactéries probiotiques ayant une activité antioxydante et leur utilisation
WO2012154738A1 (fr) 2011-05-09 2012-11-15 The Cleveland Clinic Foundation Composition et procédé pour améliorer la santé intestinale
CA2833937C (fr) 2011-05-16 2022-04-05 Organobalance Medical Ag Souches de lactobacilles, compositions comprenant ces souches et utilisation des souches pour prevenir ou traiter des maladies provoqueespar le streptocoque pyogene
CN202427429U (zh) * 2012-01-09 2012-09-12 北京大北农科技集团股份有限公司 一种多层微囊制备设备
US20130295227A1 (en) 2012-05-01 2013-11-07 Robbert H. ter Haar Composition Comprising a Sensitive Ingredient
GB201212010D0 (en) 2012-07-05 2012-08-22 Sigmoid Pharma Ltd Formulations
US20140112985A1 (en) 2012-10-22 2014-04-24 Polonez Therapeutics Llc Method of prevention and treatment of clostridium difficile infection
EP2958575B1 (fr) * 2013-02-22 2019-04-03 The Regents of The University of California Composition comprenant lactobacillus johnsonii 456 et son utilisation pour traiter ou prévenir des maladies
RU2015140610A (ru) 2013-03-14 2017-04-17 ТЕРАБАЙОМ, ЭлЭлСи Направленная доставка в желудочно-кишечный тракт пробиотических микроорганизмов и/или терапевтических средств

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ZA201608433B (en) 2023-05-31
AU2015284425A1 (en) 2017-01-05
BR112016031000A2 (fr) 2017-08-22
WO2016003870A1 (fr) 2016-01-07
RU2736823C2 (ru) 2020-11-20
EP3164145A4 (fr) 2018-01-17
BR112016031000B1 (pt) 2022-01-25
CA2951739C (fr) 2023-09-19
KR20170021350A (ko) 2017-02-27
RU2017102952A3 (fr) 2019-02-01
CN106535909A (zh) 2017-03-22
AP2016009641A0 (en) 2016-12-31
AU2015284425B2 (en) 2021-04-01
CA2951739A1 (fr) 2016-01-07
MX383492B (es) 2025-03-04
SG11201610250WA (en) 2017-01-27
PH12016502463A1 (en) 2017-04-10
CL2016003306A1 (es) 2017-06-09
JP2017520577A (ja) 2017-07-27
US20170100442A1 (en) 2017-04-13
US10799541B2 (en) 2020-10-13
EP3164145A1 (fr) 2017-05-10
MX2016016773A (es) 2017-06-30

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