MA40413B1 - Dérivés de benzodiazépine cytotoxique - Google Patents
Dérivés de benzodiazépine cytotoxiqueInfo
- Publication number
- MA40413B1 MA40413B1 MA40413A MA40413A MA40413B1 MA 40413 B1 MA40413 B1 MA 40413B1 MA 40413 A MA40413 A MA 40413A MA 40413 A MA40413 A MA 40413A MA 40413 B1 MA40413 B1 MA 40413B1
- Authority
- MA
- Morocco
- Prior art keywords
- benzodiazepine derivatives
- compounds
- conjugates
- relates
- cytotoxic benzodiazepine
- Prior art date
Links
- 125000003310 benzodiazepinyl group Chemical class N1N=C(C=CC2=C1C=CC=C2)* 0.000 title abstract 4
- 229940053197 benzodiazepine derivative antiepileptics Drugs 0.000 title abstract 2
- 231100000433 cytotoxic Toxicity 0.000 title 1
- 230000001472 cytotoxic effect Effects 0.000 title 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 230000001028 anti-proliverative effect Effects 0.000 abstract 1
- 239000011230 binding agent Substances 0.000 abstract 1
- 230000010261 cell growth Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
L'invention concerne de nouveaux dérivés de benzodiazépine à activité antiproliférative et plus spécifiquement de nouveaux composés de benzodiazépine de formules (i) à (vi). L'invention concerne également des conjugués des composés de benzodiazépine liés à un agent de liaison cellulaire. L'invention concerne en outre des compositions et des méthodes utiles pour inhiber la croissance cellulaire anormale ou traiter un trouble prolifératif chez un mammifère à l'aide des composés ou des conjugués de l'invention.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462045248P | 2014-09-03 | 2014-09-03 | |
| PCT/US2015/048059 WO2016036801A1 (fr) | 2014-09-03 | 2015-09-02 | Dérivés de benzodiazépine cytotoxique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA40413B1 true MA40413B1 (fr) | 2020-10-28 |
Family
ID=58698683
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA40413A MA40413B1 (fr) | 2014-09-03 | 2015-09-02 | Dérivés de benzodiazépine cytotoxique |
Country Status (3)
| Country | Link |
|---|---|
| AR (1) | AR101745A1 (fr) |
| HR (1) | HRP20201293T1 (fr) |
| MA (1) | MA40413B1 (fr) |
-
2015
- 2015-09-02 MA MA40413A patent/MA40413B1/fr unknown
- 2015-09-02 AR ARP150102809A patent/AR101745A1/es unknown
- 2015-09-02 HR HRP20201293TT patent/HRP20201293T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR101745A1 (es) | 2017-01-11 |
| HRP20201293T1 (hr) | 2020-11-13 |
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