MA30625B1 - Compositions et procedes pour le traitement de la mucormycose et d'autres maladies fongiques - Google Patents
Compositions et procedes pour le traitement de la mucormycose et d'autres maladies fongiquesInfo
- Publication number
- MA30625B1 MA30625B1 MA31613A MA31613A MA30625B1 MA 30625 B1 MA30625 B1 MA 30625B1 MA 31613 A MA31613 A MA 31613A MA 31613 A MA31613 A MA 31613A MA 30625 B1 MA30625 B1 MA 30625B1
- Authority
- MA
- Morocco
- Prior art keywords
- antifungal agent
- iron
- fungal
- chelating compound
- fungal condition
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- 208000031888 Mycoses Diseases 0.000 title 1
- 206010061418 Zygomycosis Diseases 0.000 title 1
- 201000007524 mucormycosis Diseases 0.000 title 1
- 229940121375 antifungal agent Drugs 0.000 abstract 7
- 239000003429 antifungal agent Substances 0.000 abstract 7
- 230000002538 fungal effect Effects 0.000 abstract 7
- 239000000797 iron chelating agent Substances 0.000 abstract 5
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 abstract 2
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 abstract 2
- 108010049047 Echinocandins Proteins 0.000 abstract 1
- TZXKOCQBRNJULO-UHFFFAOYSA-N Ferriprox Chemical compound CC1=C(O)C(=O)C=CN1C TZXKOCQBRNJULO-UHFFFAOYSA-N 0.000 abstract 1
- PMVSDNDAUGGCCE-TYYBGVCCSA-L Ferrous fumarate Chemical compound [Fe+2].[O-]C(=O)\C=C\C([O-])=O PMVSDNDAUGGCCE-TYYBGVCCSA-L 0.000 abstract 1
- 239000000589 Siderophore Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229960001489 deferasirox Drugs 0.000 abstract 1
- FMSOAWSKCWYLBB-VBGLAJCLSA-N deferasirox Chemical compound C1=CC(C(=O)O)=CC=C1N(N\C(N\1)=C\2C(C=CC=C/2)=O)C/1=C\1C(=O)C=CC=C/1 FMSOAWSKCWYLBB-VBGLAJCLSA-N 0.000 abstract 1
- 229960003266 deferiprone Drugs 0.000 abstract 1
- 230000000977 initiatory effect Effects 0.000 abstract 1
- 229910052742 iron Inorganic materials 0.000 abstract 1
- 150000004291 polyenes Chemical class 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
L'invention concerne une composition contenant au moins un composé chélateur du fer et au moins un agent antifongique. La composition peut contenir les composés chélateurs du fer, la défériprone ou le déférasirox. Un agent antifongique incorporé dans la composition peut inclure un agent antifongique du type polyène, un agent antifongique du type azole ou un agent antifongique du type échinocandine. L'invention concerne aussi un procédé de traitement ou de prévention d'un état fongique, qui consiste à administrer à un individu atteint d'un état fongique, ou y étant prédisposé, une quantité thérapeutiquement efficace d'au moins un composé chélateur du fer pendant un temps suffisant pour réduire la gravité d'un état fongique, où le composé chélateur du fer comprend un non-sidérophore ou un non-xénosidérophore relativement à l'état fongique. Un procédé de traitement ou de prévention d'un état fongique conformément à l'invention consiste à administrer à un individu atteint d'un état fongique, ou y étant prédisposé, une quantité thérapeutiquement efficace d'au moins un composé chélateur du fer et d'au moins un agent antifongique. L'invention concerne également un procédé qui comprend l'administration prophylactique de l'au moins un composé chélateur du fer et de l'au moins un agent antifongique avant le déclenchement de l'état fongique.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83109906P | 2006-07-13 | 2006-07-13 | |
| US89762007P | 2007-01-26 | 2007-01-26 | |
