White et al., 1982 - Google Patents
Iron enhances the bactericidal action of streptonigrinWhite et al., 1982
- Document ID
- 11998169684261920350
- Author
- White J
- Yeowell H
- Publication year
- Publication venue
- Biochemical and Biophysical Research Communications
External Links
Snippet
The lethal action of streptonigrin on strains of Escherichia coli is greatly enhanced by citrate (10− 2 M). Desferrioxamine (2× 10− 4 M), when added with streptonigrin and citrate, eliminates the citrate enhancement. These observations point to a role for iron in the …
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
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