[go: up one dir, main page]

MA24632A1 - DERIVATIVES OF 2- (4-ARYL-OR HETEROARYL-PIPERAZINE-1-YLMETHYLE) -1H- INDOLE - Google Patents

DERIVATIVES OF 2- (4-ARYL-OR HETEROARYL-PIPERAZINE-1-YLMETHYLE) -1H- INDOLE

Info

Publication number
MA24632A1
MA24632A1 MA25210A MA25210A MA24632A1 MA 24632 A1 MA24632 A1 MA 24632A1 MA 25210 A MA25210 A MA 25210A MA 25210 A MA25210 A MA 25210A MA 24632 A1 MA24632 A1 MA 24632A1
Authority
MA
Morocco
Prior art keywords
ylmethyle
indole
piperazine
heteroaryl
aryl
Prior art date
Application number
MA25210A
Other languages
French (fr)
Inventor
Anton Franz Josef Fliri
Stevin Howard Zorn
Mark Jerome Majchrzak
Patricia Ann Seymour
Hans Rollema
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of MA24632A1 publication Critical patent/MA24632A1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Anesthesiology (AREA)
  • Addiction (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
MA25210A 1997-08-15 1998-08-12 DERIVATIVES OF 2- (4-ARYL-OR HETEROARYL-PIPERAZINE-1-YLMETHYLE) -1H- INDOLE MA24632A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5576497P 1997-08-15 1997-08-15

Publications (1)

Publication Number Publication Date
MA24632A1 true MA24632A1 (en) 1999-04-01

Family

ID=22000003

Family Applications (1)

Application Number Title Priority Date Filing Date
MA25210A MA24632A1 (en) 1997-08-15 1998-08-12 DERIVATIVES OF 2- (4-ARYL-OR HETEROARYL-PIPERAZINE-1-YLMETHYLE) -1H- INDOLE

Country Status (30)

