MA32967B1 - Stimulateurs sgc d'activateurs sgc en combinaison avec des inhibiteurs pde5 dans le traitement du dysfonctionnement érectile - Google Patents
Stimulateurs sgc d'activateurs sgc en combinaison avec des inhibiteurs pde5 dans le traitement du dysfonctionnement érectileInfo
- Publication number
- MA32967B1 MA32967B1 MA34016A MA34016A MA32967B1 MA 32967 B1 MA32967 B1 MA 32967B1 MA 34016 A MA34016 A MA 34016A MA 34016 A MA34016 A MA 34016A MA 32967 B1 MA32967 B1 MA 32967B1
- Authority
- MA
- Morocco
- Prior art keywords
- sgc
- treatment
- combination
- pde5 inhibitors
- erectile dysfunction
- Prior art date
Links
- 229940123333 Phosphodiesterase 5 inhibitor Drugs 0.000 title abstract 3
- 239000002590 phosphodiesterase V inhibitor Substances 0.000 title abstract 3
- 208000010228 Erectile Dysfunction Diseases 0.000 title abstract 2
- 201000001881 impotence Diseases 0.000 title abstract 2
- 239000000021 stimulant Substances 0.000 title 1
- 102000007637 Soluble Guanylyl Cyclase Human genes 0.000 abstract 4
- 108010007205 Soluble Guanylyl Cyclase Proteins 0.000 abstract 4
- 102000004861 Phosphoric Diester Hydrolases Human genes 0.000 abstract 3
- 108090001050 Phosphoric Diester Hydrolases Proteins 0.000 abstract 3
- 239000012190 activator Substances 0.000 abstract 2
- 229940127296 soluble guanylate cyclase stimulator Drugs 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La présente invention concerne la cyclase guanylate soluble (sGC) et des phosphodiestérases (PDE), ainsi que la pharmacologie des stimulateurs sGC, des activateurs sGC et des inhibiteurs PDE. Plus particulièrement, l'invention concerne l'utilisation de stimulateurs sGC et d'activateurs sGC en combinaison avec des inhibiteurs PDE5, dans la préparation de médicaments destinés au traitement du dysfonctionnement érectile masculin (MED), et en particulier au traitement du MED pour des patients difficiles à traiter et des patients ne réagissant pas, ou pas totalement, aux inhibiteurs de PDE5.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09000619 | 2009-01-17 | ||
| EP09002177 | 2009-02-17 | ||
| PCT/EP2010/000029 WO2010081647A2 (fr) | 2009-01-17 | 2010-01-07 | Stimulateurs sgc d'activateurs sgc en combinaison avec des inhibiteurs pde5 dans le traitement du dysfonctionnement érectile |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA32967B1 true MA32967B1 (fr) | 2012-01-02 |
Family
ID=42153923
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA34016A MA32967B1 (fr) | 2009-01-17 | 2010-01-07 | Stimulateurs sgc d'activateurs sgc en combinaison avec des inhibiteurs pde5 dans le traitement du dysfonctionnement érectile |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US20120022028A1 (fr) |
| EP (1) | EP2387404B1 (fr) |
| JP (1) | JP5780430B2 (fr) |
| KR (1) | KR20110117655A (fr) |
| CN (1) | CN102316870A (fr) |
| AU (1) | AU2010205931A1 (fr) |
| BR (1) | BRPI1006869A2 (fr) |
| CA (1) | CA2749730C (fr) |
| CL (1) | CL2011001712A1 (fr) |
| EA (1) | EA201170942A1 (fr) |
| ES (1) | ES2493718T3 (fr) |
| IL (1) | IL213857A0 (fr) |
| MA (1) | MA32967B1 (fr) |
