MA39227B1 - Heteroaryl amides as inhibitors of protein aggregation - Google Patents
Heteroaryl amides as inhibitors of protein aggregationInfo
- Publication number
- MA39227B1 MA39227B1 MA39227A MA39227A MA39227B1 MA 39227 B1 MA39227 B1 MA 39227B1 MA 39227 A MA39227 A MA 39227A MA 39227 A MA39227 A MA 39227A MA 39227 B1 MA39227 B1 MA 39227B1
- Authority
- MA
- Morocco
- Prior art keywords
- disease
- protein aggregation
- methods
- inhibitors
- parkinson
- Prior art date
Links
- 230000004845 protein aggregation Effects 0.000 title abstract 3
- -1 Heteroaryl amides Chemical class 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 238000000034 method Methods 0.000 abstract 3
- 208000018737 Parkinson disease Diseases 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 206010003694 Atrophy Diseases 0.000 abstract 1
- 206010012289 Dementia Diseases 0.000 abstract 1
- 201000011240 Frontotemporal dementia Diseases 0.000 abstract 1
- 208000023105 Huntington disease Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 abstract 1
- 230000037444 atrophy Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 201000001441 melanoma Diseases 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La présente invention concerne certains composés d'amide hétéroaryles, des compositions pharmaceutiques les contenant et des procédés d'utilisation associés, notamment des procédés permettant de prévenir, inverser, ralentir et inhiber l'agrégation protéique, et des procédés permettant de traiter des maladies qui sont associées à l'agrégation protéique, notamment les maladies neurodégénératives telles que la maladie de parkinson, la maladie d'alzheimer, la maladie du corps de lewy, la maladie de parkinson avec démence, la démence fronto-temporale, la maladie de huntington, la sclérose latérale amyotrophique et l'atrophie multisystématisée, et le cancer et le mélanome.The present invention relates to certain heteroaryl amide compounds, pharmaceutical compositions containing them and methods of use thereof, including methods of preventing, reversing, slowing down and inhibiting protein aggregation, and methods of treating diseases that are associated with protein aggregation, including neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, Lewy's body disease, Parkinson's disease with dementia, Frontotemporal dementia, Huntington's disease, amyotrophic lateral sclerosis and multisystematous atrophy, and cancer and melanoma.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461933246P | 2014-01-29 | 2014-01-29 | |
| PCT/US2015/013263 WO2015116663A1 (en) | 2014-01-29 | 2015-01-28 | Heteroarly amides as inhibitors of protein aggregation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA39227A1 MA39227A1 (en) | 2017-09-29 |
| MA39227B1 true MA39227B1 (en) | 2018-04-30 |
Family
ID=58698445
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA39227A MA39227B1 (en) | 2014-01-29 | 2015-01-28 | Heteroaryl amides as inhibitors of protein aggregation |
Country Status (2)
| Country | Link |
|---|---|
| AR (1) | AR099208A1 (en) |
| MA (1) | MA39227B1 (en) |
-
2015
- 2015-01-28 MA MA39227A patent/MA39227B1/en unknown
- 2015-01-28 AR ARP150100239A patent/AR099208A1/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| AR099208A1 (en) | 2016-07-06 |
| MA39227A1 (en) | 2017-09-29 |
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