[go: up one dir, main page]

MA30175B1 - Ligands qui lient il-4 et/ou il-13 - Google Patents

Ligands qui lient il-4 et/ou il-13

Info

Publication number
MA30175B1
MA30175B1 MA31143A MA31143A MA30175B1 MA 30175 B1 MA30175 B1 MA 30175B1 MA 31143 A MA31143 A MA 31143A MA 31143 A MA31143 A MA 31143A MA 30175 B1 MA30175 B1 MA 30175B1
Authority
MA
Morocco
Prior art keywords
ligands
bind
interleukin
treatment
invention concerns
Prior art date
Application number
MA31143A
Other languages
English (en)
Inventor
Ian Tomlinson
Adriaan Allart Stoop
Armin Sepp
Silva Inusha De
Caroline J Dimech
Malgorzata Pupecka
Wildt Rudolf M T De
Philip D Drew
Steve Holmes
Original Assignee
Domantis Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Domantis Ltd filed Critical Domantis Ltd
Publication of MA30175B1 publication Critical patent/MA30175B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/247—IL-4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

LA PRÉSENTE INVENTION CONCERNE DES LIGANDS QUI ONT UNE SPÉCIFICITÉ DE LIAISON POUR L¿INTERLEUKINE-4 (IL-4), L¿INTERLEUKINE-13 (IL-13) OU POUR IL-4 ET IL-13. SONT ÉGALEMENT INDIQUÉS DES PROCÉDÉS D¿UTILISATION DE CES LIGANDS. L¿UTILISATION DE CES LIGANDS POUR LE TRAITEMENT D¿UN ASTHME ALLERGIQUE EST EN PARTICULIER DÉCRITE.
MA31143A 2006-01-24 2008-07-25 Ligands qui lient il-4 et/ou il-13 MA30175B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US76170806P 2006-01-24 2006-01-24

Publications (1)

Publication Number Publication Date
MA30175B1 true MA30175B1 (fr) 2009-01-02

Family

ID=38028503

Family Applications (1)

Application Number Title Priority Date Filing Date
MA31143A MA30175B1 (fr) 2006-01-24 2008-07-25 Ligands qui lient il-4 et/ou il-13

Country Status (16)