| MX (1) | MX2011007515A (fr) |
| SG (1) | SG172841A1 (fr) |
| SV (1) | SV2011003973A (fr) |
| TN (1) | TN2011000349A1 (fr) |
| TW (1) | TW201036971A (fr) |
| WO (1) | WO2010081647A2 (fr) |
| ZA (1) | ZA201105085B (fr) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011095553A1 (fr) * | 2010-02-05 | 2011-08-11 | Bayer Schering Pharma Aktiengesellschaft | Stimulateurs de sgc ou activateurs de sgc en combinaison avec des inhibiteurs de pde5 pour le traitement du dysfonctionnement érectile |
| MA34249B1 (fr) | 2010-05-26 | 2013-05-02 | Bayer Ip Gmbh | Utilisation de stimulateurs de la sgc, d'activateurs de la sgc, seuls et en association avec des inhibiteurs de la pde5 en vue du traitement de la sclérodermie systémique |
| EP2585055A1 (fr) * | 2010-06-25 | 2013-05-01 | Bayer Intellectual Property GmbH | Utilisation de stimulateurs et d'activateurs de la guanylate-cyclase soluble pour le traitement de la drépanocytose et la conservation de substituts sanguins |
| EP2683710B1 (fr) | 2011-03-10 | 2017-07-19 | Boehringer Ingelheim International GmbH | Activateurs de guanylate cyclase solubles |
| WO2013025425A1 (fr) | 2011-08-12 | 2013-02-21 | Boehringer Ingelheim International Gmbh | Activateurs de guanylate cyclase soluble |
| KR101960100B1 (ko) * | 2011-12-08 | 2019-03-19 | 에스케이케미칼 주식회사 | 미로데나필 또는 이의 약학적으로 허용 가능한 염을 함유하는 구강 투여용 필름 |
| UA115881C2 (uk) | 2012-09-07 | 2018-01-10 | Бьорінгер Інгельхайм Інтернаціональ Гмбх | Алкоксипіразоли як активатори розчинної гуанілатциклази |
| EP3024455A1 (fr) | 2013-07-25 | 2016-06-01 | Bayer Pharma Aktiengesellschaft | Stimulateurs de sgc ou activateurs de sgc et inhibiteurs de pde5 en combinaison avec un autre traitement pour la thérapie de la fibrose kystique |
| WO2015089105A1 (fr) | 2013-12-09 | 2015-06-18 | Respira Therapeutics, Inc. | Formulations en poudre d'inhibiteur pde5 et procédés y associés |
| DK3172202T3 (da) | 2014-07-22 | 2020-04-27 | Boehringer Ingelheim Int | Heterocykliske carboxylsyrer som aktivatorer af opløselig guanylatcyclase |
| AU2016355854B2 (en) | 2015-11-16 | 2021-05-06 | Topadur Pharma Ag | 2-phenyl-3,4-dihydropyrrolo[2,1 -f] [1,2,4]triazinone derivatives as phosphodiesterase inhibitors and uses thereof |
| IL269835B (en) | 2017-05-22 | 2022-08-01 | Topadur Pharma Ag | Novel dual mode of action soluble guanylate cyclase activators and phosphodiesterase inhibitors and uses thereof |
| US20220031704A1 (en) | 2018-11-28 | 2022-02-03 | Topadur Pharma Ag | Novel dual mode of action soluble guanylate cyclase activators and phosphodiesterase inhibitors and uses thereof |
| CN110305837A (zh) * | 2019-06-05 | 2019-10-08 | 西北师范大学 | 磷酸二酯酶5活性抑制剂作为诱导斑马鱼卵母细胞成熟的催熟剂的应用 |
| WO2021245192A1 (fr) | 2020-06-04 | 2021-12-09 | Topadur Pharma Ag | Nouveaux activateurs de la guanylate cyclase soluble à double mode d'action et inhibiteurs de phosphodiestérase et leurs utilisations |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB371800A (en) | 1929-10-21 | 1932-04-28 | Willem Zaadnoordijk | A process of filtering gases and fogs |
| GB369003A (en) | 1931-03-25 | 1932-03-17 | Richard Henry Sansome | Improvements in fire extinguishing fluids |
