[go: up one dir, main page]

Ajo-Franklin et al., 2023 - Google Patents

Creation of a Self-Powered, Real-Time Sensor for Therapeutics in Blood: from Protein Engineering to Electronic Integration

Ajo-Franklin et al., 2023

View PDF
Document ID
11367103998643047983
Author
Ajo-Franklin C
Cai R
Ngwadom C
Saxena R
Soman J
Bruggeman C
Hickey D
Verduzco R
Publication year

External Links

Snippet

Precision medicine is expected to revolutionize healthcare by prioritizing accuracy and e cacy over the traditional" one-ts-all" approach. Point-of-care (POC) sensors, which are low- cost and user-friendly, play a crucial role in driving this trend by providing quick results for …
Continue reading at assets-eu.researchsquare.com (PDF) (other versions)

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
    • C12Q1/006—Enzyme electrodes involving specific analytes or enzymes for glucose
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electro-chemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electro-chemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

Similar Documents

Publication Publication Date Title
Cai et al. Creation of a point-of-care therapeutics sensor using protein engineering, electrochemical sensing and electronic integration
Saunders et al. Extracellular DNA promotes efficient extracellular electron transfer by pyocyanin in Pseudomonas aeruginosa biofilms
Luong et al. Achievement and assessment of direct electron transfer of glucose oxidase in electrochemical biosensing using carbon nanotubes, graphene, and their nanocomposites
Lee et al. Construction of uniform monolayer-and orientation-tunable enzyme electrode by a synthetic glucose dehydrogenase without electron-transfer subunit via optimized site-specific gold-binding peptide capable of direct electron transfer
Yamashita et al. Direct electron transfer type disposable sensor strip for glucose sensing employing an engineered FAD glucose dehydrogenase
Lee et al. Biosensing and electrochemical properties of flavin adenine dinucleotide (FAD)-Dependent glucose dehydrogenase (GDH) fused to a gold binding peptide
Nieh et al. Amperometric biosensor based on reductive H2O2 detection using pentacyanoferrate-bound polymer for creatinine determination
Smutok et al. A novel mediatorless biosensor based on flavocytochrome b2 immobilized onto gold nanoclusters for non-invasive L-lactate analysis of human liquids
Wang et al. A multi-amplification aptasensor for highly sensitive detection of thrombin based on high-quality hollow CoPt nanoparticles decorated graphene
Fapyane et al. High performance enzyme fuel cells using a genetically expressed FAD-dependent glucose dehydrogenase α-subunit of Burkholderia cepacia immobilized in a carbon nanotube electrode for low glucose conditions
Agbo et al. Modeling dioxygen reduction at multicopper oxidase cathodes
Schlesinger et al. Electron transfer rate analysis of a site-specifically wired copper oxidase
Sowa et al. Direct electron transfer–type oxidoreductases for biomedical applications
JP6065649B2 (en) Highly active mutant of protein having laccase activity, nucleic acid molecule encoding the same, and use thereof
Algov et al. Use of protein engineering to elucidate electron transfer pathways between proteins and electrodes
Moehlenbrock et al. Bioelectrocatalytic oxidation of glucose in CNT impregnated hydrogels: advantages of synthetic enzymatic metabolon formation
Mugo et al. Integrated microcentrifuge carbon entrapped glucose oxidase poly (N-isopropylacrylamide)(pNIPAm) microgels for glucose amperometric detection
Zhao et al. A glucose/O2 biofuel cell as self-powered sensor for ultrasensitive microRNA detection based on CRISPR-Cas12a cleavage and duplex-specific nuclease-assisted target recycling
CN103472108A (en) Enzyme electrode
Zhang et al. Heterogeneous reconstitution of the PQQ-dependent glucose dehydrogenase immobilized on an electrode: A sensitive strategy for PQQ detection down to picomolar levels
Alferov et al. Electrical communication of cytochrome enriched Escherichia coli JM109 cells with graphite electrodes
Ajo-Franklin et al. Creation of a Self-Powered, Real-Time Sensor for Therapeutics in Blood: from Protein Engineering to Electronic Integration
Liu et al. Development of redox-active lyotropic lipid cubic phases for biosensing platforms
WO2006090873A1 (en) Fuel cell-type enzyme sensor
Durand et al. Effect of substrate inhibition and cooperativity on the electrochemical responses of glucose dehydrogenase. Kinetic characterization of wild and mutant types