Country Link
US (3) US20110159003A1 (fr)
EP (1) EP1976882A2 (fr)
JP (2) JP2009523460A (fr)
KR (1) KR20080098382A (fr)
CN (1) CN101578298A (fr)
AU (1) AU2007209202A1 (fr)
BR (1) BRPI0710572A2 (fr)
CA (1) CA2636854A1 (fr)
CR (1) CR10179A (fr)
EA (1) EA200801515A1 (fr)
IL (1) IL192572A0 (fr)
MA (1) MA30175B1 (fr)
NO (1) NO20082942L (fr)
TW (2) TW200804593A (fr)
WO (1) WO2007085815A2 (fr)
ZA (1) ZA200806202B (fr)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY144906A (en) 2005-10-21 2011-11-30 Novartis Ag Human antibodies against il13 and therapeutic uses
WO2009138413A1 (fr) * 2008-05-15 2009-11-19 Domantis Limited Anticorps à domaine unique qui lient il-13
WO2007134050A2 (fr) * 2006-05-09 2007-11-22 Genentech, Inc. Polypeptides de liaison à squelettes optimisés
US7608693B2 (en) 2006-10-02 2009-10-27 Regeneron Pharmaceuticals, Inc. High affinity human antibodies to human IL-4 receptor
WO2009030285A1 (fr) * 2007-09-07 2009-03-12 Ablynx N.V. Molécules de liaison présentant plusieurs sites de liaison, compositions comprenant de telles molécules et utilisations de celles-ci
EP2036980A1 (fr) * 2007-09-14 2009-03-18 Gruber, Jens Dérégulation de l'expression génétique à l'aide de particules semblables à un virus chargées d'acide nucléique
EP2050764A1 (fr) * 2007-10-15 2009-04-22 sanofi-aventis Nouveau format d'anticorps bispécifique polyvalent
AU2017201007B2 (en) * 2007-10-15 2018-12-13 Sanofi Antibodies that bind IL-4 and/or IL-13 and their uses
CA2707986A1 (fr) * 2007-12-13 2009-06-18 Glaxo Group Limited Compositions pour administration pulmonaire
EP2238165B1 (fr) * 2008-01-07 2017-07-05 Government of the United States of America, as represented by the Secretary, Department of Health and Human Services Anticorps à domaine anti-vih et procédé de fabrication et d'utilisation de ceux-ci
RU2607569C2 (ru) * 2008-03-31 2017-01-10 Дженентек, Инк. Композиции и способы для лечения и диагностики астмы
WO2009127691A1 (fr) 2008-04-17 2009-10-22 Ablynx N.V. Peptides capables de se lier à des protéines sériques et composés, constructions et polypeptides les comprenant
WO2010035012A1 (fr) * 2008-09-26 2010-04-01 Ucb Pharma S.A. Produits biologiques
AU2009306424A1 (en) * 2008-10-21 2010-04-29 Domantis Limited Ligands that have binding specificity for DC-SIGN
CN102307896B (zh) 2008-10-31 2016-10-12 森托科尔奥索生物科技公司 基于iii型纤连蛋白结构域的支架组合物、方法及用途
EP2358754A1 (fr) * 2008-11-26 2011-08-24 Glaxo Group Limited Ligands qui se lient à il-13
CN102307902B (zh) 2008-12-10 2016-02-24 埃博灵克斯股份有限公司 用于治疗与血管发生相关的疾病和病症的针对血管生成素/Tie系统的氨基酸序列和包括其的多肽
EP2435482B1 (fr) * 2009-05-28 2019-04-03 Glaxo Group Limited Protéines de liaison à l'antigène
EA201190275A1 (ru) * 2009-05-28 2012-11-30 Глаксо Груп Лимитед Белок, связывающий интерлейкин-13 (il-13)
BR112012001681A2 (pt) * 2009-07-16 2019-09-24 Graxo Group Ltd domínios variáveis de ligação de anti-albumina sérica aperfeiçoados
AU2010277629B2 (en) 2009-07-29 2016-05-19 Glaxo Group Limited Anti - TGF - beta receptor type II single domain antibodies
WO2011095545A1 (fr) 2010-02-05 2011-08-11 Ablynx Nv Peptides capables de se lier à la sérumalbumine, et composés, constructions, et polypeptides comprenant de tels peptides
HRP20191071T1 (hr) 2010-02-11 2019-09-20 Ablynx N.V. Postupci i pripravci za pripremu aerosola
HUE029622T2 (en) 2010-04-30 2017-03-28 Janssen Biotech Inc Stabilized fibronectin domain compositions, methods and uses