| US90407507P | 2007-02-27 | 2007-02-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA30625B1 true MA30625B1 (fr) | 2009-08-03 |
Family
ID=38610625
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA31613A MA30625B1 (fr) | 2006-07-13 | 2009-02-04 | Compositions et procedes pour le traitement de la mucormycose et d'autres maladies fongiques |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20100129434A1 (fr) |
| EP (2) | EP2043636A2 (fr) |
| JP (2) | JP2009543788A (fr) |
| KR (1) | KR20090036587A (fr) |
| AU (1) | AU2007272781B2 (fr) |
| BR (1) | BRPI0714221A2 (fr) |
| CA (1) | CA2657634A1 (fr) |
| CL (1) | CL2007002026A1 (fr) |
| IL (1) | IL196389A0 (fr) |
| MA (1) | MA30625B1 (fr) |
| MX (1) | MX2009000506A (fr) |
| NO (1) | NO20090565L (fr) |
| NZ (1) | NZ574862A (fr) |
| RU (1) | RU2464024C2 (fr) |
| SG (1) | SG177122A1 (fr) |
| TN (1) | TN2009000004A1 (fr) |
| TW (1) | TWI448285B (fr) |
| WO (1) | WO2008008537A2 (fr) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA33199B1 (fr) * | 2009-03-19 | 2012-04-02 | Los Angeles Biomed Res Inst | Compositions de vaccin et procédés pour le traitement de la mucormycose et d'autres maladies fongiques |
| US8980876B2 (en) | 2010-10-28 | 2015-03-17 | The Procter & Gamble Company | Inhibition of microbial growth by aconitase inhibition |
| CA2885394A1 (fr) * | 2012-11-12 | 2014-05-15 | Cipla Limited | Composition pharmaceutique a dose fixe a base de deferasirox et de deferipone |
| WO2014120774A1 (fr) | 2013-01-29 | 2014-08-07 | Case Western Reserve University | Inhibiteurs de l'acquisition du fer d'origine fongique et utilisations associées |
| US20160199361A1 (en) * | 2013-08-19 | 2016-07-14 | Rutgers, The State University Of New Jersey | Method of Inducing An Anti-Retroviral Immune Response By Counter-Acting Retro-Virus Induced Anti-Apoptosis |
| WO2016025559A1 (fr) * | 2014-08-13 | 2016-02-18 | Zoneone Pharma, Inc. | Formulations pharmaceutiques et procédés de préparation d'agents chélatants pour systèmes efficaces de traitement d'élimination des métaux |
| US20170231910A1 (en) * | 2014-08-13 | 2017-08-17 | Mark E. Hayes | Pharmaceutical formulations of chelating agents as a metal removal treatment system |
| US11298364B2 (en) * | 2015-08-31 | 2022-04-12 | The University Of Adelaide | Methods and products for preventing and/or treating microorganism infections comprising iron chelators and non-iron porphyrins |
| WO2017197386A1 (fr) * | 2016-05-13 | 2017-11-16 | The Brigham And Women's Hospital, Inc. | Profils de métabolites volatils pour le diagnostic et le traitement de champignons mucorales |
| FR3095755A1 (fr) * | 2019-05-10 | 2020-11-13 | Balmes Transplantation | Nouveaux médicaments cytoprotecteurs |
| WO2020264076A1 (fr) | 2019-06-28 | 2020-12-30 | The Procter & Gamble Company | Méthode de traitement augmenté par la lumière |
| JP2023057423A (ja) * | 2021-10-11 | 2023-04-21 | 国立大学法人 熊本大学 | ムコール症治療薬 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8329043D0 (en) * | 1983-10-31 | 1983-11-30 | Hider R C | Pharmaceutical compositions |
| US4698431A (en) * | 1985-11-12 | 1987-10-06 | The United States Of America As Represented By The United States Department Of Energy | Hydroxypyridonate chelating agents |
| TW349870B (en) * | 1993-09-30 | 1999-01-11 | Janssen Pharmaceutica Nv | An antifungal pharmaceutical composition for oral administration and a process for the preparation thereof |