| HU228111B1 (en) * | 1998-07-08 | 2012-11-28 | Sanofi Aventis Deutschland | Sulfur substituted sulfonylaminocarboxylic acid n-arylamides, their preparation, their use and pharmaceutical preparations comprising them |
| DE19834044A1 (de) * | 1998-07-29 | 2000-02-03 | Bayer Ag | Neue substituierte Pyrazolderivate |
| DE19943635A1 (de) * | 1999-09-13 | 2001-03-15 | Bayer Ag | Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| AR031176A1 (es) | 2000-11-22 | 2003-09-10 | Bayer Ag | Nuevos derivados de pirazolpiridina sustituidos con piridina |
| DE10220570A1 (de) | 2002-05-08 | 2003-11-20 | Bayer Ag | Carbamat-substituierte Pyrazolopyridine |
| US20100144864A1 (en) * | 2007-04-05 | 2010-06-10 | Ironwood Pharmaceuticals, Inc. | Soluble guanylate cyclase (sgc) modulators for treatment of lipid related disorders |
| WO2008138483A1 (fr) * | 2007-05-12 | 2008-11-20 | Bayer Schering Pharma Aktiengesellschaft | Stimulateurs de la sgc, activateurs de la sgc et combinaisons pour le traitement de troubles urologiques |
-
2010
- 2010-01-07 US US13/144,929 patent/US20120022028A1/en not_active Abandoned
- 2010-01-07 KR KR1020117016559A patent/KR20110117655A/ko not_active Withdrawn
- 2010-01-07 CN CN2010800047775A patent/CN102316870A/zh active Pending
- 2010-01-07 EA EA201170942A patent/EA201170942A1/ru unknown
- 2010-01-07 WO PCT/EP2010/000029 patent/WO2010081647A2/fr not_active Ceased
- 2010-01-07 MA MA34016A patent/MA32967B1/fr unknown
- 2010-01-07 JP JP2011545666A patent/JP5780430B2/ja not_active Expired - Fee Related
- 2010-01-07 CA CA2749730A patent/CA2749730C/fr not_active Expired - Fee Related
- 2010-01-07 EP EP10700938.3A patent/EP2387404B1/fr active Active
- 2010-01-07 AU AU2010205931A patent/AU2010205931A1/en not_active Abandoned
- 2010-01-07 SG SG2011048840A patent/SG172841A1/en unknown
- 2010-01-07 ES ES10700938.3T patent/ES2493718T3/es active Active
- 2010-01-07 BR BRPI1006869A patent/BRPI1006869A2/pt not_active Application Discontinuation
- 2010-01-07 MX MX2011007515A patent/MX2011007515A/es not_active Application Discontinuation
- 2010-01-15 TW TW099101001A patent/TW201036971A/zh unknown
-
2011
- 2011-06-30 IL IL213857A patent/IL213857A0/en unknown
- 2011-07-11 ZA ZA2011/05085A patent/ZA201105085B/en unknown
- 2011-07-14 CL CL2011001712A patent/CL2011001712A1/es unknown
- 2011-07-14 TN TN2011000349A patent/TN2011000349A1/fr unknown
- 2011-07-14 SV SV2011003973A patent/SV2011003973A/es unknown
-
2014
- 2014-03-18 US US14/217,664 patent/US20140288079A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| SG172841A1 (en) | 2011-08-29 |
| US20120022028A1 (en) | 2012-01-26 |
| JP2012515176A (ja) | 2012-07-05 |
| TN2011000349A1 (en) | 2013-03-27 |
| AU2010205931A1 (en) | 2011-07-28 |
| CN102316870A (zh) | 2012-01-11 |
| US20140288079A1 (en) | 2014-09-25 |
| ES2493718T3 (es) | 2014-09-12 |
| TW201036971A (en) | 2010-10-16 |
| IL213857A0 (en) | 2011-07-31 |
| MX2011007515A (es) | 2011-08-12 |
| ZA201105085B (en) | 2012-09-26 |
| EP2387404B1 (fr) | 2014-06-25 |
| WO2010081647A2 (fr) | 2010-07-22 |