MX2013007936A (es) 2011-01-06 2013-08-09 Glaxo Group Ltd Ligandos que se unen al receptor ii del factor de crecimiento transformante-beta.
EP2686014A1 (fr) 2011-03-16 2014-01-22 Sanofi Utilisations d'une protéine de type anticorps à région v double
US9527925B2 (en) 2011-04-01 2016-12-27 Boehringer Ingelheim International Gmbh Bispecific binding molecules binding to VEGF and ANG2
US9475879B2 (en) 2011-04-21 2016-10-25 Bristol-Myers Squibb Company Antibody polypeptides that antagonize CD40
EP2761066B1 (fr) 2011-09-27 2018-12-05 Janssen Biotech, Inc. Echafaudages protéiques à base de répétition de fibronectine type iii avec de nouvelles surfaces de liaison
US10481164B2 (en) * 2012-03-26 2019-11-19 Amgen Inc. Method for using light scattering in real time to directly monitor and control impurity removal in purification processes
CA2876904C (fr) * 2012-06-22 2019-12-03 Cytomx Therapeutics, Inc. Anticorps a reaction croisee anti-jagged 1/jagged 2, anticorps anti-jagged activables et leurs procedes d'utilisation
HUE064945T2 (hu) 2012-08-21 2024-04-28 Sanofi Biotechnology Eljárások asztma kezelésére vagy megelõzésére IL-4R antagonista beadásával
WO2014030780A1 (fr) * 2012-08-22 2014-02-27 Mogam Biotechnology Research Institute Procédé de criblage et de fabrication de domaines variables d'immunoglobulines super-stables et applications associées
US11066467B2 (en) 2013-12-17 2021-07-20 Mhs Care-Innovation Llc Compositions and methods for treating ischemic heart disease
CA2934004C (fr) * 2013-12-17 2023-07-04 The Metrohealth System Compositions et methodes permettant de lutter contre l'accumulation de tissu graisseux
IL315136A (en) * 2014-02-21 2024-10-01 Sanofi Biotechnology Methods for treating or preventing asthma by administering an il-4rantagonist
US10435475B2 (en) 2014-03-07 2019-10-08 Bristol-Myers Squibb Company Method of using antibody polypeptides that antagonize CD40 to treat IBD
CN106536754B (zh) 2014-04-11 2021-04-16 诺华股份有限公司 用il-13拮抗剂选择性治疗哮喘的方法
SI3204095T1 (sl) 2014-10-10 2019-08-30 Ablynx N.V. Inhalacijska naprava za uporabo pri zdravljenju bolezni dihal z aerosolom
RU2017115670A (ru) 2014-10-10 2018-11-15 Аблинкс Н.В. Лечение инфекции рсв
EP3218412A1 (fr) 2014-11-14 2017-09-20 Sanofi Biotechnology Méthodes de traitement de la sinusite chronique avec polypose nasale par administration d'un antagoniste d'il-4r
JP6862343B2 (ja) 2014-12-19 2021-04-21 アブリンクス エン．ヴェー． システイン結合ナノボディダイマー
WO2017191108A1 (fr) 2016-05-02 2017-11-09 Ablynx Nv Traitement d'une infection à vrs
JP6293829B2 (ja) * 2016-08-05 2018-03-14 モガム インスティチュート フォー バイオメディカル リサーチＭＯＧＡＭ Ｉｎｓｔｉｔｕｔｅ ｆｏｒ Ｂｉｏｍｅｄｉｃａｌ Ｒｅｓｅａｒｃｈ 安定化された免疫グロブリン可変ドメイン選別方法及び選別されたドメインの応用
WO2018099968A1 (fr) 2016-11-29 2018-06-07 Ablynx N.V. Traitement d'une infection par le virus respiratoire syncytial (vrs)
JP7104703B2 (ja) 2016-12-14 2022-07-21 ヤンセン バイオテツク，インコーポレーテツド Ｃｄ８ａ結合フィブロネクチンｉｉｉ型ドメイン
WO2018111976A1 (fr) 2016-12-14 2018-06-21 Janssen Biotech, Inc. Domaines de fibronectine de type iii se liant à pd-l1
EP3554561B1 (fr) 2016-12-14 2023-06-28 Janssen Biotech, Inc. Domaines de fibronectine de type iii à liaison au cd137
HUE064655T2 (hu) 2017-10-30 2024-04-28 Sanofi Biotechnology IL-4R antagonista asztma kezelésére vagy megelõzésére szolgáló eljárásban
CN108855003B (zh) * 2018-06-28 2021-01-05 南开大学 一种用于清除血液中炎性因子的免疫吸附剂及其制备方法
CN111518211B (zh) 2018-12-25 2022-06-21 江苏荃信生物医药股份有限公司 抗人白介素4受体α单克隆抗体的制药用途
JP2022541697A (ja) 2019-02-27 2022-09-27 ジャージャン ナノマブ テクノロジー センター カンパニー リミテッド 高解像度で広範なエピトープを網羅するために、ラクダ科動物抗体を生成する配列ベースのハイスループット法
