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Nielsen, 2001 - Google Patents

Peptide nucleic acid targeting of double-stranded DNA

Nielsen, 2001

Document ID
13011795774115113366
Author
Nielsen P
Publication year
Publication venue
Methods in Enzymology

External Links

Snippet

Publisher Summary The DNA mimic PNA (peptide nucleic acid) was originally conceived and designed as a DNA major groove-binding ligand mimicking triple helix-forming oligonucleotides. In a chemical sense PNA oligomers are much more closely related to …
Continue reading at www.sciencedirect.com (other versions)

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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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