| TW533205B (en) * | 1996-06-25 | 2003-05-21 | Novartis Ag | Substituted 3,5-diphenyl-l,2,4-triazoles and their pharmaceutical composition |
| WO1999009997A1 (fr) * | 1997-08-26 | 1999-03-04 | Board Of Regents, The University Of Texas System | Edta et autres agents chelatants associes ou non a des agents antimicrobiens, antifongiques, utilises pour la prevention et le traitement des mycoses |
| DE50111949D1 (de) * | 2000-12-16 | 2007-03-15 | Alstom Technology Ltd | Komponente einer Strömungsmaschine |
| GB0223978D0 (en) | 2002-10-15 | 2002-11-20 | Novartis Ag | Organic compound |
| ITMI20022447A1 (it) * | 2002-11-19 | 2004-05-20 | Carlo Ghisalberti | Uso di piridinoni nel trattamento della purpura capillare ed affezioni cutanee correlate. |
| TW200503781A (en) * | 2002-12-31 | 2005-02-01 | Nektar Therapeutics | Aerosolizable pharmaceutical formulation for fungal infection therapy |
| WO2004108114A2 (fr) * | 2003-03-31 | 2004-12-16 | Dinesh Shantilal Patel | Composition antifongique et son procede de fabrication |
| DE10356409B4 (de) * | 2003-11-28 | 2006-12-28 | Biofrontera Discovery Gmbh | Neues Arzneimittel Oxachelin und Derivate |
-
2007
- 2007-07-12 TW TW096125466A patent/TWI448285B/zh not_active IP Right Cessation
- 2007-07-12 CL CL200702026A patent/CL2007002026A1/es unknown
- 2007-07-13 RU RU2009104961/15A patent/RU2464024C2/ru not_active IP Right Cessation
- 2007-07-13 CA CA002657634A patent/CA2657634A1/fr not_active Abandoned
- 2007-07-13 EP EP07796874A patent/EP2043636A2/fr not_active Withdrawn
- 2007-07-13 AU AU2007272781A patent/AU2007272781B2/en not_active Ceased
- 2007-07-13 KR KR1020097002793A patent/KR20090036587A/ko not_active Ceased
- 2007-07-13 NZ NZ574862A patent/NZ574862A/en not_active IP Right Cessation
- 2007-07-13 MX MX2009000506A patent/MX2009000506A/es not_active Application Discontinuation
- 2007-07-13 BR BRPI0714221-8A patent/BRPI0714221A2/pt not_active IP Right Cessation
- 2007-07-13 WO PCT/US2007/016065 patent/WO2008008537A2/fr not_active Ceased
- 2007-07-13 US US12/373,511 patent/US20100129434A1/en not_active Abandoned
- 2007-07-13 EP EP11003922A patent/EP2412371A1/fr not_active Withdrawn
- 2007-07-13 JP JP2009519562A patent/JP2009543788A/ja active Pending
- 2007-07-13 SG SG2011075421A patent/SG177122A1/en unknown
-
2009
- 2009-01-08 IL IL196389A patent/IL196389A0/en unknown
- 2009-01-12 TN TN2009000004A patent/TN2009000004A1/fr unknown
- 2009-02-04 MA MA31613A patent/MA30625B1/fr unknown
- 2009-02-05 NO NO20090565A patent/NO20090565L/no not_active Application Discontinuation
-
2012
- 2012-11-27 JP JP2012258262A patent/JP2013040212A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| RU2464024C2 (ru) | 2012-10-20 |
| SG177122A1 (en) | 2012-01-30 |
| EP2043636A2 (fr) | 2009-04-08 |
| CA2657634A1 (fr) | 2008-01-17 |
| AU2007272781B2 (en) | 2012-10-18 |
| NZ574862A (en) | 2012-02-24 |
| JP2009543788A (ja) | 2009-12-10 |
| TWI448285B (zh) | 2014-08-11 |
| US20100129434A1 (en) | 2010-05-27 |
| CL2007002026A1 (es) | 2008-06-06 |
| WO2008008537A3 (fr) | 2008-04-24 |
| TW200816994A (en) | 2008-04-16 |
| MX2009000506A (es) | 2009-05-20 |
| EP2412371A1 (fr) | 2012-02-01 |
| AU2007272781A1 (en) | 2008-01-17 |
| IL196389A0 (en) | 2009-09-22 |
| TN2009000004A1 (en) | 2010-08-19 |
| JP2013040212A (ja) | 2013-02-28 |
| NO20090565L (no) | 2009-03-30 |
| WO2008008537A2 (fr) | 2008-01-17 |
| KR20090036587A (ko) | 2009-04-14 |
| BRPI0714221A2 (pt) | 2013-01-01 |
| RU2009104961A (ru) | 2010-08-20 |
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