MX2022000649A (es) 2019-07-16 2022-06-08 Sanofi Biotechnology Metodos para tratar o prevenir el asma mediante la administracion de un antagonista de il-4r.
WO2021076574A2 (fr) 2019-10-14 2021-04-22 Aro Biotherapeutics Company Conjugués domaine fn3-arnsi et leurs utilisations
WO2021076543A1 (fr) 2019-10-14 2021-04-22 Aro Biotherapeutics Company Domaines de type iii de fibronectine de liaison à cd137
EP4045061A4 (fr) 2019-10-14 2024-04-17 ARO Biotherapeutics Company Domaines de type iii de fibronectine de liaison à cd137
US20230279115A1 (en) 2020-04-22 2023-09-07 Mabwell (shanghai) Bioscience Co., Ltd. Single variable domain antibody targeting human programmed death ligand 1 (pd-l1) and derivative thereof
EP4146704A4 (fr) * 2020-05-06 2024-08-28 Dragonfly Therapeutics, Inc. Anticorps ciblant clec12a et leur utilisation
MX2022013944A (es) 2020-05-06 2022-11-30 Dragonfly Therapeutics Inc Proteinas que se unen al receptor activador de celulas asesinas naturales grupo 2 miembro d (nkg2d), cumulo de diferenciacion (cd16) y miembro a de la familia de dominios de lectina tipo c 12 (clec12a).
JP2024517610A (ja) 2021-04-14 2024-04-23 アロ・バイオセラピューティクス・カンパニー Ｃｄ７１に結合するフィブロネクチンｉｉｉ型ドメイン
BR112023021318A2 (pt) 2021-04-14 2023-12-19 Aro Biotherapeutics Company Conjugados de domínio fn3-sirna e usos dos mesmos
CA3254037A1 (fr) * 2022-03-03 2023-09-07 Pfizer Anticorps multispécifiques et leurs utilisations
WO2024038112A1 (fr) * 2022-08-17 2024-02-22 Institut National de la Santé et de la Recherche Médicale Nanocorps anti-albumine améliorés et leurs utilisations
JP7668943B2 (ja) * 2023-08-30 2025-04-25 ファイザー・インク 多重特異性抗体およびその使用
JP2025036273A (ja) * 2023-08-30 2025-03-14 ファイザー・インク 多重特異性抗体およびその使用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5869620A (en) * 1986-09-02 1999-02-09 Enzon, Inc. Multivalent antigen-binding proteins
US5637481A (en) * 1993-02-01 1997-06-10 Bristol-Myers Squibb Company Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell
ZA931148B (en) * 1992-02-19 1993-08-18 Schering Corp Cloning and expression of humanized monoclonal antibodies against human interfluekin-4.
US5596072A (en) * 1992-08-21 1997-01-21 Schering Corporation Method of refolding human IL-13
US7585847B2 (en) * 2000-02-03 2009-09-08 Coley Pharmaceutical Group, Inc. Immunostimulatory nucleic acids for the treatment of asthma and allergy
US7175988B2 (en) * 2001-02-09 2007-02-13 Human Genome Sciences, Inc. Human G-protein Chemokine Receptor (CCR5) HDGNR10
DK1517921T3 (da) * 2002-06-28 2006-10-09 Domantis Ltd Immunglobulin-enkeltvariable antigen-bindende domæner og dobbeltspecifikke konstruktioner deraf
CA2511910A1 (fr) * 2002-12-27 2004-07-15 Domantis Limited Ligand
GB0407315D0 (en) * 2003-07-15 2004-05-05 Cambridge Antibody Tech Human antibody molecules
PL1711528T3 (pl) * 2003-12-23 2012-11-30 Genentech Inc Leczenie nowotworu nowymi przeciwciałami monoklonalnymi anty-IL13
CA2554596A1 (fr) * 2004-02-27 2005-09-15 Regeneron Pharmaceuticals, Inc. Polypeptides specifiques d'il-4/il-13 et utilisations therapeutiques associees
AR049390A1 (es) * 2004-06-09 2006-07-26 Wyeth Corp Anticuerpos contra la interleuquina-13 humana y usos de los mismos
TWI307630B (en) * 2004-07-01 2009-03-21 Glaxo Group Ltd Immunoglobulins
WO2006023460A2 (fr) * 2004-08-16 2006-03-02 Theravance, Inc. Composes a activite agoniste pour recepteur ?2 adrenergique et antagoniste pour recepteur muscarinique