Country Link
EP (1) EP1003739A2 (en)
JP (1) JP2002536291A (en)
KR (1) KR20010022507A (en)
CN (1) CN1265660A (en)
AP (1) AP9801321A0 (en)
AR (1) AR017019A1 (en)
AU (1) AU8457298A (en)
BG (1) BG104069A (en)
BR (1) BR9811557A (en)
CA (1) CA2297486C (en)
CO (1) CO4960656A1 (en)
DZ (1) DZ2583A1 (en)
EA (1) EA200000023A1 (en)
HR (1) HRP980441A2 (en)
HU (1) HUP0003425A3 (en)
ID (1) ID23803A (en)
IL (1) IL133960A0 (en)
IS (1) IS5336A (en)
MA (1) MA24632A1 (en)
NO (1) NO20000722D0 (en)
OA (1) OA11286A (en)
PA (1) PA8457001A1 (en)
PE (1) PE106299A1 (en)
PL (1) PL338947A1 (en)
SK (1) SK1352000A3 (en)
TN (1) TNSN98151A1 (en)
TR (1) TR200000414T2 (en)
UY (1) UY25144A1 (en)
WO (1) WO1999009025A2 (en)
ZA (1) ZA987304B (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE278670T1 (en) * 1997-10-27 2004-10-15 Neurosearch As HETEROARYL DIAZACYCLOALKANES AS CHOLINERGIC LIGANDS FOR NICOTINE-ACETYLCHOLINE RECEPTORS
EP0953567A3 (en) * 1998-04-29 2003-04-02 Pfizer Products Inc. Bicyclic substituted piperazine-, piperidine- and tetrahydropyridine derivatives, their preparation and their use as agents with central dopaminergic (dopamine D4 receptor) activity
PL355502A1 (en) 1999-12-30 2004-05-04 H.Lundbeck A/S 4-phenyl-1-piperazinyl, -piperidinyl and -tetrahydropyridyl derivatives
GB0017952D0 (en) * 2000-07-22 2000-09-13 Univ Manchester Treatment of dyskinesia
EP1177792A3 (en) 2000-07-27 2002-10-23 Pfizer Products Inc. Dopamine D4 Ligands for the treatment of novelty-seeking disorders
US6803362B2 (en) 2001-03-09 2004-10-12 Ortho-Mcneil Pharmaceutical Inc. Heterocyclic compounds
CN1694704A (en) 2002-09-06 2005-11-09 詹森药业有限公司 Use of (1H-benzimidazole-2-yl)-(piperazineyl)- ketaderavitive and correlative compound used as histamine H4 receptor antagonist for the treatment of allergy and asthma
WO2004108671A1 (en) * 2003-06-06 2004-12-16 Suven Life Sciences Limited Substituted indoles with serotonin receptor affinity, process for their preparation and pharmaceutical compositions containing them
EP1731505B1 (en) 2004-03-30 2015-01-14 Takeda Pharmaceutical Company Limited Alkoxyphenylpropanoic acid derivatives
US7618980B2 (en) 2004-07-14 2009-11-17 Bristol-Myers Squibb Company Pyrrolo(oxo)quinolines as 5HT ligands
US7572805B2 (en) 2004-07-14 2009-08-11 Bristol-Myers Squibb Company Pyrrolo(oxo)isoquinolines as 5HT ligands
JO2769B1 (en) * 2005-10-26 2014-03-15 جانسين فارماسوتيكا ان. في Fast Dissociting Dopamine 2 Receptor Antagonists
JO2642B1 (en) 2006-12-08 2012-06-17 جانسين فارماسوتيكا ان. في Fast Dissociating Dopamine 2 Receptor Antagonists
JO2849B1 (en) 2007-02-13 2015-03-15 جانسين فارماسوتيكا ان. في Fast -Dissociating Dopamine 2 Receptor Antagonists
CA2682671C (en) 2007-04-23 2015-11-17 Janssen Pharmaceutica N.V. Thia(dia)zoles as fast dissociating dopamine 2 receptor antagonists
PL2148873T3 (en) 2007-04-23 2013-01-31 Janssen Pharmaceutica Nv 4-alkoxypyridazine derivatives as fast dissociating dopamine 2 receptor antagonists
AU2009266001B2 (en) 2008-07-03 2014-03-27 Janssen Pharmaceutica Nv Substituted 6- (1-piperazinyl) -pyridazines as 5-HT6 receptor antagonists
AU2009275887B2 (en) 2008-07-31 2013-06-20 Janssen Pharmaceutica Nv Piperazin-1-yl-trifluoromethyl-substituted-pyridines as fast dissociating dopamine 2 receptor antagonists
EP3686196B1 (en) * 2017-09-20 2024-06-12 Hangzhou Innogate Pharma Co., Ltd. Polycyclic compound acting as ido inhibitor and/or ido-hdac dual inhibitor
AU2021259580A1 (en) * 2020-04-22 2022-11-24 Anima Biotech Inc. Collagen 1 translation inhibitors and methods of use thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB944443A (en) * 1959-09-25 1900-01-01
AU653855B2 (en) * 1991-07-03 1994-10-13 Pharmacia & Upjohn Company Indolyl carbonyl pyridinyl-poperazine/piperidine derivatives
JPH05255089A (en) * 1991-12-18 1993-10-05 Sanwa Kagaku Kenkyusho Co Ltd Antiviral agent
CA2146018A1 (en) * 1992-10-23 1994-05-11 Paul David Leeson Dopamine receptor subtype ligands
AU6215594A (en) * 1993-03-18 1994-10-11 Merck Sharp & Dohme Limited Indole derivatives as dopamine d4 antagonists
GB9305644D0 (en) * 1993-03-18 1993-05-05 Merck Sharp & Dohme Therapeutic agents
US5814644A (en) * 1993-04-15 1998-09-29 Merck Sharp & Dohme, Ltd. Indole derivatives as dopamine D4 antagonists
DE4414113A1 (en) * 1994-04-22 1995-10-26 Merck Patent Gmbh 3-indolylpiperidines
TW406075B (en) * 1994-12-13 2000-09-21 Upjohn Co Alkyl substituted piperidinyl and piperazinyl anti-AIDS compounds
ZA968661B (en) * 1995-11-17 1998-04-14 Upjohn Co Oxazolidinone antibacterial agent with tricyclic substituents.
TW504510B (en) * 1996-05-10 2002-10-01 Janssen Pharmaceutica Nv 2,4-diaminopyrimidine derivatives

