MA37700B1 - N-[4-(quinolin-4-yloxy)cyclohexyl(méthyl)](hétéro)arylcarboxamides utilisables en tant qu'antagonistes des récepteurs aux androgènes, leur production et leur utilisation en tant que médicaments - Google Patents
N-[4-(quinolin-4-yloxy)cyclohexyl(méthyl)](hétéro)arylcarboxamides utilisables en tant qu'antagonistes des récepteurs aux androgènes, leur production et leur utilisation en tant que médicamentsInfo
- Publication number
- MA37700B1 MA37700B1 MA37700A MA37700A MA37700B1 MA 37700 B1 MA37700 B1 MA 37700B1 MA 37700 A MA37700 A MA 37700A MA 37700 A MA37700 A MA 37700A MA 37700 B1 MA37700 B1 MA 37700B1
- Authority
- MA
- Morocco
- Prior art keywords
- arylcarboxamides
- quinolin
- yloxy
- hetero
- cyclohexyl
- Prior art date
Links
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 125000005842 heteroatom Chemical group 0.000 title abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 title abstract 2
- -1 quinolin-4-yloxy Chemical group 0.000 title abstract 2
- 229940123407 Androgen receptor antagonist Drugs 0.000 title 1
- 239000003936 androgen receptor antagonist Substances 0.000 title 1
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000006806 disease prevention Effects 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000003463 hyperproliferative effect Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Quinoline Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Apparatus For Radiation Diagnosis (AREA)
Abstract
La présente invention concerne les n-[4-(quinolin-4-yloxy)cyclohexyl (méthyl)](hétéro)arylcarboxamides, leurs intermédiaires et leurs procédés de production, leur utilisation pour traiter et/ou prévenir des maladies et leur utilisation en vue de la production de médicaments, ainsi que l'utilisation de ces derniers en vue du traitement et/ou de la prévention de maladies, dont, plus particulièrement, les maladies hyperprolifératives.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12004764 | 2012-06-26 | ||
| PCT/EP2013/063118 WO2014001247A1 (fr) | 2012-06-26 | 2013-06-24 | N-[4-(quinolin-4-yloxy)cyclohexyl(méthyl)](hétéro)arylcarboxamides utilisables en tant qu'antagonistes des récepteurs aux androgènes, leur production et leur utilisation en tant que médicaments |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA20150269A1 MA20150269A1 (fr) | 2015-08-31 |
| MA37700B1 true MA37700B1 (fr) | 2018-03-30 |
Family
ID=48699019
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA37700A MA37700B1 (fr) | 2012-06-26 | 2013-06-24 | N-[4-(quinolin-4-yloxy)cyclohexyl(méthyl)](hétéro)arylcarboxamides utilisables en tant qu'antagonistes des récepteurs aux androgènes, leur production et leur utilisation en tant que médicaments |
Country Status (40)
| Country | Link |
|---|---|
| US (1) | US9428460B2 (fr) |
| EP (1) | EP2864291B1 (fr) |
| JP (1) | JP6181172B2 (fr) |
| KR (1) | KR20150023880A (fr) |
| AP (1) | AP3919A (fr) |
| AR (1) | AR091565A1 (fr) |
| AU (1) | AU2013283543B2 (fr) |
| BR (1) | BR112014032538A2 (fr) |
| CA (1) | CA2877786C (fr) |
| CL (1) | CL2014003443A1 (fr) |
| CO (1) | CO7170167A2 (fr) |
| CR (1) | CR20140593A (fr) |
| CU (1) | CU20140144A7 (fr) |
| CY (1) | CY1118412T1 (fr) |
| DK (1) | DK2864291T3 (fr) |
| DO (1) | DOP2014000295A (fr) |
| EA (1) | EA028063B1 (fr) |
| EC (1) | ECSP14032516A (fr) |
| ES (1) | ES2609455T3 (fr) |
| HR (1) | HRP20161745T1 (fr) |
| HU (1) | HUE032306T2 (fr) |
| IL (1) | IL236146B (fr) |
| JO (1) | JO3342B1 (fr) |
| LT (1) | LT2864291T (fr) |
| MA (1) | MA37700B1 (fr) |
| ME (1) | ME02590B (fr) |
| MX (1) | MX2014016054A (fr) |
| NZ (1) | NZ703100A (fr) |
| PE (1) | PE20150154A1 (fr) |
