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Heinrich et al., 2013 - Google Patents

Synthesis and structure–activity relationships for 1-(4-(piperidin-1-ylsulfonyl) phenyl) pyrrolidin-2-ones as novel non-carboxylate inhibitors of the aldo-keto reductase …

Heinrich et al., 2013

Document ID
15588263978208144457
Author
Heinrich D
Flanagan J
Jamieson S
Silva S
Rigoreau L
Trivier E
Raynham T
Turnbull A
Denny W
Publication year
Publication venue
European journal of medicinal chemistry

External Links

Snippet

High expression of the aldo-keto reductase enzyme AKR1C3 in the human prostate and breast has implicated it in the development and progression of leukemias and of prostate and breast cancers. Inhibitors are thus of interest as potential drugs. Most inhibitors of …
Continue reading at www.sciencedirect.com (other versions)

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    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with heteroatoms or with carbon atoms having three bonds to hetero atoms, with at the most one to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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