Also Published As

Publication number Publication date
NO20000722L (en) 2000-02-14
BR9811557A (en) 2000-08-22
ID23803A (en) 2000-05-11
ZA987304B (en) 2000-02-14
WO1999009025A2 (en) 1999-02-25
AR017019A1 (en) 2001-08-22
AP9801321A0 (en) 2000-02-14
TNSN98151A1 (en) 2005-03-15
CA2297486A1 (en) 1999-02-25
CN1265660A (en) 2000-09-06
NO20000722D0 (en) 2000-02-14
DZ2583A1 (en) 2003-02-22
EA200000023A1 (en) 2000-08-28
UY25144A1 (en) 2000-12-29
CA2297486C (en) 2005-05-03
KR20010022507A (en) 2001-03-15
OA11286A (en) 2003-10-22
PA8457001A1 (en) 2000-09-29
HRP980441A2 (en) 1999-04-30
TR200000414T2 (en) 2000-08-21
PL338947A1 (en) 2000-12-04
IL133960A0 (en) 2001-04-30
WO1999009025A3 (en) 1999-04-15
CO4960656A1 (en) 2000-09-25
SK1352000A3 (en) 2000-08-14
JP2002536291A (en) 2002-10-29
IS5336A (en) 2000-01-11
EP1003739A2 (en) 2000-05-31
BG104069A (en) 2001-05-31
AU8457298A (en) 1999-03-08
HUP0003425A2 (en) 2001-10-28
PE106299A1 (en) 1999-11-02
HUP0003425A3 (en) 2002-02-28

Similar Documents

Publication Publication Date Title
PT994890E (en) BENZIMIDAZOLE DERIVATIVES
MA24632A1 (en) DERIVATIVES OF 2- (4-ARYL-OR HETEROARYL-PIPERAZINE-1-YLMETHYLE) -1H- INDOLE
PT1005446E (en) N-AROYLPHENYLALANINE DERIVATIVES
ATE426598T1 (en) EPOTHILONE DERIVATIVES
ATE235220T1 (en) RESOCINE DERIVATIVES
ID22781A (en) Nicotynamide derivatives
DE69817186D1 (en) DIAMINORHODAMIN DERIVATIVES
PT915088E (en) D-PROLINA DERIVATIVES
PT1000048E (en) SUBSTITUTED DERIVATIVES OF 1,2,3,4-TETRAHYDROFOLATALENE
DK0842143T3 (en) 2- (4-substituted) -benzylamino-2-methyl-propanamide derivatives
ATE255098T1 (en) SUBSTITUTED CHROMEDER DERIVATIVES
PT921125E (en) DERIVATIVES OF 1,38-TRIAZA-ESPIRO 4,5 DECAN-4-ONA
PT1003719E (en) N-SULFONYL-GLYCINALQUINYLXXYLENEEMETHYLAMIDE MICROBICIDARY DERIVATIVES
PT869121E (en) PROPANOLAMINE HIPOLIPIDEMIC DERIVATIVES
PT1027362E (en) 2-HALOGEN-6-O-SUBSTITUTED CETOLID DERIVATIVES
DE69841086D1 (en) 5-deoxy-cytidine derivatives
ATE255099T1 (en) SUBSTITUTED CHROMEDER DERIVATIVES
PT966437E (en) 5-AROILNAPHALAL DERIVATIVES
DE69829682D1 (en) CIS-DISUBSTITUTED AMINOCYCLOALKYL-PYRROLIDINE DERIVATIVES
MA26480A1 (en) PHENOXYMETHYLPIPERIDINE DERIVATIVES
DE69828780D1 (en) AMIDINOCAMPTPTHECIN DERIVATIVES
PT1178984E (en) DERIVATIVES OF 1-TRIFLUOROMETHYL-4-HYDROXY-7-PIPERIDINYLAMIMOME
DK1030850T3 (en) Azoline derivatives
MA26756A1 (en) THIAZOLE DERIVATIVES
DE69710921D1 (en) HETEROCYCLIC SUBSTITUTED PYRROLIDINAMIDE DERIVATIVES