| PH (1) | PH12014502869B1 (fr) |
| PL (1) | PL2864291T3 (fr) |
| PT (1) | PT2864291T (fr) |
| RS (1) | RS55500B1 (fr) |
| SG (1) | SG11201408254UA (fr) |
| SI (1) | SI2864291T1 (fr) |
| TN (1) | TN2014000532A1 (fr) |
| TW (1) | TWI600646B (fr) |
| UA (1) | UA115447C2 (fr) |
| UY (1) | UY34881A (fr) |
| WO (1) | WO2014001247A1 (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2016013668A (es) * | 2014-04-22 | 2017-01-20 | Nimbus Iris Inc | Inhibidores de cinasas asociadas al receptor de interleucina-1 (irak) y usos de los mismos. |
| UY36391A (es) * | 2014-11-05 | 2016-06-01 | Flexus Biosciences Inc | Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido1), sus métodos de síntesis y composiciones farmacèuticas que las contienen |
| TWI726969B (zh) | 2016-01-11 | 2021-05-11 | 比利時商健生藥品公司 | 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物 |
| KR20190003686A (ko) | 2016-05-04 | 2019-01-09 | 브리스톨-마이어스 스큅 컴퍼니 | 인돌아민 2,3-디옥시게나제의 억제제 및 그의 사용 방법 |
| EP3452451A4 (fr) * | 2016-05-04 | 2019-11-13 | Bristol-Myers Squibb Company | Inhibiteurs d'indoleamine 2,3-dioxygénase et leurs méthodes d'utilisation |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5328821A (en) | 1991-12-12 | 1994-07-12 | Robyn Fisher | Cold and cryo-preservation methods for human tissue slices |
| US6566372B1 (en) | 1999-08-27 | 2003-05-20 | Ligand Pharmaceuticals Incorporated | Bicyclic androgen and progesterone receptor modulator compounds and methods |
| US6686376B2 (en) | 2000-06-23 | 2004-02-03 | Eli Lilly And Company | Methods and compounds for inhibiting MRP1 |
| DE60233736D1 (de) | 2001-06-22 | 2009-10-29 | Kirin Pharma K K | Chinolinderivat und chinazolinderivat, die die selbstphosphorylierung des hepatocytus-proliferator-rezeptors hemmen, und diese enthaltende medizinische zusammensetzung |
| JP3714948B2 (ja) | 2002-09-11 | 2005-11-09 | 呉羽化学工業株式会社 | アミン化合物及びその用途 |
| US20050227932A1 (en) | 2002-11-13 | 2005-10-13 | Tianbao Lu | Combinational therapy involving a small molecule inhibitor of the MDM2: p53 interaction |
| EP1590334B1 (fr) | 2003-01-30 | 2009-08-19 | Boehringer Ingelheim Pharmaceuticals Inc. | Derives de 2,4-diaminopyrimidine utiles en tant qu'inhibiteurs de l'enzyme pkc-theta |
| SE0302573D0 (sv) | 2003-09-26 | 2003-09-26 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
| EP1725238A4 (fr) | 2004-03-17 | 2009-04-01 | Glaxo Group Ltd | Antagonistes du recepteur muscarinique a l'acetylcholine m 3 |
| SE0401342D0 (sv) | 2004-05-25 | 2004-05-25 | Astrazeneca Ab | Therapeutic compounds |
| WO2005117570A1 (fr) | 2004-05-27 | 2005-12-15 | Jack Saffron | Coupelle pour aliments empechant l'infestation par des parasites |
| JP2008519761A (ja) | 2004-11-09 | 2008-06-12 | スミスクライン ビーチャム コーポレーション | グリコーゲンホスホリラーゼ阻害化合物およびその医薬組成物 |
| JO2787B1 (en) * | 2005-04-27 | 2014-03-15 | امجين إنك, | Alternative amide derivatives and methods of use |
| GB0509224D0 (en) | 2005-05-05 | 2005-06-15 | Chroma Therapeutics Ltd | Inhibitors of intracellular enzymatic activity |
| GB0509227D0 (en) | 2005-05-05 | 2005-06-15 | Chroma Therapeutics Ltd | Intracellular enzyme inhibitors |
| US20060293341A1 (en) | 2005-06-23 | 2006-12-28 | Vrej Jubian | Alkyl sulfonamide derivatives |
| WO2007091694A1 (fr) | 2006-02-06 | 2007-08-16 | Showa Denko K.K. | Préparations dermatologiques de blanchiment |
| US20110053931A1 (en) | 2006-06-08 | 2011-03-03 | John Gaudino | Quinoline compounds and methods of use |
| GB0619753D0 (en) | 2006-10-06 | 2006-11-15 | Chroma Therapeutics Ltd | Enzyme inhibitors |
| WO2008064432A1 (fr) | 2006-12-01 | 2008-06-05 | The University Of Sydney | Composés moléculaires polycycliques |