Also Published As

Publication number Publication date
BRPI0710572A2 (pt) 2013-01-08
AU2007209202A1 (en) 2007-08-02
TW200740843A (en) 2007-11-01
CN101578298A (zh) 2009-11-11
JP2009523459A (ja) 2009-06-25
CR10179A (es) 2008-10-29
EA200801515A1 (ru) 2009-02-27
ZA200806202B (en) 2009-11-25
NO20082942L (no) 2008-10-15
EP1976882A2 (fr) 2008-10-08
CA2636854A1 (fr) 2007-08-02
KR20080098382A (ko) 2008-11-07
WO2007085815A3 (fr) 2007-11-15
US20090060916A1 (en) 2009-03-05
JP2009523460A (ja) 2009-06-25
IL192572A0 (en) 2009-02-11
TW200804593A (en) 2008-01-16
WO2007085815A8 (fr) 2008-07-31
US20120093830A1 (en) 2012-04-19
US20110159003A1 (en) 2011-06-30
WO2007085815A2 (fr) 2007-08-02

Similar Documents

Publication Publication Date Title
MA30175B1 (fr) Ligands qui lient il-4 et/ou il-13
SG147444A1 (en) Anti-ox40l antibodies
MA30021B1 (fr) Ligands presentant une specificite de liaison avec l'egfr et/ou le vegf et leurs procedes d'utilisation
NO20083712L (no) Peptider som blokkerer bindingen av IGG til FCRN
EA200971131A1 (ru) Биомаркеры для прогнозирования чувствительности или отсутствия чувствительности к анти-фно агентам
MX337778B (es) Anticuerpos contra il-22 humana y usos para los mismos.
MA31918B1 (fr) Agents et épitopes de liaison à wise
WO2006105304A3 (fr) Modulateurs lta4h de phenyle et pyridyle
MA34527B1 (fr) Anticorps contre la metalloproteinase de matrice 9
MX2010009724A (es) Procedimientos de tratamiento del dolor inflamatorio-.
MA31304B1 (fr) Molecules et procedes de modulation de proproteine convertase subtilisine/kexine de type 9 (pcsk9)
MX2008011874A (es) Composiciones estabilizadas de polipeptidos.
MA30872B1 (fr) Compositions d'inhibiteurs de la chk1.
MA35174B1 (fr) Molécules de liaison des cd3 capables de se lier aux cd3 humaines et non humaines
WO2003105840A3 (fr) Inhibiteurs de sphingosine kinase
WO2008030892A3 (fr) Concept de médicament pour inhibiteurs de tubuline, compositions et procédés de traitement
DE602005017893D1 (de) Drehverfahren für silikonhydrogel-linsen
WO2007100643A3 (fr) Procédés d'utilisation d'anticorps contre l'il-22 humaine
DK1261367T3 (da) Anvendelse af interleukin-6-antagonister til behandling af östrogenafhængige tumorer
WO2007111938A3 (fr) Facteurs seriques inhibiteurs de l'inflammation et leurs utilisations
WO2007120651A3 (fr) Utilisation et compositions pour le traitement de l'arthrite rhumatoïde juvénile
NO20084320L (no) Antistoffer mot EGFL7 og fremgangsmater for anvendelse av disse
ATE471032T1 (de) Verfahren und system zur echolöschung bei wenig verzögerung
WO2007028088A3 (fr) Methodes d'amelioration de la capacite de deshydratation de boue avec un traitement d'alpha-amylase
SE0402536D0 (sv) Immunoregulation in cancer, chronic inflammatory and autoimmune diseases