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Tahiri-Alaoui et al., 2002 - Google Patents

High affinity nucleic acid aptamers for streptavidin incorporated into bi-specific capture ligands

Tahiri-Alaoui et al., 2002

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Document ID
18392496921608195304
Author
Tahiri-Alaoui A
Frigotto L
Manville N
Ibrahim J
Romby P
James W
Publication year
Publication venue
Nucleic acids research

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Abstract We have isolated 2′-Fluoro-substituted RNA aptamers that bind to streptavidin (SA) with an affinity around 7±1.8 nM, comparable with that of recently described peptide aptamers. Binding to SA was not prevented by prior saturation with biotin, enabling nucleic …
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