MA35215B1 - Inhibitors of activity akt - Google Patents
Inhibitors of activity aktInfo
- Publication number
- MA35215B1 MA35215B1 MA30546A MA30546A MA35215B1 MA 35215 B1 MA35215 B1 MA 35215B1 MA 30546 A MA30546 A MA 30546A MA 30546 A MA30546 A MA 30546A MA 35215 B1 MA35215 B1 MA 35215B1
- Authority
- MA
- Morocco
- Prior art keywords
- akt
- inhibitors
- compounds
- activity
- activity akt
- Prior art date
Links
- 230000000694 effects Effects 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102000001708 Protein Isoforms Human genes 0.000 abstract 1
- 108010029485 Protein Isoforms Proteins 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000005054 naphthyridines Chemical class 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
L'invention concerne des composés de naphthyridine substitués qui inhibent l'activité akt. Notamment, les composés de cette invention permettent d'inhiber sélectivement au moins deux des isoformes akt. Ladite invention a aussi pour objet des compositions renfermant de tels composés inhibiteurs et des méthodes d'inhibition de l'activité akt par administration du composé à un patient nécessitant un traitement contre le cancer.The invention provides substituted naphthyridine compounds that inhibit akt activity. In particular, the compounds of this invention can selectively inhibit at least two of the akt isoforms. The invention also relates to compositions comprising such inhibitory compounds and methods of inhibiting akt activity by administering the compound to a patient in need of cancer treatment.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68972605P | 2005-06-10 | 2005-06-10 | |
| PCT/US2006/022079 WO2006135627A2 (en) | 2005-06-10 | 2006-06-07 | Inhibitors of akt activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA35215B1 true MA35215B1 (en) | 2014-07-03 |
Family
ID=40448246
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA30546A MA35215B1 (en) | 2005-06-10 | 2008-01-07 | Inhibitors of activity akt |
Country Status (5)
| Country | Link |
|---|---|
| CN (1) | CN101374515B (en) |
| MA (1) | MA35215B1 (en) |
| SI (1) | SI1898903T1 (en) |
| UA (1) | UA87929C2 (en) |
| ZA (1) | ZA200709762B (en) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030187026A1 (en) * | 2001-12-13 | 2003-10-02 | Qun Li | Kinase inhibitors |
-
2006
- 2006-06-07 UA UAA200800331A patent/UA87929C2/en unknown
- 2006-06-07 CN CN200680020507.7A patent/CN101374515B/en not_active Expired - Fee Related
- 2006-06-07 SI SI200631603T patent/SI1898903T1/en unknown
-
2007
- 2007-11-13 ZA ZA200709762A patent/ZA200709762B/en unknown
-
2008
- 2008-01-07 MA MA30546A patent/MA35215B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| UA87929C2 (en) | 2009-08-25 |
| CN101374515A (en) | 2009-02-25 |
| CN101374515B (en) | 2013-01-09 |
| ZA200709762B (en) | 2009-08-26 |
| SI1898903T1 (en) | 2013-07-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TN2009000224A1 (en) | Inhibitors of akt activity | |
| GEAP202416515A (en) | Quinoline compounds as inhibitors of kras | |
| WO2006135627A3 (en) | Inhibitors of akt activity | |
| WO2006091395A3 (en) | Inhibitors of akt activity | |
| MY148480A (en) | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 | |
| MXPA05012812A (en) | Compounds, methods and pharmaceutical compositions for inhibiting parp. | |
| TNSN07161A1 (en) | Compounds and compositions as inhibitors of cannabinoid receptor 1 activity | |
| MA32135B1 (en) | Pim kinase inhibitors and methods of use | |
| MY162157A (en) | Substituted indole mcl-1 inhibitors | |
| PL360495A1 (en) | Arylmethylamine derivatives for use as tryptase inhibitors | |
| BG106020A (en) | Inhibitors of impdh enzyme | |
| TNSN08373A1 (en) | Azolopyrimidines as inhibitors of cannabinoid 1 activity | |
| MA57412B1 (en) | SUBSTITUTED BENZOPYRROLE AND STRUCTURALLY RELATED COMPLEMENT INHIBITORS | |
| MXPA05009535A (en) | N-alkyl-hydroxamic acid-isoindolyl compounds and their pharmaceutical uses. | |
| MEP54608A (en) | Arylmethylamine derivatives for use as tryptase inhibitors | |
| WO2006110638A3 (en) | Inhibitors of akt activity | |
| MA43052B1 (en) | Human Plasma Kallikrein Inhibitors | |
| BRPI0411864A (en) | combination of src kinase inhibitors and chemotherapeutic agents for the treatment of proliferative diseases | |
| WO2006068796A3 (en) | Inhibitors of akt activity | |
| WO2006108680A3 (en) | Substances and pharmaceutical compositions for the inhibition of glyoxalases and their use against protozoa and helminthes | |
| ATE423102T1 (en) | 4-SUBSTITUTED-5-CYANO-1H-PYRIMIDINE-6-(TH)IONES AS A GSK-3 INHIBITOR | |
| MA35215B1 (en) | Inhibitors of activity akt | |
| TW200719903A (en) | Compositions for the treatment of neoplasms | |
| WO2007008502A3 (en) | Inhibitors of checkpoint kinases | |
| WO2007084135A3 (en) | Inhibitors of checkpoint kinases |