| EA201170942A1 (ru) | 2012-02-28 |
| CA2749730A1 (fr) | 2010-07-22 |
| KR20110117655A (ko) | 2011-10-27 |
| WO2010081647A3 (fr) | 2010-10-21 |
| CA2749730C (fr) | 2017-02-14 |
| BRPI1006869A2 (pt) | 2016-03-15 |
| JP5780430B2 (ja) | 2015-09-16 |
| SV2011003973A (es) | 2011-12-06 |
| EP2387404A2 (fr) | 2011-11-23 |
| CL2011001712A1 (es) | 2012-04-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MA32967B1 (fr) | Stimulateurs sgc d'activateurs sgc en combinaison avec des inhibiteurs pde5 dans le traitement du dysfonctionnement érectile | |
| MA33984B1 (fr) | Stimulateurs de sgc ou activateurs de sgc seuls ou en combinaison avec des inhibiteurs de pde5 pour le traitement de la fibrose kystique | |
| MA34655B1 (fr) | Dérivés de 2,3- dihydroimidazo[1,2-c]quinazoléine substitués par un aminoalcool utiles pour traiter des troubles hyperprolifératifs et des maladies associées à l'angiogenèse | |
| EP4275752A3 (fr) | Traitement d'addiction et de troubles de contrôle des impulsions au moyen d'inhibiteurs de la pde7 | |
| MA34002B1 (fr) | Thérapie antivirale | |
| MA29378B1 (fr) | Composition pharmaceutique comprenant une diphenyluree substituee par un omega-carboxyaryle pour le traitement du cancer | |
| RU2009120992A (ru) | Применение 3-андростандиола, необязательно в сочетании с агонистом 5-ht1а для лечения сексуальной дисфункции | |
| TNSN08283A1 (en) | Cytotoxic agents comprising new tomaymycin derivatives and their therapeutic use | |
| TW200510425A (en) | Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor | |
| MA32903B1 (fr) | Inhibiteurs de proteine-kinases | |
| SG170828A1 (en) | Deazapurines useful as inhibitors of janus kinases | |
| MA39211B1 (fr) | Composés tricycliques comme agents anti-cancers | |
| MA33734B1 (fr) | N1-pyrazolospirocétone inhibitrices d'acétyl-coa carboxylase | |
| MA29615B1 (fr) | Preparations et methodes pour le diagnostic et le traitement d'une tumeur | |
| MX2010004281A (es) | Composiciones y metodos para el tratamiento de la retinopatia diabetica. | |
| MA33768B1 (fr) | Triazolopyridines | |
| BRPI0611705A2 (pt) | composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso de composto | |
| ATE502633T1 (de) | Cyclosporins zur behandlung und vorbeugung von augenerkrankungen | |
| MA45598B1 (fr) | Stéroles 24-hydroxylés substitués en position 11 pour le traitement des maladies liées au récepteur nmda | |
| MA31335B1 (fr) | Procédés de traitement impliquant l'inhibition de pi3k-alpha au moyen d'inhibiteurs de type quinaxoline | |
| TW200634006A (en) | Tetrahydroquinoline analogues as muscarinic agonists | |
| MA31663B1 (fr) | Dosage oral et interveineux de l'inhibiteur p2y12 reverisble et a action directe | |
| MY144773A (en) | 6-(heterocycle-susbtituted benzyl) -4-oxoquinoline compound and use of the same as hiv integrase inhibitor | |
| TW200621236A (en) | Use of inhibitors of jun n-terminal kinases for the treatment of glaucomatous retinopathy and ocular diseases | |
| WO2013176877A3 (fr) | Traitement de la dépendance et des troubles du contrôle des impulsions à l'aide d'inhibiteurs de pde7 |