| JP5634263B2 (ja) | 2007-08-16 | 2014-12-03 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | キナゾリンジオンキマーゼ阻害剤 |
| US8680291B2 (en) * | 2007-10-26 | 2014-03-25 | The Regents Of The University Of California | Diarylhydantoin compounds |
| EP2288383A1 (fr) | 2008-05-14 | 2011-03-02 | Amgen, Inc | Combinaisons d'inhibiteurs de vegf(r) et d'inhibiteurs du facteur de croissance d'hépatocyte (c-met) pour le traitement du cancer |
| MX2011003363A (es) | 2008-10-01 | 2011-04-27 | Ludwig Inst Cancer Res | Metodos para el tratamiento de cancer. |
| UY32793A (es) | 2009-07-21 | 2011-01-31 | Gilead Sciences Inc | Compuestos inhibidores de los virus flaviviridae, composición farmacéutica que los contiene y sus usos |
| JP2013504531A (ja) | 2009-09-11 | 2013-02-07 | バイエル・ファルマ・アクチェンゲゼルシャフト | 抗癌薬としての置換（ヘテロアリールメチル）チオヒダントイン |
| PT2592933T (pt) | 2010-07-16 | 2017-05-23 | Gaweco Anderson | Inibidores de mif e suas utilizações |
-
2013
- 2013-06-24 MA MA37700A patent/MA37700B1/fr unknown
- 2013-06-24 MX MX2014016054A patent/MX2014016054A/es unknown
- 2013-06-24 PL PL13731325T patent/PL2864291T3/pl unknown
- 2013-06-24 SI SI201330440A patent/SI2864291T1/sl unknown
- 2013-06-24 US US14/408,876 patent/US9428460B2/en not_active Expired - Fee Related
- 2013-06-24 ES ES13731325.0T patent/ES2609455T3/es active Active
- 2013-06-24 AU AU2013283543A patent/AU2013283543B2/en not_active Ceased
- 2013-06-24 AP AP2014008141A patent/AP3919A/en active
- 2013-06-24 PT PT137313250T patent/PT2864291T/pt unknown
- 2013-06-24 ME MEP-2016-292A patent/ME02590B/fr unknown
- 2013-06-24 JP JP2015519023A patent/JP6181172B2/ja not_active Expired - Fee Related
- 2013-06-24 NZ NZ703100A patent/NZ703100A/en not_active IP Right Cessation
- 2013-06-24 LT LTEP13731325.0T patent/LT2864291T/lt unknown
- 2013-06-24 PE PE2014002495A patent/PE20150154A1/es active IP Right Grant
- 2013-06-24 EP EP13731325.0A patent/EP2864291B1/fr active Active
- 2013-06-24 KR KR20157001996A patent/KR20150023880A/ko not_active Ceased
- 2013-06-24 UA UAA201500561A patent/UA115447C2/uk unknown
- 2013-06-24 CA CA2877786A patent/CA2877786C/fr not_active Expired - Fee Related
- 2013-06-24 DK DK13731325.0T patent/DK2864291T3/en active
- 2013-06-24 SG SG11201408254UA patent/SG11201408254UA/en unknown
- 2013-06-24 WO PCT/EP2013/063118 patent/WO2014001247A1/fr not_active Ceased
- 2013-06-24 HR HRP20161745TT patent/HRP20161745T1/hr unknown
- 2013-06-24 EA EA201500039A patent/EA028063B1/ru not_active IP Right Cessation
- 2013-06-24 BR BR112014032538A patent/BR112014032538A2/pt not_active Application Discontinuation
- 2013-06-24 RS RS20161149A patent/RS55500B1/sr unknown
- 2013-06-24 HU HUE13731325A patent/HUE032306T2/en unknown
- 2013-06-24 JO JOP/2013/0192A patent/JO3342B1/ar active
- 2013-06-26 UY UY0001034881A patent/UY34881A/es not_active Application Discontinuation
- 2013-06-26 AR ARP130102253 patent/AR091565A1/es unknown
- 2013-06-26 TW TW102122775A patent/TWI600646B/zh not_active IP Right Cessation
-
2014
- 2014-12-09 IL IL236146A patent/IL236146B/en active IP Right Grant
- 2014-12-18 CL CL2014003443A patent/CL2014003443A1/es unknown
- 2014-12-18 CR CR20140593A patent/CR20140593A/es unknown
- 2014-12-18 CU CUP2014000144A patent/CU20140144A7/es unknown
- 2014-12-19 DO DO2014000295A patent/DOP2014000295A/es unknown
- 2014-12-19 EC ECIEPI201432516A patent/ECSP14032516A/es unknown
- 2014-12-19 CO CO14279115A patent/CO7170167A2/es unknown
- 2014-12-22 PH PH12014502869A patent/PH12014502869B1/en unknown
- 2014-12-25 TN TN2014000532A patent/TN2014000532A1/fr unknown
-
2016
- 2016-12-23 CY CY20161101343T patent/CY1118412T1/el unknown
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