MA37955A1 - Beta-secretase inhibitors - Google Patents
Beta-secretase inhibitorsInfo
- Publication number
- MA37955A1 MA37955A1 MA37955A MA37955A MA37955A1 MA 37955 A1 MA37955 A1 MA 37955A1 MA 37955 A MA37955 A MA 37955A MA 37955 A MA37955 A MA 37955A MA 37955 A1 MA37955 A1 MA 37955A1
- Authority
- MA
- Morocco
- Prior art keywords
- beta
- secretase inhibitors
- inhibitors
- disorders
- bace1
- Prior art date
Links
- 239000002439 beta secretase inhibitor Substances 0.000 title 1
- 208000010877 cognitive disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 102000002659 Amyloid Precursor Protein Secretases Human genes 0.000 abstract 1
- 108010043324 Amyloid Precursor Protein Secretases Proteins 0.000 abstract 1
- 102000013455 Amyloid beta-Peptides Human genes 0.000 abstract 1
- 108010090849 Amyloid beta-Peptides Proteins 0.000 abstract 1
- 208000028698 Cognitive impairment Diseases 0.000 abstract 1
- 206010012289 Dementia Diseases 0.000 abstract 1
- 230000006999 cognitive decline Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La présente invention concerne des acylguanidines spirocycliques et leur utilisation en tant qu'inhibiteurs de l'activité enzymatique bêta-secrétase (bace1), des compositions pharmaceutiques contenant celles-ci, et des procédés d'utilisation de celles-ci comme agents thérapeutiques dans le traitement de troubles neurodégénératifs, de troubles caractérisés par un déclin cognitif, un déficit cognitif, la démence et des maladies caractérisées par la production d'agrégats de ß-amyloïdes.The present invention relates to spirocyclic acylguanidines and their use as inhibitors of enzymatic beta-secretase activity (bace1), pharmaceutical compositions containing them, and methods of using them as therapeutic agents in the treatment of neurodegenerative disorders, disorders characterized by cognitive decline, cognitive impairment, dementia and diseases characterized by the production of β-amyloid aggregates.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261693512P | 2012-08-27 | 2012-08-27 | |
| PCT/US2013/056566 WO2014035860A1 (en) | 2012-08-27 | 2013-08-26 | Inhibitors of beta-secretase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA37955A1 true MA37955A1 (en) | 2017-10-31 |
Family
ID=60765487
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA37955A MA37955A1 (en) | 2012-08-27 | 2013-08-26 | Beta-secretase inhibitors |
Country Status (1)
| Country | Link |
|---|---|
| MA (1) | MA37955A1 (en) |
-
2013
- 2013-08-26 MA MA37955A patent/MA37955A1/en unknown
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